Abstract:
:Appositional and longitudinal growth of long bones are influenced by mechanical stimuli. Using the noninvasive rat ulna loading model, we tested the hypothesis that brief-duration (10 min/day) static loads have an inhibitory effect on appositional bone formation in the middiaphysis of growing rat ulnae. Several reports have shown that ulnar loading, when applied to growing rats, results in suppressed longitudinal growth. We tested a second hypothesis that load-induced longitudinal growth suppression in the growing rat ulna is proportional to time-averaged load, and that growth plate dimensions and chondrocyte populations are reduced in the loaded limbs. Growing male rats were divided into one of three groups receiving daily 10 min bouts of static loading at 17 N, static loading at 8.5 N, or dynamic loading at 17 N. Periosteal bone formation rates, measured 3 mm distal to the ulnar midshaft, were suppressed significantly (by 28-41%) by the brief static loading sessions despite normal (dynamic) limb use between the daily loading bouts. Static loading neither suppressed nor enhanced endocortical bone formation. Dynamic loading increased osteogenesis significantly on both surfaces. At the end of the 2 week loading experiment, loaded ulnae were approximately 4% shorter than the contralateral controls in the 17 N static and dynamic groups, and approximately 2% shorter than the control side in the 8.5 N static group, suggesting that growth suppression was proportional to peak load magnitude, regardless of whether the load was static or dynamic. The suppressed growth in loaded limbs was associated with thicker distal growth plates, particularly in the hypertrophic zone, and a concurrent retention of hypertrophic cell lacunae. Negligible effects were observed in the proximal growth plate. The results demonstrate that, in growing animals, even short periods of static loading can significantly suppress appositional growth; that dynamic loads trigger the adaptive response in bone; and that longitudinal growth suppression resulting from compressive end-loads is proportional to load magnitude and not average load.
journal_name
Bonejournal_title
Boneauthors
Robling AG,Duijvelaar KM,Geevers JV,Ohashi N,Turner CHdoi
10.1016/s8756-3282(01)00488-4subject
Has Abstractpub_date
2001-08-01 00:00:00pages
105-13issue
2eissn
8756-3282issn
1873-2763pii
S8756-3282(01)00488-4journal_volume
29pub_type
杂志文章相关文献
BONE文献大全abstract::The combination of PTH with OPG has been proposed as a potential therapy in patients with severe osteoporosis. In the present study, we examined the bone material of aged ovariectomized (OVX) rats treated either with PTH (1-34) or OPG alone or in combination of both. The micro- and nanostructural characteristics of th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.03.013
更新日期:2005-07-01 00:00:00
abstract::It is well known that porosity has an inverse relationship with the mechanical properties of bones. We examined cortical and trabecular porosity of antlers, and mineral composition, thickness and mechanical properties in the cortical wall. Samples belonged to two deer populations: a captive population of an experiment...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.026
更新日期:2012-01-01 00:00:00
abstract::The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone. These studies were based on whole bone homogenates or cortical bone. By...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.018
更新日期:2013-04-01 00:00:00
abstract::To determine the ability of bone turnover to predict the response in bone mass during treatment with Tibolone, two biochemical markers of bone metabolism were evaluated [CrossLaps corrected for urinary creatinine (CrossLaps/Cr.) and serum osteocalcin measured in a newly developed assay (N-Mid)]. Data from a 2-year dou...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(96)00335-3
更新日期:1997-02-01 00:00:00
abstract::Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two major age-related skeletal disorders: osteoporosis and spondylosis. Analysis of th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00786-x
更新日期:2002-07-01 00:00:00
abstract::We examined the effects of estrogen and calcium supplementation upon bone loss among a cohort of Japanese-American women. The women averaged 64 years of age (age range 45-81) and 14 years postmenopause at their initial examination in 1981. They returned at 1-3-year intervals for subsequent examinations, most recently ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(95)00249-9
更新日期:1995-10-01 00:00:00
abstract:OBJECTIVES:Osteoporosis results in loss of bone mass and microarchitectural deterioration. Dental radiographs potentially offer a means of screening for osteoporosis as they are commonly made on adults. Spatial frequency analyses are well suited to detect subtle changes in image patterns. We hypothesize that individual...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.002
更新日期:2004-08-01 00:00:00
abstract::Bone morphogenetic protein 2 (BMP-2) is a secreted signaling molecule that acts as an inducer of bone formation and a regulator of embryonic development. The objectives of this work were as follows: (1) to clone the full-length cDNA of BMP-2 in a marine fish model, (2) analyze its gene expression during development, i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.06.021
更新日期:2006-12-01 00:00:00
abstract::To investigate whether exercise training can produce increases in bone mass in spinal cord-injured (SCI) individuals with established disuse osteopenia, nine subjects (age 28.2 years, time since injury 6.0 years, level of injury C5-T7) were recruited for a 9-month training program using functional electrical stimulati...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(96)00109-3
更新日期:1996-07-01 00:00:00
abstract::The objective was to quantify the outcome of osteoporosis (OP) in terms of health-related quality of life (HR-QOL) and cost of ambulatory care and to look at the association between these two outcomes variables. A cross-sectional health survey of 4800 Belgian individuals over the age of 45 years was used. Individuals ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00089-9
更新日期:2003-06-01 00:00:00
abstract:PURPOSE:To evaluate the effects of different definitions of glucocorticoid (GC) exposure on the magnitude and pattern of fracture risk using the same dataset. METHODS:Data from patients with rheumatoid arthritis (RA) were extracted from the Clinical Practice Research Datalink, a primary care database with electronic h...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.004
更新日期:2018-12-01 00:00:00
abstract::This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2021.115847
更新日期:2021-01-13 00:00:00
abstract::Disuse osteoporosis, which occurs commonly in prolonged bed rest and immobilization, is becoming a major problem in modern societies; however, the molecular mechanisms underlying unloading-driven bone loss have not been fully elucidated. The osteocyte network is considered to be an ideal mechanosensor and mechanotrans...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.07.012
更新日期:2012-01-01 00:00:00
abstract::Osteoarthritis (OA) is closely related to the function of several inflammatory cytokines. It has been reported that older age is associated with higher serum levels of the inflammatory cytokine IL-18. In the present study, we investigated the long-term role of serum IL-18 in cartilage loss in vivo using a new strain o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.01.031
更新日期:2008-06-01 00:00:00
abstract::Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.026
更新日期:2019-06-01 00:00:00
abstract::Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.021
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:WNT signaling plays a major role in bone and cartilage metabolism. Impaired WNT/β-catenin signaling leads to early-onset osteoporosis, but specific features in bone and other tissues remain inadequately characterized. We have identified two large Finnish families with early-onset osteoporosis due to a hetero...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.04.001
更新日期:2017-08-01 00:00:00
abstract::Endoplasmic reticulum (ER) stress is associated with increased reactive oxygen species (ROS), results from accumulation of misfolded/unfolded proteins, and can trigger apoptosis. ER stress is alleviated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which inhibits protein translation allowi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.012
更新日期:2015-04-01 00:00:00
abstract::Previously we observed that capsaicin treatment in rats inhibited sensory neuropeptide signaling, with a concurrent reduction in trabecular bone formation and bone volume, and an increase in osteoclast numbers and bone resorption. Calcitonin-gene-related peptide (CGRP) is a neuropeptide richly distributed in sensory n...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.029
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Currently, bone densitometry fails to identify nearly half of those elderly patients at immediate fracture risk. To improve clinical assessment of vertebral fracture risk, we aimed to determine how the DXA-based 2D parameter Trabecular Bone Score (TBS) relates to subregional variability in 3D trabecular micr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.02.014
更新日期:2019-05-01 00:00:00
abstract::The prediction of bone strength can be improved when determining bone mineral density (BMD) in combination with measures of trabecular microarchitecture. The goal of this study was to assess parameters of trabecular bone structure and texture of the calcaneus by clinical multi-detector row computed tomography (MDCT) i...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.01.372
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:The clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to ess...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.08.005
更新日期:2009-12-01 00:00:00
abstract:AIM:Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. MATERIALS AND METHODS:Forty-five 12-month-ol...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.11.019
更新日期:2006-06-01 00:00:00
abstract::A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in osteoblasts is not well understood. Two major events for bone formation include osteoblast differentiation by bone marker gene expression, which is mainly regulated by bone-specific transcription factor Runx2 and extracellula...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.003
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Vertebral fracture (VF) is the most common osteoporotic fracture in postmenopausal women, although most VFs are subclinical. Prevalent VFs are a significant predictor of subsequent fracture and therefore, identification of VF improves the identification of those with high fracture risk. The aim of present st...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115358
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.01.014
更新日期:2019-04-01 00:00:00
abstract::Bone sialoprotein (BSP) is highly expressed in early bone deposition and may play a part in primary bone mineralization. We previously showed that while BSP−/− mice have a mild secondary bone phenotype and are responsive to mechanical (unloading) and hormonal (ovariectomy, parathyroid hormone (PTH)) challenges, repair...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.02.014
更新日期:2012-05-01 00:00:00
abstract::We investigated the bone remodeling activity on titanium implants with different surface roughnesses using a confocal laser scanning microscope (CLSM). Two kinds of implants were used, the machined smooth-surfaced titanium and the plasma-sprayed rough-surfaced titanium. These implants were randomly inserted in a rabbi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00204-4
更新日期:1997-12-01 00:00:00
abstract::The effects of porosity and pore size; osteonal area, size, and density; mineral content; water content; wet and dry apparent densities; and age on mode I (tensile) and mode II (shear) strain energy release rate were investigated for femoral neck cortical bone from human cadavers aged >/=50 years. The results suggest ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/S8756-3282(00)00258-1
更新日期:2000-05-01 00:00:00
abstract::This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00050-n
更新日期:1995-04-01 00:00:00