Abstract:
:The underlying causes of maxillary bone loss during lactation remain poorly understood. We evaluated the impact of lactation on physiological and mechanically-induced alveolar bone remodeling. Nulliparous non-lactating (N-LAC) and 21-day lactating (LAC) mice underwent mechanically-induced bone remodeling by orthodontic tooth movement (OTM). Micro-computed tomography (microCT) was performed in the maxilla, femur and vertebra. Tartrate-resistant-acid phosphatase (TRAP) and Masson's trichrome labelling was performed in the maxillary bone and gene expression was determined in the periodontal ligament. The effect of prolactin on osteoclast (OCL) and osteoblast (OBL) differentiation was also investigated in N-LAC and LAC mice. Lactation increased alveolar bone loss in the maxilla, femur and vertebra, while OTM was enhanced. The number of OCL and OBL was higher in the maxilla of LAC mice. OTM increased OCL in both groups; while OBL was increased only in N-LAC but not in LAC mice, in which cell numbers were already elevated. The alveolar bone loss during lactation was associated with increased expression of receptor activator of nuclear factor-KappaB (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) in the maxilla. OTM induced the same responses in N-LAC mice, whereas it had no further effect in LAC mice. Lactation enhanced differentiation of OCL and OBL from bone marrow cells, and prolactin recapitulated OCL differentiation in N-LAC mice. Thus, lactation increases physiological maxillary bone remodeling and OTM, and both require activation of RANK/RANKL/OPG system. These findings expand our knowledge of lactation-induced osteopenia and have possible impact on clinical practice regarding orthodontic treatments and dental implants in lactating women.
journal_name
Bonejournal_title
Boneauthors
Macari S,Sharma LA,Wyatt A,da Silva JM,Dias GJ,Silva TA,Szawka RE,Grattan DRdoi
10.1016/j.bone.2018.01.032subject
Has Abstractpub_date
2018-05-01 00:00:00pages
160-169eissn
8756-3282issn
1873-2763pii
S8756-3282(18)30054-1journal_volume
110pub_type
杂志文章相关文献
BONE文献大全abstract::Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.06.014
更新日期:2016-09-01 00:00:00
abstract::Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in patients with osteoarthritis and fracture of the femoral neck are described. Femoral heads were obtained from patients who had surgery for the treatment of femoral neck fracture or total hip replacement for...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(85)90044-4
更新日期:1985-01-01 00:00:00
abstract::The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were us...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.07.015
更新日期:2013-10-01 00:00:00
abstract::Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.07.017
更新日期:2010-10-01 00:00:00
abstract::Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have been reported to vary depending on the donor, but the biological mecha...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.05.003
更新日期:2006-11-01 00:00:00
abstract::A computerised technique is described for the quantitative assessment of resorption cavities in iliac trabecular bone. Using an Ibas II image analyser, the original bone surface, eroded by bone resorbing cells, is reconstructed using a curve fitting technique that maintains a smooth continuity with the trabecular bone...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(90)90076-b
更新日期:1990-01-01 00:00:00
abstract::A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.04.008
更新日期:2012-07-01 00:00:00
abstract::It was the aim of this retrospective analysis to examine the influence of low-dose monophasic oral contraceptives (OCs) on bone mineral density (BMD) of the femoral neck and of the spine in young female endurance athletes. Data on training intensity, dietary intake, menarche, menstrual cycle disorders, years of OC use...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.05.017
更新日期:2004-10-01 00:00:00
abstract::Bone healing is a complex multi-step process, which depends on the position and size of the lesion, and on the mechanical stability of the wounded area. To address more specifically the mechanisms involved in cortical bone healing, we created drill-hole defects in the cortex of mouse femur, a lesion that triggers intr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.09.007
更新日期:2010-02-01 00:00:00
abstract::One of the side effects associated with glucocorticoid therapy is glucocorticoid-induced bone loss. Glucocorticoids partly detain bone formation via the inhibition of osteoblastic function, however, the exact mechanism of this inhibition remains elusive. In this study, we examined the effect of dexamethasone, an activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.01.017
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To compare the effects of TNF-α and IL-17A on osteogenic differentiation of isolated fibroblast-like synoviocytes (FLS) from healthy donors, osteoarthritis (OA) and rheumatoid arthritis (RA) patients. METHODS:FLS were cultured in osteogenic medium, with and without TNF-α and/or IL-17A. Extracellular matrix m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.04.008
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND AND AIM:The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. METHODS:Patients were recruited through 3 teratogen information centres...
journal_title:Bone
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.bone.2008.11.001
更新日期:2009-03-01 00:00:00
abstract::The relative bioavailability of enteric-coated sodium fluoride (NaF) tablets (10 mg F-) has been assessed following administration with a standard calcium-rich breakfast or calcium-poor lunch, and 2 h before or simultaneously with antacid administration (2.4 g aluminum-magnesium hydroxide), versus intake on an empty s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(89)90070-7
更新日期:1989-01-01 00:00:00
abstract::This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00050-n
更新日期:1995-04-01 00:00:00
abstract::Large, cylindrical implants of a porous calcium phosphate ceramic ("hydroxyapatite" starting material, HAC) were used to replace far greater than critical-sized sections of the midshaft of sheep tibiae and retrieved at 2 and 9 months; external fixation was used in the first 5 months. Excellent clinical function of the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00083-6
更新日期:1999-06-01 00:00:00
abstract::In recent years, great interest in combined treatment of parathyroid hormone (PTH) with anti-resorptive therapy has emerged. PTH has been suggested to aid bridging of atrophic fractures and improve strength in closed fracture models. Bisphosphonate treatments typically result in a larger woven bone callus that is slow...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.012
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To establish a drill-hole defect model in osteoporotic mouse femur by comparing temporal cortical bone healing pattern between OVX-induced osteoporotic bone and sham-operated bone. METHODS:3-month-old female C57BL/6 mice were randomly divided into an ovariectomy group (OVX) and a sham-operated group (Sham). ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.03.720
更新日期:2011-06-01 00:00:00
abstract::Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western worl...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/s8756-3282(02)00845-1
更新日期:2002-10-01 00:00:00
abstract::Tooth eruption involves the movement of a tooth from its site of development within the alveolar bone to its functional position in the oral cavity. Because this process is dependent upon monocytes and formation of osteoclasts, it represents an excellent model for examination of these processes under developmental reg...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00829-3
更新日期:2002-08-01 00:00:00
abstract::Rodent models suggest that estradiol deficiency promotes bone loss through increasing interleukin-6 (IL-6) activity. However, it is controversial as to whether these findings are applicable to humans. To evaluate estradiol-mediated modulation of IL-6 activity in relation to bone metabolism in humans, we measured serum...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00243-4
更新日期:2000-01-01 00:00:00
abstract::In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90316-3
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Preterm infants are at risk for impaired bone mineralization and growth in length later in life due to inadequate nutritional intake in the early postnatal period. OBJECTIVE:To investigate whether increased nutritional supplementation of calcium, phosphate and protein in Very Low Birth Weight (VLBW) infants...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.12.022
更新日期:2018-03-01 00:00:00
abstract::Bone morbidity associated with antineoplastic treatment is a significant health concern for postmenopausal breast cancer patients. Trials have demonstrated that adjuvant therapy with an Aromatase Inhibitor is associated with an increase in musculoskeletal disorders and bone fractures. The objective of this study was t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.09.025
更新日期:2011-02-01 00:00:00
abstract::Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.03.022
更新日期:2012-06-01 00:00:00
abstract::Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone density compared to normal mice. In order to further define the role of myostatin in regulating bone mass we sought to determine if loss of myostatin function significantly ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.02.012
更新日期:2007-06-01 00:00:00
abstract::Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.026
更新日期:2019-06-01 00:00:00
abstract::Bone marrow mesenchymal stem cells (BMMSCs) provide the biological basis for bone reconstruction. Mechanical tension stimulation as a potent modulator is able to promote osteogenic capability of BMMSCs. Long non-coding RNAs (LncRNAs) as competing endogenous RNAs (ceRNAs) for microRNAs, are postulated to regulate the o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.12.013
更新日期:2018-03-01 00:00:00
abstract::Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90073-1
更新日期:1987-01-01 00:00:00
abstract::Osteoclast differentiation and activation is controlled, at least in part, by the counterbalancing influences of osteoprotegerin ligand (OPGL) and osteoprotegerin (OPG). Nonsteroidal anti-inflammatory drugs have been shown to inhibit bone loss in vivo and bone resorption in vitro, and this is associated with a loss of...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00431-2
更新日期:2001-02-01 00:00:00
abstract::Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone biology in humans with NF1. The goal of our work was to determine if loss-of-function of Nf1 gene was associate...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.01.022
更新日期:2005-05-01 00:00:00