Abstract:
:Fracture healing is influenced by numerous hormones, growth factors, and cytokines. The systemic administration of growth hormone (GH) has shown to accelerate bone regeneration. Local application of growth factors, such as insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta-1 (TGF-beta1), are known to stimulate bone metabolism. Until now, the exact local and systemic mechanisms that lead to improved bone regeneration remain unclear. In addition, the effect of systemic administration of GH as compared with locally delivered growth factors on fracture healing in rats is not known. A midshaft fracture of the right tibia of 5-month-old female Sprague-Dawley rats (n = 80) was intramedullary stabilized with IGF-1 and TGF-beta1 coated vs. uncoated titanium K-wires. The growth factors were incorporated in a poly(D,L-lactide) (PDLLA) coating and released continuously throughout the experiment. Recombinant species-specific (rat) GH was applied systemically (2 mg/kg body weight) by daily subcutaneous injection and compared with a placebo group. The healing process was radiologically monitored. Twenty-eight days after fracture biomechanical torsional testing was performed. The consolidation and callus composition, including quantification of cartilage and mineralized tissue, was traced in histomorphometrical investigations using an image analysis system. Both methods, the systemic administration of GH and the local application of growth factors, showed significant biomechanical and histological effects on fracture healing. The local growth factor application showed a stronger effect on fracture healing than the systemic GH injection. The combined application of both methods did not accelerate the effect on bone healing compared with the single application. It is therefore concluded that combining local and systemic stimulating methods does not provide further additive effects with regard to fracture healing.
journal_name
Bonejournal_title
Boneauthors
Schmidmaier G,Wildemann B,Heeger J,Gäbelein T,Flyvbjerg A,Bail HJ,Raschke Mdoi
10.1016/s8756-3282(02)00798-6subject
Has Abstractpub_date
2002-07-01 00:00:00pages
165-72issue
1eissn
8756-3282issn
1873-2763pii
S8756328202007986journal_volume
31pub_type
杂志文章相关文献
BONE文献大全abstract::Oral bisphosphonates are established therapeutics for postmenopausal osteoporosis. Alternative, simplified dosing regimens that improve tolerability and promote convenience may be advantageous. Ibandronate is a highly potent, nitrogen-containing bisphosphonate that can be administered as a convenient intravenous (i.v....
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.01.007
更新日期:2004-05-01 00:00:00
abstract::Microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1), or Taybi-Linder syndrome is characterized by distinctive skeletal dysplasia, severe intrauterine and postnatal growth retardation, microcephaly, dysmorphic features, and neurological malformations. It is an autosomal recessive disorder caused by homozyg...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.023
更新日期:2016-11-01 00:00:00
abstract::Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115615
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:Studies on the association of vitamin D and bone mineral density (BMD) in adolescence and young adults have shown contrasting results. None of these studies have examined the course and baseline in vitamin D intake. The purpose of this study was to examine the association between baseline and the course of...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.10.055
更新日期:2009-03-01 00:00:00
abstract::It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis o...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00180-l
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:X-linked hypophosphatemia (XLH) causes rickets, osteomalacia, skeletal deformities and growth impairment, due to elevated fibroblast growth factor 23 and hypophosphatemia. Conventional therapy requires high doses of phosphate salts combined with active vitamin D analogues. Risks of this regimen include nephr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.06.025
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Episodic flare-ups of fibrodysplasia ossificans progressiva (FOP) are characterized clinically by severe, often posttraumatic, connective tissue swelling and intramuscular edema, followed histologically by an intense and highly angiogenic fibroproliferative reaction. This early inflammatory and angiogenic fi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.08.023
更新日期:2018-04-01 00:00:00
abstract::Osteocytes are suggested to play a central role in bone remodeling. Evaluation of iliac crest biopsies is a standard procedure for evaluating bone conditions in the clinical setting. Despite the widespread use of such biopsies, little is known about the population of osteocytes in the iliac crest from normal individua...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.07.003
更新日期:2016-10-01 00:00:00
abstract::The role of prostaglandins (PGs) in physiological remodeling has not yet been defined. The present study was undertaken to determine whether they intervene during the activation phase in a highly reproducible and synchronized model of bone remodeling. Indomethacin was employed to inhibit PG synthesis. This treatment t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90003-8
更新日期:1988-01-01 00:00:00
abstract::Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified cell culture model...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.008
更新日期:2018-12-01 00:00:00
abstract:CONTEXT:Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications to treat depression and anxiety. SSRIs exert their effects by inhibiting the serotonin transporter and modulating extracellular serotonin levels, a neurotransmitter that has been shown to affect bone metabolism in animals. Studi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.04.042
更新日期:2015-09-01 00:00:00
abstract::In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites. The information provided by each assessment will describe the clinical characteristics, fracture risk and epidemio...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2007.11.001
更新日期:2008-03-01 00:00:00
abstract::GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1 encoding a lysosomal β-galactosidase. This disease is a continuum from the severe infantile form with rapid neurological decline to the chronic adult form, which is not life-limiting. The intermediate or type 2 form can be further classifie...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115142
更新日期:2020-02-01 00:00:00
abstract::It was the aim of this retrospective analysis to examine the influence of low-dose monophasic oral contraceptives (OCs) on bone mineral density (BMD) of the femoral neck and of the spine in young female endurance athletes. Data on training intensity, dietary intake, menarche, menstrual cycle disorders, years of OC use...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.05.017
更新日期:2004-10-01 00:00:00
abstract::Osteoclasts form when hematopoietic cells are stimulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) or tumor necrosis factor-alpha (TNFalpha). Osteoclast precursors derive from M-CSF-dependent proliferating hematopoietic cells but cannot yet be purified from mixe...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00654-8
更新日期:2002-01-01 00:00:00
abstract::Although it is generally acknowledged that matrix vesicles and alkaline phosphatase are required for cartilage calcification, their precise role in initiation or propagation of mineralization remains controversial. We have investigated this problem in a neoplastic model of chondrogenesis, the Swarm rat chondrosarcoma....
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90036-1
更新日期:1988-01-01 00:00:00
abstract::It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(91)90011-7
更新日期:1991-01-01 00:00:00
abstract::In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90316-3
更新日期:1993-11-01 00:00:00
abstract::Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone Score (TBS) in addition to areal bone mineral density (aBMD) for fracture risk assessment has been documented in cross-sectional ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.06.007
更新日期:2015-10-01 00:00:00
abstract::This study is designed to test how intermittent application of prostaglandin E2 (PGE2) and risedronate (Ris) alone or in combination acts on the cancellous bone mass in estrogen-deficient rats. Sprague-Dawley rats were ovariectomized (ovx) or sham-ovx'd at 6 months of age. PGE2 (6mg/kg/d), Ris (5 micrograms/kg/twice a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00305-w
更新日期:1995-10-01 00:00:00
abstract:INTRODUCTION:The elderly population is growing fast worldwide, and therefore, investigation of health outcomes peculiar to these individuals is a public health priority nowadays. The decade between 2000 and 2010 is denominated as the Bone and Joint Decade, and researchers are encouraged to quantity the burden of muscul...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.04.002
更新日期:2005-08-01 00:00:00
abstract::Numerous studies have investigated the effects of physical activity on bone health; however, little is known about the effects of isokinetic strength training on bone. While bone mineral density (BMD) is widely used to assess bone health and fracture risk, there are several limitations of this measure that warrant new...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.07.004
更新日期:2007-10-01 00:00:00
abstract::Serum PINP has emerged as a reliable marker of bone turnover in humans and is routinely used to monitor bone formation. However, the effects of PTH (1-34) on bone turnover have not been evaluated following short-term treatment. We present data demonstrating that PINP is an early serum biomarker in the rat for assessin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.11.027
更新日期:2007-04-01 00:00:00
abstract::Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in the improvement of bone metabolism, the relationship between diet...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.01.020
更新日期:2011-05-01 00:00:00
abstract::Fibrillin-containing microfibrils are structural components of extracellular matrices of a diverse range of tissues, including bone. Their importance in bone biology is illustrated by the skeletal abnormalities manifest in the congenital disorder, Marfan syndrome, which results from mutations in the fibrillin-1 gene. ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00292-1
更新日期:2000-07-01 00:00:00
abstract::We previously reported the effects of cyclic therapy with etidronate (CTE) on periprosthetic bone mineral density (BMD) after cementless total hip arthroplasty (THA). This study aimed to evaluate the effects of withdrawal and intervention of CTE after cementless THA. The control group consisted of 24 patients without ...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.03.017
更新日期:2004-07-01 00:00:00
abstract::Osteoblast-like cells express receptors for various hormones and neurotransmitters that induce widespread actions in the bone to which intercellular communication and its modulation may contribute. Therefore, we examined the effects of the osteotropic hormones vitamin D3 (vitD3) and 17beta-estradiol (17beta-E2) as wel...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00142-2
更新日期:1998-12-01 00:00:00
abstract::Osteocyte apoptosis precedes osteoclast resorption, and may act as a critical signal to trigger bone remodeling. While osteoclast precursors are known to travel via the circulation, the specific mechanisms by which they accumulate at remodeling sites are unclear. We hypothesized that osteocyte apoptosis mediates osteo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.09.052
更新日期:2012-01-01 00:00:00
abstract::The topological changes in vertebral cancellous bone were estimated in vertebrae from calcium-restricted ovariectomized Sinclair S-1 minipigs, a recently described animal model of cancellous osteopenia. Connectivity was estimated using unbiased stereological principles in disector pairs of sections from the first lumb...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00116-u
更新日期:1995-06-01 00:00:00
abstract::We believe that the assembled data are consistent with the presence of mRNA species and/or proteins in pagetic bone that are recognized by some paramyxovirus antibodies and nucleic acid probes. The evidence presented so far is insufficient to substantiate claims for the "unequivocal" presence of paramyxovirus sequence...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(99)00032-0
更新日期:1999-05-01 00:00:00