听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览JOURNAL OF HEPATOLOGY期刊下所有文献
  • A placebo-controlled randomised trial of budesonide for PBC following an insufficient response to UDCA.

    abstract:BACKGROUND & AIMS:In patients with primary biliary cholangitis (PBC), the efficacy of budesonide, a synthetic corticosteroid displaying high first-pass metabolism, is unresolved. In a placebo-controlled, double-blind trial, we evaluated the added-value of budesonide in those with PBC and ongoing risk of progressive dis...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.09.011

    authors: Hirschfield GM,Beuers U,Kupcinskas L,Ott P,Bergquist A,Färkkilä M,Manns MP,Parés A,Spengler U,Stiess M,Greinwald R,Pröls M,Wendum D,Drebber U,Poupon R

    更新日期:2021-02-01 00:00:00

  • The changing scenario of hepatitis D.

    abstract::The global scenario of hepatitis D is changing with the widespread implementation of vaccination against hepatitis B. In high-income countries that achieved optimal control of HBV, the epidemiology of hepatitis D is dual, consisting of an ageing cohort of domestic patients with advanced liver fibrosis who represent th...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2021.01.014

    authors: Rizzetto M,Hamid S,Negro F

    更新日期:2021-01-20 00:00:00

  • Safety and efficacy of in vitro fertilisation in patients with chronic liver disease and liver transplantation recipients.

    abstract:BACKGROUND:Chronic liver disease and liver transplantation (LT) can delay both timing and ability of women to conceive. With increased awareness and availability of in vitro fertilisation (IVF), the need for accurate counselling is paramount. To date, minimal data exists to inform outcomes of IVF in patients with chron...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.12.022

    authors: Rahim MN,Theocharidou E,Yen Lau KG,Ahmed R,Marattukalam F,Long L,Cannon MD,Heneghan MA

    更新日期:2021-01-15 00:00:00

  • Next-generation sequencing in the diagnosis of non-cirrhotic splanchnic vein thrombosis.

    abstract:BACKGROUND & AIMS:Myeloproliferative neoplasms (MPNs) are the most frequent cause of non-tumoural non-cirrhotic splanchnic vein thrombosis (NC-SVT). Diagnosis of MPN is based on blood cell count alterations, bone marrow histology, and detection of specific gene mutations. Next-generation sequencing (NGS) allows the sim...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.06.045

    authors: Magaz M,Alvarez-Larrán A,Colomer D,López-Guerra M,García-Criado MÁ,Mezzano G,Belmonte E,Olivas P,Soy G,Cervantes F,Darnell A,Ferrusquía-Acosta J,Baiges A,Turon F,Hernández-Gea V,García-Pagán JC

    更新日期:2021-01-01 00:00:00

  • p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:p53 mutations occur frequently in human HCC. Activation of the mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is still unknown whether these changes together initiate HCC and can be targeted as a potential therapeutic strategy. METHODS:We generated mouse models ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.07.036

    authors: Luo YD,Fang L,Yu HQ,Zhang J,Lin XT,Liu XY,Wu D,Li GX,Huang D,Zhang YJ,Chen S,Jiang Y,Shuai L,He Y,Zhang LD,Bie P,Xie CM

    更新日期:2021-01-01 00:00:00

  • Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications.

    abstract:BACKGROUND & AIMS:Despite the clinical and genetic significance of macrotrabecular-massive hepatocellular carcinoma (MTM-HCC), its characteristics on imaging have not been described. This study aimed to characterise MTM-HCC on gadoxetic acid-enhanced MRI and to evaluate the diagnostic accuracy and prognostic value of t...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.08.013

    authors: Rhee H,Cho ES,Nahm JH,Jang M,Chung YE,Baek SE,Lee S,Kim MJ,Park MS,Han DH,Choi JY,Park YN

    更新日期:2021-01-01 00:00:00

  • Endpoints and design of clinical trials in patients with decompensated cirrhosis: Position paper of the LiverHope Consortium.

    abstract::Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease and preventing the development of complications in patients with decompensated cirrhosis. The design of...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.08.009

    authors: Solà E,Pose E,Campion D,Piano S,Roux O,Simon-Talero M,Uschner F,de Wit K,Zaccherini G,Alessandria C,Beuers U,Caraceni P,Francoz C,Mookerjee RP,Trebicka J,Vargas V,Serra M,Torres F,Montagnese S,Krag A,Hernaez R,K

    更新日期:2021-01-01 00:00:00

  • Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension.

    abstract:BACKGROUND & AIMS:Clinically significant portal hypertension (CSPH), defined as a hepatic venous pressure gradient (HVPG) ≥10 mmHg, persists 24 weeks after sustained virological response (SVR) in up to 78% of patients with HCV-related cirrhosis treated with direct-acting antivirals. These patients remain at risk of dec...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.05.050

    authors: Lens S,Baiges A,Alvarado-Tapias E,LLop E,Martinez J,Fortea JI,Ibáñez-Samaniego L,Mariño Z,Rodríguez-Tajes S,Gallego A,Bañares R,Puente Á,Albillos A,Calleja JL,Torras X,Hernández-Gea V,Bosch J,Villanueva C,García-Pagán

    更新日期:2020-12-01 00:00:00

  • Extracellular vesicles as biomarkers in liver diseases: A clinician's point of view.

    abstract::Extracellular vesicles are membrane-bound vesicles containing proteins, lipids, RNAs and microRNAs. They can originate from both healthy and stressed cells, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2020.07.014

    authors: Thietart S,Rautou PE

    更新日期:2020-12-01 00:00:00

  • CD40-mediated immune cell activation enhances response to anti-PD1 in murine intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND & AIMS:Cholangiocarcinoma (CCA) carries a very poor prognosis due to a typically late clinical presentation and a poor response to current therapeutics. While these tumors commonly express PD-1 and PD-L1, the response to immune checkpoint inhibitors (ICI) is poor. Stimulating antigen-presenting cells includi...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.11.037

    authors: Diggs LP,Ruf B,Ma C,Heinrich B,Cui L,Zhang Q,McVey JC,Wabitsch S,Heinrich S,Rosato U,Lai W,Subramanyam V,Longerich T,Loosen SH,Luedde T,Neumann UP,Desar S,Kleiner D,Gores G,Wang XW,Greten TF

    更新日期:2020-12-01 00:00:00

  • Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.

    abstract:BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into t...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.11.024

    authors: Bianco C,Jamialahmadi O,Pelusi S,Baselli G,Dongiovanni P,Zanoni I,Santoro L,Maier S,Liguori A,Meroni M,Borroni V,D'Ambrosio R,Spagnuolo R,Alisi A,Federico A,Bugianesi E,Petta S,Miele L,Vespasiani-Gentilucci U,Anstee

    更新日期:2020-11-25 00:00:00

  • PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

    abstract:INTRODUCTION:Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF phenotype (AD-ACLF) defined by organ failure(s). Precipitants may induce AD. This multicenter, prospective, observational PREDICT study (NCT03056612) analyzes and characterizes the pr...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.11.019

    authors: Trebicka J,Fernandez J,Papp M,Caraceni P,Laleman W,Gambino C,Giovo I,Uschner FE,Jansen C,Jimenez C,Mookerjee R,Gustot T,Albillos A,Bañares R,Jarcuska P,Steib C,Reiberger T,Acevedo J,Gatti P,Shawcross DL,Zeuzem S,

    更新日期:2020-11-20 00:00:00

  • Clinicopathologic features, tumor immune microenvironment and genomic landscape of Epstein-Barr virus-associated intrahepatic cholangiocarcinoma.

    abstract:BACKGROUND AND AIMS:Little is known about EBV-associated intrahepatic cholangiocarcinoma (EBVaICC) due to its rarity. We aimed to comprehensively investigate the clinicopathology, tumor immune microenvironment (TIME) and genomic landscape of this entity in southern China. METHODS:We evaluated 303 ICCs using in situ hy...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.10.037

    authors: Huang YH,Zhang CZ,Huang QS,Yeong J,Wang F,Yang X,He YF,Zhang XL,Zhang H,Chen SL,Zheng YL,Deng R,Lin CS,Yang MM,Li Y,Jiang C,Kin-Wah Lee T,Ma S,Zeng MS,Yun JP

    更新日期:2020-11-16 00:00:00

  • Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis.

    abstract:BACKGROUND & AIMS:Autophagy plays a crucial role in hepatic homeostasis and its deregulation has been associated with chronic liver disease. However, the effect of autophagy on the release of fibrogenic extracellular vesicles (EVs) by platelet-derived growth factor (PDGF)-stimulated hepatic stellate cells (HSCs) remain...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.04.044

    authors: Gao J,Wei B,de Assuncao TM,Liu Z,Hu X,Ibrahim S,Cooper SA,Cao S,Shah VH,Kostallari E

    更新日期:2020-11-01 00:00:00

  • Advances in functional and molecular MRI technologies in chronic liver diseases.

    abstract::MRI has emerged as the most comprehensive non-invasive diagnostic tool for liver diseases. In recent years, the value of MRI in hepatology has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, that add functional information to anatomically detailed morpho...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2020.06.020

    authors: Zhou IY,Catalano OA,Caravan P

    更新日期:2020-11-01 00:00:00

  • Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Macrophages (Mϕ) represent a major component of tumor tissues and play an important role in both tumor progression and therapeutic response. Although tumor Mϕ are generally considered to be derived from circulating monocytes, emerging evidence indicates that tissue Mϕ pools can be maintained by self-r...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.10.021

    authors: Wang J,Wang Y,Chu Y,Li Z,Yu X,Huang Z,Xu J,Zheng L

    更新日期:2020-10-31 00:00:00

  • SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19.

    abstract:Background & Aims:Liver enzyme abnormalities are common in patients with coronavirus disease 2019 (COVID-19). Whether or not severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to liver damage per se remains unknown. Herein, we reported the clinical characteristics and liver pathological man...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.05.002

    authors: Wang Y,Liu S,Liu H,Li W,Lin F,Jiang L,Li X,Xu P,Zhang L,Zhao L,Cao Y,Kang J,Yang J,Li L,Liu X,Li Y,Nie R,Mu J,Lu F,Zhao S,Lu J,Zhao J

    更新日期:2020-10-01 00:00:00

  • Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.

    abstract:BACKGROUND & AIMS:Current antiviral therapies help keep HBV under control, but they are not curative, as they are unable to eliminate the intracellular viral replication intermediate termed covalently closed circular DNA (cccDNA). Therefore, there remains an urgent need to develop strategies to cure CHB. Functional sil...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.09.019

    authors: Cheng ST,Hu JL,Ren JH,Yu HB,Zhong S,Wai Wong VK,Kwan Law BY,Chen WX,Xu HM,Zhang ZZ,Cai XF,Hu Y,Zhang WL,Long QX,Ren F,Zhou HZ,Huang AL,Chen J

    更新日期:2020-09-25 00:00:00

  • DAA therapy and long-term hepatic function in advanced/decompensated cirrhosis: Real-world experience from HCV-TARGET cohort.

    abstract:BACKGROUND & AIMS:Direct-acting antiviral (DAA) therapy is used in patients with HCV-related decompensated cirrhosis with the expectation of improving hepatic function. However, little is known about the long-term hepatic benefit of successful antiviral treatment. METHODS:Patients with advanced/decompensated cirrhosis...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.03.031

    authors: Verna EC,Morelli G,Terrault NA,Lok AS,Lim JK,Di Bisceglie AM,Zeuzem S,Landis CS,Kwo P,Hassan M,Manns MP,Vainorius M,Akushevich L,Nelson DR,Fried MW,Reddy KR

    更新日期:2020-09-01 00:00:00

  • Treatment of HCV reduces viral hepatitis-associated liver-related mortality in patients: An ERCHIVES study.

    abstract:BACKGROUND & AIMS:Treating HCV infection reduces overall mortality and reduces the risk of multiple extrahepatic complications. Whether the reduction in mortality is primarily due to a reduction in liver-related causes or extrahepatic complications is unknown. METHODS:We identified HCV-positive individuals treated for...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.02.022

    authors: Butt AA,Yan P,Shaikh OS,Lo Re V 3rd,Abou-Samra AB,Sherman KE

    更新日期:2020-08-01 00:00:00

  • Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping.

    abstract:BACKGROUND & AIMS:Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and obesity are epidemiologically correlated with each other but the causal inter-relationships between them remain incompletely understood. We aimed to explore the causal relationships between the 3 diseases. METHODS:Using both UK Biob...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.03.006

    authors: Liu Z,Zhang Y,Graham S,Wang X,Cai D,Huang M,Pique-Regi R,Dong XC,Chen YE,Willer C,Liu W

    更新日期:2020-08-01 00:00:00

  • Alternatively activated macrophages promote resolution of necrosis following acute liver injury.

    abstract:BACKGROUND & AIM:Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation, and death. Macrophages influence the progression and resolution of ALI due to their innate imm...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.02.031

    authors: Starkey Lewis P,Campana L,Aleksieva N,Cartwright JA,Mackinnon A,O'Duibhir E,Kendall T,Vermeren M,Thomson A,Gadd V,Dwyer B,Aird R,Man TY,Rossi AG,Forrester L,Park BK,Forbes SJ

    更新日期:2020-08-01 00:00:00

  • Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure.

    abstract:BACKGROUND & AIMS:Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic liver failure (ACLF). Herein, we assess whether inhibiting TLR4 signaling can ameliorate liver failure and serve as a potential treatment. METHODS:Circulating TLR4 ligands a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.01.011

    authors: Engelmann C,Sheikh M,Sharma S,Kondo T,Loeffler-Wirth H,Zheng YB,Novelli S,Hall A,Kerbert AJC,Macnaughtan J,Mookerjee R,Habtesion A,Davies N,Ali T,Gupta S,Andreola F,Jalan R

    更新日期:2020-07-01 00:00:00

  • Hepatitis B core-specific memory B cell responses associate with clinical parameters in patients with chronic HBV.

    abstract:BACKGROUND & AIMS:Little is known about the frequency, phenotype and function of HBV-specific B cells during chronic infection. Here we study HBcAg and HBsAg-specific B cells in different clinical phases of a chronic HBV infection. METHODS:We included 118 treatment naïve and 34 nucleos(t)ide analogue-treated patients ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.01.024

    authors: Vanwolleghem T,Groothuismink ZMA,Kreefft K,Hung M,Novikov N,Boonstra A

    更新日期:2020-07-01 00:00:00

  • HDL-related biomarkers are robust predictors of survival in patients with chronic liver failure.

    abstract:BACKGROUND & AIMS:High-density lipoprotein cholesterol (HDL-C) levels are reduced in patients with chronic liver disease and inversely correlate with disease severity. During acute conditions such as sepsis, HDL-C levels decrease rapidly and HDL particles undergo profound changes in their composition and function. We a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.01.026

    authors: Trieb M,Rainer F,Stadlbauer V,Douschan P,Horvath A,Binder L,Trakaki A,Knuplez E,Scharnagl H,Stojakovic T,Heinemann Á,Mandorfer M,Paternostro R,Reiberger T,Pitarch C,Amorós A,Gerbes A,Caraceni P,Alessandria C,Moreau

    更新日期:2020-07-01 00:00:00

  • Genotype correlates with the natural history of severe bile salt export pump deficiency.

    abstract:BACKGROUND & AIMS:Mutations in ABCB11 can cause deficiency of the bile salt export pump (BSEP), leading to cholestasis and end-stage liver disease. Owing to the rarity of the disease, the associations between genotype and natural history, or outcomes following surgical biliary diversion (SBD), remain elusive. We aimed ...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.02.007

    authors: van Wessel DBE,Thompson RJ,Gonzales E,Jankowska I,Sokal E,Grammatikopoulos T,Kadaristiana A,Jacquemin E,Spraul A,Lipiński P,Czubkowski P,Rock N,Shagrani M,Broering D,Algoufi T,Mazhar N,Nicastro E,Kelly DA,Nebbia G,A

    更新日期:2020-07-01 00:00:00

  • NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly.

    abstract:BACKGROUND & AIMS:Hepatomegaly can be triggered by insulin and insulin-unrelated etiologies. Insulin acts via AKT, but how other challenges cause hepatomegaly is unknown. METHODS:Since many hepatomegaly-inducing toxicants and stressors activate NRF2, we examined the effect of NRF2 activation on liver size and metaboli...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2020.01.023

    authors: He F,Antonucci L,Yamachika S,Zhang Z,Taniguchi K,Umemura A,Hatzivassiliou G,Roose-Girma M,Reina-Campos M,Duran A,Diaz-Meco MT,Moscat J,Sun B,Karin M

    更新日期:2020-06-01 00:00:00

  • Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension.

    abstract:BACKGROUND & AIMS:Emricasan, an oral pan-caspase inhibitor, decreased portal pressure in experimental cirrhosis and in an open-label study in patients with cirrhosis and severe portal hypertension, defined as a hepatic venous pressure gradient (HVPG) ≥12 mmHg. We aimed to confirm these results in a placebo-controlled s...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.12.010

    authors: Garcia-Tsao G,Bosch J,Kayali Z,Harrison SA,Abdelmalek MF,Lawitz E,Satapathy SK,Ghabril M,Shiffman ML,Younes ZH,Thuluvath PJ,Berzigotti A,Albillos A,Robinson JM,Hagerty DT,Chan JL,Sanyal AJ,IDN-6556-14 Investigators(‡).

    更新日期:2020-05-01 00:00:00

  • Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:The presence of multifocal tumors, developed either from intrahepatic metastasis (IM) or multicentric occurrence (MO), is a distinct feature of hepatocellular carcinoma (HCC). Immunogenomic characterization of multifocal HCC is important for understanding immune escape in different lesions and develop...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.12.014

    authors: Dong LQ,Peng LH,Ma LJ,Liu DB,Zhang S,Luo SZ,Rao JH,Zhu HW,Yang SX,Xi SJ,Chen M,Xie FF,Li FQ,Li WH,Ye C,Lin LY,Wang YJ,Wang XY,Gao DM,Zhou H,Yang HM,Wang J,Zhu SD,Wang XD,Cao Y,Zhou J,Fan J,Wu K,Gao

    更新日期:2020-05-01 00:00:00

  • Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLK...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.11.008

    authors: Majdi A,Aoudjehane L,Ratziu V,Islam T,Afonso MB,Conti F,Mestiri T,Lagouge M,Foufelle F,Ballenghien F,Ledent T,Moldes M,Cadoret A,Fouassier L,Delaunay JL,Aït-Slimane T,Courtois G,Fève B,Scatton O,Prip-Buus C,Rodrig

    更新日期:2020-04-01 00:00:00

  • Epidemiology and surveillance for hepatocellular carcinoma: New trends.

    abstract::The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a di...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jhep.2019.08.025

    authors: Singal AG,Lampertico P,Nahon P

    更新日期:2020-02-01 00:00:00

  • TNF-α/IFN-γ profile of HBV-specific CD4 T cells is associated with liver damage and viral clearance in chronic HBV infection.

    abstract:BACKGROUND & AIMS:The role of hepatitis B virus (HBV)-specific CD4 T cells in patients with chronic HBV infection is not clear. Thus, we aimed to elucidate this in patients with chronic infection, and those with hepatitis B flares. METHODS:Through intracellular IFN-γ and TNF-α staining, HBV-specific CD4 T cells were a...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.08.024

    authors: Wang H,Luo H,Wan X,Fu X,Mao Q,Xiang X,Zhou Y,He W,Zhang J,Guo Y,Tan W,Deng G

    更新日期:2020-01-01 00:00:00

  • Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1.

    abstract:BACKGROUND & AIMS:Clinical evidence has indicated a close link between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial in...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.09.014

    authors: Jiang F,Chen Q,Wang W,Ling Y,Yan Y,Xia P

    更新日期:2020-01-01 00:00:00

  • Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection.

    abstract:BACKGROUND & AIMS:Liver macrophages can be involved in both pathogen clearance and/or pathogenesis. To get further insight on their role during chronic hepatitis B virus (HBV) infections, our aim was to phenotypically and functionally characterize in vivo and ex vivo the interplay between HBV, primary human liver macro...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.06.032

    authors: Faure-Dupuy S,Delphin M,Aillot L,Dimier L,Lebossé F,Fresquet J,Parent R,Matter MS,Rivoire M,Bendriss-Vermare N,Salvetti A,Heide D,Flores L,Klumpp K,Lam A,Zoulim F,Heikenwälder M,Durantel D,Lucifora J

    更新日期:2019-12-01 00:00:00

  • Management of adverse events with tailored sorafenib dosing prolongs survival of hepatocellular carcinoma patients.

    abstract:BACKGROUND & AIMS:Sorafenib is associated with multiple adverse events (AEs), potentially causing its permanent interruption. It is unknown how physicians' experience has impacted on the management of these AEs and consequently on clinical outcomes. We aimed to assess whether AE management changed over time and if thes...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.08.015

    authors: Tovoli F,Ielasi L,Casadei-Gardini A,Granito A,Foschi FG,Rovesti G,Negrini G,Orsi G,Renzulli M,Piscaglia F

    更新日期:2019-12-01 00:00:00

  • O-GlcNAcylation-dependent upregulation of HO1 triggers ammonia-induced oxidative stress and senescence in hepatic encephalopathy.

    abstract:BACKGROUND & AIMS:Cerebral oxidative stress plays an important role in the pathogenesis of hepatic encephalopathy (HE), but the underlying mechanisms are incompletely understood. Herein, we analyzed a role of heme oxygenase (HO)1, iron and NADPH oxidase 4 (Nox4) for the induction of oxidative stress and senescence in H...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.06.020

    authors: Görg B,Karababa A,Schütz E,Paluschinski M,Schrimpf A,Shafigullina A,Castoldi M,Bidmon HJ,Häussinger D

    更新日期:2019-11-01 00:00:00

  • Anti-PD-1 blockade with nivolumab with and without therapeutic vaccination for virally suppressed chronic hepatitis B: A pilot study.

    abstract:BACKGROUND & AIMS:To evaluate the hypothesis that increasing T cell frequency and activity may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a programmed death receptor 1 (PD-1) inhibitor, with or without GS-4774, an HBV therapeutic vaccine, in virally suppressed patients with HBV e ant...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.06.028

    authors: Gane E,Verdon DJ,Brooks AE,Gaggar A,Nguyen AH,Subramanian GM,Schwabe C,Dunbar PR

    更新日期:2019-11-01 00:00:00

  • The prognostic role of hepatic venous pressure gradient in cirrhotic patients undergoing elective extrahepatic surgery.

    abstract:BACKGROUND & AIMS:Surgery in cirrhosis is associated with a high morbidity and mortality. Retrospectively reported prognostic factors include emergency procedures, liver function (MELD/Child-Pugh scores) and portal hypertension (assessed by indirect markers). This study assessed the prognostic role of hepatic venous pr...

    journal_title:Journal of hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jhep.2019.07.007

    authors: Reverter E,Cirera I,Albillos A,Debernardi-Venon W,Abraldes JG,Llop E,Flores A,Martínez-Palli G,Blasi A,Martínez J,Turon F,García-Valdecasas JC,Berzigotti A,de Lacy AM,Fuster J,Hernández-Gea V,Bosch J,García-Pagán JC

    更新日期:2019-11-01 00:00:00

  • Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.

    abstract:BACKGROUND AND AIMS:Primary sclerosing cholangitis (PSC) is an idiopathic, chronic cholestatic liver disorder characterized by biliary inflammation and fibrosis. Increased numbers of intrahepatic interferon-γ- (IFNγ) producing lymphocytes have been documented in patients with PSC, yet their functional role remains to b...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.05.023

    authors: Ravichandran G,Neumann K,Berkhout LK,Weidemann S,Langeneckert AE,Schwinge D,Poch T,Huber S,Schiller B,Hess LU,Ziegler AE,Oldhafer KJ,Barikbin R,Schramm C,Altfeld M,Tiegs G

    更新日期:2019-10-01 00:00:00

  • Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis.

    abstract:BACKGROUND & AIMS:Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore the role of TLR3-triggered apoptosis in HC...

    journal_title:Journal of hepatology

    pub_type: 杂志文章

    doi:10.1016/j.jhep.2019.05.031

    authors: Bonnin M,Fares N,Testoni B,Estornes Y,Weber K,Vanbervliet B,Lefrançois L,Garcia A,Kfoury A,Pez F,Coste I,Saintigny P,Viari A,Lang K,Guey B,Hervieu V,Bancel B,Bartoch B,Durantel D,Renno T,Merle P,Lebecque S

    更新日期:2019-10-01 00:00:00

788 条记录 1/20 页 « 12345678...1920 »