SIRT6 deficiency culminates in low-turnover osteopenia.

abstract：:Interleukin (IL)-17 is crucial to osteoclast differentiation and activation. Osteocytes support osteoclast formation and are thought to orchestrate bone remodeling in response to fluid flow. The contribution of IL-17 to osteocyte-related bone resorption remains unclear. Here, we used the osteocyte-like MLO-Y4 cell lin...

journal_title：Bone

authors： Liao C,Cheng T,Wang S,Zhang C,Jin L,Yang Y

更新日期：2017-08-01 00:00:00

abstract：:End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic mechanical tension (ICMT), exacerbate end plate chondrocyte degeneration. However, the underlying molecular mechanism of mechanical stretch-induced end plate chondrocyte...

journal_title：Bone

authors： Zheng Q,Li XX,Xiao L,Shao S,Jiang H,Zhang XL,Sun LY,Xu HG

更新日期：2019-11-01 00:00:00

abstract：:Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...

journal_title：Bone

authors： Pavey GJ,Qureshi AT,Tomasino AM,Honnold CL,Bishop DK,Agarwal S,Loder S,Levi B,Pacifici M,Iwamoto M,Potter BK,Davis TA,Forsberg JA

更新日期：2016-09-01 00:00:00

abstract：:Recent proton magnetic resonance (MR) spectroscopy studies have shown that cortical bone exists as different components which have distinct transverse relaxation times (T2s). However, cortical bone shows zero or near zero signal with all conventional MR sequences on clinical scanners and the different water components...

journal_title：Bone

authors： Biswas R,Bae W,Diaz E,Masuda K,Chung CB,Bydder GM,Du J

更新日期：2012-03-01 00:00:00

abstract：:Strontium ranelate (S12911) has previously been shown to stimulate bone formation and inhibit bone resorption in rats. To determine whether strontium ranelate affects normal bone remodeling, we studied the effect of strontium ranelate on alveolar bone in monkeys. Strontium ranelate, at dosages of 100, 275, and 750 mg/...

journal_title：Bone

authors： Buehler J,Chappuis P,Saffar JL,Tsouderos Y,Vignery A

更新日期：2001-08-01 00:00:00

abstract：:The influence of porosity, osteon density, osteonal area, osteonal lamellar area, osteon size, and haversian canal size on the tension and shear fracture toughness, that is, the mode I and mode II strain energy release rate (GIc and GIIc), respectively, were investigated for the human femur and the tibia. The results ...

journal_title：Bone

authors： Yeni YN,Brown CU,Wang Z,Norman TL

更新日期：1997-11-01 00:00:00

abstract：:Cyclic mechanical loading augments trabecular bone mass, mainly by increasing trabecular thickness. For this reason, we hypothesized that an in silico thickening algorithm using open-loop control would be sufficient to reliably predict the response of trabecular bone to cyclic mechanical loading. This would also mean ...

journal_title：Bone

authors： Schulte FA,Lambers FM,Webster DJ,Kuhn G,Müller R

更新日期：2011-12-01 00:00:00

abstract：:Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumption that the material is linearly elastic. In the present study, we adjusted the constraint of linearly elastic behavior...

journal_title：Bone

authors： Wang X,Allen MR,Burr DB,Lavernia EJ,Jeremić B,Fyhrie DP

更新日期：2008-10-01 00:00:00

abstract：:Microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1), or Taybi-Linder syndrome is characterized by distinctive skeletal dysplasia, severe intrauterine and postnatal growth retardation, microcephaly, dysmorphic features, and neurological malformations. It is an autosomal recessive disorder caused by homozyg...

journal_title：Bone

authors： Krøigård AB,Frost M,Larsen MJ,Ousager LB,Frederiksen AL

更新日期：2016-11-01 00:00:00

abstract：:We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...

journal_title：Bone

authors： McDonald AC,Schuijers JA,Gundlach AL,Grills BL

更新日期：2007-04-01 00:00:00

abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To elucidate this mechanism, we investigated the effects...

journal_title：Bone

authors： Tanno M,Furukawa KI,Ueyama K,Harata S,Motomura S

更新日期：2003-10-01 00:00:00

abstract：:The striking predilection of temporomandibular disorders (TMD) in women, especially during gonad-intact puberty or reproductive years, indicates that oestrogen plays an important role in the progression of TMD, but the underlying mechanism remains unclear. In this study, unilateral anterior crossbite (UAC) was used to...

journal_title：Bone

authors： Ye T,Sun D,Mu T,Chu Y,Miao H,Zhang M,Yang H,Liu Q,Lu L,Xing X,Yu S

更新日期：2018-06-01 00:00:00

abstract：:Numerous studies have investigated the effects of physical activity on bone health; however, little is known about the effects of isokinetic strength training on bone. While bone mineral density (BMD) is widely used to assess bone health and fracture risk, there are several limitations of this measure that warrant new...

journal_title：Bone

authors： Miller LE,Wootten DF,Nickols-Richardson SM,Ramp WK,Steele CR,Cotton JR,Carneal JP,Herbert WG

更新日期：2007-10-01 00:00:00

abstract：:We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...

journal_title：Bone

authors： Gasser JA

更新日期：1995-10-01 00:00:00

abstract：:Fracture healing is a regenerative process in which bone is restored without scar tissue formation. The healing cascade initiates with a cycle of inflammation, cell migration, proliferation and differentiation. Immune cells invade the fracture site immediately upon bone damage and contribute to the initial phase of th...

journal_title：Bone

authors： Könnecke I,Serra A,El Khassawna T,Schlundt C,Schell H,Hauser A,Ellinghaus A,Volk HD,Radbruch A,Duda GN,Schmidt-Bleek K

更新日期：2014-07-01 00:00:00

abstract：:Bone is a hierarchical, multiphasic and anisotropic structure which in addition possess piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical a...

journal_title：Bone

authors： Mohammadkhah M,Marinkovic D,Zehn M,Checa S

更新日期：2019-10-01 00:00:00

abstract：:During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oils (sage, rosemary, and thyme) and essential oils extracted from these herbs and other plants (oils of sage, r...

journal_title：Bone

authors： Mühlbauer RC,Lozano A,Palacio S,Reinli A,Felix R

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Fibrodysplasia ossificans progressiva (FOP) is a rare, disabling genetic disorder characterized by episodic soft tissue swelling (flare-ups) that leads to progressive heterotopic ossification and restricted joint mobility. METHODS:Here we present the first longitudinal patient-reported mobility assessment (...

journal_title：Bone

authors： Kaplan FS,Al Mukaddam M,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：:Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...

journal_title：Bone

authors： Iwasaki Y,Kazama JJ,Yamato H,Fukagawa M

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The association between beta-blockers (BB) and fracture risk is controversial, due largely to conflicting findings from previous studies. The present study sought to evaluate the effect of BB on fracture risk by using a Bayesian meta-analysis approach. METHODS AND RESULTS:We systematically retrieved 13 obse...

journal_title：Bone

authors： Yang S,Nguyen ND,Eisman JA,Nguyen TV

更新日期：2012-11-01 00:00:00

abstract：:Hormone replacement therapy is effectively used to prevent postmenopausal bone loss. Variation in response to the therapy is, however, frequently seen. In addition, the direct effects of sex steroids on isolated human bone marrow stromal cells have been reported to vary depending on the donor, but the biological mecha...

journal_title：Bone

authors： Leskelä HV,Olkku A,Lehtonen S,Mahonen A,Koivunen J,Turpeinen M,Uusitalo J,Pelkonen O,Kangas L,Selander K,Lehenkari P

更新日期：2006-11-01 00:00:00

abstract：:The aims of this study were to clarify the role of cell maturation stage on chondrocyte response to parathyroid hormone (PTH) by examining the effect of PTH(1-34) on alkaline-phosphatase-specific activity (ALPase) of chondrocyte cultures at two distinct stages of maturation, and to determine the signaling pathways use...

journal_title：Bone

authors： Schwartz Z,Semba S,Graves D,Dean DD,Sylvia VL,Boyan BD

更新日期：1997-09-01 00:00:00

abstract：:The underlying causes of maxillary bone loss during lactation remain poorly understood. We evaluated the impact of lactation on physiological and mechanically-induced alveolar bone remodeling. Nulliparous non-lactating (N-LAC) and 21-day lactating (LAC) mice underwent mechanically-induced bone remodeling by orthodonti...

journal_title：Bone

authors： Macari S,Sharma LA,Wyatt A,da Silva JM,Dias GJ,Silva TA,Szawka RE,Grattan DR

更新日期：2018-05-01 00:00:00

abstract：:We performed a comprehensive analysis of the relationships between histologic indices in the iliac crest (cancellous bone volume, trabecular structural indices, cortical width, and core width) and bone density in the spine, hip, and wrist in 81 patients with various metabolic bone diseases including osteoporosis, oste...

journal_title：Bone

authors： Cosman F,Schnitzer MB,McCann PD,Parisien MV,Dempster DW,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...

journal_title：Bone

authors： Takaiwa M,Aya K,Miyai T,Hasegawa K,Yokoyama M,Kondo Y,Kodani N,Seino Y,Tanaka H,Morishima T

更新日期：2010-08-01 00:00:00

abstract：:High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...

journal_title：Bone

authors： McCabe LR,Irwin R,Tekalur A,Evans C,Schepper JD,Parameswaran N,Ciancio M

更新日期：2019-01-01 00:00:00

abstract：:Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...

journal_title：Bone

authors： Horiuchi H,Saito N,Kinoshita T,Wakabayashi S,Yotsumoto N,Takaoka K

更新日期：2002-04-01 00:00:00

abstract：:Approximately 7.9 million fractures occur annually in the United States with 5-10% of these resulting in delayed or impaired healing. Nearly half of the trauma cost of $56 billion per year is used for the treatment of fractures. More importantly, fracture results in a substantial reduction in the quality of life. New ...

journal_title：Bone

authors： Bragdon B,Thinakaran S,Moseychuk O,Gurski L,Bonor J,Price C,Wang L,Beamer WG,Nohe A

更新日期：2011-11-01 00:00:00

abstract：:The effects of prostaglandin E2 (PGE2) were histomorphometrically evaluated in cancellous bone of the axial skeleton of ovariectomized, osteopenic rats. Four months following bilateral ovariectomy (OVX) and sham-ovariectomy (SHAM) at 3 months of age, rats received daily subcutaneous injections of PGE2 at 0, 0.3, 1.0, ...

journal_title：Bone

authors： Mori S,Jee WS,Li XJ,Chan S,Kimmel DB

更新日期：1990-01-01 00:00:00

abstract：:Bone is a nanocomposite consisting of two main components, nano-hydroxyapatite (n-HA) and Type I collagen (Col). The aim is to exploit the nano-scale functional and material characteristics of natural bone in order to modulate cellular functions for optimal bone repair in bone graft systems. Here, we present an effect...

journal_title：Bone

authors： Ngiam M,Liao S,Patil AJ,Cheng Z,Chan CK,Ramakrishna S

更新日期：2009-07-01 00:00:00