Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans.

abstract：BACKGROUND:Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bon...

journal_title：Bone

authors： Romagnoli E,Cipriani C,Nofroni I,Castro C,Angelozzi M,Scarpiello A,Pepe J,Diacinti D,Piemonte S,Carnevale V,Minisola S

更新日期：2013-03-01 00:00:00

abstract：:Acceleration of remodeling activity after menopause leads to bone loss and fragility, however, whether this is associated with modifications of bone matrix quality has been less studied. The impact of variation in bone remodeling rate on bone matrix has been studied mainly in pathologies or anti-osteoporotic treatment...

journal_title：Bone

authors： Farlay D,Bala Y,Rizzo S,Bare S,Lappe JM,Recker R,Boivin G

更新日期：2019-11-01 00:00:00

abstract：:Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone Score (TBS) in addition to areal bone mineral density (aBMD) for fracture risk assessment has been documented in cross-sectional ...

journal_title：Bone

authors： Muschitz C,Kocijan R,Haschka J,Pahr D,Kaider A,Pietschmann P,Hans D,Muschitz GK,Fahrleitner-Pammer A,Resch H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Vertebral fractures are associated with persistent pain, disability and mortality. However, around two thirds of women with vertebral fractures are unaware of them. We aimed to analyze which factors could mostly be associated to the presence of vertebral fractures in post-menopausal women, and evaluate the effe...

journal_title：Bone

authors： Pizzato S,Trevisan C,Lucato P,Girotti G,Mazzochin M,Zanforlini BM,Bano G,Piovesan F,Bertocco A,Zoccarato F,Dianin M,Manzato E,Sergi G

更新日期：2018-08-01 00:00:00

abstract：:Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Several salient observations have emerged. Numerous studies have examined the relationship be...

journal_title：Bone

authors： Martineau P,Leslie WD

更新日期：2017-11-01 00:00:00

abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...

journal_title：Bone

authors： Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

更新日期：2010-08-01 00:00:00

abstract：:Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now al...

journal_title：Bone

authors： Simon D,Kleyer A,Englbrecht M,Stemmler F,Simon C,Berlin A,Kocijan R,Haschka J,Hirschmann S,Atreya R,Neurath MF,Sticherling M,Rech J,Hueber AJ,Engelke K,Schett G

更新日期：2018-11-01 00:00:00

abstract：:Osteoarthritis (OA) occurs naturally in cynomolgus macaques. The purposes of the present study were to: 1) develop histological measurement schemes to measure the cross-sectional area of axial and abaxial osteophytes in the proximal tibia; 2) determine the effects of long-term estrogen replacement therapy (ERT) on ost...

journal_title：Bone

authors： Olson EJ,Lindgren BR,Carlson CS

更新日期：2007-08-01 00:00:00

abstract：:Skeletal unloading in an animal hindlimb suspension model and microgravity experienced by astronauts or as a result of prolonged bed rest causes site-specific losses in bone mineral density of 1%-2% per month. This is accompanied by reductions in circulating levels of 1,25-(OH)(2)D(3), the active metabolite of vitamin...

journal_title：Bone

authors： Narayanan R,Smith CL,Weigel NL

更新日期：2002-09-01 00:00:00

abstract：:The potential of whole body vibration (WBV) to maintain or enhance musculoskeletal strength during ageing is of increasing interest, with both low and high magnitude WBV having been shown to maintain or increase bone mineral density (BMD) at the lumbar spine and femoral neck. The aim of this study was to determine how...

journal_title：Bone

authors： Spain L,Yang L,Wilkinson JM,McCloskey E

更新日期：2021-03-01 00:00:00

abstract：:The Euler number and the connectivity of an arbitrary object is defined, and it is illustrated why the connectivity of an n-dimensional object cannot be estimated in an (n-1)-dimensional section. The disector--principle for 3-D counting of the Euler--events is illustrated in cancellous bone. The correct handling for u...

journal_title：Bone

authors： Gundersen HJ,Boyce RW,Nyengaard JR,Odgaard A

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is a common surgical procedure for treatment of morbid obesity. RYGB induces considerable and sustained weight loss, and remission of obesity related-comorbidities. While studies have suggested negative effects of RYGB on bone health, long-term data are lacking. We aimed to ev...

journal_title：Bone

authors： Blom-Høgestøl IK,Hewitt S,Chahal-Kummen M,Brunborg C,Gulseth HL,Kristinsson JA,Eriksen EF,Mala T

更新日期：2019-10-01 00:00:00

abstract：:In elderly subjects and in particular in those with osteoporosis the evidence on age related volume changes of the hip is still very limited. Even less is known about bone changes of the femoral head. The aim of this study is to explore associations of bone size of the femoral head and neck with age in postmenopausal ...

journal_title：Bone

authors： Su Y,Wang L,Liu X,Yang M,Yi C,Liu Y,Huang P,Guo Z,Yu A,Cheng X,Wu X,Blake GM,Engelke K

更新日期：2020-10-01 00:00:00

abstract：:Thanatophoric dysplasia (TD) is a lethal human bone dysplasia characterized by severe dwarfism. It pathogenesis is thought to involve an abnormal ossifying fibrous tissue that disrupts the skeletal growth plate. We employed a combined morphologic, immunohistochemical and biochemical approach to better define the natur...

journal_title：Bone

authors： Horton WA,Hood OJ,Machado MA,Ahmed S,Griffey ES

更新日期：1988-01-01 00:00:00

abstract：:Death certification data has shown that death rates due to Paget's disease of bone and osteosarcoma in older people (assumed to be attributable to Paget's) declined in the latter part of the 19th and in the early 20th century, suggesting that there may be a secular trend toward less severe disease. We have reviewed a ...

journal_title：Bone

authors： Cundy T,McAnulty K,Wattie D,Gamble G,Rutland M,Ibbertson HK

更新日期：1997-01-01 00:00:00

abstract：:Runx2 and Axin2 regulate skeletal development. We recently determined that Axin2 and Runx2 molecularly interact in differentiating osteoblasts to regulate intramembranous bone formation, but the relationship between these factors in endochondral bone formation was unresolved. To address this, we examined the effects o...

journal_title：Bone

authors： McGee-Lawrence ME,Carpio LR,Bradley EW,Dudakovic A,Lian JB,van Wijnen AJ,Kakar S,Hsu W,Westendorf JJ

更新日期：2014-09-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) are defined as plastic-adherent, clonal cells that are common progenitors for osteoblasts and adipocytes. An inverse relationship between bone and fat has been observed in several clinical conditions and has been suggested to be caused by re-directing MSC differentiation into one particula...

journal_title：Bone

authors： Post S,Abdallah BM,Bentzon JF,Kassem M

更新日期：2008-07-01 00:00:00

abstract：:Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 transcripts, but not of ...

journal_title：Bone

authors： Juneja SC,Vonica A,Zeiss C,Lezon-Geyda K,Yatsula B,Sell DR,Monnier VM,Lin S,Ardito T,Eyre D,Reynolds D,Yao Z,Awad HA,Yu H,Wilson M,Honnons S,Boyce BF,Xing L,Zhang Y,Perkins AS

更新日期：2014-03-01 00:00:00

abstract：:Bisphosphonates (BP), especially alendronate and risedronate, are the drugs most commonly used for osteoporosis treatment, being incorporated into the skeleton where they inhibit bone resorption and are thereafter slowly released during bone turnover. However, there are few data on the release of BP in patients who ha...

journal_title：Bone

authors： Peris P,Torra M,Olivares V,Reyes R,Monegal A,Martínez-Ferrer A,Guañabens N

更新日期：2011-10-01 00:00:00

abstract：:Mitochondria play a key role in cell physiology including cell differentiation and proliferation. We investigated the changes of mitochondrial biogenesis during Wnt-induced osteoblastic differentiation of murine mesenchymal C3H10T1/2 cells. Scanning electron microscopy demonstrated that activation of Wnt signaling by ...

journal_title：Bone

authors： An JH,Yang JY,Ahn BY,Cho SW,Jung JY,Cho HY,Cho YM,Kim SW,Park KS,Kim SY,Lee HK,Shin CS

更新日期：2010-07-01 00:00:00

abstract：:This paper describes a new alternative for individualized mechanical analysis of bone trabecular structure. This new method closes the gap between the classic homogenization approach that is applied to macro-scale models and the modern micro-finite element method that is applied directly to micro-scale high-resolution...

journal_title：Bone

authors： Podshivalov L,Fischer A,Bar-Yoseph PZ

更新日期：2011-04-01 00:00:00

abstract：:In this study we report on histological and ultrastructural investigations of the mandibular cortical bone in a case of autosomal dominant osteopetrosis type II complicated by mandibular osteomyelitis. Histologically, there was a marked increase in the number and size of osteoclasts on the inner bone surface. An undec...

journal_title：Bone

authors： Semba I,Ishigami T,Sugihara K,Kitano M

更新日期：2000-09-01 00:00:00

abstract：:In this study we describe the generation and influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with growth and differentiation factor 5 (GDF-5). Prior to loading GDF-5, we characterized the release profiles from these hydrogels and tested their respective cell viabili...

journal_title：Bone

authors： Bae MS,Ohe JY,Lee JB,Heo DN,Byun W,Bae H,Kwon YD,Kwon IK

更新日期：2014-02-01 00:00:00

abstract：:A theory is developed to resolve several inconsistencies between current concepts and observations about bone remodeling. For example, the observation that remodeling increases both when mechanical loading is excessively low, that is, in a disuse state, and when it is excessively high, producing substantial fatigue da...

journal_title：Bone

authors： Martin RB

更新日期：2000-01-01 00:00:00

abstract：:The assessment of fracture risk often relies primarily on measuring bone mineral density, thereby accounting for only a single pathology: the loss of bone mass. However, bone's ability to resist fracture is a result of its biphasic composition and hierarchical structure that imbue it with high strength and toughness. ...

journal_title：Bone

authors： Abraham AC,Agarwalla A,Yadavalli A,Liu JY,Tang SY

更新日期：2016-06-01 00:00:00

abstract：:New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...

journal_title：Bone

authors： Freilich M,M Patel C,Wei M,Shafer D,Schleier P,Hortschansky P,Kompali R,Kuhn L

更新日期：2008-10-01 00:00:00

abstract：:Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...

journal_title：Bone

authors： Horiuchi H,Saito N,Kinoshita T,Wakabayashi S,Yotsumoto N,Takaoka K

更新日期：2002-04-01 00:00:00

abstract：:Although osteoporosis is usually associated with women, 1 in 12 men in the UK have the disease, and a third of these cases are idiopathic. Estrogen is now known to be associated with bone loss in older men, but we found, previously, that levels of this hormone were normal in younger cases of male idiopathic osteoporos...

journal_title：Bone

authors： Braidman I,Baris C,Wood L,Selby P,Adams J,Freemont A,Hoyland J

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To establish a drill-hole defect model in osteoporotic mouse femur by comparing temporal cortical bone healing pattern between OVX-induced osteoporotic bone and sham-operated bone. METHODS:3-month-old female C57BL/6 mice were randomly divided into an ovariectomy group (OVX) and a sham-operated group (Sham). ...

journal_title：Bone

authors： He YX,Zhang G,Pan XH,Liu Z,Zheng LZ,Chan CW,Lee KM,Cao YP,Li G,Wei L,Hung LK,Leung KS,Qin L

更新日期：2011-06-01 00:00:00