Role of prostaglandins in bone resorption in a synchronized remodeling sequence in the rat.

abstract：:Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...

journal_title：Bone

authors： Durand M,Boire G,Komarova SV,Dixon SJ,Sims SM,Harrison RE,Nabavi N,Maria O,Manolson MF,Mizianty M,Kurgan L,de Brum-Fernandes AJ

更新日期：2011-03-01 00:00:00

abstract：:In the present study, we evaluated an autologous bone graft substitute (ABGS) composed of recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) used as a physiological carrier for new bone formation in spine fusion sheep models. The application of ABGS included cervical cage for use in the a...

journal_title：Bone

authors： Grgurevic L,Erjavec I,Gupta M,Pecin M,Bordukalo-Niksic T,Stokovic N,Vnuk D,Farkas V,Capak H,Milosevic M,Bubic Spoljar J,Peric M,Vuckovic M,Maticic D,Windhager R,Oppermann H,Sampath TK,Vukicevic S

更新日期：2020-09-01 00:00:00

abstract：:The temporal expression of bone microsomal casein kinase II, osteopontin, bone sialoprotein, alkaline phosphatase, and the accumulation of a solid calcium-inorganic orthophosphate mineral phase, have been charted from day 2 to day 21 during the repair of calvarial defects in rats induced by the implantation of decalci...

journal_title：Bone

authors： Wang J,Glimcher MJ,Mah J,Zhou HY,Salih E

更新日期：1998-06-01 00:00:00

abstract：:There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...

journal_title：Bone

authors： Li X,Shet K,Xu K,Rodríguez JP,Pino AM,Kurhanewicz J,Schwartz A,Rosen CJ

更新日期：2017-12-01 00:00:00

abstract：:Rodent models suggest that estradiol deficiency promotes bone loss through increasing interleukin-6 (IL-6) activity. However, it is controversial as to whether these findings are applicable to humans. To evaluate estradiol-mediated modulation of IL-6 activity in relation to bone metabolism in humans, we measured serum...

journal_title：Bone

authors： Chiu KM,Arnaud CD,Ju J,Mayes D,Bacchetti P,Weitz S,Keller ET

更新日期：2000-01-01 00:00:00

abstract：:The hypocalcemic and hypophosphatemic effect of salmon calcitonin (sCT) given by intranasal (i.n.) spray to 12 patients with histological confirmed primary hyperparathyroidism (1 degree HPT) was studied. The concentration of ionized calcium in whole blood (B-Ca++), serum phosphate (S-P), magnesium (S-Mg), plasma sCT (...

journal_title：Bone

authors： Tørring O,Bucht E,Sjöstedt U,Sjöberg HE

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the morphological changes that take place in the subchondral bone and calcified cartilage zone in the experimental anterior cruciate ligament (ACL) dog model of osteoarthritis (OA) and analyze concomitant changes in the level of MMP-13 and cathepsin K, as well as examine the therapeutic effects of...

journal_title：Bone

authors： Pelletier JP,Boileau C,Brunet J,Boily M,Lajeunesse D,Reboul P,Laufer S,Martel-Pelletier J

更新日期：2004-03-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the...

journal_title：Bone

authors： Tanaka M,Sakai A,Uchida S,Tanaka S,Nagashima M,Katayama T,Yamaguchi K,Nakamura T

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To investigate the effectiveness of the T-score values provided by Radiofrequency Echographic Multi Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures. METHODS:A population of Caucasian women (30-90 years), enrolled from 2013 to 2016, underwent dual X-ray absorpti...

journal_title：Bone

authors： Adami G,Arioli G,Bianchi G,Brandi ML,Caffarelli C,Cianferotti L,Gatti D,Girasole G,Gonnelli S,Manfredini M,Muratore M,Quarta E,Quarta L

更新日期：2020-05-01 00:00:00

abstract：:The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...

journal_title：Bone

authors： Okihana H,Shimomura Y

更新日期：1992-01-01 00:00:00

abstract：:Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or cli...

journal_title：Bone

authors： Uttarilli A,Shah H,Bhavani GS,Upadhyai P,Shukla A,Girisha KM

更新日期：2019-03-01 00:00:00

abstract：:Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we examined the effects o...

journal_title：Bone

authors： McGee-Lawrence ME,Carpio LR,Bradley EW,Dudakovic A,Lian JB,van Wijnen AJ,Kakar S,Hsu W,Westendorf JJ

更新日期：2014-09-01 00:00:00

abstract：:Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...

journal_title：Bone

authors： Nakano T,Kaibara K,Ishimoto T,Tabata Y,Umakoshi Y

更新日期：2012-10-01 00:00:00

abstract：:We report the establishment in vitro of three-dimensional (3D) cultures of human osteoblasts (hOB) derived from normal adults and supported uniquely by the extracellular matrix (ECM) they deposit. Osteoblasts were cultured in 3D cultures in vitro for up to 120 days. The 3D cultures, examined at 25, 31, and 48 days, ex...

journal_title：Bone

authors： Ferrera D,Poggi S,Biassoni C,Dickson GR,Astigiano S,Barbieri O,Favre A,Franzi AT,Strangio A,Federici A,Manduca P

更新日期：2002-05-01 00:00:00

abstract：:SAM-P/6 is a recently developed strain of osteoporotic mice. In this study we tried to determine whether calcium, vitamin D3, parathyroid hormone (PTH), and estrogen modified the peak bone mass of young SAM-P/6 mice, and whether the effect of these medications persisted after treatment had been discontinued. Calcium s...

journal_title：Bone

authors： Takahashi K,Tsuboyama T,Matsushita M,Kasai R,Okumura H,Yamamuro T,Okamoto Y,Kitagawa K,Takeda T

更新日期：1994-03-01 00:00:00

abstract：:Tooth eruption involves the movement of a tooth from its site of development within the alveolar bone to its functional position in the oral cavity. Because this process is dependent upon monocytes and formation of osteoclasts, it represents an excellent model for examination of these processes under developmental reg...

journal_title：Bone

authors： Graves DT,Alsulaimani F,Ding Y,Marks SC Jr

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. In children these interactions and modifying factors are largely unknown. PARTICIPANTS AND METHODS:This study evaluates temporal changes and modifiers of FGF23 concentrations from 12 to 24 months,...

journal_title：Bone

authors： Enlund-Cerullo M,Hauta-Alus H,Valkama S,Rosendahl J,Andersson S,Mäkitie O,Holmlund-Suila E

更新日期：2020-12-01 00:00:00

abstract：:Women with prevalent fractures have an increased risk of developing additional, incident fractures. This article examines the relation between the location of prevalent fractures within the spine and the risk of subsequent vertebral fractures. The subjects were 721 Japanese-American women of mean age 69.5 +/- 5.3 (SD)...

journal_title：Bone

authors： Davis JW,Grove JS,Wasnich RD,Ross PD

更新日期：1999-03-01 00:00:00

abstract：:We present a three-dimensional mineralizing model based on a hollow fiber bioreactor (HFBR) inoculated with primary osteoblasts isolated from embryonic chick calvaria. Using non-invasive magnetic resonance microscopy (MRM), the growth and development of the mineralized tissue around the individual fibers were monitore...

journal_title：Bone

authors： Chesnick IE,Avallone FA,Leapman RD,Landis WJ,Eidelman N,Potter K

更新日期：2007-04-01 00:00:00

abstract：:The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...

journal_title：Bone

authors： Puntila E,Kröger H,Lakka T,Honkanen R,Tuppurainen M

更新日期：1997-10-01 00:00:00

abstract：:Tropomyosins are coiled-coil dimers that bind to the major groove of F-actin and regulate its accessibility to actin-modifying proteins. Although approximately 40 tropomyosin isoforms have been identified in mammals, they can broadly be classified into two groups based on protein size, that is, high molecular weight a...

journal_title：Bone

authors： Kotadiya P,McMichael BK,Lee BS

更新日期：2008-11-01 00:00:00

abstract：:The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...

journal_title：Bone

authors： Zhuo Y,Gauthier JY,Black WC,Percival MD,Duong LT

更新日期：2014-10-01 00:00:00

abstract：:Bone is a nanocomposite consisting of two main components, nano-hydroxyapatite (n-HA) and Type I collagen (Col). The aim is to exploit the nano-scale functional and material characteristics of natural bone in order to modulate cellular functions for optimal bone repair in bone graft systems. Here, we present an effect...

journal_title：Bone

authors： Ngiam M,Liao S,Patil AJ,Cheng Z,Chan CK,Ramakrishna S

更新日期：2009-07-01 00:00:00

abstract：:In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...

journal_title：Bone

authors： Bollerslev J,Marks SC Jr,Pockwinse S,Kassem M,Brixen K,Steiniche T,Mosekilde L

更新日期：1993-11-01 00:00:00

abstract：:Bone has the unique capacity to heal without the formation of a fibrous scar, likely because several of the cellular and molecular processes governing bone healing recapitulate the events during skeletal development. A critical component in bone healing is the timely appearance of blood vessels in the fracture callus....

journal_title：Bone

authors： Stegen S,van Gastel N,Carmeliet G

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

journal_title：Bone

authors： Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

更新日期：2020-09-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...

journal_title：Bone

authors： Takaiwa M,Aya K,Miyai T,Hasegawa K,Yokoyama M,Kondo Y,Kodani N,Seino Y,Tanaka H,Morishima T

更新日期：2010-08-01 00:00:00

abstract：:Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS. Here we show that mutant mice carrying the activat...

journal_title：Bone

authors： Chen L,Li D,Li C,Engel A,Deng CX

更新日期：2003-08-01 00:00:00

abstract：:Combat-related heterotopic ossification (HO) has emerged as a common and problematic complication of modern wartime extremity injuries, contributing to substantial patient morbidity and loss of function. We have previously reported that HO-forming patients exhibit a more pronounced systemic and local inflammatory resp...

journal_title：Bone

authors： Davis TA,Lazdun Y,Potter BK,Forsberg JA

更新日期：2013-09-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is associated with increased reactive oxygen species (ROS), results from accumulation of misfolded/unfolded proteins, and can trigger apoptosis. ER stress is alleviated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which inhibits protein translation allowi...

journal_title：Bone

authors： Sato AY,Tu X,McAndrews KA,Plotkin LI,Bellido T

更新日期：2015-04-01 00:00:00