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BMPs and the muscle-bone connection.

Abstract：

:Muscle and bone are two intimately connected tissues. A coordinated interplay between these tissues at mechanical levels is required for their development, function and ageing. Evidence is emerging that several genes and molecular pathways exert a pleiotropic effect on both muscle and bone. Bone morphogenetic proteins (BMPs) are secreted signal factors belonging to the transforming growth factor β (TGFβ) superfamily. BMPs have an essential role during bone and cartilage formation and maintenance. Recently, we and others have demonstrated that the BMP pathway also has a role in controlling adult skeletal muscle mass. Thus, BMPs become crucial regulators of both bone and muscle formation and homeostasis. In this review we will discuss the signalling downstream BMP and its role in muscle-bone interaction. This article is part of a Special Issue entitled "Muscle Bone Interactions".

journal_name

Bone

journal_title

Bone

authors

Sartori R,Sandri M

doi

10.1016/j.bone.2015.05.023

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

37-42

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(15)00204-5

journal_volume

80

pub_type

杂志文章,评审

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