Inflammation-mediated osteopenia in the rat: the effects of artificial granuloma and sham operation on cortical and trabecular bone.

abstract：INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...

journal_title：Bone

authors： Ng AH,Hercz G,Kandel R,Grynpas MD

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Currently, bone densitometry fails to identify nearly half of those elderly patients at immediate fracture risk. To improve clinical assessment of vertebral fracture risk, we aimed to determine how the DXA-based 2D parameter Trabecular Bone Score (TBS) relates to subregional variability in 3D trabecular micr...

journal_title：Bone

authors： Vom Scheidt A,Grisolia Seifert EF,Pokrant C,Püschel K,Amling M,Busse B,Milovanovic P

更新日期：2019-05-01 00:00:00

abstract：:To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knockout. Although suppression of the ligand to the ERs (i.e., estradiol) after menopause or gonadectomy in females...

journal_title：Bone

authors： Sims NA,Dupont S,Krust A,Clement-Lacroix P,Minet D,Resche-Rigon M,Gaillard-Kelly M,Baron R

更新日期：2002-01-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the...

journal_title：Bone

authors： Tanaka M,Sakai A,Uchida S,Tanaka S,Nagashima M,Katayama T,Yamaguchi K,Nakamura T

更新日期：2004-06-01 00:00:00

abstract：:G protein-coupled receptor kinase 2 interacting protein-1 (GIT1) is a scaffold protein that plays a vital role in bone modeling and remodeling during osteogenesis coupled with angiogenesis. Recent studies have shown that a specialized subset of vascular endothelium strongly positive for CD31 and Endomucin (CD31hiEmcnh...

journal_title：Bone

authors： Xu T,Luo Y,Kong F,Lv B,Zhao S,Chen J,Liu W,Cheng L,Zhou Z,Zhou Z,Huang Y,Li L,Zhao X,Qian D,Fan J,Yin G

更新日期：2019-05-01 00:00:00

abstract：:Recent in vitro and animal studies suggest that cholesterol and its metabolites inhibit the functional activity of osteoblasts and thereby induce reduced bone mineralization. However, scant information is available on the clinical implication of these findings with special regard to postmenopausal bone loss. Therefore...

journal_title：Bone

authors： Tankó LB,Bagger YZ,Nielsen SB,Christiansen C

更新日期：2003-01-01 00:00:00

abstract：:The total remodeling sequences in 19 primary hyperparathyroid patients and 16 approximately age-matched and sex-matched controls were reconstructed from histomorphometric analyses of bone specimens obtained after intravital tetracycline double labeling. In the primary hyperparathyroid group the total amount of work pe...

journal_title：Bone

authors： Eriksen EF,Mosekilde L,Melsen F

更新日期：1986-01-01 00:00:00

abstract：:Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP in healthy individuals is on cell surfaces richly in bone, liver, and kidney. Thus, TNSALP natural substrates accumulat...

journal_title：Bone

authors： Whyte MP,Zhang F,Wenkert D,Mumm S,Berndt TJ,Kumar R

更新日期：2020-05-01 00:00:00

abstract：:In order to analyze the role of the estrogen receptor (ER) gene allelic polymorphisms on bone mineral density (BMD), 173 pre- and postmenopausal women were divided into four groups according to their menstrual status (group A: premenopausal women; group B: late premenopausal women; group C: postmenopausal women who ha...

journal_title：Bone

authors： Mizunuma H,Hosoi T,Okano H,Soda M,Tokizawa T,Kagami I,Miyamoto S,Ibuki Y,Inoue S,Shiraki M,Ouchi Y

更新日期：1997-11-01 00:00:00

abstract：:Bone sialoprotein (BSP) is highly expressed in early bone deposition and may play a part in primary bone mineralization. We previously showed that while BSP−/− mice have a mild secondary bone phenotype and are responsive to mechanical (unloading) and hormonal (ovariectomy, parathyroid hormone (PTH)) challenges, repair...

journal_title：Bone

authors： Wade-Gueye NM,Boudiffa M,Vanden-Bossche A,Laroche N,Aubin JE,Vico L,Lafage-Proust MH,Malaval L

更新日期：2012-05-01 00:00:00

abstract：:Parathyroid hormone (PTH) is used clinically in osteoporotic patients to increase bone mass by enhancing bone formation. PTH therapy is not uniformly effective at all skeletal sites and "life-style" factors may modulate the skeletal response to PTH. Alcohol may represent one of these factors. Chronic alcohol abuse is ...

journal_title：Bone

authors： Iwaniec UT,Trevisiol CH,Maddalozzo GF,Rosen CJ,Turner RT

更新日期：2008-04-01 00:00:00

abstract：:High doses of caffeine will induce calcium loss and influence the normal development of bone, whereas the proper exercise has positive effects on bone metabolism. This study investigated the possible effects of exercise to antagonize the caffeine-induced impairment of bone development in young male Wistar rats. A tota...

journal_title：Bone

authors： Huang TH,Yang RS,Hsieh SS,Liu SH

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The present study aimed to investigate the association between type 2 diabetes mellitus (T2DM) and hip fractures using a large-scale nationwide population-based cohort that is representative of the Republic of Korea. We determined the risks of hip fractures in individuals with prediabetes and T2DM with diffe...

journal_title：Bone

authors： Park HY,Han K,Kim Y,Kim YH,Sur YJ

更新日期：2021-01-01 00:00:00

abstract：:A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in osteoblasts is not well understood. Two major events for bone formation include osteoblast differentiation by bone marker gene expression, which is mainly regulated by bone-specific transcription factor Runx2 and extracellula...

journal_title：Bone

authors： Kwun IS,Cho YE,Lomeda RA,Shin HI,Choi JY,Kang YH,Beattie JH

更新日期：2010-03-01 00:00:00

abstract：:Osteoporosis is the consequence of altered bone metabolism resulting in the systemic reduction of bone strength and increased risk of fragility fractures. MicroRNAs (miRNAs) regulate gene expression on a post-transcriptional level and are known to take part in the control of bone formation and bone resorption. In addi...

journal_title：Bone

authors： Weilner S,Skalicky S,Salzer B,Keider V,Wagner M,Hildner F,Gabriel C,Dovjak P,Pietschmann P,Grillari-Voglauer R,Grillari J,Hackl M

更新日期：2015-10-01 00:00:00

abstract：:The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...

journal_title：Bone

authors： Zhuo Y,Gauthier JY,Black WC,Percival MD,Duong LT

更新日期：2014-10-01 00:00:00

abstract：:Osteoarthritis (OA) is closely related to the function of several inflammatory cytokines. It has been reported that older age is associated with higher serum levels of the inflammatory cytokine IL-18. In the present study, we investigated the long-term role of serum IL-18 in cartilage loss in vivo using a new strain o...

journal_title：Bone

authors： Inoue H,Hiraoka K,Hoshino T,Okamoto M,Iwanaga T,Zenmyo M,Shoda T,Aizawa H,Nagata K

更新日期：2008-06-01 00:00:00

abstract：:Obesity in humans is associated with increased bone mass. Leptin, a hormone produced by fat cells, functions as a sentinel of energy balance, and may mediate the putative positive effects of body mass on bone. We performed studies in male C57Bl/6 wild type (WT) and leptin-deficient ob/ob mice to determine whether body...

journal_title：Bone

authors： Iwaniec UT,Dube MG,Boghossian S,Song H,Helferich WG,Turner RT,Kalra SP

更新日期：2009-03-01 00:00:00

abstract：:Human osteoclast formation from mononuclear phagocyte precursors involves interactions between lectins and their receptors. A type-2 ribosome inactivating protein consists of an A chain and a B chain. The glycosylated B chain binds specifically to galactose moieties of sugar molecules. In this study we showed that the...

journal_title：Bone

authors： Wang YM,Lu TL,Hsu PN,Tang CH,Chen JH,Liu KC,Kao JT,Tzen JT,Wu YY

更新日期：2011-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSC) are defined as plastic-adherent, clonal cells that are common progenitors for osteoblasts and adipocytes. An inverse relationship between bone and fat has been observed in several clinical conditions and has been suggested to be caused by re-directing MSC differentiation into one particula...

journal_title：Bone

authors： Post S,Abdallah BM,Bentzon JF,Kassem M

更新日期：2008-07-01 00:00:00

abstract：:Genetic mouse models are widely used for understanding human diseases but we know much less about the anatomical structure of the auditory ossicles in the mouse than we do about human ossicles. Furthermore, current studies have mainly focused on disease conditions such as osteomalacia and rickets in patients with hypo...

journal_title：Bone

authors： Lv K,Huang H,Yi X,Chertoff ME,Li C,Yuan B,Hinton RJ,Feng JQ

更新日期：2017-10-01 00:00:00

abstract：:Over 60% of our severely combat-injured patient population develops radiographically apparent heterotopic ossification. Nearly a third of these require surgical excision of symptomatic lesions, a procedure that is fraught with complications, and delays or regresses functional rehabilitation in many cases. Unfortunatel...

journal_title：Bone

authors： Crane NJ,Polfer E,Elster EA,Potter BK,Forsberg JA

更新日期：2013-12-01 00:00:00

abstract：:Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...

journal_title：Bone

authors： Lynn H,Kwok T,Wong SY,Woo J,Leung PC

更新日期：2006-04-01 00:00:00

abstract：:Although osteoporosis is usually associated with women, 1 in 12 men in the UK have the disease, and a third of these cases are idiopathic. Estrogen is now known to be associated with bone loss in older men, but we found, previously, that levels of this hormone were normal in younger cases of male idiopathic osteoporos...

journal_title：Bone

authors： Braidman I,Baris C,Wood L,Selby P,Adams J,Freemont A,Hoyland J

更新日期：2000-05-01 00:00:00

abstract：:The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...

journal_title：Bone

authors： Siebler T,Robson H,Shalet SM,Williams GR

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Dietary acid charge enhances bone loss. Bicarbonate or alkali diet decreases bone resorption in humans. We compared the effect of an alkaline mineral water, rich in bicarbonate, with that of an acid one, rich in calcium only, on bone markers, in young women with a normal calcium intake. METHODS:This study c...

journal_title：Bone

authors： Wynn E,Krieg MA,Aeschlimann JM,Burckhardt P

更新日期：2009-01-01 00:00:00

abstract：:This study reports the elastic material properties of cortical bone in the mandible of juvenile Alligator mississippiensis obtained by using an ultrasonic wave technique. The elastic modulus, the shear modulus, and Poisson's ratio were measured on 42 cylindrical Alligator bone specimens obtained from the lingual and f...

journal_title：Bone

authors： Zapata U,Metzger K,Wang Q,Elsey RM,Ross CF,Dechow PC

更新日期：2010-03-01 00:00:00

abstract：:Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastati...

journal_title：Bone

authors： Pauly S,Luttosch F,Morawski M,Haas NP,Schmidmaier G,Wildemann B

更新日期：2009-09-01 00:00:00

abstract：:The effects of tumor-conditioned media (TCM) derived from cultured cells from an oncogenic hypophosphatemic osteomalacia (OHO) tumor on transformed human kidney cells were investigated. Dose-dependent cell detachment and aggregation occurred in kidney cells cultured in serum-free medium supplemented with TCM, but not ...

journal_title：Bone

authors： Rowe PS,Ong AC,Cockerill FJ,Goulding JN,Hewison M

更新日期：1996-02-01 00:00:00

abstract：INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...

journal_title：Bone

authors： Delmas PD,Licata AA,Reginster JY,Crans GG,Chen P,Misurski DA,Wagman RB,Mitlak BH

更新日期：2006-08-01 00:00:00