Abstract：
:Exercise during growth can be important for attaining optimal bone mass. High-intensity long-duration protocols, however, can have detrimental effects on immature bone morphology and mechanics. The underlying mechanisms are poorly understood. Here, we quantified the mechanical environment of the middiaphyseal rooster tarsometatarsus during high-speed running and examined whether short bouts of this exercise-related mechanical milieu can induce positive changes in cortical bone morphology, mechanics, and mineral ash content. At 9 weeks of age, roosters were assigned to controls (n = 9) and runners (n = 8). Treadmill running was applied in loading sessions of 5 min, three times per day (approximately 2600 cycles/day) for 8 weeks. Both controls and runners received double-fluorochrome labels during weeks 3 and 8 of the protocol. Middiaphyseal distributions of tarsometatarsal longitudinal normal strain, strain rate, and strain gradients engendered by walking and running were determined via in vivo strain gauges. Compared with walking, running elevated mean peak strain magnitude by 19%, peak strain rates by 136%, and peak strain gradients by approximately 18%. After 8 weeks of running, middiaphyseal areal and mechanical properties and normalized ash weight were no different between runners and controls. Transient and focal reductions in periosteal mineral apposition rates occurred during the exercise protocol. Our current data suggest that reducing the number of loading cycles can mitigate the adverse response previously observed in this model with long-duration running. This study also supports the tenet that the exercise-generated mechanical milieu must differ substantially from the habitual milieu to induce significant adaptations.
journal_name
Bonejournal_title
Boneauthors
Judex S,Zernicke RFdoi
10.1016/s8756-3282(99)00256-2subject
Has Abstractpub_date
2000-02-01 00:00:00pages
153-9issue
2eissn
8756-3282issn
1873-2763pii
S8756-3282(99)00256-2journal_volume
26pub_type
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