Abstract：
:Sclerostin, product of the SOST gene, is an important determinant of bone formation and resorption. Adolescents with anorexia nervosa (AN) have low bone density and decreased levels of bone turnover markers. However, sclerostin has not been examined in AN as a potential mediator of impaired bone metabolism. Our study objectives were to (i) assess associations of sclerostin with surrogate bone turnover markers in girls with AN and controls and (ii) examine effects of transdermal estradiol on sclerostin in AN. 69 girls (44 with AN and 25 normal-weight controls) 13-18 years old were studied at baseline. 22 AN girls were randomized to transdermal estradiol (plus cyclic medroxyprogesterone) or placebo in a double-blind study for 12 months. Sclerostin correlated positively with P1NP and CTX in controls (r=0.67 and 0.53, p=0.0002 and 0.005, respectively) but not in AN despite comparable levels at baseline. Changes in sclerostin over twelve months did not differ in girls randomized to estradiol or placebo. The relationship between sclerostin and bone turnover markers is disrupted in adolescent girls with AN. Despite an increase in BMD with estradiol administration in AN, estrogen does not impact sclerostin levels in this group.
journal_name
Bonejournal_title
Boneauthors
Faje AT,Fazeli PK,Katzman DK,Miller KK,Breggia A,Rosen CJ,Mendes N,Klibanski A,Misra Mdoi
10.1016/j.bone.2012.06.006subject
Has Abstractpub_date
2012-09-01 00:00:00pages
474-9issue
3eissn
8756-3282issn
1873-2763pii
S8756-3282(12)00929-5journal_volume
51pub_type
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