Abstract：
:Bone remodeling is required for healthy calcium homeostasis and for repair of damage occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These processes normally occur in a tightly regulated sequence of events, where the amount of formed bone equals the amount of resorbed bone, thereby restoring the removed bone completely. Osteocytes are the third cell type playing an essential role in bone turnover. They appear to regulate activation of bone remodeling, and they exert both positive and negative regulation on both osteoclasts and osteoblasts. In this review, we consider the intricate communication between these bone cells in relation to bone remodeling, reviewing novel data from patients with mutations rendering different cell populations inactive, which have shown that these interactions are more complex than originally thought. We highlight the high probability that a detailed understanding of these processes will aid in the development of novel treatments for bone metabolic disorders, i.e. we discuss the possibility that bone resorption can be attenuated pharmacologically without a secondary reduction in bone formation.
journal_name
Bonejournal_title
Boneauthors
Henriksen K,Neutzsky-Wulff AV,Bonewald LF,Karsdal MAdoi
10.1016/j.bone.2009.03.671subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1026-33issue
6eissn
8756-3282issn
1873-2763pii
S8756-3282(09)01242-3journal_volume
44pub_type
杂志文章,评审相关文献
BONE文献大全abstract：:This cohort study of postmenopausal women in the United Kingdom aged ≥50years determined the incremental cost of health care and clinical outcomes in the 12months following incident, selected fractures (non-vertebral non-hip [NVNHF], vertebral [VF] and multiple [MF]). Incremental costs and outcomes of the fracture coh...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.05.020
更新日期：2012-09-01 00:00:00
abstract：:We hypothesized that estrogen deficiency induces changes in bone vascularization which might be involved in bone loss mechanisms. First, we studied gene expression of angiogenic (vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2)) and vasodilator (endothelial nitric oxide synthase (ecNOS), n...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(03)00099-1
更新日期：2003-06-01 00:00:00
abstract：:Second generation antipsychotics (SGAs) have been linked to metabolic and bone disorders in clinical studies, but the mechanisms of these side effects remain unclear. Additionally, no studies have examined whether SGAs cause bone loss in mice. Using in vivo and in vitro modeling we examined the effects of risperidone,...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.08.005
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:Vertebral fractures are associated with persistent pain, disability and mortality. However, around two thirds of women with vertebral fractures are unaware of them. We aimed to analyze which factors could mostly be associated to the presence of vertebral fractures in post-menopausal women, and evaluate the effe...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.05.007
更新日期：2018-08-01 00:00:00
abstract：:The topological changes in vertebral cancellous bone were estimated in vertebrae from calcium-restricted ovariectomized Sinclair S-1 minipigs, a recently described animal model of cancellous osteopenia. Connectivity was estimated using unbiased stereological principles in disector pairs of sections from the first lumb...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(95)00116-u
更新日期：1995-06-01 00:00:00
abstract：:Chronic alcohol abuse is a risk factor for osteoporosis in men. Human recombinant parathyroid hormone (1-34) (PTH) therapy increases bone mass in patients with osteoporosis. The purpose of the present study was to determine whether PTH is effective in increasing bone formation and bone mass in a rat model for establis...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.11.002
更新日期：2007-04-01 00:00:00
abstract：:Solute transport in the lacunar-canalicular system (LCS) is essential for bone metabolism and mechanotransduction. Using the technique of fluorescence recovery after photobleaching (FRAP) we have been quantifying solute transport in the LCS of murine long bone as a function of loading parameters and molecular size. Ho...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.06.026
更新日期：2009-10-01 00:00:00
abstract：:Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(09)80010-0
更新日期：1992-01-01 00:00:00
abstract：:We compared the distribution of a cysteine proteinase inhibitor, cystatin C, with that of cathepsin K in osteoclasts of the mouse tibia by immunolight and immunoelectron microscopy. Light microscopically, strong immunoreactivity for cystatin C was found extracellularly along the resorption lacuna and intracellularly i...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(01)00466-5
更新日期：2001-07-01 00:00:00
abstract：:Bisphosphonates increase bone mass and reduce fracture risk, but their anti-resorptive action may lead to increases in fatigue microdamage. To investigate how bisphosphonate effects influence changes in bone volume and microdamage in the long term, a strain-adaptive model of bone remodeling and microdamage balance was...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.03.007
更新日期：2004-07-01 00:00:00
abstract：:Dynamic mechanical loading increases bone density and strength and promotes osteoblast proliferation, differentiation and matrix production, by acting at the gene expression level. Molecular mechanisms through which mechanical forces are conversed into biochemical signalling in bone are still poorly understood. A grow...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.10.016
更新日期：2005-03-01 00:00:00
abstract：:This paper describes a new alternative for individualized mechanical analysis of bone trabecular structure. This new method closes the gap between the classic homogenization approach that is applied to macro-scale models and the modern micro-finite element method that is applied directly to micro-scale high-resolution...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.12.022
更新日期：2011-04-01 00:00:00
abstract：:The underlying causes of maxillary bone loss during lactation remain poorly understood. We evaluated the impact of lactation on physiological and mechanically-induced alveolar bone remodeling. Nulliparous non-lactating (N-LAC) and 21-day lactating (LAC) mice underwent mechanically-induced bone remodeling by orthodonti...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.01.032
更新日期：2018-05-01 00:00:00
abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.01.018
更新日期：2018-05-01 00:00:00
abstract：:Previously we observed that capsaicin treatment in rats inhibited sensory neuropeptide signaling, with a concurrent reduction in trabecular bone formation and bone volume, and an increase in osteoclast numbers and bone resorption. Calcitonin-gene-related peptide (CGRP) is a neuropeptide richly distributed in sensory n...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.11.029
更新日期：2010-05-01 00:00:00
abstract：:Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural fea...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.04.006
更新日期：2004-09-01 00:00:00
abstract：:Controversial results were reported on the association of vitamin D receptor (VDR) polymorphisms and bone mineral density (BMD). We studied allelic frequencies of the BsmI, ApaI, and TaqI restriction fragment length polymorphisms (RFLPs) in 144 normal healthy southern Chinese premenopausal women aged between 30 and 40...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00301-3
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.09.016
更新日期：2018-04-01 00:00:00
abstract：:Although basic fibroblast growth factor (bFGF) is a potent stimulator of bone formation when administered intravenously, less is known regarding the effects of this peptide on bone following subcutaneous (s.c.) administration. In addition, it is unknown whether coadministration of estrogen enhances the bone response t...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(03)00118-2
更新日期：2003-09-01 00:00:00
abstract：:We report the establishment in vitro of three-dimensional (3D) cultures of human osteoblasts (hOB) derived from normal adults and supported uniquely by the extracellular matrix (ECM) they deposit. Osteoblasts were cultured in 3D cultures in vitro for up to 120 days. The 3D cultures, examined at 25, 31, and 48 days, ex...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(02)00691-9
更新日期：2002-05-01 00:00:00
abstract：:The prediction of bone strength can be improved when determining bone mineral density (BMD) in combination with measures of trabecular microarchitecture. The goal of this study was to assess parameters of trabecular bone structure and texture of the calcaneus by clinical multi-detector row computed tomography (MDCT) i...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.01.372
更新日期：2009-05-01 00:00:00
abstract：:A macro-micro-nano-multi-level study was conducted to explore age-related structural and mechanical properties of bone, as well as the effects of aging on bone properties. A total of 70 male Wistar rats were used, ranging in the ages of 1, 3, 5, 7, 9, 11, 14, 15, 16, and 17 months (n = 7/age group). After micro-comput...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2015.03.022
更新日期：2015-07-01 00:00:00
abstract：:New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.05.021
更新日期：2008-10-01 00:00:00
abstract：:Bone marrow adipose tissue (BMAT) is preserved or increased in states of caloric restriction. Similarly, we found that BMAT in the tail vertebrae, but not the red marrow in the tibia, resists loss of neutral lipid with acute, 48-hour fasting in rats. The mechanisms underlying this phenomenon and its seemingly distinct...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.01.016
更新日期：2019-01-01 00:00:00
abstract：:We previously reported that osteoclast formation in vitro, by coculture of mouse bone marrow and primary osteoblastic cells, occurs in two phases: proliferation of osteoclast progenitors followed by terminal differentiation into mature osteoclasts. Using this coculture system, we examined the effects of c-fos antisens...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(96)00076-2
更新日期：1996-06-01 00:00:00
abstract：:Bone mineral density is under strong genetic control and polymorphisms of the vitamin D receptor (VDR) have been suggested to account for some of the genetic variation in bone mass. However, the relationship between VDR polymorphisms and bone density is controversial and has not been confirmed by all workers. Since th...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(95)00483-1
更新日期：1996-03-01 00:00:00
abstract：:Bone structure is an important determinant of osteoporotic fracture. In women, bone structure is highly heritable, and several quantitative trait loci (QTL) have been reported. There are few comparable data in men. This study in men aimed at establishing the heritability of bone structure at the proximal femur, identi...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.05.005
更新日期：2005-10-01 00:00:00
abstract：:Recent studies have shown that treatment with bisphosphonates could be effective against the myelomatous skeletal deterioration. However, the mechanisms of action of these drugs in multiple myeloma (MM) have been poorly studied. In the present study, 11 patients with MM and bone lesions were treated orally with 30 mg/...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(94)90890-7
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is a common surgical procedure for treatment of morbid obesity. RYGB induces considerable and sustained weight loss, and remission of obesity related-comorbidities. While studies have suggested negative effects of RYGB on bone health, long-term data are lacking. We aimed to ev...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.07.014
更新日期：2019-10-01 00:00:00
abstract：:In order to analyze the role of the estrogen receptor (ER) gene allelic polymorphisms on bone mineral density (BMD), 173 pre- and postmenopausal women were divided into four groups according to their menstrual status (group A: premenopausal women; group B: late premenopausal women; group C: postmenopausal women who ha...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00178-6
更新日期：1997-11-01 00:00:00
