The genetic architecture of osteoporosis and fracture risk.

abstract：:Exercise during growth can be important for attaining optimal bone mass. High-intensity long-duration protocols, however, can have detrimental effects on immature bone morphology and mechanics. The underlying mechanisms are poorly understood. Here, we quantified the mechanical environment of the middiaphyseal rooster ...

journal_title：Bone

authors： Judex S,Zernicke RF

更新日期：2000-02-01 00:00:00

abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...

journal_title：Bone

authors： Cao Y,Mori S,Mashiba T,Kaji Y,Manabe T,Iwata K,Miyamoto K,Komatsubara S,Yamamoto T

更新日期：2007-01-01 00:00:00

abstract：:The osteoprotegerin (OPG)/receptor activator of NF-kappaB ligand (RANKL) axis is thought to be involved in the upregulation of bone turnover following sex steroid deficiency. Here, we investigated the effects of orchiectomy (ORX) on bone turnover and free soluble RANKL (sRANKL) in aged rats. Free, bioactive sRANKL is ...

journal_title：Bone

authors： Proell V,Xu H,Schüler C,Weber K,Hofbauer LC,Erben RG

更新日期：2009-10-01 00:00:00

abstract：:Death certification data has shown that death rates due to Paget's disease of bone and osteosarcoma in older people (assumed to be attributable to Paget's) declined in the latter part of the 19th and in the early 20th century, suggesting that there may be a secular trend toward less severe disease. We have reviewed a ...

journal_title：Bone

authors： Cundy T,McAnulty K,Wattie D,Gamble G,Rutland M,Ibbertson HK

更新日期：1997-01-01 00:00:00

abstract：:In order to delineate the influence of mechanical unloading on the formation and resorption of trabecular and cortical bone, the effects of mechanical unloading on the volume, structure, and turnover of hindlimbs were examined using tail-suspended rapidly growing rats. In addition, to clarify the mechanism of how mech...

journal_title：Bone

authors： Matsumoto T,Nakayama K,Kodama Y,Fuse H,Nakamura T,Fukumoto S

更新日期：1998-05-01 00:00:00

abstract：:The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of bone cells together with the time course of mineralization of newly formed bone matrix generate a characteristic bone mineralization density distribution (BMDD)...

journal_title：Bone

authors： Roschger P,Gupta HS,Berzlanovich A,Ittner G,Dempster DW,Fratzl P,Cosman F,Parisien M,Lindsay R,Nieves JW,Klaushofer K

更新日期：2003-03-01 00:00:00

abstract：:Popular psychotropic drugs, like the antidepressant selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), and the mood stabilizer lithium, may have skeletal effects. In particular, preclinical observations suggest a direct negative effect of SSRIs on the skeleton. A potential caveat in ...

journal_title：Bone

authors： Warden SJ,Hassett SM,Bond JL,Rydberg J,Grogg JD,Hilles EL,Bogenschutz ED,Smith HD,Fuchs RK,Bliziotes MM,Turner CH

更新日期：2010-04-01 00:00:00

abstract：:Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...

journal_title：Bone

authors： He L,Lee J,Jang JH,Lee SH,Nan MH,Oh BC,Lee SG,Kim HH,Soung NK,Ahn JS,Kim BY

更新日期：2012-06-01 00:00:00

abstract：:Despite the potential biological importance of sympathetic activity in human bone metabolism, its effects on bone microarchitecture, a key determinant of bone quality, has not been thoroughly studied. In the present study, we investigated the lumbar spine trabecular bone score (TBS) as an indicator of skeletal deterio...

journal_title：Bone

authors： Kim BJ,Kwak MK,Kim JS,Lee SH,Koh JM

更新日期：2018-11-01 00:00:00

abstract：:Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...

journal_title：Bone

authors： Xie C,Ming X,Wang Q,Schwarz EM,Guldberg RE,O'Keefe RJ,Zhang X

更新日期：2008-12-01 00:00:00

abstract：:We proposed a novel surface modification for an artificial hip joint stem from the viewpoint of maintenance and establishment of appropriate bone function and microstructure, represented by the preferred alignment of biological apatite (BAp) and collagen (Col). Oriented grooves were introduced into the proximal medial...

journal_title：Bone

authors： Noyama Y,Nakano T,Ishimoto T,Sakai T,Yoshikawa H

更新日期：2013-02-01 00:00:00

abstract：:The hips are frequently involved in inheritable diseases which affect the bones. The clinical and radiological presentation of these diseases may be very similar to common hip disorders as developmental dysplasia of the hip, osteoarthritis and avascular necrosis, so the diagnosis may be easily overlooked and treatment...

journal_title：Bone

authors： Oussoren E,Wagenmakers MAEM,Link B,van der Meijden JC,Pijnappel WWMP,Ruijter GJG,Langeveld M,van der Ploeg AT

更新日期：2021-02-01 00:00:00

abstract：:We investigated the effect of 2-beta-(3-hydroxypropoxy)-1alpha,25-dihydroxyvitamin D3 (ED-71) on the modeling of bone in distraction osteogenesis. The tibiae of 30 rabbits were lengthened by 10 mm in 10 days. Following osteotomy, ED-71 (0.05 microg/kg) was administered subcutaneously twice a week to the ED-71 group un...

journal_title：Bone

authors： Yamane K,Okano T,Kishimoto H,Hagino H

更新日期：1999-03-01 00:00:00

abstract：:Although it is generally acknowledged that matrix vesicles and alkaline phosphatase are required for cartilage calcification, their precise role in initiation or propagation of mineralization remains controversial. We have investigated this problem in a neoplastic model of chondrogenesis, the Swarm rat chondrosarcoma....

journal_title：Bone

authors： Miller GJ,DeMarzo AM

更新日期：1988-01-01 00:00:00

abstract：:Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...

journal_title：Bone

authors： de Jong WC,van Ruijven LJ,Brugman P,Langenbach GE

更新日期：2013-08-01 00:00:00

abstract：:Vitamin K may be important in bone metabolism. Notably, high-dose menaquinone-4 (menatetrenone, MK4) has been reported to reduce ovariectomy (ovx)-induced bone loss in rats and to decrease osteoporotic fracture in postmenopausal women. However, it is unclear whether these beneficial effects reflect a physiologic effec...

journal_title：Bone

authors： Binkley N,Krueger D,Engelke J,Crenshaw T,Suttie J

更新日期：2002-06-01 00:00:00

abstract：AIM:Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. MATERIALS AND METHODS:Forty-five 12-month-ol...

journal_title：Bone

authors： Zhang G,Qin L,Hung WY,Shi YY,Leung PC,Yeung HY,Leung KS

更新日期：2006-06-01 00:00:00

abstract：:Calcification of end plate chondrocytes is a major cause of intervertebral disc (IVD) degeneration. However, the underlying molecular mechanism of end plate chondrocyte calcification is still unclear. The aim of this study was to clarify whether autophagy in end plate chondrocytes could protect the calcification of en...

journal_title：Bone

authors： Xu HG,Yu YF,Zheng Q,Zhang W,Wang CD,Zhao XY,Tong WX,Wang H,Liu P,Zhang XL

更新日期：2014-09-01 00:00:00

abstract：:If muscle force is a primary source for triggering bone adaptation, with disuse and reloading, bone changes should follow muscle changes. We examined the timing and magnitude of changes in muscle cross-sectional area (MCSA) and bone architecture in response to muscle inactivity following botulinum toxin (BTX) injectio...

journal_title：Bone

authors： Manske SL,Boyd SK,Zernicke RF

更新日期：2010-01-01 00:00:00

abstract：:Bisphosphonates are one of the most well studied groups of medications and they are bone specific. This tissue specificity is a rare property for a drug introduced into clinical practice as long as 40 years ago. Over the years, the therapeutic boundaries of bisphosphonates were explored and their safety profile has wi...

journal_title：Bone

authors： Pazianas M,Abrahamsen B

更新日期：2011-07-01 00:00:00

abstract：:This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...

journal_title：Bone

authors： Schneiders W,Reinstorf A,Pompe W,Grass R,Biewener A,Holch M,Zwipp H,Rammelt S

更新日期：2007-04-01 00:00:00

abstract：:There is a lot of interest for how and how much osteoclasts resorb bone. However, little is known about the mechanism which controls the orientation and the duration of a resorptive event, thereby determining the specific geometry of a cavitation. Here we show that the relative rate of collagenolysis vs. demineralizat...

journal_title：Bone

authors： Søe K,Merrild DM,Delaissé JM

更新日期：2013-09-01 00:00:00

abstract：:The degradation of the main fibrillar collagens, collagens I and II, is a crucial process for skeletal development. The most abundant dipeptides generated from the catabolism of collagens contain proline and hydroxyproline. In humans, prolidase is the only enzyme able to hydrolyze dipeptides containing these amino aci...

journal_title：Bone

authors： Besio R,Maruelli S,Gioia R,Villa I,Grabowski P,Gallagher O,Bishop NJ,Foster S,De Lorenzi E,Colombo R,Diaz JL,Moore-Barton H,Deshpande C,Aydin HI,Tokatli A,Kwiek B,Kasapkara CS,Adisen EO,Gurer MA,Di Rocco M,Phang J

更新日期：2015-03-01 00:00:00

abstract：:In order to assess the ability of six potential bone graft substitutes to support the growth of human osteoblasts, these cells were grown in culture and then plated onto fragments of the six materials and cultured for a further period of 15 days. Tests to confirm the osteoblastic phenotype of the cells included spectr...

journal_title：Bone

authors： Begley CT,Doherty MJ,Hankey DP,Wilson DJ

更新日期：1993-07-01 00:00:00

abstract：:Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...

journal_title：Bone

authors： Horiuchi H,Saito N,Kinoshita T,Wakabayashi S,Yotsumoto N,Takaoka K

更新日期：2002-04-01 00:00:00

abstract：:A serious side effect of glucocorticoid treatment is the development of osteoporosis. We have earlier shown that long-term glucocorticoid administration results in a decrease in longitudinal bone growth, cortical bone mass, and biomechanical strength, while growth hormone administration increases these parameters. The...

journal_title：Bone

authors： Ortoft G,Oxlund H

更新日期：1996-06-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...

journal_title：Bone

authors： Sakai S,Endo K,Takeda S,Mihara M,Shiraishi A

更新日期：2012-05-01 00:00:00

abstract：:Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Several salient observations have emerged. Numerous studies have examined the relationship be...

journal_title：Bone

authors： Martineau P,Leslie WD

更新日期：2017-11-01 00:00:00

abstract：:G protein-coupled receptor kinase 2 interacting protein-1 (GIT1) is a scaffold protein that plays a vital role in bone modeling and remodeling during osteogenesis coupled with angiogenesis. Recent studies have shown that a specialized subset of vascular endothelium strongly positive for CD31 and Endomucin (CD31hiEmcnh...

journal_title：Bone

authors： Xu T,Luo Y,Kong F,Lv B,Zhao S,Chen J,Liu W,Cheng L,Zhou Z,Zhou Z,Huang Y,Li L,Zhao X,Qian D,Fan J,Yin G

更新日期：2019-05-01 00:00:00