abstract：:Pregabalin is one of the first-line treatments approved for the management of neuropathic pain (NeP). While many patients benefit from treatment with pregabalin, they are often treated with suboptimal doses, possibly due to unfamiliarity around prescribing the drug and/or side effects that can occur with up-titration....

journal_title：Postgraduate medicine

authors： Freynhagen R,Baron R,Kawaguchi Y,Malik RA,Martire DL,Parsons B,Rey RD,Schug SA,Jensen TS,Tölle TR,Ushida T,Whalen E

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To evaluate healthcare resource utilization (HCRU) by osteoarthritis (OA) pain severity. METHODS:Cross-sectional surveys of US physicians and their patients were conducted between February and May 2017. Using the Numeric Rating Scale, patients were classified by self-reported pain intensity in the last week ...

journal_title：Postgraduate medicine

authors： Nalamachu S,Robinson RL,Viktrup L,Cappelleri JC,Bushmakin AG,Tive L,Mellor J,Hatchell N,Jackson J

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:The clinical significance of hyperplastic polyp-like histologic changes in random biopsy samples ('serrated epithelial change' or SEC) from patients with inflammatory bowel disease (IBD) remains uncertain, with some studies suggesting an increased risk of dysplasia and even carcinoma. Controlled studies are ...

journal_title：Postgraduate medicine

authors： Batts KP,Atwaibi M,Weinberg DI,McCabe RP

更新日期：2021-01-01 00:00:00

abstract：:Over the past decade, despite the controversies surrounding prostate cancer screening, significant refinements have improved its application. PSA screening, although it has been questioned, appears to confer a mortality benefit and remains the most effective way to identify the possible presence of prostate cancer. Me...

journal_title：Postgraduate medicine

authors： French WW,Wallen EM

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the proportion and the long-term prognostic significance of heart failure (HF) in sarcoidosis patients. METHODS:Data extracted from a large Israeli healthcare provider's database were used to study sarcoidosis patients and matched non-sarcoidosis controls since 2000 to 2016. The proportion of HF ...

journal_title：Postgraduate medicine

authors： Etinger R,Comaneshter D,Amital H,Cohen AD,Tiosano S

更新日期：2020-11-01 00:00:00

abstract：:Objective: Abnormal pro-inflammatory regulation of the immune system might contribute to the pathogenesis of hyperglycemia during pregnancy. We examined the correlations of neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) with disease severity and assessed their predictive values. Methods: This re...

journal_title：Postgraduate medicine

authors： Wang J,Zhu QW,Cheng XY,Sha CX,Cui YB

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:This study aimed to investigate the prevalence and associated factors of inter-arm blood pressure difference (IAD) in Chinese community hypertensive population. METHODS:The cross-sectional study included 7788 hypertensive patients (3673 male and 4115 female, aged 62.3 ± 13.6 years) in Guangdong, China. IAD ...

journal_title：Postgraduate medicine

authors： Yu Y,Liu L,Lo K,Tang S,Feng Y

更新日期：2020-10-29 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly spread all over the globe from China. Pleural involvement is not common; around 5-10% of patients can develop pleural effusion and little is known about the involvement of pleural str...

journal_title：Postgraduate medicine

authors： Bennett D,Franchi F,De Vita E,Mazzei MA,Volterrani L,Disanto MG,Garosi G,Guarnieri A,Cusi MG,Bargagli E,Scolletta S,Valente S,Gusinu R,Frediani B

更新日期：2020-10-27 00:00:00

abstract：PURPOSE:To evaluate patient access, provider productivity, and patient satisfaction during a 24-month redesign process of an academic medical center, which requires balance between clinical and educational missions. METHODS:A series of activities were conducted to optimize primary care across 17 attending physicians, ...

journal_title：Postgraduate medicine

authors： Egede LE,Walker RJ,Nagavally S,Thakkar M,O'Sullivan M,Stulac Motzel W

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:With rising health care costs in the United States, trainees will be increasingly challenged in discussing testing stewardship with patients. OBJECTIVE:We piloted a high-value care (HVC) communication skills curriculum utilizing the Four Habits Model for communication. We hoped residents would 1) learn to...

journal_title：Postgraduate medicine

authors： Duran A,Donelan C,Bowman Peterson J,Gladding SP,Weissmann P,Roth CS

更新日期：2020-08-22 00:00:00

abstract：:Objective: To examine the mean carotid intima-media thickness (CIMT) and potentially relevant determinants of increased CIMT in elders. Method: Stroke-free and cardiovascular disease-free residents aged ≥65 years were recruited in a low-income population in China. B-mode ultrasonography was performed to measure CIMT. ...

journal_title：Postgraduate medicine

authors： Yu X,Bian B,Huang J,Yao W,Wu X,Huang J,Wang J,Yang Q,Ning X

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:There are no evidence-based recommendations to screen for iron deficiency in non-anemic patients, even though symptoms may be present. The aim of this study is to measure the prevalence of iron deficiency (ID) without anemia in the general population aged 18-50 presenting to primary care along with the incid...

journal_title：Postgraduate medicine

authors： Abuaisha M,Itani H,El Masri R,Antoun J

更新日期：2020-04-01 00:00:00

abstract：:Primary adrenal insufficiency due to tumor involvement is very rare. We herein report a case of adrenal insufficiency caused by cancer metastasis to a remaining single adrenal gland in a renal cell carcinoma patient who had undergone radical nephrectomy including removal of the right adrenal gland. The patient present...

journal_title：Postgraduate medicine

authors： Lee MW,Lee HJ

更新日期：2020-04-01 00:00:00

abstract：:Objectives: To understand the role of ophthalmoscopic examination (dilated retina examination and widefield fundus photography) in the diagnosis and management of nosocomial acquisition of Mycobacterium chimaera following open heart surgery with cardiopulmonary bypass utilizing a heater-cooler unit, an entity that is ...

journal_title：Postgraduate medicine

authors： Colucciello M

更新日期：2020-03-01 00:00:00

abstract：:Introduction: Adolescents and young adults are the primary reservoirs and transmitters of meningococci. In the US, meningococcal serogroup B (MenB) disease predominates over A, C, W, and Y; ACIP-recommended MenACWY and MenB vaccines are available. We investigated invasive meningococcal disease (IMD) burden and vaccina...

journal_title：Postgraduate medicine

authors： Alderfer JT,Moran MM,Srivastava A,Isturiz RE

更新日期：2019-11-01 00:00:00

abstract：:Objectives: The commonest types of peripheral neuropathy in the context of Coeliac Disease (CD) and gluten sensitivity (GS) are length-dependent symmetrical sensorimotor neuropathies and sensory ganglionopathies. In patients with such neuropathy, (gluten neuropathy), peripheral neuropathic pain is prevalent suggesting...

journal_title：Postgraduate medicine

authors： Zis P,Sarrigiannis PG,Rao DG,Sanders DS,Hadjivassiliou M

更新日期：2019-09-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and is associated with poor clinical outcomes, including an increased risk of all-cause and cardiovascular mortality, as well as adverse economic and social effects. Slowing the development and progression of CKD remains an unme...

journal_title：Postgraduate medicine

authors： Davidson JA

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abus...

journal_title：Postgraduate medicine

authors： Cicero TJ,Mendoza M,Cattaneo M,Dart RC,Mardekian J,Polson M,Roland CL,Schnoll SH,Webster LR,Park PW

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:Multilevel noncontiguous thoracic and lumbar spinal tuberculosis (MNST) is a relatively rare entity. The objective of this retrospective study was to investigate whether a technique involving a one-stage posterior debridement and decompression, combined with an intervertebral fusion and posterior instrumenta...

journal_title：Postgraduate medicine

authors： Chen RS,Liao X,Xiong ML,Chen FR,Wang BW,Huang JM,Chen XL,Yin GH,Liu HY,Jin DD

更新日期：2019-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is quickly emerging as a global epidemic in parallel with the rise in obesity and the Metabolic Syndrome. NAFLD, once seen simply as a passive consequence of the Metabolic Syndrome (MetS), has been found to interact with other features of MetS to exacerbate insulin resistance, ...

journal_title：Postgraduate medicine

authors： Jensen T,Wieland A,Cree-Green M,Nadeau K,Sullivan S

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To review glucose-lowering efficacy and changes in renal function associated with sodium-glucose co-transporter 2 (SGLT2) inhibitors among patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). DATA SOURCES:A literature search of MEDLINE and Cochrane databases was performed from 2000...

journal_title：Postgraduate medicine

authors： Kelly MS,Lewis J,Huntsberry AM,Dea L,Portillo I

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:We investigated whether there was a higher prevalence of cognitive impairment (CI) and/or physical frailty (PF) in persons with diabetes compared to their non-diabetic counterparts, and the individual and combined impact of CI and PF on functional and mortality outcomes among diabetic older persons. METHOD:...

journal_title：Postgraduate medicine

authors： Thein FS,Li Y,Nyunt MSZ,Gao Q,Wee SL,Ng TP

更新日期：2018-08-01 00:00:00

abstract：:In this review, we focus on current trends in the management of male lower urinary tract symptoms (LUTS), defined here as LUTS, namely, storage, voiding, and post-micturition symptoms presumed secondary to benign prostatic hyperplasia (BPH), and discuss possible novel approaches toward better care. According to result...

journal_title：Postgraduate medicine

authors： Roehrborn CG,Miner MM,Sadovsky R

更新日期：2018-06-01 00:00:00

abstract：:The prevalence of chronic kidney disease (CKD) has increased markedly over past decades due to the aging of the worldwide population. Despite the progress in the prevention and treatment, the cardiovascular (CV) morbidity and mortality remain high among patients with CKD. Although CKD is a progressive and irreversible...

journal_title：Postgraduate medicine

authors： Bazyluk A,Malyszko J,Zbroch E

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:There is evidence that increasing severity of hypertriglyceridemia increases the risk of acute pancreatitis. There is a debate about superiority of treatment methods and previous works have specifically called for direct comparison between IV insulin and apheresis techniques. Identify patient characteristics...

journal_title：Postgraduate medicine

authors： Frankova D,Olson KM,Whyms BJ,Guevara Hernandez MA,Franko J

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:The goal of this study was to identify opportunities among gastroenterologists and gastroenterology nurse practitioners (NPs)/physician assistants (PAs) for continuing medical education (CME) related to functional constipation. METHODS:An online, case-vignette survey was designed to identify and quantify pr...

journal_title：Postgraduate medicine

authors： Barnes J,Coleman B,Hwang S,Stolic A,Bousvaros A,Nurko S,Salinas GD

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:The majority of patients seeking medical care for chronic pain consult a primary care physician (PCP). Because systemic opioids are commonly prescribed to patients with chronic pain, PCPs are attempting to balance the competing priorities of providing adequate pain relief while reducing risks for opioid misu...

journal_title：Postgraduate medicine

authors： McDowell GC 2nd,Winchell J

更新日期：2018-05-01 00:00:00

abstract：:Systolic hypertension, especially isolated systolic hypertension (ISH) is very common in older subjects aged ≥ 65 years and is a major risk factor for cardiovascular disease (CVD), strokes, heart failure (HF) and chronic kidney disease (CKD). It is also, directly and linearly related with these complications irrespect...

journal_title：Postgraduate medicine

authors： Chrysant SG

更新日期：2018-03-01 00:00:00

abstract：:Syndromes of delusional misidentification consist of disordered familiarity and have been reported in diverse diagnoses, including Parkinson's disease. Although the most common delusional misidentification is Capgras syndrome, in which the sufferer believes a familiar person has been replaced by an identical imposter,...

journal_title：Postgraduate medicine

authors： Hermanowicz N

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:There is a need to identify safe and effective opioid-sparing multimodal alternative treatment strategies and approaches, including topical analgesics, for opioid-experienced chronic pain patients to mitigate the risk of addiction, misuse, and abuse of opioids. METHODS:This subset analysis from a prospective...

journal_title：Postgraduate medicine

authors： Gudin JA,Brennan MJ,Harris ED,Hurwitz PL,Dietze DT,Strader JD

更新日期：2018-01-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used to treat inflammatory pain for decades. More recently, newer NSAIDs were developed to target the inducible isoform of cyclooxygenase (COX), COX-2, with the aim of reducing gastrointestinal toxicity. While the COX-2 selective inhibitors were effective...

journal_title：Postgraduate medicine

authors： Walker C,Biasucci LM

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:With advancements in medical imaging and current emphasis on regular physical examinations, multiple pulmonary lesions increasingly are being detected, including bilateral pulmonary lesions. Video-assisted thoracic surgery is an important method for treating such lesions. Most of video-assisted thoracic surg...

journal_title：Postgraduate medicine

authors： Yang X,Wang L

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Ibuprofen is a commonly used non-steroidal anti-inflammatory drug administered to treat injuries, joint pain, and recurrent muscular skeletal pain. The aim of this study was to determine the cutaneous irritancy of a medicated ibuprofen plaster compared with a placebo plaster in healthy volunteers. METHODS:He...

journal_title：Postgraduate medicine

authors： Maganji M,Connolly MP,Bhatt A

更新日期：2018-01-01 00:00:00

abstract：:Irritable bowel syndrome (IBS), which is characterized by recurrent abdominal pain and disordered bowel habits, is one of the most common functional bowel disorders. IBS is a substantial burden on both patient health-related quality of life and healthcare costs. Several pathophysiologic mechanisms have been postulated...

journal_title：Postgraduate medicine

authors： Harris LA,Baffy N

更新日期：2017-11-01 00:00:00

abstract：:Osteoblasts are mesenchymal cells that play a key role in maintaining bone homeostasis; they are responsible for the production of extracellular matrix proteins, regulation of matrix mineralization, control of bone remodeling and regulate osteoclast differentiation. Osteoblasts have an essential role in the pathogenes...

journal_title：Postgraduate medicine

authors： Corrado A,Sanpaolo ER,Di Bello S,Cantatore FP

更新日期：2017-11-01 00:00:00

abstract：:While there is evidence for cardiac arrhythmias associated with macrolide and fluoroquinolone antibiotics, there is still debate among health care providers as to whether this risk of arrhythmia is overstated. A joint panel of the US Food and Drug Administration suggested that macrolide and fluoroquinolone labels need...

journal_title：Postgraduate medicine

authors： Cornett E,Novitch MB,Kaye AD,Pann CA,Bangalore HS,Allred G,Bral M,Jhita PK,Kaye AM

更新日期：2017-09-01 00:00:00

abstract：:Views and clinical practice on hormone replacement therapy (HRT) for postmenopausal women have varied widely over the last several decades. The 1990s showed a dramatic decline in prescribing and only recently are prescription rates increasing again. Use of HRT is first line for women suffering from the symptoms of men...

journal_title：Postgraduate medicine

authors： Beck KL,Anderson MC,Kirk JK

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:The diagnosis of malignant pleural effusion (MPE) remains a clinical challenge. As a negative regulator of T-cell activation, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has been associated with many malignant diseases. However, there is limited data about the relationship between CTLA-4 and MPE. Th...

journal_title：Postgraduate medicine

authors： Chen M,Xie S,Wan C,Zeng N,Wu Y,Qin J,Shen Y,Wen F

更新日期：2017-08-01 00:00:00

abstract：:The hydroxyl-methyl-glutaryl-coenzyme-A (HMG-CoA) reductase inhibitors of statin action are very effective and safe drugs, and they are widely used for the treatment of hyperlipidemia and the prevention of primary and secondary cardiovascular diseases (CVDs). However, recent meta-analyses of previous studies done with...

journal_title：Postgraduate medicine

authors： Chrysant SG

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:We aimed to determine the prevalence of chronic diseases and unhealthy lifestyle behaviors of Turkish doctors as compared with the general population and the frequency of compliance with preventive clinical practices among doctors. METHODS:This was an observational, prospective cohort study that enrolled gr...

journal_title：Postgraduate medicine

authors： Unal S,Tanriover MD,Ascioglu S,Demirkazik A,Ertenli I,Eskioglu E,Guler K,Kiraz S,Ozbakkaloglu M,Ozer B,Tukek T,Akyar S,Erdem Y

更新日期：2017-04-01 00:00:00