Tiludronate: development as an osteoporosis therapy.

abstract：AIM:Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. MATERIALS AND METHODS:Forty-five 12-month-ol...

journal_title：Bone

authors： Zhang G,Qin L,Hung WY,Shi YY,Leung PC,Yeung HY,Leung KS

更新日期：2006-06-01 00:00:00

abstract：:We hypothesized that estrogen deficiency induces changes in bone vascularization which might be involved in bone loss mechanisms. First, we studied gene expression of angiogenic (vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2)) and vasodilator (endothelial nitric oxide synthase (ecNOS), n...

journal_title：Bone

authors： Mekraldi S,Lafage-Proust MH,Bloomfield S,Alexandre C,Vico L

更新日期：2003-06-01 00:00:00

abstract：:Muscle and bone are two intimately connected tissues. A coordinated interplay between these tissues at mechanical levels is required for their development, function and ageing. Evidence is emerging that several genes and molecular pathways exert a pleiotropic effect on both muscle and bone. Bone morphogenetic proteins...

journal_title：Bone

authors： Sartori R,Sandri M

更新日期：2015-11-01 00:00:00

abstract：:Osteosarcoma is a highly metastatic tumor affecting adolescents, for which there is no second-line chemotherapy. As suggested for most tumors, its capability to overgrow is probably driven by cancer stem cells (CSCs), and finding new targets to kill CSCs may be critical for improving patient survival. TP53 is the most...

journal_title：Bone

authors： Di Fiore R,Marcatti M,Drago-Ferrante R,D'Anneo A,Giuliano M,Carlisi D,De Blasio A,Querques F,Pastore L,Tesoriere G,Vento R

更新日期：2014-03-01 00:00:00

abstract：:Ovariectomized cynomolgus monkeys have previously been investigated as a nonhuman primate model of postmenopausal osteoporosis (Jerome et al., Bone Miner 9:527-540; 1994). In the present study, Fourier transform infrared microspectroscopy (FTIRM) was used to verify that differences in bone mineral quality and quantity...

journal_title：Bone

authors： Gadeleta SJ,Boskey AL,Paschalis E,Carlson C,Menschik F,Baldini T,Peterson M,Rimnac CM

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVES:Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartila...

journal_title：Bone

authors： Zarka M,Hay E,Ostertag A,Marty C,Chappard C,Oudet F,Engelke K,Laredo JD,Cohen-Solal M

更新日期：2019-06-01 00:00:00

abstract：:Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...

journal_title：Bone

authors： Dennison EM,Jameson KA,Edwards MH,Denison HJ,Aihie Sayer A,Cooper C

更新日期：2014-07-01 00:00:00

abstract：:To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6° head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n=8) which performed no countermeasure, an exercise group (EXE, n=8) undertaking a combi...

journal_title：Bone

authors： Beller G,Belavý DL,Sun L,Armbrecht G,Alexandre C,Felsenberg D

更新日期：2011-10-01 00:00:00

abstract：:Despite the remarkable healing potential of long bone fractures, traumatic injuries that result in critical defects require challenging reconstructive limb sparing surgery. While devitalized allografts are the gold standard for these procedures, they are prone to failure due to their limited osseointegration with the ...

journal_title：Bone

authors： Reynolds DG,Takahata M,Lerner AL,O'Keefe RJ,Schwarz EM,Awad HA

更新日期：2011-03-01 00:00:00

abstract：:Localized proton spectra of the human lumbar vertebral body were recorded in vivo at 1.5 T, using the STEAM (stimulated echo acquisition mode) pulse sequence. Thirty-seven patients (18 men, 19 women) were examined, ranging in age from 21 to 68 years (mean = 40, SD = 13). The fat fraction of the bone marrow was calcula...

journal_title：Bone

authors： De Bisschop E,Luypaert R,Louis O,Osteaux M

更新日期：1993-03-01 00:00:00

abstract：:Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical testing of therapies. A reference point indentation technique (BioDent) has recently been deve...

journal_title：Bone

authors： Carriero A,Bruse JL,Oldknow KJ,Millán JL,Farquharson C,Shefelbine SJ

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...

journal_title：Bone

authors： Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

更新日期：2020-12-01 00:00:00

abstract：:The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...

journal_title：Bone

authors： Siebler T,Robson H,Shalet SM,Williams GR

更新日期：2002-10-01 00:00:00

abstract：:Mandibuloacral dysplasia (MAD) is a rare recessively inherited premature aging disease characterized by skeletal and metabolic anomalies. It is part of the spectrum of diseases called laminopathies and results from mutations in genes regulating the synthesis of the nuclear laminar protein, lamin A. Homozygous or compo...

journal_title：Bone

authors： Cunningham VJ,D'Apice MR,Licata N,Novelli G,Cundy T

更新日期：2010-09-01 00:00:00

abstract：:Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...

journal_title：Bone

authors： Surowiec RK,Ram S,Idiyatullin D,Goulet R,Schlecht SH,Galban CJ,Kozloff KM

更新日期：2021-02-01 00:00:00

abstract：:Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...

journal_title：Bone

authors： Lynn H,Kwok T,Wong SY,Woo J,Leung PC

更新日期：2006-04-01 00:00:00

abstract：:While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures is not well established. We used prospectively-collected data from a large cohort to examine the role of these factors on the ris...

journal_title：Bone

authors： Armstrong ME,Cairns BJ,Banks E,Green J,Reeves GK,Beral V,Million Women Study Collaborators.

更新日期：2012-06-01 00:00:00

abstract：:Osteoclast differentiation and activation is controlled, at least in part, by the counterbalancing influences of osteoprotegerin ligand (OPGL) and osteoprotegerin (OPG). Nonsteroidal anti-inflammatory drugs have been shown to inhibit bone loss in vivo and bone resorption in vitro, and this is associated with a loss of...

journal_title：Bone

authors： O'Brien EA,Williams JH,Marshall MJ

更新日期：2001-02-01 00:00:00

abstract：:The temporal expression of bone microsomal casein kinase II, osteopontin, bone sialoprotein, alkaline phosphatase, and the accumulation of a solid calcium-inorganic orthophosphate mineral phase, have been charted from day 2 to day 21 during the repair of calvarial defects in rats induced by the implantation of decalci...

journal_title：Bone

authors： Wang J,Glimcher MJ,Mah J,Zhou HY,Salih E

更新日期：1998-06-01 00:00:00

abstract：:Bone metastases and skeletal complications are major causes of morbidity in prostate cancer patients. Despite the osteoblastic appearance of bone metastases on imaging studies, patients have elevated serum and urinary markers of bone resorption, indicative of high osteoclast activity. Increased osteoclast activity is ...

journal_title：Bone

authors： Lee RJ,Saylor PJ,Smith MR

更新日期：2011-01-01 00:00:00

abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which in most species is the predominant noncollagenous protein of bone and dentin, has been postulated to play roles in bone formation and remodeling. Recently, genetic studies showed that osteocalcin acts as an inhibitor of osteoblast function. Based on...

journal_title：Bone

authors： Boskey AL,Gadaleta S,Gundberg C,Doty SB,Ducy P,Karsenty G

更新日期：1998-09-01 00:00:00

abstract：:Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...

journal_title：Bone

authors： Saito M,Grynpas MD,Burr DB,Allen MR,Smith SY,Doyle N,Amizuka N,Hasegawa T,Kida Y,Marumo K,Saito H

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. MET...

journal_title：Bone

authors： Alfred T,Ben-Shlomo Y,Cooper R,Hardy R,Cooper C,Deary IJ,Gunnell D,Harris SE,Kumari M,Martin RM,Sayer AA,Starr JM,Kuh D,Day IN,HALCyon study team.

更新日期：2013-01-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Type IIB procollagen is characteristic of cartilage, comprising 50% of the extracellular matrix. The NH(2)-propeptide of type IIB collagen, PIIBNP, can kill tumor cells via binding to integrins α(V)β(3) and α(V)β(5). As osteoclasts rely on α(V)β(3) integrins for function in bone erosion, we sought to determin...

journal_title：Bone

authors： Hayashi S,Wang Z,Bryan J,Kobayashi C,Faccio R,Sandell LJ

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:To investigate the effectiveness of the T-score values provided by Radiofrequency Echographic Multi Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures. METHODS:A population of Caucasian women (30-90 years), enrolled from 2013 to 2016, underwent dual X-ray absorpti...

journal_title：Bone

authors： Adami G,Arioli G,Bianchi G,Brandi ML,Caffarelli C,Cianferotti L,Gatti D,Girasole G,Gonnelli S,Manfredini M,Muratore M,Quarta E,Quarta L

更新日期：2020-05-01 00:00:00

abstract：:Ewing's sarcoma of bone is a primary childhood malignancy of bone that is treated with X-radiation therapy in combination with surgical excision and chemotherapy. To better study Ewing's sarcoma of bone we developed a novel model of primary Ewing's sarcoma of bone and then treated animals with X-radiation therapy. We ...

journal_title：Bone

authors： Margulies BS,DeBoyace SD,Damron TA,Allen MJ

更新日期：2015-10-01 00:00:00

abstract：:Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of these multinucleated giant cells from precursors is controlled by the cytokine R...

journal_title：Bone

authors： Charles JF,Coury F,Sulyanto R,Sitara D,Wu J,Brady N,Tsang K,Sigrist K,Tollefsen DM,He L,Storm D,Aliprantis AO

更新日期：2012-11-01 00:00:00

abstract：:Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...

journal_title：Bone

authors： Ganesh T,Laughrey LE,Niroobakhsh M,Lara-Castillo N

更新日期：2020-08-01 00:00:00

abstract：:Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...

journal_title：Bone

authors： Mallin MM,Pienta KJ,Amend SR

更新日期：2020-12-03 00:00:00