Abstract：
:We believe that the assembled data are consistent with the presence of mRNA species and/or proteins in pagetic bone that are recognized by some paramyxovirus antibodies and nucleic acid probes. The evidence presented so far is insufficient to substantiate claims for the "unequivocal" presence of paramyxovirus sequences in pagetic bone, because the molecular targets for these probes could be endogenous mRNA's and proteins rather than viruses. Positive reports of a viral presence in Paget's disease have so far been confined to two laboratories, both of which have consistently demonstrated evidence for the virus they have worked on most. We argue that independent replication of the aforementioned findings is necessary to conclude that pagetic bone can be considered a site of chronic paramyxovirus infection. For this to be convincing, we would expect to see colocalization of viral antigens, mRNA, and genomic RNA in cells that also show ultrastructural evidence of viral infection. If virus is indeed present, it should, in addition, be possible to clone and characterize extensive tracts of viral cDNA from samples of pagetic tissue. Although we acknowledge that the absence of evidence for viral mRNA in some RT-PCR studies does not constitute evidence of absence, the data implicating paramyxoviruses as causal agents is conflicting and insufficient to prove a cause-effect relationship. In view of this, we believe that the role of paramyxovirus infection as a cause Paget's disease remains uncertain.
journal_name
Bonejournal_title
Boneauthors
Ralston SH,Helfrich MHdoi
10.1016/s8756-3282(99)00032-0subject
Has Abstractpub_date
1999-05-01 00:00:00pages
17S-18Sissue
5 Suppleissn
8756-3282issn
1873-2763pii
S8756-3282(99)00032-0journal_volume
24pub_type
杂志文章,评审相关文献
BONE文献大全abstract：:Endochondral bone growth is abnormal in 6 of the 11 types of mucopolysaccharidoses (MPS) disorders; resulting in short stature, reduced size of the thoracic cavity and compromised manual dexterity. Current therapies for MPS have had a limited effect on bone growth and to improve these therapies or develop adjunct appr...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.115195
更新日期：2020-03-01 00:00:00
abstract：:Osteocytes, the most abundant cells in the cortical bone matrix, are thought to have mechanosensory and chemosensory regulatory roles. Marotti theorized that osteocytes signal to osteoblasts to recruit them into the osteocyte lineage. Martin extended this theory, assuming that osteocytes display a general inhibitory e...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(03)00245-x
更新日期：2003-11-01 00:00:00
abstract：:Osteocyte apoptosis precedes osteoclast resorption, and may act as a critical signal to trigger bone remodeling. While osteoclast precursors are known to travel via the circulation, the specific mechanisms by which they accumulate at remodeling sites are unclear. We hypothesized that osteocyte apoptosis mediates osteo...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.09.052
更新日期：2012-01-01 00:00:00
abstract：:Nearly all bone fractures in humans can deteriorate into a non-union fracture, often due to formation of fibrotic tissue. Cranial allogeneic bone grafts present a striking example: although seemingly attractive for craniofacial reconstructions, they often fail due to fibrosis at the host-graft junction, which physical...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.01.020
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Radiation treatment results in a severe diminution of osseous vascularity. Intermittent parathyroid hormone (PTH) has been shown to have an anabolic effect on osteogenesis, though its impact on angiogenesis remains unknown. In this murine model of distraction osteogenesis, we hypothesize that radiation treat...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.04.022
更新日期：2013-09-01 00:00:00
abstract：:The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2014.07.013
更新日期：2014-10-01 00:00:00
abstract：:Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2014.03.040
更新日期：2014-07-01 00:00:00
abstract：:Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.07.003
更新日期：2012-10-01 00:00:00
abstract：:Compounds, like beta-aminopropionitrile (bAPN) and homocysteine (hcys), are known to inhibit a stable matrix formation. Osteoblast-synthesized collagen matrix regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase, an enzyme involved in the collagen cross-linking process. ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.10.038
更新日期：2010-03-01 00:00:00
abstract：:Understanding the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the analysis of the mechanism of osseointegration, a requirement of long-term orthopedic implant stability. Clinically, the amount of bone ingrowth is variable, and cellular parameters that influence ingrowth have yet to be cle...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00077-0
更新日期：1999-05-01 00:00:00
abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.03.020
更新日期：2010-08-01 00:00:00
abstract：:Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that oxidizes the acetaldehyde produced by alcohol metabolism. This variant not only affects the response to alcohol but is also associated with several diseases, such as esophageal cancer, myocardial infarction, and particularly osteoporosis. In our previous study, we re...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115370
更新日期：2020-07-01 00:00:00
abstract：:Changes in skeletal remodeling (biochemical bone markers) and regional bone mineral density (spine, hip, and forearm bone mineral density [BMD]) were observed for 3 years in 20 patients (15 women and 5 men; age 54 +/- 11 years, range 29-69 years) after successful surgery for primary hyperparathyroidism (PHPT). Fifteen...
journal_title：Bone
pub_type： 临床试验,杂志文章
doi：10.1016/s8756-3282(99)00207-0
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2021.115842
更新日期：2021-01-07 00:00:00
abstract：:Interstitial bone fluid flow (IBFF) is suggested as a communication medium that bridges external physical signals and internal cellular activities in the bone, which thus regulates bone remodeling. Intramedullary pressure (ImP) is one main regulatory factor of IBFF and bone adaptation related mechanotransduction. Our ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2014.05.018
更新日期：2014-09-01 00:00:00
abstract：:The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(92)90455-6
更新日期：1992-01-01 00:00:00
abstract：:In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the a...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115448
更新日期：2020-09-01 00:00:00
abstract：:Osteoblasts are believed to differentiate into osteocytes, becoming embedded in bone, or to undergo apoptosis after the bone formation phase. The regulation of this terminal differentiation seems to be critical for bone homeostasis. However the mechanism remains unclear and there is no assay system currently available...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.09.001
更新日期：2013-01-01 00:00:00
abstract：:Sulfate conjugation is an important pathway in the metabolism of many drugs, xenobiotic compounds, and hormones. Sulfotransferases (SULTs) catalyze these reactions and have been detected and characterized in various human tissues including the liver and small intestine. Substrates for SULTs that include estrogen and t...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(01)00463-x
更新日期：2001-06-01 00:00:00
abstract：INTRODUCTION:Osteocalcin (OC) is the most abundant non-collagenous bone protein and is determinant for bone mineralization. We aimed to compare OC bone expression and serum factors related to its carboxylation in hip fragility fracture and osteoarthritis patients. We also aimed to identify which of these factors were a...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.08.129
更新日期：2012-12-01 00:00:00
abstract：:Cancer chemotherapy often causes significant bone loss, marrow adiposity and haematopoietic defects, yet the underlying mechanisms and recovery potential remain unclear. Wnt/β-catenin signalling is integral to the regulation of osteogenesis, adipogenesis and haematopoiesis; using a rat model, the current study investi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.03.027
更新日期：2012-06-01 00:00:00
abstract：:MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115757
更新日期：2021-02-01 00:00:00
abstract：:The lamellar bone's strength is mainly affected by the organization of its mineralized collagen fibers and material composition. In the present study, Raman microspectroscopic and imaging analyses were employed to study a normal human femoral midshaft bone cube-like specimen with a spatial resolution of approximately ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2007.04.200
更新日期：2007-09-01 00:00:00
abstract：:Mesenchymal stem cells (MSC) are defined as plastic-adherent, clonal cells that are common progenitors for osteoblasts and adipocytes. An inverse relationship between bone and fat has been observed in several clinical conditions and has been suggested to be caused by re-directing MSC differentiation into one particula...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.03.011
更新日期：2008-07-01 00:00:00
abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...
journal_title：Bone
pub_type： 杂志文章,多中心研究
doi：10.1016/j.bone.2006.10.024
更新日期：2007-04-01 00:00:00
abstract：:Interaction of the cytoplasmic adaptor molecule beta-arrestin2 with the activated parathyroid hormone (PTH)/PTHrP receptor inhibits G protein mediated signaling and triggers MAPKs signaling. In turn, the effects of both intermittent (i.) and continuous (c.) PTH on bone are altered in beta-arrestin2-deficient (Arrb2(-/...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.06.020
更新日期：2009-10-01 00:00:00
abstract：:Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level and are known to take part in the control of bone formation and bone resorption. In addi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2015.05.027
更新日期：2015-10-01 00:00:00
abstract：:Ovariectomized cynomolgus monkeys have previously been investigated as a nonhuman primate model of postmenopausal osteoporosis (Jerome et al., Bone Miner 9:527-540; 1994). In the present study, Fourier transform infrared microspectroscopy (FTIRM) was used to verify that differences in bone mineral quality and quantity...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(00)00362-8
更新日期：2000-10-01 00:00:00
abstract：:This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.11.019
更新日期：2007-04-01 00:00:00
abstract：:Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naïve (T...
journal_title：Bone
pub_type： 临床试验,杂志文章
doi：10.1016/j.bone.2013.11.011
更新日期：2014-02-01 00:00:00
