Abstract：
:Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biological apatite (BAp) crystallites by a microbeam X-ray diffractometer system is proposed as a new index of bone quality for the evaluation of regenerated bone microstructure. Preferential alignment of the BAp c-axis in the rabbit ulna and skull bone, regenerated by controlled release of basic fibroblast growth factor (bFGF) was investigated. The BAp c-axis orientation was evaluated by the relative intensity between the (002) and (310) diffraction peaks, or the three-dimensional texture for the (002) peak. It was found that new bone in the defects was initially produced without preferential alignment of the BAp c-axis, and subsequently reproduced to recover towards the original alignment. In other words, the BAp density recovered prior to the BAp orientation. Perfect recovery of BAp alignment was not achieved in the ulna and skull defects after 4 weeks and 12 weeks, respectively. Apparent recovery of the macroscopic shape and bio-mineralization of BAp was almost complete in the ulna defect after 4 weeks. However, an additional 2 weeks was required for complete repair of BAp orientation. It is finally concluded that orientation distribution of BAp crystallites offers an effective means of evaluating the degree of microstructural regeneration, and also the related mechanical function, in regenerated hard tissues.
journal_name
Bonejournal_title
Boneauthors
Nakano T,Kaibara K,Ishimoto T,Tabata Y,Umakoshi Ydoi
10.1016/j.bone.2012.07.003subject
Has Abstractpub_date
2012-10-01 00:00:00pages
741-7issue
4eissn
8756-3282issn
1873-2763pii
S8756-3282(12)00955-6journal_volume
51pub_type
杂志文章相关文献
BONE文献大全abstract：:Bone structure is the key to the understanding of fracture risk. The hypothesis tested in this prospective study is that dense mandibular trabeculation predicts low fracture risk, whereas sparse trabeculation is predictive of high fracture risk. Out of 731 women from the Prospective Population Study of Women in Gothen...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.06.036
更新日期：2011-10-01 00:00:00
abstract：:Bone mineral density is under strong genetic control and polymorphisms of the vitamin D receptor (VDR) have been suggested to account for some of the genetic variation in bone mass. However, the relationship between VDR polymorphisms and bone density is controversial and has not been confirmed by all workers. Since th...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(95)00483-1
更新日期：1996-03-01 00:00:00
abstract：:Osteopetrotic bone shows dissociation between bone mineral density (BMD) and bone strength. In this study, volumetric BMD; preferential orientation of the extracellular matrix (ECM), which is composed of collagen fibers and apatite crystals as bone material quality; and mechanical properties of the src-/- osteopetroti...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.06.023
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.115184
更新日期：2020-03-01 00:00:00
abstract：:Principal strains and their orientation, determined from in vivo and in situ strains recorded from the lateral cortical surface of the calcaneus of potoroos (a small marsupial) during treadmill exercise and tension applied via the Achilles tendon, were compared with the underlying trabecular architecture and its align...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(96)00116-0
更新日期：1996-07-01 00:00:00
abstract：:Both bone density and quality are important determinants of bone strength. Bone quality is prescribed by matrix characteristic including collagen cross-linking and bone structural characteristics and is important in reinforcement of bone strength. We investigated the effects of alfacalcidol (ALF), a prodrug of calcitr...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.12.008
更新日期：2010-04-01 00:00:00
abstract：:Large, cylindrical implants of a porous calcium phosphate ceramic ("hydroxyapatite" starting material, HAC) were used to replace far greater than critical-sized sections of the midshaft of sheep tibiae and retrieved at 2 and 9 months; external fixation was used in the first 5 months. Excellent clinical function of the...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00083-6
更新日期：1999-06-01 00:00:00
abstract：:Female Wistar rats aged 3 months were ovariectomized (OX, n = 27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls (OXc). Bending fracture load of femur diaphyses, reduced in OXc, was recovered by olpadronate. This effect wa...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(95)00314-4
更新日期：1995-10-01 00:00:00
abstract：:We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.10.018
更新日期：2007-04-01 00:00:00
abstract：:Skeleton is the most common organ targeted by breast cancer cells, especially from estrogen receptor alpha (ER)-positive neoplasms. Metastatic cells can stimulate directly or indirectly osteoclast-mediated bone resorption. Tumor-induced osteolysis is often extensive and leads to the release of large quantities of calc...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.03.021
更新日期：2004-08-01 00:00:00
abstract：:Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation. Hence, the limb has been chosen as a model to study the process o...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.07.005
更新日期：2007-01-01 00:00:00
abstract：:Gap junctional intercellular communication (GJIC) may contribute to cellular differentiation. To examine this possibility in bone cells we examined markers of cellular differentiation, including alkaline phosphatase, osteocalcin, and osteopontin, in ROS17/2.8 cells (ROS), a rat osteoblastic cell line expressing phenot...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00227-6
更新日期：1999-12-01 00:00:00
abstract：:A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in osteoblasts is not well understood. Two major events for bone formation include osteoblast differentiation by bone marker gene expression, which is mainly regulated by bone-specific transcription factor Runx2 and extracellula...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.11.003
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115795
更新日期：2021-03-01 00:00:00
abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(90)90070-f
更新日期：1990-01-01 00:00:00
abstract：:It is well-known that pathways normally functioning during embryonic development are dysregulated in cancer. Experimental and clinical studies have established strong connections between aberrant developmental pathways and transformation, as well as other early stage events of cancer progression. There is now emerging...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/j.bone.2010.07.005
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:Progression of an incomplete atypical femoral fracture (IF) to a complete fracture in patients on long term bisphosphonate (BP) therapy can be catastrophic. We aimed to determine the frequency and imaging features of IF in asymptomatic patients on long-term BP therapy and to identify distinguishing clinical ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.03.018
更新日期：2013-07-01 00:00:00
abstract：:Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.03.036
更新日期：2019-06-01 00:00:00
abstract：:We studied the differences in the patterns of trabecular bone loss induced by various kinds of experimental osteopenia in the rat, including ovariectomy, sciatic neurotomy (partial paralysis of hind-limb), hemicordotomy (complete paralysis of hind-limb), and their combinations. The cut surface of the metaphysis of pro...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(91)90041-g
更新日期：1991-01-01 00:00:00
abstract：:We investigated the bone remodeling activity on titanium implants with different surface roughnesses using a confocal laser scanning microscope (CLSM). Two kinds of implants were used, the machined smooth-surfaced titanium and the plasma-sprayed rough-surfaced titanium. These implants were randomly inserted in a rabbi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00204-4
更新日期：1997-12-01 00:00:00
abstract：:Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.03.026
更新日期：2019-06-01 00:00:00
abstract：:Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence. These regions have been proposed to contribute to the attachment of...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(00)00392-6
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Episodic flare-ups of fibrodysplasia ossificans progressiva (FOP) are characterized clinically by severe, often posttraumatic, connective tissue swelling and intramuscular edema, followed histologically by an intense and highly angiogenic fibroproliferative reaction. This early inflammatory and angiogenic fi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.08.023
更新日期：2018-04-01 00:00:00
abstract：:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shaft...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(94)00049-2
更新日期：1995-03-01 00:00:00
abstract：:In elderly subjects and in particular in those with osteoporosis the evidence on age related volume changes of the hip is still very limited. Even less is known about bone changes of the femoral head. The aim of this study is to explore associations of bone size of the femoral head and neck with age in postmenopausal ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115545
更新日期：2020-10-01 00:00:00
abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.10.025
更新日期：2017-01-01 00:00:00
abstract：:New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.05.021
更新日期：2008-10-01 00:00:00
abstract：:Bisphosphonates (BPs) are the first-line therapy for osteoporosis. In recent years, atypical femoral fractures (AFF) have been described in patients on BPs therapy. However, the relationship between BPs and AFF remains to be clarified. We evaluated clinical and hormonal characteristics of AFF patients, in order to det...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.07.010
更新日期：2013-10-01 00:00:00
abstract：:While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115335
更新日期：2020-07-01 00:00:00
abstract：:Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extrac...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.06.011
更新日期：2016-09-01 00:00:00
