Raman imaging of two orthogonal planes within cortical bone.

abstract：:Anterior cruciate ligament (ACL) tears are a common sports-related knee injury that increases the risk of developing post-traumatic osteoarthritis (OA). During OA progression bone microarchitecture changes in the affected knee, however, little is known about bone microarchitecture in knees with early stage OA. The pur...

journal_title：Bone

authors： Kroker A,Bhatla JL,Emery CA,Manske SL,Boyd SK

更新日期：2018-06-01 00:00:00

abstract：:Previously we observed that capsaicin treatment in rats inhibited sensory neuropeptide signaling, with a concurrent reduction in trabecular bone formation and bone volume, and an increase in osteoclast numbers and bone resorption. Calcitonin-gene-related peptide (CGRP) is a neuropeptide richly distributed in sensory n...

journal_title：Bone

authors： Wang L,Shi X,Zhao R,Halloran BP,Clark DJ,Jacobs CR,Kingery WS

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts is involved in the progression of osteoarthritis (OA). Human osteoblasts isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/ß-catenin pathway, and a reduced mine...

journal_title：Bone

authors： Abed E,Bouvard B,Martineau X,Jouzeau JY,Reboul P,Lajeunesse D

更新日期：2015-06-01 00:00:00

abstract：:Tumor necrosis factor (TNF) actions in target tissues are mediated by various signalling pathways. The effect of TNF to stimulate resorption in fetal rat limb bones is not inhibited by indomethacin. The current studies were designed to assess the role of cyclic AMP (cAMP) and calcium as second messengers in this prost...

journal_title：Bone

authors： Shankar G,Stern PH

更新日期：1993-11-01 00:00:00

abstract：:To facilitate an understanding of the dependence of ultrasound velocity and attenuation upon the material and structural properties of cancellous bone, several theoretical concepts for ultrasound propagation have been adapted or developed, including the Biot theory and several scattering theories. Biot theory consider...

journal_title：Bone

authors： Haire TJ,Langton CM

更新日期：1999-04-01 00:00:00

abstract：:Fracture healing is influenced by numerous hormones, growth factors, and cytokines. The systemic administration of growth hormone (GH) has shown to accelerate bone regeneration. Local application of growth factors, such as insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta-1 (TGF-beta1), are know...

journal_title：Bone

authors： Schmidmaier G,Wildemann B,Heeger J,Gäbelein T,Flyvbjerg A,Bail HJ,Raschke M

更新日期：2002-07-01 00:00:00

abstract：:Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...

journal_title：Bone

authors： Fiorano-Charlier C,Ostertag A,Aquino JP,de Vernejoul MC,Baudoin C

更新日期：2002-07-01 00:00:00

abstract：:Low body weight is associated with an increased risk for osteoporosis and fractures, but the contribution of other lifestyle related factors have not been previously studied within lean elderly women. The present study evaluated the association between lifelong lifestyle factors and bone density, falls and postmenopau...

journal_title：Bone

authors： Korpelainen R,Korpelainen J,Heikkinen J,Väänänen K,Keinänen-Kiukaanniemi S

更新日期：2006-08-01 00:00:00

abstract：:We have recently cloned cathepsin K from a human bone cDNA library. Since cathepsins are proposed to be involved in the degradation of mineralized bone matrix, we have investigated, by in situ hybridization and immunocytochemistry, the expression of the cathepsin K mRNA transcripts and protein in sections of bone and ...

journal_title：Bone

authors： Littlewood-Evans A,Kokubo T,Ishibashi O,Inaoka T,Wlodarski B,Gallagher JA,Bilbe G

更新日期：1997-02-01 00:00:00

abstract：:Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteoporosis. However, a comprehensive in vivo assessment of intervention-related changes in multiple bone properties, and in multiple mouse strains, is required in order to identify an appropriate model for future evaluatio...

journal_title：Bone

authors： Roberts BC,Giorgi M,Oliviero S,Wang N,Boudiffa M,Dall'Ara E

更新日期：2019-10-01 00:00:00

abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

journal_title：Bone

authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Prior research on the ability of bisphosphonates to prevent fractures and related health care utilization has been based on high levels of compliance achievable in clinical trial settings. This study was undertaken to assess rates of osteoporotic fractures and health care utilization as a function of bisphos...

journal_title：Bone

authors： Briesacher BA,Andrade SE,Yood RA,Kahler KH

更新日期：2007-11-01 00:00:00

abstract：:Several studies have shown that treatment with bisphosphonates can reduce the pain associated with different painful diseases. In a previous study we demonstrated that in mice two bisphosponates, clodronate and pamidronate, had an antinociceptive effect under acute conditions not related to bone processes, after in ve...

journal_title：Bone

authors： Bonabello A,Galmozzi MR,Canaparo R,Serpe L,Zara GP

更新日期：2003-10-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the...

journal_title：Bone

authors： Tanaka M,Sakai A,Uchida S,Tanaka S,Nagashima M,Katayama T,Yamaguchi K,Nakamura T

更新日期：2004-06-01 00:00:00

abstract：:Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two major age-related skeletal disorders: osteoporosis and spondylosis. Analysis of th...

journal_title：Bone

authors： Ogata N,Matsumura Y,Shiraki M,Kawano K,Koshizuka Y,Hosoi T,Nakamura K,Kuro-O M,Kawaguchi H

更新日期：2002-07-01 00:00:00

abstract：:Tropomyosins are coiled-coil dimers that bind to the major groove of F-actin and regulate its accessibility to actin-modifying proteins. Although approximately 40 tropomyosin isoforms have been identified in mammals, they can broadly be classified into two groups based on protein size, that is, high molecular weight a...

journal_title：Bone

authors： Kotadiya P,McMichael BK,Lee BS

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

journal_title：Bone

authors： Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

更新日期：2020-09-01 00:00:00

abstract：:Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...

journal_title：Bone

authors： Lu Y,Alharbi M,Zhang C,O'Connor JP,Graves DT

更新日期：2019-06-01 00:00:00

abstract：:The magnetic resonance-guided focused ultrasound (MRgFUS) system uses MR imaging for real-time aiming of thermal ablation of bone and soft tissue tumors. Past clinical studies showed no increase in fracture rate after MRgFUS treatment. The purpose of this study was to determine the effect of MRgFUS treatment on mechan...

journal_title：Bone

authors： Herman A,Avivi E,Brosh T,Schwartz I,Liberman B

更新日期：2013-11-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) has been identified as a secretory protein encoded by an immediate early gene and is a member of the CCN family. In vitro CTGF directly regulates the proliferation and differentiation of chondrocytes; however, a previous study showed that it was localized only in the hypertrophic...

journal_title：Bone

authors： Fukunaga T,Yamashiro T,Oya S,Takeshita N,Takigawa M,Takano-Yamamoto T

更新日期：2003-12-01 00:00:00

abstract：:Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...

journal_title：Bone

authors： Adami S,Rossini M

更新日期：1992-01-01 00:00:00

abstract：:Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...

journal_title：Bone

authors： van Beek E,Oostendorp-van de Ruit M,van der Wee-Pals L,Bloys H,van de Bent C,Papapoulos S,Löwik C

更新日期：1995-07-01 00:00:00

abstract：:Bisphosphonates are a unique class of drugs. As a family, they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution, and elimination. Although all bisphosphonates have similar physicochemical p...

journal_title：Bone

authors： Lin JH

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...

journal_title：Bone

authors： Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：:FGF23 is an O-glycosylated circulating peptide hormone with a critical role in phosphate homeostasis; it is inactivated by cellular proprotein convertases in a pre-release degradative pathway. We have here examined the metabolism of FGF23 in a model bone cell line, IDG-SW3, prior to and following differentiation, as w...

journal_title：Bone

authors： Yamamoto H,Ramos-Molina B,Lick AN,Prideaux M,Albornoz V,Bonewald L,Lindberg I

更新日期：2016-03-01 00:00:00

abstract：:Disuse osteoporosis, which occurs commonly in prolonged bed rest and immobilization, is becoming a major problem in modern societies; however, the molecular mechanisms underlying unloading-driven bone loss have not been fully elucidated. The osteocyte network is considered to be an ideal mechanosensor and mechanotrans...

journal_title：Bone

authors： Wang Y,Liu W,Masuyama R,Fukuyama R,Ito M,Zhang Q,Komori H,Murakami T,Moriishi T,Miyazaki T,Kitazawa R,Yoshida CA,Kawai Y,Izumi S,Komori T

更新日期：2012-01-01 00:00:00

abstract：:Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...

journal_title：Bone

authors： Iwasaki Y,Kazama JJ,Yamato H,Fukagawa M

更新日期：2011-06-01 00:00:00

abstract：:Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early onset osteoporosis, or progressive spinal rigidit...

journal_title：Bone

authors： Maulding ND,Kavanagh D,Zimmerman K,Coppola G,Carpenter TO,Jue NK,Braddock DT

更新日期：2021-01-01 00:00:00

abstract：:Matrix extracellular phosphoglycoprotein (MEPE) is an extracellular matrix protein that was first detected in tumor-induced osteomalacia (TIO). Investigations in mice revealed that MEPE is expressed in bone and teeth in a maturation-dependent manner, reaching its maximum during mineralization. However, from knockout e...

journal_title：Bone

authors： Siggelkow H,Schmidt E,Hennies B,Hüfner M

更新日期：2004-08-01 00:00:00

abstract：:Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...

journal_title：Bone

authors： Hokugo A,Kanayama K,Sun S,Morinaga K,Sun Y,Wu Q,Sasaki H,Okawa H,Evans C,Ebetino FH,Lundy MW,Sadrerafi K,McKenna CE,Nishimura I

更新日期：2019-06-01 00:00:00