Abstract:
:Preliminary studies have shown that dual-energy X-ray absorptiometry (DXA) produces images of sufficient quality for a precise and accurate measurement at density of the subchondral bone. The objective of this study was to investigate the relationship between baseline subchondral tibial bone mineral density (BMD) and joint space narrowing observed after 1 year at the medial femoro-tibial compartment of the knee joint. Fifty-six consecutive patients, from both genders, with knee osteoarthritis diagnosed according to the American College of Rheumatology criteria, were included in the study. Radiographic posteroanterior views were taken, at baseline and after 1 year of follow-up. Minimum joint space width (JSW) measurement, at the medial femoro-tibial joint, was performed with a 0.1-mm graduated magnifying lens. Baseline BMD of the subchondral tibial bone was assessed by DXA. The mean +/- SD age of the patients was 65.3 +/- 8.7 years, with a body mass index of 28.0 +/- 4.9 kg/m(2). The minimum JSW was 3.5 +/- 1.5 mm and the mean BMD of the subchondral bone was 0.848 +/- 0.173 g/cm(2). There was a significant negative correlation between subchondral BMD and 1-year changes in minimum JSW (r = -0.43, p = 0.02). When performing a multiple regression analysis with age, sex, body mass index, and minimum JSW at baseline as concomitant variables, BMD of the subchondral bone as well as JSW at baseline were independent predictors of 1-year changes in JSW (p = 0.02 and p = 0.005, respectively). Patients in the lowest quartile of baseline BMD (<0.73 g/cm(2)) experienced less joint space narrowing than those in the highest BMD quartile (>0.96 g/cm(2)) (+0.61 +/- 0.69 mm versus -0.13 +/- 0.27 mm; p = 0.03). Assessment of BMD of the subchondral tibial bone is significantly correlated with future joint space narrowing and could be used as a predictor of knee osteoarthritis progression.
journal_name
Bonejournal_title
Boneauthors
Bruyere O,Dardenne C,Lejeune E,Zegels B,Pahaut A,Richy F,Seidel L,Ethgen O,Henrotin Y,Reginster JYdoi
10.1016/s8756-3282(03)00059-0subject
Has Abstractpub_date
2003-05-01 00:00:00pages
541-5issue
5eissn
8756-3282issn
1873-2763pii
S8756328203000590journal_volume
32pub_type
杂志文章相关文献
BONE文献大全abstract:PURPOSE:Low trauma rib fracture (hereinafter, rib fracture) is common in the elderly, but its risk factors and mortality consequence are rarely studied. We sought to define the epidemiology of rib fracture and the association between rib fracture and postfracture mortality. METHODS:The study was part of the Dubbo Oste...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.08.016
更新日期:2018-11-01 00:00:00
abstract::The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90066-4
更新日期:1987-01-01 00:00:00
abstract::Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naïve (T...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/j.bone.2013.11.011
更新日期:2014-02-01 00:00:00
abstract::High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.05.005
更新日期:2018-08-01 00:00:00
abstract::Subject motion during high-resolution peripheral quantitative computed tomography (HR-pQCT) causes image artifacts that affect morphological analysis of bone quality. The aim of our study was to determine effectiveness of techniques for quality control in the presence of motion in vivo including automated and manual a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.03.003
更新日期:2012-06-01 00:00:00
abstract::During the 40 years since its discovery, calcitonin (CT) has been regarded primarily as an inhibitor of bone resorption and its therapeutic applications have been based on this property. A significant body of literature also indicates additional anabolic effects in animal and in vitro models. In a variety of bone loss...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(99)00200-8
更新日期:1999-11-01 00:00:00
abstract::Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.068
更新日期:2015-05-01 00:00:00
abstract::Second generation antipsychotics (SGAs) have been linked to metabolic and bone disorders in clinical studies, but the mechanisms of these side effects remain unclear. Additionally, no studies have examined whether SGAs cause bone loss in mice. Using in vivo and in vitro modeling we examined the effects of risperidone,...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.08.005
更新日期:2012-02-01 00:00:00
abstract::Profound bone loss at weight bearing sites is a primary effect of long-duration spaceflight. Moreover, a significant increase in estimated fracture risk remains even 1 year after returning to Earth; hence, it is important to define how quickly bone integrity can recover following prolonged disuse. This study character...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.09.021
更新日期:2013-01-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.05.024
更新日期:2010-08-01 00:00:00
abstract::Osteoarthritis (OA) occurs naturally in cynomolgus macaques. The purposes of the present study were to: 1) develop histological measurement schemes to measure the cross-sectional area of axial and abaxial osteophytes in the proximal tibia; 2) determine the effects of long-term estrogen replacement therapy (ERT) on ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.175
更新日期:2007-08-01 00:00:00
abstract::Twenty patients with mild Paget's disease of bone were given either 20 (10 patients) or 40 mg alendronate daily for 6 months. The 20-mg dose was well tolerated, but in 3 patients on 40 mg/d alendronate, the treatment was withdrawn after 3-5 months because of gastric and oesophageal disturbances. Urinary hydroxyproline...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(94)90818-4
更新日期:1994-07-01 00:00:00
abstract::Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00164-2
更新日期:1995-08-01 00:00:00
abstract::It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis o...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00180-l
更新日期:1995-08-01 00:00:00
abstract::Osteopontin (OPN) gene expression and alkaline phosphatase activity were evaluated in the epiphyseal growth plates of normal chickens and in diet-induced tibial dyschdroplasia (TD)-afflicted chickens. In the normal growth plate, OPN gene was expressed by a) cells of the subperichondrial zone surrounding the articular ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)00048-5
更新日期:1995-04-01 00:00:00
abstract::E-Series prostaglandins (PGE) are powerful osteogenic substances when given in vivo. The purpose of this work was to determine the ability of locally administered PGE1 to promote alveolar bone formation. Controlled-release pellets containing PGE1 were implanted on the lateral mandibular surface of Beagle dogs and tiss...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90198-j
更新日期:1993-05-01 00:00:00
abstract::The effect of clodronate on healing of the fracture of osteopenic bone was studied in rats. A total of 165 female rats (14 +/- 1 weeks, 216 +/- 2 g) were divided into five fracture groups (n = 30), and a neurectomized group (n = 15). Osteopenia (op) was induced by right sciatic neurectomy 4 weeks before the fracture. ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)90320-4
更新日期:1994-11-01 00:00:00
abstract::Skeleton is the most common organ targeted by breast cancer cells, especially from estrogen receptor alpha (ER)-positive neoplasms. Metastatic cells can stimulate directly or indirectly osteoclast-mediated bone resorption. Tumor-induced osteolysis is often extensive and leads to the release of large quantities of calc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.021
更新日期:2004-08-01 00:00:00
abstract::To examine the ability of tamoxifen (TAM) to conserve bone in the estrogen-deficient ovariectomized (OVX) rat in the presence and absence of parathyroid hormone (PTH) six groups of rats with 45Ca-labeled bones were studied for 12 weeks. Rats were OVX, parathyroidectomized (PTX), or given sham operations and treated wi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)90273-9
更新日期:1994-09-01 00:00:00
abstract::Much is known about skeletal adaptation in relation to the mechanical functions that bones serve. This includes how bone adapts to mechanical loading during an individual's lifetime as well as over evolutionary time. Although controlled loading in animal models allows us to observe short-term bone adaptation (epigenet...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2019.115114
更新日期:2020-02-01 00:00:00
abstract::We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00287-n
更新日期:1995-10-01 00:00:00
abstract::Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been deve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.09.020
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115702
更新日期:2021-01-01 00:00:00
abstract::Low-trauma fractures of older women are a major public health problem. Nevertheless, nationwide information on recent trends of proximal humeral fractures is sparse. We assessed the current trend in the number and rate (per 100,000 persons) of low-trauma fractures of the proximal humerus among 80-year-old or older wom...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.12.007
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:Vertebral fractures are associated with persistent pain, disability and mortality. However, around two thirds of women with vertebral fractures are unaware of them. We aimed to analyze which factors could mostly be associated to the presence of vertebral fractures in post-menopausal women, and evaluate the effe...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.05.007
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Rheumatoid arthritis (RA) is accompanied by potential risk of bone mineral loss. In this study, we developed a screening index for the osteoporosis related level of bone mineral density loss for RA patients as a substitute to the dual-energy X-ray absorptiometry (DXA) method. METHODS:X-ray pictures of both s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115405
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:Mechanical stresses on the bone are an important aspect of physical activity that promotes bone preservation and increases in bone mass. Exercise intensities leading to bone preservation and accrual have not been adequately defined for humans in general, and postmenopausal women in particular. MATERIALS A...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2007.06.009
更新日期:2007-10-01 00:00:00
abstract::The variability of different primary tumors in the susceptibility to metastatic bone disease is poorly understood. Factors that determine the viability of metastatic cells are also poorly understood, but may depend in part upon gene expression of PTHrP and the vitamin D receptor. In contrast, much more is known of the...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00194-i
更新日期:1995-08-01 00:00:00
abstract::The prediction of bone strength can be improved when determining bone mineral density (BMD) in combination with measures of trabecular microarchitecture. The goal of this study was to assess parameters of trabecular bone structure and texture of the calcaneus by clinical multi-detector row computed tomography (MDCT) i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.01.372
更新日期:2009-05-01 00:00:00
abstract::The degradation of the main fibrillar collagens, collagens I and II, is a crucial process for skeletal development. The most abundant dipeptides generated from the catabolism of collagens contain proline and hydroxyproline. In humans, prolidase is the only enzyme able to hydrolyze dipeptides containing these amino aci...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.11.009
更新日期:2015-03-01 00:00:00