Abstract:
:Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural features of bone are responsible for either the viscoelastic properties themselves, or for the changes in those properties that were observed with estrogen depletion. In this study, we examined the relationship between these viscoelastic mechanical properties and features involving bone architecture (BV/TV), materials parameters (ash density, %mineralization), and histologic evidence of remodeling (%remodeled, cement line interface). The extent of mineralization was inversely proportional to the material's efficiency in damping stress oscillations. The damping characteristics of bone material from ovariectomized animals were significantly more sensitive to variation in mineralization than was bone from control animals. At low frequencies (6 Hz or less), increased histologic evidence of remodeling was positively correlated with increased damping efficiency. However, the dramatic decreases in stress-rate sensitivity that accompanied 3-year ovariectomy were seen throughout the bone structure and occurred even in areas with little or no secondary Haversian remodeling as well as in areas of complete remodeling. Taken together, these data suggest that, while the mineral component may modify the viscoelastic behavior of bone, the basic mechanism underlying bone viscoelastic behavior, and of the changes in that behavior with estrogen depletion, reside in a non-mineral component of the bone that can be significantly altered in the absence of secondary remodeling.
journal_name
Bonejournal_title
Boneauthors
Les CM,Spence CA,Vance JL,Christopherson GT,Patel B,Turner AS,Divine GW,Fyhrie DPdoi
10.1016/j.bone.2004.04.006subject
Has Abstractpub_date
2004-09-01 00:00:00pages
729-38issue
3eissn
8756-3282issn
1873-2763pii
S8756328204001681journal_volume
35pub_type
杂志文章相关文献
BONE文献大全abstract:OBJECTIVE:The pathogenesis of osteonecrosis of the femoral head (ONFH) probably reflects multiple etiologies. Recent studies have explored associations between genetic mutations and/or polymorphisms and ONFH. Annexins (ANXs) have been implicated in many physiological functions, including blood coagulation, inflammation...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.03.670
更新日期:2009-07-01 00:00:00
abstract::Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which in most species is the predominant noncollagenous protein of bone and dentin, has been postulated to play roles in bone formation and remodeling. Recently, genetic studies showed that osteocalcin acts as an inhibitor of osteoblast function. Based on...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00092-1
更新日期:1998-09-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP)-immunoreactive sensory nerve terminals infiltrate all tissues including bone, in which CGRP may play a local regulatory role. To initiate studies on the role of this neuropeptide in bone, osteoblasts were isolated from fetal rat calvariae, treated with CGRP, and analyzed for cAMP...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(96)00017-8
更新日期:1996-04-01 00:00:00
abstract::The purpose of our study was to investigate the recovery of bone disease in celiac patients during 5 years of a gluten-free diet. The study group consisted of 28 newly diagnosed celiac patients (9 men, 19 women) recruited between 1990 and 1991. Six patients withdrew from the 5-year follow-up. Compliance with the glute...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/s8756-3282(99)00171-4
更新日期:1999-09-01 00:00:00
abstract::We previously reported the effects of cyclic therapy with etidronate (CTE) on periprosthetic bone mineral density (BMD) after cementless total hip arthroplasty (THA). This study aimed to evaluate the effects of withdrawal and intervention of CTE after cementless THA. The control group consisted of 24 patients without ...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.03.017
更新日期:2004-07-01 00:00:00
abstract::The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.004
更新日期:2012-03-01 00:00:00
abstract::The Mediterranean osteoporosis (MEDOS) study was carried out in 14 centres from six countries in Southern Europe to determine the incidence rates and risk factors associated with hip fracture over the age of 50 years. This paper discusses both the validity and relevance of the data, that is, whether the number of coll...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/8756-3282(93)90349-f
更新日期:1993-01-01 00:00:00
abstract::Large segmental defects of the weight bearing long bones are very difficult to reconstruct. Current treatment options are afflicted with several limitations and disadvantages. We describe a novel approach to regenerate a segmental long bone defect in a patient using a multiple disc graft. Decellularized bovine trabecu...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.02.011
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Skeletal loading and proper nutrition are necessary for optimal bone health. The appropriate amount of dietary protein to maximize skeletal health, however, is under constant debate. OBJECTIVE:To determine if 6 months of protein supplementation in conjunction with a strength and conditioning training progra...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2005.10.020
更新日期:2006-06-01 00:00:00
abstract::As the world's population ages, the occurrence of osteoporosis-related fractures is projected to increase. Low areal bone mineral density (aBMD), a well-known risk factor for fractures, may be influenced by physical activity (PA). In this cross-sectional study, we aimed to investigate potential associations between ob...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/j.bone.2015.07.001
更新日期:2015-12-01 00:00:00
abstract::To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knockout. Although suppression of the ligand to the ERs (i.e., estradiol) after menopause or gonadectomy in females...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00643-3
更新日期:2002-01-01 00:00:00
abstract::Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.11.025
更新日期:2015-04-01 00:00:00
abstract::The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.07.013
更新日期:2014-10-01 00:00:00
abstract::Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastati...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.05.010
更新日期:2009-09-01 00:00:00
abstract::An increase in procollagen type I amino-terminal propeptide (PINP) early after teriparatide initiation was shown to correlate with increased lumbar spine areal BMD and is a good predictor of the anabolic response to teriparatide. Few data exist correlating PINP and bone microstructure, and no data exist in patients on...
journal_title:Bone
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.bone.2016.05.004
更新日期:2016-08-01 00:00:00
abstract::Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss. The aim of this study was to assess the effects of prescribed walking programmes on bone mineral density (BMD) at the hip and spi...
journal_title:Bone
pub_type: 杂志文章,meta分析
doi:10.1016/j.bone.2008.05.012
更新日期:2008-09-01 00:00:00
abstract::Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.07.003
更新日期:2012-10-01 00:00:00
abstract::Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115659
更新日期:2021-02-01 00:00:00
abstract::Platelets play a key role in the replacement of the blood clot with granulation tissue during the early steps of bone regeneration. We hypothesized that activated platelets can neutralize locally produced reactive oxygen species, thereby protecting cells involved in granulation tissue formation. The potential of plate...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.01.015
更新日期:2005-04-01 00:00:00
abstract::The long-term protective effect of stronger back muscles on the spine was determined in 50 healthy white postmenopausal women, aged 58-75 years, 8 years after they had completed a 2 year randomized, controlled trial. Twenty-seven subjects had performed progressive, resistive back-strengthening exercises for 2 years an...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(02)00739-1
更新日期:2002-06-01 00:00:00
abstract::The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.02.010
更新日期:2019-05-01 00:00:00
abstract::The combination of PTH with OPG has been proposed as a potential therapy in patients with severe osteoporosis. In the present study, we examined the bone material of aged ovariectomized (OVX) rats treated either with PTH (1-34) or OPG alone or in combination of both. The micro- and nanostructural characteristics of th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.03.013
更新日期:2005-07-01 00:00:00
abstract::Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been deve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.09.020
更新日期:2014-12-01 00:00:00
abstract::Hypercalcemia results from an imbalance between the fluxes of calcium (Ca) entering and leaving the extracellular space. The two most important influxes are the net intestinal Ca absorption and the net skeletal Ca resorption, whereas the renal excretion represents the main route of elimination. When produced in excess...
journal_title:Bone
pub_type: 杂志文章,评审
doi:
更新日期:1987-01-01 00:00:00
abstract::The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90066-4
更新日期:1987-01-01 00:00:00
abstract::Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone Score (TBS) in addition to areal bone mineral density (aBMD) for fracture risk assessment has been documented in cross-sectional ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.06.007
更新日期:2015-10-01 00:00:00
abstract::The purpose was to investigate whether the reduction in bone mechanical strength induced by immobilization could be prevented by a bisphosphonate compound, clodronate. The torsional breaking strength of the tibia was measured using a specially constructed torsion machine. Maximum torque capacity, maximum angle of defo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)90302-6
更新日期:1994-05-01 00:00:00
abstract::Postmenopausal osteoporosis is characterized by a reduction in the numbers of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion suggesting a role of vascular component in the pathogenesis of osteoporosis. Previous studies have shown that bone formation and angiogenesis are positively co...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.12.003
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To compare the effects of TNF-α and IL-17A on osteogenic differentiation of isolated fibroblast-like synoviocytes (FLS) from healthy donors, osteoarthritis (OA) and rheumatoid arthritis (RA) patients. METHODS:FLS were cultured in osteogenic medium, with and without TNF-α and/or IL-17A. Extracellular matrix m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.04.008
更新日期:2016-06-01 00:00:00
abstract::Spinal cord injury (SCI) results in a dramatic loss of bone mineral and a marked increase in fracture incidence in the femur; however, its effect on the femur's geometric structure and strength is poorly studied. The primary purpose of the present study was to assess the geometric structure, composition, and strength ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.10.012
更新日期:2005-02-01 00:00:00