Changes in vasoactive factors associated with altered vessel morphology in the tibial metaphysis during ovariectomy-induced bone loss in rats.

abstract：:Despite the fact that the medications used to treat abnormal bone conditions often induce osteonecrosis of the jaw (ONJ), previous attempts to establish an animal model for ONJ have shown insufficient consideration for this important prerequisite for the development of the disease. The purpose of this study was to est...

journal_title：Bone

authors： Kim JW,Tatad JCI,Landayan MEA,Kim SJ,Kim MR

更新日期：2015-12-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which in most species is the predominant noncollagenous protein of bone and dentin, has been postulated to play roles in bone formation and remodeling. Recently, genetic studies showed that osteocalcin acts as an inhibitor of osteoblast function. Based on...

journal_title：Bone

authors： Boskey AL,Gadaleta S,Gundberg C,Doty SB,Ducy P,Karsenty G

更新日期：1998-09-01 00:00:00

abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...

journal_title：Bone

authors： Heveran CM,Rauff A,King KB,Carpenter RD,Ferguson VL

更新日期：2018-05-01 00:00:00

abstract：:A more accurate understanding of the molecular mechanisms and signaling pathways underpinning human mesenchymal stem cell (MSC) plasticity and differentiation properties is pivotal for accomplishing solid and diligent translation of MSC-based experimental therapeutics and clinical trials to broad clinical practice. In...

journal_title：Bone

authors： Ishiy FAA,Fanganiello RD,Kobayashi GS,Kague E,Kuriki PS,Passos-Bueno MR

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Traditional epidemiological studies suggest that there is an association between age at menarche (years) (AAM) and bone mineral density (BMD) at the sites of the femoral neck and lumbar spine (FNK and LS BMD), indicating a potentially important relationship between AAM and the development of osteoporosis (OP). ...

journal_title：Bone

authors： Zhang Q,Greenbaum J,Zhang WD,Sun CQ,Deng HW

更新日期：2018-12-01 00:00:00

abstract：:The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...

journal_title：Bone

authors： Jandl NM,von Kroge S,Stürznickel J,Baranowsky A,Stockhausen KE,Mushumba H,Beil FT,Püschel K,Amling M,Rolvien T

更新日期：2020-06-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) require G proteins for intracellular signaling to regulate a variety of growth and maintenance processes, including osteogenesis and bone turnover. Bone maintenance events may be altered by changes in the activity or level of G proteins, which then modify signaling in bone cells suc...

journal_title：Bone

authors： Dela Cruz A,Mattocks M,Sugamori KS,Grynpas MD,Mitchell J

更新日期：2014-02-01 00:00:00

abstract：:Cancer chemotherapy often causes significant bone loss, marrow adiposity and haematopoietic defects, yet the underlying mechanisms and recovery potential remain unclear. Wnt/β-catenin signalling is integral to the regulation of osteogenesis, adipogenesis and haematopoiesis; using a rat model, the current study investi...

journal_title：Bone

authors： Georgiou KR,King TJ,Scherer MA,Zhou H,Foster BK,Xian CJ

更新日期：2012-06-01 00:00:00

abstract：:The long prevailing view that obesity is generally associated with beneficial effects on the skeleton has recently been challenged. Apolipoprotein E (apoE) is known to influence both adipose tissue and bone. The goal of the current study was to examine the impact of apoE on the development of fat mass and bone mass in...

journal_title：Bone

authors： Bartelt A,Beil FT,Schinke T,Roeser K,Ruether W,Heeren J,Niemeier A

更新日期：2010-10-01 00:00:00

abstract：:One of the side effects associated with glucocorticoid therapy is glucocorticoid-induced bone loss. Glucocorticoids partly detain bone formation via the inhibition of osteoblastic function, however, the exact mechanism of this inhibition remains elusive. In this study, we examined the effect of dexamethasone, an activ...

journal_title：Bone

authors： Kósa JP,Kis A,Bácsi K,Balla B,Nagy Z,Takács I,Speer G,Lakatos P

更新日期：2011-05-01 00:00:00

abstract：:Genetic mouse models are widely used for understanding human diseases but we know much less about the anatomical structure of the auditory ossicles in the mouse than we do about human ossicles. Furthermore, current studies have mainly focused on disease conditions such as osteomalacia and rickets in patients with hypo...

journal_title：Bone

authors： Lv K,Huang H,Yi X,Chertoff ME,Li C,Yuan B,Hinton RJ,Feng JQ

更新日期：2017-10-01 00:00:00

abstract：:Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...

journal_title：Bone

authors： van Wijnen AJ,Bagheri L,Badreldin AA,Larson AN,Dudakovic A,Thaler R,Paradise CR,Wu Z

更新日期：2021-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) are defined as plastic-adherent, clonal cells that are common progenitors for osteoblasts and adipocytes. An inverse relationship between bone and fat has been observed in several clinical conditions and has been suggested to be caused by re-directing MSC differentiation into one particula...

journal_title：Bone

authors： Post S,Abdallah BM,Bentzon JF,Kassem M

更新日期：2008-07-01 00:00:00

abstract：:The variability of different primary tumors in the susceptibility to metastatic bone disease is poorly understood. Factors that determine the viability of metastatic cells are also poorly understood, but may depend in part upon gene expression of PTHrP and the vitamin D receptor. In contrast, much more is known of the...

journal_title：Bone

authors： Kanis JA

更新日期：1995-08-01 00:00:00

abstract：:Osteoclasts (OCs) attach to the extracellular matrix via specialized attachment structures called podosomes, which form a prominent F-actin-rich ring that is thought to correspond to the sealing zone of resorbing OCs. Calcitonin (CT), a 32-amino acid polypeptide, inhibits bone resorption by decreasing motility, induci...

journal_title：Bone

authors： Shyu JF,Shih C,Tseng CY,Lin CH,Sun DT,Liu HT,Tsung HC,Chen TH,Lu RB

更新日期：2007-05-01 00:00:00

abstract：:Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural fea...

journal_title：Bone

authors： Les CM,Spence CA,Vance JL,Christopherson GT,Patel B,Turner AS,Divine GW,Fyhrie DP

更新日期：2004-09-01 00:00:00

abstract：:Both clinical and laboratory studies have shown that the chemotherapy drug, Methotrexate (MTX), has adverse short-term effects on bone. There are no studies that demonstrate the long-term response of bone to MTX. The purpose of this study was to determine the short- and long-term effects of MTX on bone volume, turnove...

journal_title：Bone

authors： Wheeler DL,Vander Griend RA,Wronski TJ,Miller GJ,Keith EE,Graves JE

更新日期：1995-02-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between b...

journal_title：Bone

authors： Zhang H,Zhang Y,Terajima M,Romanowicz G,Liu Y,Omi M,Bigelow E,Joiner DM,Waldorff EI,Zhu P,Raghavan M,Lynch M,Kamiya N,Zhang R,Jepsen KJ,Goldstein S,Morris MD,Yamauchi M,Kohn DH,Mishina Y

更新日期：2020-08-01 00:00:00

abstract：:We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...

journal_title：Bone

authors： McDonald AC,Schuijers JA,Gundlach AL,Grills BL

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...

journal_title：Bone

authors： Cao Y,Mori S,Mashiba T,Kaji Y,Manabe T,Iwata K,Miyamoto K,Komatsubara S,Yamamoto T

更新日期：2007-01-01 00:00:00

abstract：:Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...

journal_title：Bone

authors： Ardawi MS,Maimani AA,Bahksh TA,Rouzi AA,Qari MH,Raddadi RM

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:The GH-IGF axis has profound effects on bone metabolism and may be important in the etiology of idiopathic osteoporosis. Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to...

journal_title：Bone

authors： Patel MB,Arden NK,Masterson LM,Phillips DI,Swaminathan R,Syddall HE,Byrne CD,Wood PJ,Cooper C,Holt RI,Hertfordshire Cohort Study Group.

更新日期：2005-12-01 00:00:00

abstract：:The effects of tumor-conditioned media (TCM) derived from cultured cells from an oncogenic hypophosphatemic osteomalacia (OHO) tumor on transformed human kidney cells were investigated. Dose-dependent cell detachment and aggregation occurred in kidney cells cultured in serum-free medium supplemented with TCM, but not ...

journal_title：Bone

authors： Rowe PS,Ong AC,Cockerill FJ,Goulding JN,Hewison M

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:In the Fracture Prevention Trial, the risks of any nonvertebral fracture (relative risk [RR] 0.65, P=0.04) and any fragility nonvertebral fracture (RR 0.47, P=0.02) were significantly reduced in the teriparatide 20 μg/day (teriparatide) versus placebo group. The purpose of this analysis was to examine the effic...

journal_title：Bone

authors： Krege JH,Wan X

更新日期：2012-01-01 00:00:00

abstract：:The R51Q mutation in sorting nexin 10 (SNX10) was shown to cause a lethal genetic disease in humans, namely autosomal recessive osteopetrosis (ARO). We describe here the first R51Q SNX10 knock-in mouse model and show that mice homozygous for this mutation exhibit massive, early-onset, and widespread osteopetrosis. The...

journal_title：Bone

authors： Stein M,Barnea-Zohar M,Shalev M,Arman E,Brenner O,Winograd-Katz S,Gerstung J,Thalji F,Kanaan M,Elinav H,Stepensky P,Geiger B,Tuckermann J,Elson A

更新日期：2020-07-01 00:00:00

abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To elucidate this mechanism, we investigated the effects...

journal_title：Bone

authors： Tanno M,Furukawa KI,Ueyama K,Harata S,Motomura S

更新日期：2003-10-01 00:00:00

abstract：:FGF23 is an O-glycosylated circulating peptide hormone with a critical role in phosphate homeostasis; it is inactivated by cellular proprotein convertases in a pre-release degradative pathway. We have here examined the metabolism of FGF23 in a model bone cell line, IDG-SW3, prior to and following differentiation, as w...

journal_title：Bone

authors： Yamamoto H,Ramos-Molina B,Lick AN,Prideaux M,Albornoz V,Bonewald L,Lindberg I

更新日期：2016-03-01 00:00:00

abstract：:Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extrac...

journal_title：Bone

authors： Soundia A,Hadaya D,Esfandi N,de Molon RS,Bezouglaia O,Dry SM,Pirih FQ,Aghaloo T,Tetradis S

更新日期：2016-09-01 00:00:00

abstract：:To examine the ability of tamoxifen (TAM) to conserve bone in the estrogen-deficient ovariectomized (OVX) rat in the presence and absence of parathyroid hormone (PTH) six groups of rats with 45Ca-labeled bones were studied for 12 weeks. Rats were OVX, parathyroidectomized (PTX), or given sham operations and treated wi...

journal_title：Bone

authors： Goulding A,Gold E

更新日期：1994-09-01 00:00:00