The long-term prognostic significance of heart failure in sarcoidosis patients ─ a cohort study.

Abstract:

OBJECTIVE:To evaluate the proportion and the long-term prognostic significance of heart failure (HF) in sarcoidosis patients. METHODS:Data extracted from a large Israeli healthcare provider's database were used to study sarcoidosis patients and matched non-sarcoidosis controls since 2000 to 2016. The proportion of HF was compared between the groups, and the associations between sarcoidosis, HF, and all-cause mortality were assessed. RESULTS:Included were 3,993 sarcoidosis patients and 19,856 age- and sex-matched controls. The proportion of HF patients was higher among the former (10.9% and 5.3%, respectively). A logistic regression model for multivariable analysis for covariates found sarcoidosis to be independently associated with HF (Odds Ratio (OR) 2.09 confidence interval (CI) 1.83-2.39). A total of 710 sarcoidosis patients (17.8%) and 2,121 controls (10.7%) died during the study period (p < 0.001). A multivariable survival analysis found an estimated hazard ratio (HR) of 1.84 (95%CI 1.67-2.02), indicating a significant association between sarcoidosis and risk for all-cause mortality. Our analysis also revealed a significant association between HF and risk for all-cause mortality (HR 3.05, 95%CI 2.77-3.36). CONCLUSIONS:Sarcoidosis is independently associated with HF, and both are independently associated with all-cause mortality.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Etinger R,Comaneshter D,Amital H,Cohen AD,Tiosano S

doi

10.1080/00325481.2020.1832773

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1-7

eissn

0032-5481

issn

1941-9260

pub_type

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