听力与言语-语言病理学

行为科学

医学伦理学

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  • Treatment persistence of biologics among patients with psoriatic arthritis.

    abstract:BACKGROUND:Persistence of biologic therapy in psoriatic arthritis (PsA) patients is an important factor in individualized patient treatment planning and healthcare policy and guideline development. OBJECTIVE:To estimate the persistence of biologic agents prescribed to PsA patients in a real-life setting as well as fac...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-021-02417-x

    authors: Haddad A,Gazitt T,Feldhamer I,Feld J,Cohen AD,Lavi I,Tatour F,Bergman I,Zisman D

    更新日期:2021-01-29 00:00:00

  • Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms.

    abstract:BACKGROUND:Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects. Here, we investigate the role of PCSK9 in relation to the inflammatory activity in patients with rheumatoid arthritis (RA). METHODS:PCSK9-le...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02386-7

    authors: Frostegård J,Ahmed S,Hafström I,Ajeganova S,Rahman M

    更新日期:2021-01-19 00:00:00

  • Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.

    abstract:BACKGROUND:Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of idiopathic inflammatory myopathies (IIM). Jo-1-binding B cells (JBCs) are implicated in disease patho...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02412-8

    authors: Young-Glazer J,Cisneros A 3rd,Wilfong EM,Smith SA,Crofford LJ,Bonami RH

    更新日期:2021-01-19 00:00:00

  • Hsa_circ_0123190 acts as a competitive endogenous RNA to regulate APLNR expression by sponging hsa-miR-483-3p in lupus nephritis.

    abstract:BACKGROUND:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, which is involved in mechanism of many diseases. However, the role of circRNA in lupus nephritis has bee...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02404-8

    authors: Zhang C,Gao C,Di X,Cui S,Liang W,Sun W,Yao M,Liu S,Zheng Z

    更新日期:2021-01-13 00:00:00

  • Association between acute phase reactants, interleukin-6, tumor necrosis factor-α, and disease activity in Takayasu's arteritis patients.

    abstract:BACKGROUND:To investigate the association between blood biomarkers and disease activity of Takayasu's arteritis (TAK) in a follow-up cohort. METHODS:Disease activity was assessed by clinical manifestations and repeated vascular Doppler examinations. The association between erythrocyte sedimentation rate (ESR), serum l...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02365-y

    authors: Li J,Wang Y,Wang Y,Wang Y,Yang Y,Zhao J,Li M,Tian X,Zeng X

    更新日期:2020-12-10 00:00:00

  • Clinical predictors of multiple failure to biological therapy in patients with rheumatoid arthritis.

    abstract:BACKGROUND:Biological therapies have improved the clinical course and quality of life of rheumatoid arthritis (RA) patients. Despite the availability and effectiveness of these treatments, some patients experience multiple failures to biologic disease-modifying antirheumatic drugs (bDMARDs), constituting a particular c...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02354-1

    authors: Novella-Navarro M,Plasencia C,Tornero C,Navarro-Compán V,Cabrera-Alarcón JL,Peiteado-López D,Nuño L,Monjo-Henry I,Franco-Gómez K,Villalba A,Balsa A

    更新日期:2020-12-09 00:00:00

  • Gene expression identifies patients who develop inflammatory arthritis in a clinically suspect arthralgia cohort.

    abstract:BACKGROUND:Established rheumatoid arthritis (RA) patients display differentially expressed genes coding for cytokine/chemokine-mediated immunity compared to healthy controls. It is unclear, however, if in the pre-arthritis phase of clinically suspect arthralgia (CSA) expression of immune genes differ between patients w...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02361-2

    authors: Niemantsverdriet E,van den Akker EB,Boeters DM,van den Eeden SJF,Geluk A,van der Helm-van Mil AHM

    更新日期:2020-11-09 00:00:00

  • Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency.

    abstract:BACKGROUND:The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP antibody and, thus, may ultimately develop RA. We retrospectively investigated whether anti-CCP-positi...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02351-4

    authors: Iwasaki T,Nakabo S,Terao C,Murakami K,Nakashima R,Hashimoto M,Imura Y,Yukawa N,Yoshifuji H,Miura Y,Yurugi K,Maekawa T,van Delft MAM,Trouw LA,Fujii T,Mimori T,Ohmura K

    更新日期:2020-10-19 00:00:00

  • Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.

    abstract:BACKGROUND:Porphyromonas gingivalis (Pg) infection causes periodontal disease and exacerbates rheumatoid arthritis (RA). It is reported that inoculation of periodontopathogenic bacteria (i.e., Pg) can alter gut microbiota composition in the animal models. Gut microbiota dysbiosis in human has shown strong associations ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02348-z

    authors: Hamamoto Y,Ouhara K,Munenaga S,Shoji M,Ozawa T,Hisatsune J,Kado I,Kajiya M,Matsuda S,Kawai T,Mizuno N,Fujita T,Hirata S,Tanimoto K,Nakayama K,Kishi H,Sugiyama E,Kurihara H

    更新日期:2020-10-19 00:00:00

  • Associations between Patient Global Assessment scores and pain, physical function, and fatigue in rheumatoid arthritis: a post hoc analysis of data from phase 3 trials of tofacitinib.

    abstract:BACKGROUND:Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We examined the degree to which Patient Global Assessment of Disease Activity (PtGA) was driven by patient-reported assessments of pain (Pain), physical function, and fatigue in patients receiving tofacitinib 5 mg t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02324-7

    authors: Strand V,Kaine J,Alten R,Wallenstein G,Diehl A,Shi H,Germino R,Murray CW

    更新日期:2020-10-15 00:00:00

  • Rheumatoid arthritis patients on persistent moderate disease activity on biologics have adverse 5-year outcome compared to persistent low-remission status and represent a heterogeneous group.

    abstract:BACKGROUND:The long-term outcome of rheumatoid arthritis (RA) patients who in clinical practice exhibit persistent moderate disease activity (pMDA) despite treatment with biologics has not been adequately studied. Herein, we analyzed the 5-year outcome of the pMDA group and assessed for within-group heterogeneity. MET...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02313-w

    authors: Genitsaridi I,Flouri I,Plexousakis D,Marias K,Boki K,Skopouli F,Drosos A,Bertsias G,Boumpas D,Sidiropoulos P

    更新日期:2020-09-29 00:00:00

  • Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway.

    abstract:BACKGROUND:The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). METHODS:Serum from patients with RA and osteoarthritis (OA), and healthy controls, and synov...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02315-8

    authors: Min HK,Won JY,Kim BM,Lee KA,Lee SJ,Lee SH,Kim HR,Kim KW

    更新日期:2020-09-23 00:00:00

  • AST/ALT ratio as a predictor of mortality and exacerbations of PM/DM-ILD in 1 year-a retrospective cohort study with 522 cases.

    abstract:OBJECTIVE:To assess the associations between aspartate transaminase/alanine transaminase ratio (DRR) and mortality in patients with polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). PATIENTS AND METHODS:This was a retrospective cohort study, which included 522 patients with PM/DM-ILD whose...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02286-w

    authors: Li R,Zhu WJ,Wang F,Tang X,Luo F

    更新日期:2020-09-20 00:00:00

  • Children with oligoarticular juvenile idiopathic arthritis have skewed synovial monocyte polarization pattern with functional impairment-a distinct inflammatory pattern for oligoarticular juvenile arthritis.

    abstract:BACKGROUND:Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JI...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02279-9

    authors: Schmidt T,Berthold E,Arve-Butler S,Gullstrand B,Mossberg A,Kahn F,Bengtsson AA,Månsson B,Kahn R

    更新日期:2020-08-12 00:00:00

  • Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population.

    abstract:BACKGROUND:Differences in the expression of variants across ethnic groups in the systemic lupus erythematosus (SLE) patients have been well documented. However, the genetic architecture in the Thai population has not been thoroughly examined. In this study, we carried out genome-wide association study (GWAS) in the Tha...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02276-y

    authors: Tangtanatakul P,Thumarat C,Satproedprai N,Kunhapan P,Chaiyasung T,Klinchanhom S,Wang YF,Wei W,Wongshinsri J,Chiewchengchol D,Rodsaward P,Ngamjanyaporn P,Suangtamai T,Mahasirimongkol S,Pisitkun P,Hirankarn N

    更新日期:2020-08-08 00:00:00

  • Does periodontitis affect the treatment response of biologics in the treatment of rheumatoid arthritis?

    abstract:BACKGROUND:Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the treatment response to RA. This study aimed to examine the relationship between the extent of PD and t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02269-x

    authors: Tachibana M,Yonemoto Y,Okamura K,Suto T,Sakane H,Kaneko T,Dam TT,Okura C,Tajika T,Tsushima Y,Chikuda H

    更新日期:2020-07-25 00:00:00

  • Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis.

    abstract:BACKGROUND:Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rarely analysed, although both are known to play vital roles in the mechanical stability of the joint. T...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02261-5

    authors: Ramos-Mucci L,Javaheri B,van 't Hof R,Bou-Gharios G,Pitsillides AA,Comerford E,Poulet B

    更新日期:2020-07-16 00:00:00

  • IgG anti-hinge antibodies against IgG4 F(ab')2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes.

    abstract:BACKGROUND:Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region at different sites. Moreover,...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02251-7

    authors: Ota T,Ota SI,Uchino A,Nagano S

    更新日期:2020-06-26 00:00:00

  • DNA vaccine encoding heat shock protein 90 protects from murine lupus.

    abstract:BACKGROUND:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune responses to it in SLE, we investigated whether an HSP90 DNA vacc...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02246-4

    authors: Liu A,Shi FD,Cohen IR,Castaldo G,Matarese G,Quintana FJ,La Cava A

    更新日期:2020-06-22 00:00:00

  • Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment: data from the BIOBADASER III register.

    abstract:OBJECTIVES:To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA). METHODS:All patients in the BIOBADASER registry diagnosed with RA, AS, and PsA,...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02231-x

    authors: Vela P,Sanchez-Piedra C,Perez-Garcia C,Castro-Villegas MC,Freire M,Mateo L,Díaz-Torné C,Bohorquez C,Blanco-Madrigal JM,Ros-Vilamajo I,Gómez S,Caño R,Sánchez-Alonso F,Díaz-González F,Gómez-Reino JJ

    更新日期:2020-06-15 00:00:00

  • Interleukin-32 in systemic sclerosis, a potential new biomarker for pulmonary arterial hypertension.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc), associated with a progressive elevation in pulmonary vascular resistance and subsequent right heart failure and death. Due to unspecific symptoms, the diagnosis of PAH is often delayed. On this basis, it is of great v...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02218-8

    authors: Di Benedetto P,Guggino G,Manzi G,Ruscitti P,Berardicurti O,Panzera N,Grazia N,Badagliacca R,Riccieri V,Vizza CD,Radchenko G,Liakouli V,Ciccia F,Cipriani P,Giacomelli R

    更新日期:2020-06-01 00:00:00

  • The effect of nicotinamide adenine dinucleotide phosphate oxidase 4 on migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.

    abstract:BACKGROUND:Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) induces ROS generation and, consequently, enhances cell migration. Desp...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02204-0

    authors: Lee HR,Yoo SJ,Kim J,Yoo IS,Park CK,Kang SW

    更新日期:2020-05-15 00:00:00

  • The role of baseline BLyS levels and type 1 interferon-inducible gene signature status in determining belimumab response in systemic lupus erythematosus: a post hoc meta-analysis.

    abstract:BACKGROUND:Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway activation. This post hoc meta-analysis of BLISS-52 and BLISS-76 explored the relationship between base...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02177-0

    authors: Wilkinson C,Henderson RB,Jones-Leone AR,Flint SM,Lennon M,Levy RA,Ji B,Bass DL,Roth D

    更新日期:2020-05-04 00:00:00

  • Differential regulation and correlation between galectin-9 and anti-CCP antibody (ACPA) in rheumatoid arthritis patients.

    abstract:BACKGROUND:Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and its relationship with RA disease activity and phenotype. METHODS:A total of 116 RA patients and 31 ag...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02158-3

    authors: Fujita Y,Asano T,Matsuoka N,Temmoku J,Sato S,Matsumoto H,Furuya MY,Suzuki E,Watanabe H,Kawakami A,Migita K

    更新日期:2020-04-15 00:00:00

  • Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany.

    abstract:BACKGROUND:To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome. METHODS:Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02166-3

    authors: Heiligenhaus A,Klotsche J,Niewerth M,Horneff G,Ganser G,Haas JP,Minden K

    更新日期:2020-04-15 00:00:00

  • Disease features associated with a low disease impact in patients with psoriatic arthritis: results of a cross-sectional multicenter study.

    abstract:BACKGROUND:Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of long-term outcomes, and the impact of psoriatic arthritis (PsA) on patients' lives. The objective...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02168-1

    authors: Queiro R,Cañete JD,Montoro M,Gómez S,Cábez A,MAAPS study group.

    更新日期:2020-04-15 00:00:00

  • Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis.

    abstract:BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective tissue growth factor (CTGF) is a critical factor in RA progression, which promotes fibroblast-like synoviocyte (FLS) proliferation, pannus formation, ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-2133-2

    authors: Sun W,Ma J,Zhao H,Xiao C,Zhong H,Ling H,Xie Z,Tian Q,Chen H,Zhang T,Chen M,Jin S,Wang J

    更新日期:2020-03-27 00:00:00

  • Spondyloarthritis Research Consortium of Canada sacroiliac joint inflammation and structural scores: change score reliability and recalibration utility in children.

    abstract:BACKGROUND:The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibration modules for the SIS and SSS and the reliability of their component change scores. METHODS:Chang...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02157-4

    authors: Weiss PF,Maksymowych WP,Xiao R,Biko DM,Francavilla ML,Lambert RG,Jaremko JL,Heshin-Bekenstein M,Brandon TG,Chauvin NA

    更新日期:2020-03-24 00:00:00

  • Post-traumatic osteoarthritis following ACL injury.

    abstract::Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest p...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,评审

    doi:10.1186/s13075-020-02156-5

    authors: Wang LJ,Zeng N,Yan ZP,Li JT,Ni GX

    更新日期:2020-03-24 00:00:00

  • The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis.

    abstract:BACKGROUND:Osteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H2S) has been implicated in mineralization but has never been studied in OA. Here, we investigated t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-02147-6

    authors: Nasi S,Ehirchiou D,Chatzianastasiou A,Nagahara N,Papapetropoulos A,Bertrand J,Cirino G,So A,Busso N

    更新日期:2020-03-17 00:00:00

  • Insensitivity versus poor response to tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective cohort study.

    abstract:BACKGROUND:With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivity to first-line biologic disease-modifying anti-rheumatic drugs (bDMARD) is becoming a significant ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-2122-5

    authors: Ochi S,Saito K,Mizoguchi F,Kato S,Tanaka Y

    更新日期:2020-03-04 00:00:00

  • Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior.

    abstract:BACKGROUND:Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. METHODS:Eighty 10-week-old male C57BL/6 mice w...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-020-2129-y

    authors: Li H,Ding X,Terkeltaub R,Lin H,Zhang Y,Zhou B,He K,Li K,Liu Z,Wei J,Yang Y,Xie H,Zeng C,Lei G

    更新日期:2020-02-22 00:00:00

  • Validation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort.

    abstract:BACKGROUND:Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or over-treatment. Our objective was to externally validate Nordic clinical prediction models in Canad...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-2091-8

    authors: Henrey A,Rypdal V,Rypdal M,Loughin T,Nordal E,Guzman J,ReACCh-Out and NoSPeR Investigators.

    更新日期:2020-01-15 00:00:00

  • Rule-based and machine learning algorithms identify patients with systemic sclerosis accurately in the electronic health record.

    abstract:BACKGROUND:Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated methods are needed. We developed and validated EHR-based algorithms that incorporate billing codes ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-2092-7

    authors: Jamian L,Wheless L,Crofford LJ,Barnado A

    更新日期:2019-12-30 00:00:00

  • Protein profiling and network enrichment analysis in individuals before and after the onset of rheumatoid arthritis.

    abstract:BACKGROUND:Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well as potential novel biomarkers, using multiple protein analyses. METHODS:A case-control study was co...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-2066-9

    authors: Brink M,Lundquist A,Alexeyenko A,Lejon K,Rantapää-Dahlqvist S

    更新日期:2019-12-16 00:00:00

  • Improved RA classification among early arthritis patients with the concordant presence of three RA autoantibodies: analysis in two early arthritis clinics.

    abstract:BACKGROUND:The patients with RA benefit from early identification soon after the first clinical symptoms appear. The 2010 ACR/EULAR classification criteria were developed to fulfill this need and their application has been demonstrated to be effective. However, there is still room for improvement. Therefore, we aimed t...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-2079-4

    authors: Regueiro C,Rodríguez-Martínez L,Nuño L,Ortiz AM,Villalba A,Pascual-Salcedo D,Martínez-Feito A,González-Alvaro I,Balsa A,Gonzalez A

    更新日期:2019-12-11 00:00:00

  • Diagnostic performance of serum cystatin C and complement component 1q in lupus nephritis.

    abstract:BACKGROUND:The information concerning non-invasive, easily obtainable, and accurate biomarkers for diagnosis of lupus nephritis (LN) is extremely limited. The aim of this study was to evaluate the diagnostic performance of cystatin C (CysC) and complement component 1q (C1q) for LN. METHODS:A case-control study that in...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-2065-x

    authors: Xu B,Zhang YM,Yang YW,Liu YS,Feng JF

    更新日期:2019-12-04 00:00:00

  • Progressive structural bone changes and their relationship with treatment in patients with psoriatic arthritis: a longitudinal HR-pQCT study.

    abstract:BACKGROUND:Although the short-term effects of tumor necrosis factor alpha (TNF-α) and interleukin-17A (IL-17A) inhibition on the structural changes in psoriatic arthritis (PsA) using high-resolution peripheral quantitative computed tomography (HR-pQCT) have been reported, no studies have investigated the long-term stru...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-2043-3

    authors: Wu D,Griffith JF,Lam SHM,Wong PCH,Shi L,Li EK,Cheng IT,Li TK,Hung VW,Qin L,Tam LS

    更新日期:2019-12-04 00:00:00

  • Secukinumab efficacy on resolution of enthesitis in psoriatic arthritis: pooled analysis of two phase 3 studies.

    abstract:BACKGROUND:Enthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies. METHOD:Assessm...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s13075-019-2055-z

    authors: Coates LC,Wallman JK,McGonagle D,Schett GA,McInnes IB,Mease PJ,Rasouliyan L,Quebe-Fehling E,Asquith DL,Fasth AER,Pricop L,Gaillez C

    更新日期:2019-12-04 00:00:00

  • NEMO score in nailfold videocapillaroscopy is a good tool to assess both steady state levels and overtime changes of disease activity in patients with systemic sclerosis: a comparison with the proposed composite indices for this disease status entity.

    abstract:BACKGROUND:In previous studies, we demonstrated that the NEMO score, i.e. the cumulative number of microhaemorrhages (MHEs) and microthromboses (MTs), observed in nailfold videocapillaroscopy was a good indicator of the steady state level of disease activity (DA) in patients with systemic sclerosis (SSc) when the Europ...

    journal_title:Arthritis research & therapy

    pub_type: 杂志文章

    doi:10.1186/s13075-019-2032-6

    authors: Pignataro F,Maglione W,Minniti A,Sambataro D,Sambataro G,Campanaro F,Valentini G,Vitali C,Del Papa N

    更新日期:2019-11-29 00:00:00

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