A cumulative analogue joint involvement scale (CAJIS) for fibrodysplasia ossificans progressiva (FOP).

abstract：:Skeletal disorders in rapidly growing poultry are commonplace. This study was performed to investigate the effect of ornithine alpha-ketoglutarate (OKG) administration during the last 7 weeks of life on structural properties, mineralization, and mechanical endurance of skeleton in turkeys at slaughter. Healthy HB Medi...

journal_title：Bone

authors： Tatara MR,Sliwa E,Krupski W,Brodzki A,Pasternak K

更新日期：2006-07-01 00:00:00

abstract：:General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...

journal_title：Bone

authors： Devlin H,Allen PD,Graham J,Jacobs R,Karayianni K,Lindh C,van der Stelt PF,Harrison E,Adams JE,Pavitt S,Horner K

更新日期：2007-04-01 00:00:00

abstract：:Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase inhibitors suppress the degradation of AXIN protein, a negative regulator of the canonical Wnt pathway, they effectively act as Wnt inhibitors. Small molecule tankyrase inhibitors are being inve...

journal_title：Bone

authors： Fujita S,Mukai T,Mito T,Kodama S,Nagasu A,Kittaka M,Sone T,Ueki Y,Morita Y

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To compare the power of FRAX® without bone mineral density (BMD) and simpler screening tools (OST, ORAI, OSIRIS, SCORE and age alone) in predicting fractures. METHODS:This study was a prospective, population-based study performed in Denmark comprising 3614 women aged 40-90 years, who returned a questionnaire c...

journal_title：Bone

authors： Rubin KH,Abrahamsen B,Friis-Holmberg T,Hjelmborg JV,Bech M,Hermann AP,Barkmann R,Glüer CC,Brixen K

更新日期：2013-09-01 00:00:00

abstract：:New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...

journal_title：Bone

authors： Freilich M,M Patel C,Wei M,Shafer D,Schleier P,Hortschansky P,Kompali R,Kuhn L

更新日期：2008-10-01 00:00:00

abstract：:The long prevailing view that obesity is generally associated with beneficial effects on the skeleton has recently been challenged. Apolipoprotein E (apoE) is known to influence both adipose tissue and bone. The goal of the current study was to examine the impact of apoE on the development of fat mass and bone mass in...

journal_title：Bone

authors： Bartelt A,Beil FT,Schinke T,Roeser K,Ruether W,Heeren J,Niemeier A

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...

journal_title：Bone

authors： Ng AH,Hercz G,Kandel R,Grynpas MD

更新日期：2004-01-01 00:00:00

abstract：:The multi-domain neutral endopeptidase, ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin repeats) is induced by parathyroid hormone (PTH) in rat osteoblasts and has therefore been suggested to be involved in initiation of bone remodeling. However, its function(s) in bone cells have not been studied. Her...

journal_title：Bone

authors： Rehn AP,Birch MA,Karlström E,Wendel M,Lind T

更新日期：2007-08-01 00:00:00

abstract：:Glucocorticoids have marked effects on bone metabolism, and continued exposure of skeletal tissue to excessive amounts of these steroids results in osteoporosis. Therefore, in the present proteomic study, we characterized the potential effects of glucocorticoids on protein expression in human osteoblastic cells. Using...

journal_title：Bone

authors： Olkku A,Bodine PV,Linnala-Kankkunen A,Mahonen A

更新日期：2004-02-01 00:00:00

abstract：:Recent in vitro and animal studies suggest that cholesterol and its metabolites inhibit the functional activity of osteoblasts and thereby induce reduced bone mineralization. However, scant information is available on the clinical implication of these findings with special regard to postmenopausal bone loss. Therefore...

journal_title：Bone

authors： Tankó LB,Bagger YZ,Nielsen SB,Christiansen C

更新日期：2003-01-01 00:00:00

abstract：:Estrogen and calcium deficiencies increase both bone resorption and formation, whereas immobilization mainly decreases bone formation. How these functionally different risk factors for bone loss interact in cancellous bone undergoing modeling or remodeling activity is not well understood. Mature (6-month-old) female r...

journal_title：Bone

authors： Shen V,Liang XG,Birchman R,Wu DD,Healy D,Lindsay R,Dempster DW

更新日期：1997-07-01 00:00:00

abstract：:Due to the reduction in bone mass and deterioration in bone microarchitecture, osteoporosis is an important risk factor for impairing implant osseointegration. Recently, low-magnitude, high-frequency (LMHF) vibration (LM: <1×g; HF: 20-90Hz) has been shown to exhibit anabolic, but anti-resorptive effects on skeletal ho...

journal_title：Bone

authors： Zhou Y,Guan X,Liu T,Wang X,Yu M,Yang G,Wang H

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:The elderly population is growing fast worldwide, and therefore, investigation of health outcomes peculiar to these individuals is a public health priority nowadays. The decade between 2000 and 2010 is denominated as the Bone and Joint Decade, and researchers are encouraged to quantity the burden of muscul...

journal_title：Bone

authors： Siqueira FV,Facchini LA,Hallal PC

更新日期：2005-08-01 00:00:00

abstract：:The Microphthalmia-associated transcription factor (Mitf) is required for the proper development of several cell lineages including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. Mutations in Mitf in multiple organisms result in osteopetrosis due to defective osteoclas...

journal_title：Bone

authors： Hershey CL,Fisher DE

更新日期：2004-04-01 00:00:00

abstract：:In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites. The information provided by each assessment will describe the clinical characteristics, fracture risk and epidemio...

journal_title：Bone

authors： Kanis JA,McCloskey EV,Johansson H,Oden A,Melton LJ 3rd,Khaltaev N

更新日期：2008-03-01 00:00:00

abstract：:Osteogenesis imperfecta (OI) is a rare and severe skeletal dysplasia marked by low bone mass and poor bone quality which is especially burdensome during childhood. Since clinical trials for pediatric OI are difficult, there is a widespread reliance on genetically modified murine models to understand the skeletal effec...

journal_title：Bone

authors： Surowiec RK,Battle LF,Ward FS,Schlecht SH,Khoury BM,Robbins C,Wojtys EM,Caird MS,Kozloff KM

更新日期：2020-01-01 00:00:00

abstract：:Adipose-derived adult stem cells (ASCs), like their bone-marrow derived counterparts, possess the ability to differentiate down osteogenic, chondrogenic, adipogenic, and myogenic pathways. For bone differentiation of mouse ASCs (mASCs), retinoic-acid mediated upregulation of BMPR-IB has been found to be necessary. Int...

journal_title：Bone

authors： Quarto N,Wan DC,Longaker MT

更新日期：2008-06-01 00:00:00

abstract：:Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi). This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1(-...

journal_title：Bone

authors： Hajjawi MO,MacRae VE,Huesa C,Boyde A,Millán JL,Arnett TR,Orriss IR

更新日期：2014-12-01 00:00:00

abstract：INTRODUCTION:Angiogenesis is closely associated with bone formation, especially endochondral ossification. Angiopoietin 1 (Ang1) is a specific growth factor functioning to generate a stable and matured vasculature through the Tie2 receptor/PI3K/AKT pathway. Recently cartilage oligomeric matrix protein (COMP)-Ang1, an A...

journal_title：Bone

authors： Jeong BC,Kim HJ,Bae IH,Lee KN,Lee KY,Oh WM,Kim SH,Kang IC,Lee SE,Koh GY,Kim KK,Koh JT

更新日期：2010-02-01 00:00:00

abstract：:Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical featur...

journal_title：Bone

authors： Braithwaite V,Pettifor JM,Prentice A

更新日期：2013-03-01 00:00:00

abstract：:The SIBLINGs are a subfamily of the secreted calcium-binding phosphoproteins and comprise five small integrin-binding ligand N-linked glycoproteins [dentin matrix protein-1 (DMP1), secreted phosphoprotein-1 (SPP1) also called osteopontin (OPN), integrin-binding sialoprotein (IBSP) also called bone sialoprotein (BSP), ...

journal_title：Bone

authors： Whyte MP,Amalnath SD,McAlister WH,McKee MD,Veis DJ,Huskey M,Duan S,Bijanki VN,Alur S,Mumm S

更新日期：2020-03-01 00:00:00

abstract：:To elucidate the histological events that follow administration of eldecalcitol, a second-generation of vitamin D analog currently awaiting approval as a drug for treatment of osteoporosis, we employed the ovariectomy (OVX) rat model. OVX rats received vehicle or 30ng/kg of eldecalcitol, and sham-operated animals rece...

journal_title：Bone

authors： de Freitas PH,Hasegawa T,Takeda S,Sasaki M,Tabata C,Oda K,Li M,Saito H,Amizuka N

更新日期：2011-09-01 00:00:00

abstract：:Gap junctional intercellular communication (GJIC) may contribute to cellular differentiation. To examine this possibility in bone cells we examined markers of cellular differentiation, including alkaline phosphatase, osteocalcin, and osteopontin, in ROS17/2.8 cells (ROS), a rat osteoblastic cell line expressing phenot...

journal_title：Bone

authors： Li Z,Zhou Z,Yellowley CE,Donahue HJ

更新日期：1999-12-01 00:00:00

abstract：:Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 transcripts, but not of ...

journal_title：Bone

authors： Juneja SC,Vonica A,Zeiss C,Lezon-Geyda K,Yatsula B,Sell DR,Monnier VM,Lin S,Ardito T,Eyre D,Reynolds D,Yao Z,Awad HA,Yu H,Wilson M,Honnons S,Boyce BF,Xing L,Zhang Y,Perkins AS

更新日期：2014-03-01 00:00:00

abstract：:Recent studies have identified that Interleukin (IL)-23/IL-17 axis plays crucial role in pathogenesis of inflammation and bone destruction. IL-23 is thought to promote joint destruction in arthritis by stimulating Th17 cells. IL-23 directly mediates bone loss by inducing osteoclastogenesis and receptor activator of ka...

journal_title：Bone

authors： Shukla P,Mansoori MN,Singh D

更新日期：2018-05-01 00:00:00

abstract：:FGF23 is an O-glycosylated circulating peptide hormone with a critical role in phosphate homeostasis; it is inactivated by cellular proprotein convertases in a pre-release degradative pathway. We have here examined the metabolism of FGF23 in a model bone cell line, IDG-SW3, prior to and following differentiation, as w...

journal_title：Bone

authors： Yamamoto H,Ramos-Molina B,Lick AN,Prideaux M,Albornoz V,Bonewald L,Lindberg I

更新日期：2016-03-01 00:00:00

abstract：:Saracatinib (AZD0530) is an orally active once-daily Src kinase inhibitor which modulates key signaling pathways in cancer cells. In a Phase I study in patients with advanced solid malignancies resistant to standard treatment we assessed the effect of saracatinib on bone turnover. Fifty-one patients were randomized in...

journal_title：Bone

authors： Hannon RA,Finkelman RD,Clack G,Iacona RB,Rimmer M,Gossiel F,Baselga J,Eastell R

更新日期：2012-04-01 00:00:00

abstract：:Many osteoporotic fracture patients are candidates for concurrent treatment with bisphosphonates and bioceramic bone graft substitutes. Osteopromotive silica-based bioactive glasses are known to induce accelerated local bone turnover and adjunct antiresorptive agents, such as zoledronic acid, may affect the process. T...

journal_title：Bone

authors： Välimäki VV,Moritz N,Yrjans JJ,Vuorio E,Aro HT

更新日期：2006-03-01 00:00:00

abstract：:It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis o...

journal_title：Bone

authors： Manolagas SC

更新日期：1995-08-01 00:00:00

abstract：:Ovariectomized cynomolgus monkeys have previously been investigated as a nonhuman primate model of postmenopausal osteoporosis (Jerome et al., Bone Miner 9:527-540; 1994). In the present study, Fourier transform infrared microspectroscopy (FTIRM) was used to verify that differences in bone mineral quality and quantity...

journal_title：Bone

authors： Gadeleta SJ,Boskey AL,Paschalis E,Carlson C,Menschik F,Baldini T,Peterson M,Rimnac CM

更新日期：2000-10-01 00:00:00