Fracture toughness of human femoral neck: effect of microstructure, composition, and age.

abstract：:Fracture healing is impaired in osteoporotic bone. Low-magnitude high-frequency vibration (LMHFV) has recently been proven to be osteogenic in osteoporotic intact bone. Our previous study found that LMHFV significantly enhanced fracture healing in adult rats. This study was designed to explore whether LMHFV was able t...

journal_title：Bone

authors： Shi HF,Cheung WH,Qin L,Leung AH,Leung KS

更新日期：2010-05-01 00:00:00

abstract：:Both bone density and quality are important determinants of bone strength. Bone quality is prescribed by matrix characteristic including collagen cross-linking and bone structural characteristics and is important in reinforcement of bone strength. We investigated the effects of alfacalcidol (ALF), a prodrug of calcitr...

journal_title：Bone

authors： Saito M,Shiraishi A,Ito M,Sakai S,Hayakawa N,Mihara M,Marumo K

更新日期：2010-04-01 00:00:00

abstract：:Given the adaptation of bone to prevalent loading, bone loss should follow, but lag behind, the decline in physical performance during aging. Furthermore, bone responsiveness to load-induced strains is believed to decrease with aging. However, the relationship between bone and lean body ( approximately muscle) mass ap...

journal_title：Bone

authors： Rantalainen T,Sievänen H,Linnamo V,Hoffrén M,Ishikawa M,Kyröläinen H,Avela J,Selänne H,Komi PV,Heinonen A

更新日期：2009-11-01 00:00:00

abstract：:The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...

journal_title：Bone

authors： Okihana H,Shimomura Y

更新日期：1992-01-01 00:00:00

abstract：:Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...

journal_title：Bone

authors： Davis HM,Essex AL,Valdez S,Deosthale PJ,Aref MW,Allen MR,Bonetto A,Plotkin LI

更新日期：2019-07-01 00:00:00

abstract：:We examined the effect of nicotine on cellular proliferation, as measured by [3H]thymidine (TdR) incorporation and cell count, and on alkaline phosphatase activity in UMR 106-01 rat osteoblastic osteosarcoma cells. The cells were cultured with varying concentrations of nicotine in serum-free medium for 2 to 72 hours. ...

journal_title：Bone

authors： Fang MA,Frost PJ,Iida-Klein A,Hahn TJ

更新日期：1991-01-01 00:00:00

abstract：:In this study we investigate bone metabolism in patients with rheumatoid arthritis (RA), with or without joint destruction, using serum biochemical markers of bone turnover. Three hundred eighteen patients (disease duration >2 years; mean 9 years) were divided into those with joint destruction, that is, with Larsen wr...

journal_title：Bone

authors： Garnero P,Jouvenne P,Buchs N,Delmas PD,Miossec P

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures. METHODS:This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40-90 years, who returned a questionnaire c...

journal_title：Bone

authors： Rubin KH,Abrahamsen B,Friis-Holmberg T,Hjelmborg JV,Bech M,Hermann AP,Barkmann R,Glüer CC,Brixen K

更新日期：2013-09-01 00:00:00

abstract：:Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two major age-related skeletal disorders: osteoporosis and spondylosis. Analysis of th...

journal_title：Bone

authors： Ogata N,Matsumura Y,Shiraki M,Kawano K,Koshizuka Y,Hosoi T,Nakamura K,Kuro-O M,Kawaguchi H

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVES:The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potentia...

journal_title：Bone

authors： Caliaperoumal G,Souyet M,Bensidhoum M,Petite H,Anagnostou F

更新日期：2018-07-01 00:00:00

abstract：:Bone is a hierarchical, multiphasic and anisotropic structure which in addition possess piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical a...

journal_title：Bone

authors： Mohammadkhah M,Marinkovic D,Zehn M,Checa S

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Detraining after dedicated exercise programs might be a frequent situation in older people's exercise patterns. The aim of the present study was thus to determine the effects of 6 months of detraining after 18 months of high intensity resistance exercise (HIT-RT) on musculoskeletal outcomes in older men with sa...

journal_title：Bone

authors： Kemmler W,Kohl M,Fröhlich M,Schoene D,von Stengel S

更新日期：2021-01-01 00:00:00

abstract：:Osteoporotic bone fragility is due not only to decreased bone mass but to inadequate repair of fatigue damage and to trabecular disconnection. The precise roles and relative contributions of these three factors are not known for osteoporosis in general, and certainly not in any individual case. However, it is known th...

journal_title：Bone

authors： Heaney RP

更新日期：1992-01-01 00:00:00

abstract：:Clinically, osteopenia or low bone mass has been observed in a variety of chronic inflammatory diseases, and elevated proinflammatory mediators have implicated this process. The purpose of this study was to develop an in vivo model of bone loss induced by chronic systemic inflammation. Time-release pellets designed to...

journal_title：Bone

authors： Smith BJ,Lerner MR,Bu SY,Lucas EA,Hanas JS,Lightfoot SA,Postier RG,Bronze MS,Brackett DJ

更新日期：2006-03-01 00:00:00

abstract：:Recent proton magnetic resonance (MR) spectroscopy studies have shown that cortical bone exists as different components which have distinct transverse relaxation times (T2s). However, cortical bone shows zero or near zero signal with all conventional MR sequences on clinical scanners and the different water components...

journal_title：Bone

authors： Biswas R,Bae W,Diaz E,Masuda K,Chung CB,Bydder GM,Du J

更新日期：2012-03-01 00:00:00

abstract：:Tight interactions among different cell types contributing to bone formation are of key importance in the maintenance of bone homeostasis. Based on the high similarity in responses to (anti)osteogenic signals between zebrafish scales and mammalian bone, we developed and validated a model to screen large numbers of com...

journal_title：Bone

authors： de Vrieze E,Zethof J,Schulte-Merker S,Flik G,Metz JR

更新日期：2015-05-01 00:00:00

abstract：:Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...

journal_title：Bone

authors： Fiorano-Charlier C,Ostertag A,Aquino JP,de Vernejoul MC,Baudoin C

更新日期：2002-07-01 00:00:00

abstract：:Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we have focused on the function of one of the matrix proteins expressed in bones and teeth, the matrix adhesion protein ameloblastin (AMBN). Transgenic mice with 5-fold elev...

journal_title：Bone

authors： Lu X,Ito Y,Atsawasuwan P,Dangaria S,Yan X,Wu T,Evans CA,Luan X

更新日期：2013-05-01 00:00:00

abstract：:It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...

journal_title：Bone

authors： Kulkarni RN,Voglewede PA,Liu D

更新日期：2013-12-01 00:00:00

abstract：:Oral bisphosphonates are established therapeutics for postmenopausal osteoporosis. Alternative, simplified dosing regimens that improve tolerability and promote convenience may be advantageous. Ibandronate is a highly potent, nitrogen-containing bisphosphonate that can be administered as a convenient intravenous (i.v....

journal_title：Bone

authors： Adami S,Felsenberg D,Christiansen C,Robinson J,Lorenc RS,Mahoney P,Coutant K,Schimmer RC,Delmas PD

更新日期：2004-05-01 00:00:00

abstract：CONTEXT:Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications to treat depression and anxiety. SSRIs exert their effects by inhibiting the serotonin transporter and modulating extracellular serotonin levels, a neurotransmitter that has been shown to affect bone metabolism in animals. Studi...

journal_title：Bone

authors： Feuer AJ,Demmer RT,Thai A,Vogiatzi MG

更新日期：2015-09-01 00:00:00

abstract：:The objective was to quantify the outcome of osteoporosis (OP) in terms of health-related quality of life (HR-QOL) and cost of ambulatory care and to look at the association between these two outcomes variables. A cross-sectional health survey of 4800 Belgian individuals over the age of 45 years was used. Individuals ...

journal_title：Bone

authors： Ethgen O,Tellier V,Sedrine WB,De Maeseneer J,Gosset C,Reginster JY

更新日期：2003-06-01 00:00:00

abstract：:The clinical development of tiludronate (tiludronic acid, disodium salt) for the treatment of Paget's disease of bone is now being complemented by another clinical trials program to investigate its use in osteoporosis. It is expected that osteoporosis will become a major indication for tiludronate, and this paper desc...

journal_title：Bone

authors： Chesnut CH 3rd

更新日期：1995-11-01 00:00:00

abstract：:This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

journal_title：Bone

authors： Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

更新日期：2021-01-13 00:00:00

abstract：:Serum PINP has emerged as a reliable marker of bone turnover in humans and is routinely used to monitor bone formation. However, the effects of PTH (1-34) on bone turnover have not been evaluated following short-term treatment. We present data demonstrating that PINP is an early serum biomarker in the rat for assessin...

journal_title：Bone

authors： Hale LV,Galvin RJ,Risteli J,Ma YL,Harvey AK,Yang X,Cain RL,Zeng Q,Frolik CA,Sato M,Schmidt AL,Geiser AG

更新日期：2007-04-01 00:00:00

abstract：:It is now well established that important regulatory interactions occur between the cells in the hematopoietic, immune and skeletal systems (osteoimmunology). B lymphocytes (B cells) are responsible for the generation and production of antibodies or immunoglobulins in the body. Together with T cells these lymphocytes ...

journal_title：Bone

authors： Horowitz MC,Fretz JA,Lorenzo JA

更新日期：2010-09-01 00:00:00

abstract：:Fracture healing is influenced by numerous hormones, growth factors, and cytokines. The systemic administration of growth hormone (GH) has shown to accelerate bone regeneration. Local application of growth factors, such as insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta-1 (TGF-beta1), are know...

journal_title：Bone

authors： Schmidmaier G,Wildemann B,Heeger J,Gäbelein T,Flyvbjerg A,Bail HJ,Raschke M

更新日期：2002-07-01 00:00:00

abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

journal_title：Bone

authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

更新日期：2011-05-01 00:00:00

abstract：:Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...

journal_title：Bone

authors： Saito M,Grynpas MD,Burr DB,Allen MR,Smith SY,Doyle N,Amizuka N,Hasegawa T,Kida Y,Marumo K,Saito H

更新日期：2015-04-01 00:00:00

abstract：:E-Series prostaglandins (PGE) are powerful osteogenic substances when given in vivo. The purpose of this work was to determine the ability of locally administered PGE1 to promote alveolar bone formation. Controlled-release pellets containing PGE1 were implanted on the lateral mandibular surface of Beagle dogs and tiss...

journal_title：Bone

authors： Miller SC,Marks SC Jr

更新日期：1993-05-01 00:00:00