Abstract:
:It was the aim of this retrospective analysis to examine the influence of low-dose monophasic oral contraceptives (OCs) on bone mineral density (BMD) of the femoral neck and of the spine in young female endurance athletes. Data on training intensity, dietary intake, menarche, menstrual cycle disorders, years of OC use, and age at first OC use were determined by a self-report questionnaire. Only athletes performing regular endurance exercise for more than 3 years with more than 3 h of exercise per week were included in this study and underwent a clinical assessment including measurement of weight, height, spine, and hip BMD by dual-energy X-ray absorptiometry, and collection of a blood sample. The data from 75 regularly exercising endurance athletes aged 18-35 years (26.5 +/- 4.8 years) were initially included in this analysis. Six athletes were later excluded due to oligo-/amenorrhea. Subjects were allocated into the OC group when they reported OC use for more than 3 years in women younger than 22 years of age, or when they reported OC use for more than 50% of the time after menarche in women aged 22-35 years. There were no differences in age, weight, height, body mass index (BMI), body fat, menarche, training intensity, age at start of training, or any serum parameters between OC users (n = 31) and control subjects (n = 38). However, OC users had 7.9% lower spine BMD and 8.8% lower proximal femur BMD (P < 0.01 for both sites). When the relationship between BMD of the spine and OC use was further analyzed by a stepwise model of multiple regression analysis using OC years, age at OC initiation, BMI, and menarche as independent variables, age at first OC use was found to be the best predictor of vertebral BMD, while the only significant predictor of femoral neck BMD was BMI. We conclude that OC use is associated with decreased BMD of the spine and the femoral neck in female endurance athletes, and that early age at initiation of OC use may be an important risk factor for low peak bone mass in young women.
journal_name
Bonejournal_title
Boneauthors
Hartard M,Kleinmond C,Kirchbichler A,Jeschke D,Wiseman M,Weissenbacher ER,Felsenberg D,Erben RGdoi
10.1016/j.bone.2004.05.017subject
Has Abstractpub_date
2004-10-01 00:00:00pages
836-41issue
4eissn
8756-3282issn
1873-2763pii
S8756328204002091journal_volume
35pub_type
杂志文章相关文献
BONE文献大全abstract::Paralysis of the masticatory muscles using botulinum toxin (BTX) is a common treatment for cosmetic reduction of the masseters as well as for conditions involving muscle spasm and pain. The effects of this treatment on mastication have not been evaluated, and claims that the treatment unloads the jaw joint and mandibl...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.11.015
更新日期:2012-03-01 00:00:00
abstract::High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.02.022
更新日期:2011-06-01 00:00:00
abstract::One hundred Sprague-Dawley rats were ovariectomized (OVX) or sham-operated (Sham) at the age of 12 weeks. Eight or six animals from each group were sacrificed at the following time points: 0, 2, 4, 8, 16, 28, and 40 weeks. Mechanical testing of the bones showed that the maximal load of the femoral neck remained at the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00369-9
更新日期:1997-03-01 00:00:00
abstract::Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN), which is the most common bisphosphonate used for the treatment of osteopor...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.09.031
更新日期:2013-01-01 00:00:00
abstract::Global gene expression profiling has been used to study the molecular mechanisms of increased bone remodeling caused by PHPT. This disease is a model for chronic over-stimulation of target organs by PTH due to an inappropriate overproduction of the hormone. Hyperactivity of osteoblasts and osteoclasts lead to increase...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.12.020
更新日期:2006-07-01 00:00:00
abstract::The lung interfaces with atmospheric oxygen via a large surface area and is perfused by the entire venous return bearing waste products collected from the whole body. It is logical that the lung is endowed with generous anti-oxidative capacity derived both locally and from the circulation. The single-pass pleiotropic ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2017.03.047
更新日期:2017-07-01 00:00:00
abstract::On the basis of studies with bone-seeking isotopes, it is generally believed that the metabolic activity of osteoblasts of the trabecular bone is greater than that of the osteoblasts of the cortex. This implies that the oxidative activity, which provides the energy for biosyntheses, will also be greater in the former ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(89)90061-6
更新日期:1989-01-01 00:00:00
abstract::Approximately 7.9 million fractures occur annually in the United States with 5-10% of these resulting in delayed or impaired healing. Nearly half of the trauma cost of $56 billion per year is used for the treatment of fractures. More importantly, fracture results in a substantial reduction in the quality of life. New ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.06.037
更新日期:2011-11-01 00:00:00
abstract::Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical featur...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.12.003
更新日期:2013-03-01 00:00:00
abstract::The prediction of bone strength can be improved when determining bone mineral density (BMD) in combination with measures of trabecular microarchitecture. The goal of this study was to assess parameters of trabecular bone structure and texture of the calcaneus by clinical multi-detector row computed tomography (MDCT) i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.01.372
更新日期:2009-05-01 00:00:00
abstract::Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.08.109
更新日期:2008-12-01 00:00:00
abstract::Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(09)80010-0
更新日期:1992-01-01 00:00:00
abstract::Bone morphogenetic protein 2 (BMP2), a very potent bone-inducing agent, promotes the differentiation of bone marrow stem cells (BMSCs) to osteoblasts. However, the potency of BMP2 action is variable and its perturbed dynamic signaling pathways in human BMSCs has not been fully elucidated. In this study, we used a comb...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.02.013
更新日期:2010-06-01 00:00:00
abstract::This multicenter study assessed the safety and efficacy of teriparatide 20 microg/day in Japanese men and women with osteoporosis at high risk of fracture during a 12-month, randomized, double-blind, placebo-controlled treatment period followed by second and third treatment periods (to 18 and 24 months, respectively,)...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2010.05.022
更新日期:2010-09-01 00:00:00
abstract::Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.04.026
更新日期:2013-08-01 00:00:00
abstract::Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglobulin (Ig) superfamily, negatively regulates T cell activation. The deficiency of CTLA-4 induces profound ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.06.018
更新日期:2004-11-01 00:00:00
abstract::Matrix extracellular phosphoglycoprotein (MEPE) is an extracellular matrix protein that was first detected in tumor-induced osteomalacia (TIO). Investigations in mice revealed that MEPE is expressed in bone and teeth in a maturation-dependent manner, reaching its maximum during mineralization. However, from knockout e...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.033
更新日期:2004-08-01 00:00:00
abstract:INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.07.023
更新日期:2007-01-01 00:00:00
abstract::In an attempt to elucidate the biochemical defect in pseudoachondroplasia, proteoglycan metabolism was investigated in cartilage from a patient with the dominant form of this condition. Iliac-crest cartilage was radioactively labeled with 35S-sulfate and the newly synthesized proteoglycans examined for their hydrodyna...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90118-4
更新日期:1988-01-01 00:00:00
abstract::Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteoporosis. However, a comprehensive in vivo assessment of intervention-related changes in multiple bone properties, and in multiple mouse strains, is required in order to identify an appropriate model for future evaluatio...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.06.024
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The pathogenesis of osteonecrosis of the femoral head (ONFH) probably reflects multiple etiologies. Recent studies have explored associations between genetic mutations and/or polymorphisms and ONFH. Annexins (ANXs) have been implicated in many physiological functions, including blood coagulation, inflammation...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.03.670
更新日期:2009-07-01 00:00:00
abstract::Thanatophoric dysplasia (TD) is a lethal human bone dysplasia characterized by severe dwarfism. It pathogenesis is thought to involve an abnormal ossifying fibrous tissue that disrupts the skeletal growth plate. We employed a combined morphologic, immunohistochemical and biochemical approach to better define the natur...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90027-0
更新日期:1988-01-01 00:00:00
abstract::X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (ve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.09.004
更新日期:2004-01-01 00:00:00
abstract::Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(03)00112-1
更新日期:2003-09-01 00:00:00
abstract::Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from l-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of receptor activator of nuclear factor KappaB (RANKL)/osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.09.051
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The RANKL-OPG axis is a key regulator of osteoclastogenesis and bone turnover activity. Its contribution to bone resorption under altered mechanical states, however, has not been fully elucidated. Here we examined the role of OPG in regulating mechanically induced bone modeling in a rat model of orthodonti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.194
更新日期:2007-09-01 00:00:00
abstract::Osteocytes play an important role in signaling within bone. Communication of osteocytes with each other and with bone lining cells may have a function in mineral homeostasis and mechanotransduction. However, very little is known of the expression of ion channels in these cells. Using the whole-cell patch-clamp techniq...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00439-7
更新日期:2001-01-01 00:00:00
abstract::We report the establishment in vitro of three-dimensional (3D) cultures of human osteoblasts (hOB) derived from normal adults and supported uniquely by the extracellular matrix (ECM) they deposit. Osteoblasts were cultured in 3D cultures in vitro for up to 120 days. The 3D cultures, examined at 25, 31, and 48 days, ex...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00691-9
更新日期:2002-05-01 00:00:00
abstract::Metastatic bone disease has a major impact on the morbidity and mortality of breast cancer patients, and studies on bone metastasis biology have led to the development of the most widely used drugs for bone metastases treatment: zoledronate (Zol) and denosumab (Den). The aim of the present study was to assess the effe...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.06.017
更新日期:2014-09-01 00:00:00
abstract::Principal strains and their orientation, determined from in vivo and in situ strains recorded from the lateral cortical surface of the calcaneus of potoroos (a small marsupial) during treadmill exercise and tension applied via the Achilles tendon, were compared with the underlying trabecular architecture and its align...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(96)00116-0
更新日期:1996-07-01 00:00:00