你正在浏览Particle and Fibre Toxicology期刊下所有文献
  • Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities.

    abstract:BACKGROUND:Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer sim...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Fraser K,Kodali V,Yanamala N,Birch ME,Cena L,Casuccio G,Bunker K,Lersch TL,Evans DE,Stefaniak A,Hammer MA,Kashon ML,Boots T,Eye T,Hubczak J,Friend SA,Dahm M,Schubauer-Berigan MK,Siegrist K,Lowry D,Bauer AK,Sarge

    更新日期:2020-12-07 00:00:00

  • Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults.

    abstract:BACKGROUND:Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies. METHODS:To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, ...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Wyatt LH,Devlin RB,Rappold AG,Case MW,Diaz-Sanchez D

    更新日期:2020-11-16 00:00:00

  • Occupational exposure to carbon black nanoparticles increases inflammatory vascular disease risk: an implication of an ex vivo biosensor assay.

    abstract:BACKGROUND:Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the risk for cardiovascular disease in carbon black exposed populations. An endothelial biosensor assay...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Tang J,Cheng W,Gao J,Li Y,Yao R,Rothman N,Lan Q,Campen MJ,Zheng Y,Leng S

    更新日期:2020-09-29 00:00:00

  • Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation".

    abstract::In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to...

    journal_title:Particle and fibre toxicology

    pub_type: 评论,信件


    authors: Driscoll KE,Borm PA,Chaudhuri I,Levy L,Yong M,Warheit D,McCunney R,Oberdörster G

    更新日期:2020-07-16 00:00:00

  • Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes.

    abstract:BACKGROUND:Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related to abnormal calcium handling and energetic failure in cardiomyocytes. Moreover, t...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Lozano O,Silva-Platas C,Chapoy-Villanueva H,Pérez BE,Lees JG,Ramachandra CJA,Contreras-Torres FF,Lázaro-Alfaro A,Luna-Figueroa E,Bernal-Ramírez J,Gordillo-Galeano A,Benitez A,Oropeza-Almazán Y,Castillo EC,Koh PL,Hausenloy D

    更新日期:2020-05-07 00:00:00

  • Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats.

    abstract:BACKGROUND:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular mor...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Carll AP,Salatini R,Pirela SV,Wang Y,Xie Z,Lorkiewicz P,Naeem N,Qian Y,Castranova V,Godleski JJ,Demokritou P

    更新日期:2020-01-29 00:00:00

  • Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats.

    abstract:BACKGROUND:Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Benzalkonium chloride (BAC or BKC) is a non-toxic substance used to control pests. Recently, BAC has been increasingly us...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Choi HY,Lee YH,Lim CH,Kim YS,Lee IS,Jo JM,Lee HY,Cha HG,Woo HJ,Seo DS

    更新日期:2020-01-28 00:00:00

  • Mechanisms of lung toxicity induced by biomass burning aerosols.

    abstract:BACKGROUND:Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Pardo M,Li C,He Q,Levin-Zaidman S,Tsoory M,Yu Q,Wang X,Rudich Y

    更新日期:2020-01-20 00:00:00

  • Inhalation of welding fumes reduced sperm counts and high fat diet reduced testosterone levels; differential effects in Sprague Dawley and Brown Norway rats.

    abstract:BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Skovmand A,Erdely A,Antonini JM,Nurkiewicz TR,Shoeb M,Eye T,Kodali V,Loeschner K,Vidmar J,Agerholm JS,Goericke-Pesch S,Vogel U,Hougaard KS

    更新日期:2020-01-10 00:00:00

  • Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells.

    abstract:BACKGROUND:The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer desig...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Siegrist KJ,Reynolds SH,Porter DW,Mercer RR,Bauer AK,Lowry D,Cena L,Stueckle TA,Kashon ML,Wiley J,Salisbury JL,Mastovich J,Bunker K,Sparrow M,Lupoi JS,Stefaniak AB,Keane MJ,Tsuruoka S,Terrones M,McCawley M,Sargent

    更新日期:2019-10-07 00:00:00

  • The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?

    abstract:BACKGROUND:Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of silica is variable, depending on the physico-chemical features of the particles. In the...

    journal_title:Particle and fibre toxicology

    pub_type: 信件


    authors: Pavan C,Delle Piane M,Gullo M,Filippi F,Fubini B,Hoet P,Horwell CJ,Huaux F,Lison D,Lo Giudice C,Martra G,Montfort E,Schins R,Sulpizi M,Wegner K,Wyart-Remy M,Ziemann C,Turci F

    更新日期:2019-08-16 00:00:00

  • Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation.

    abstract:BACKGROUND:The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxyla...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Palmer BC,Phelan-Dickenson SJ,DeLouise LA

    更新日期:2019-01-08 00:00:00

  • Graphene quantum dots in alveolar macrophage: uptake-exocytosis, accumulation in nuclei, nuclear responses and DNA cleavage.

    abstract:BACKGROUND:Given the tremendous potential for graphene quantum dots (QDs) in biomedical applications, a thorough understanding of the interaction of these materials with macrophages is essential because macrophages are one of the most important barriers against exogenous particles. Although the cytotoxicity and cellula...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Xu L,Dai Y,Wang Z,Zhao J,Li F,White JC,Xing B

    更新日期:2018-11-13 00:00:00

  • In vitro nanoparticle dosimetry for adherent growing cell monolayers covering bottom and lateral walls.

    abstract:BACKGROUND:Even though a continuously high number of in vitro studies on nanoparticles are being published, the issue of correct dose matter is often not sufficiently taken into account. Due to their size, the diffusion of nanoparticles is slower, as compared to soluble chemicals, and they sediment slowly. Therefore, t...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Böhmert L,König L,Sieg H,Lichtenstein D,Paul N,Braeuning A,Voigt A,Lampen A

    更新日期:2018-10-30 00:00:00

  • Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil.

    abstract:BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: de Oliveira AAF,de Oliveira TF,Dias MF,Medeiros MHG,Di Mascio P,Veras M,Lemos M,Marcourakis T,Saldiva PHN,Loureiro APM

    更新日期:2018-10-19 00:00:00

  • Carbon load in airway macrophages as a biomarker of exposure to particulate air pollution; a longitudinal study of an international Panel.

    abstract:BACKGROUND:Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by changes in exposure. We studied the clearance kinetics of black carbon (BC) in AM, obtained by sput...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Bai Y,Bové H,Nawrot TS,Nemery B

    更新日期:2018-03-14 00:00:00

  • Ambient air pollution and thrombosis.

    abstract::Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several plausible biological mechanisms have been proposed for these associations, however, at present, the pathways ...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章,评审


    authors: Robertson S,Miller MR

    更新日期:2018-01-03 00:00:00

  • Towards a more effective and efficient governance and regulation of nanomaterials.

    abstract::The uncertainty regarding the effects and risks of nanomaterials on human health and the environment, and how they should be tested and assessed in the context of current regulations, is clearly holding back the full exploitation of the innovative potential of nanomaterials. To reduce this uncertainty, the European Un...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Teunenbroek TV,Baker J,Dijkzeul A

    更新日期:2017-12-19 00:00:00

  • Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon.

    abstract:BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Vignal C,Pichavant M,Alleman LY,Djouina M,Dingreville F,Perdrix E,Waxin C,Ouali Alami A,Gower-Rousseau C,Desreumaux P,Body-Malapel M

    更新日期:2017-11-22 00:00:00

  • Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework.

    abstract:BACKGROUND:The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A pu...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Nikota J,Banville A,Goodwin LR,Wu D,Williams A,Yauk CL,Wallin H,Vogel U,Halappanavar S

    更新日期:2017-09-13 00:00:00

  • Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

    abstract:BACKGROUND:Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urb...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Hullmann M,Albrecht C,van Berlo D,Gerlofs-Nijland ME,Wahle T,Boots AW,Krutmann J,Cassee FR,Bayer TA,Schins RPF

    更新日期:2017-08-30 00:00:00

  • Prenatal tobacco smoke exposure predisposes offspring mice to exacerbated allergic airway inflammation associated with altered innate effector function.

    abstract:BACKGROUND:Epidemiological studies suggest that prenatal and early life environmental exposures have adverse effects on pulmonary function and are important contributors in the development of childhood asthma and allergic disease. The mechanism by which environmental tobacco smoke (ETS) exposure in utero promotes the d...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Ferrini M,Carvalho S,Cho YH,Postma B,Miranda Marques L,Pinkerton K,Roberts K,Jaffar Z

    更新日期:2017-08-22 00:00:00

  • Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection.

    abstract:BACKGROUND:Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-inf...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Sattler C,Moritz F,Chen S,Steer B,Kutschke D,Irmler M,Beckers J,Eickelberg O,Schmitt-Kopplin P,Adler H,Stoeger T

    更新日期:2017-01-10 00:00:00

  • Combined exposure of diesel exhaust particles and respirable Soufrière Hills volcanic ash causes a (pro-)inflammatory response in an in vitro multicellular epithelial tissue barrier model.

    abstract:BACKGROUND:There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, ...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Tomašek I,Horwell CJ,Damby DE,Barošová H,Geers C,Petri-Fink A,Rothen-Rutishauser B,Clift MJ

    更新日期:2016-12-12 00:00:00

  • Early signs of multi-walled carbon nanotbues degradation in macrophages, via an intracellular pH-dependent biological mechanism; importance of length and functionalization.

    abstract:BACKGROUND:Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to deciph...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Landry M,Pinault M,Tchankouo S,Charon É,Ridoux A,Boczkowski J,Mayne-L'Hermite M,Lanone S

    更新日期:2016-11-24 00:00:00

  • Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.

    abstract:BACKGROUND:Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles, as representative transition and rare earth oxides, exhibit distinct material properties that may result in different hazardous potential in the lung. The current study was undertaken to compare the pulmonar...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Sisler JD,Li R,McKinney W,Mercer RR,Ji Z,Xia T,Wang X,Shaffer J,Orandle M,Mihalchik AL,Battelli L,Chen BT,Wolfarth M,Andrew ME,Schwegler-Berry D,Porter DW,Castranova V,Nel A,Qian Y

    更新日期:2016-08-15 00:00:00

  • Increase in oxidative stress levels following welding fume inhalation: a controlled human exposure study.

    abstract:BACKGROUND:Tungsten inert gas (TIG) welding represents one of the most widely used metal joining processes in industry. It has been shown to generate a large majority of particles at the nanoscale and to have low mass emission rates when compared to other types of welding. Despite evidence that TIG fume particles may p...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Graczyk H,Lewinski N,Zhao J,Sauvain JJ,Suarez G,Wild P,Danuser B,Riediker M

    更新日期:2016-06-10 00:00:00

  • Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP).

    abstract::Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, not clearly elucidated. The purpose of the present review was to analyze the key events involved in the lung f...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章,评审


    authors: Vietti G,Lison D,van den Brule S

    更新日期:2016-02-29 00:00:00

  • Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles.

    abstract:OBJECTIVE:The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to support the development of regulations to reduce the risk of particle exposure. We tried to provide fund...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Lu S,Zhang W,Zhang R,Liu P,Wang Q,Shang Y,Wu M,Donaldson K,Wang Q

    更新日期:2015-03-19 00:00:00

  • Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum.

    abstract:BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Banda NK,Mehta G,Chao Y,Wang G,Inturi S,Fossati-Jimack L,Botto M,Wu L,Moghimi SM,Simberg D

    更新日期:2014-11-26 00:00:00

  • Bioavailability, distribution and clearance of tracheally-instilled and gavaged uncoated or silica-coated zinc oxide nanoparticles.

    abstract:BACKGROUND:Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO2 coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS:Uncoated and SiO2-coated ZnO NPs were ...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Konduru NV,Murdaugh KM,Sotiriou GA,Donaghey TC,Demokritou P,Brain JD,Molina RM

    更新日期:2014-09-03 00:00:00

  • Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres.

    abstract:OBJECTIVE:Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in p...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: You J,Zhou J,Zhou M,Liu Y,Robertson JD,Liang D,Van Pelt C,Li C

    更新日期:2014-05-30 00:00:00

  • An integrated approach for the in vitro dosimetry of engineered nanomaterials.

    abstract:BACKGROUND:There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening methods is the need for accurate measures of cellular dose. We present here a methodology that enables accurate determination of delivered to cell dos...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Cohen JM,Teeguarden JG,Demokritou P

    更新日期:2014-05-01 00:00:00

  • Cytotoxicity and genotoxicity of nano - and microparticulate copper oxide: role of solubility and intracellular bioavailability.

    abstract:BACKGROUND:Nano- or microscale copper oxide particles (CuO NP, CuO MP) are increasingly applied as catalysts or antimicrobial additives. This increases the risk of adverse health effects, since copper ions are cytotoxic under overload conditions. METHODS:The extra- and intracellular bioavailability of CuO NP and CuO M...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Semisch A,Ohle J,Witt B,Hartwig A

    更新日期:2014-02-13 00:00:00

  • Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes.

    abstract:BACKGROUND:Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are among the more widely used nanoparticles and come in two major commercial forms, single-walled carbon...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Sargent LM,Porter DW,Staska LM,Hubbs AF,Lowry DT,Battelli L,Siegrist KJ,Kashon ML,Mercer RR,Bauer AK,Chen BT,Salisbury JL,Frazer D,McKinney W,Andrew M,Tsuruoka S,Endo M,Fluharty KL,Castranova V,Reynolds SH

    更新日期:2014-01-09 00:00:00

  • Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice.

    abstract:BACKGROUND:Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood brain barrier (BBB) have been implicated as a potential mechanism of air...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Oppenheim HA,Lucero J,Guyot AC,Herbert LM,McDonald JD,Mabondzo A,Lund AK

    更新日期:2013-12-17 00:00:00

  • Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells.

    abstract:BACKGROUND:Inhaled nanoparticles have been reported in some instances to translocate from the nostril to the olfactory bulb in exposed rats. In close proximity to the olfactory bulb is the olfactory mucosa, within which resides a niche of multipotent cells. Cells isolated from this area may provide a relevant in vitro ...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Osmond-McLeod MJ,Osmond RI,Oytam Y,McCall MJ,Feltis B,Mackay-Sim A,Wood SA,Cook AL

    更新日期:2013-10-21 00:00:00

  • Rat pulmonary responses to inhaled nano-TiO₂: effect of primary particle size and agglomeration state.

    abstract:BACKGROUND:The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonar...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Noël A,Charbonneau M,Cloutier Y,Tardif R,Truchon G

    更新日期:2013-10-04 00:00:00

  • A new approach to design safe CNTs with an understanding of redox potential.

    abstract:BACKGROUND:Carbon nanotubes (CNTs) are being increasingly industrialized and applied for various products. As of today, although several toxicological evaluations of CNTs have been conducted, designing safer CNTs is not practiced because reaction kinetics of CNTs with bioactive species is not fully understood. RESULTS...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Tsuruoka S,Cassee FR,Castranova V

    更新日期:2013-09-02 00:00:00

  • Evaluation of cytotoxic, genotoxic and inflammatory responses of nanoparticles from photocopiers in three human cell lines.

    abstract:BACKGROUND:Photocopiers emit nanoparticles with complex chemical composition. Short-term exposures to modest nanoparticle concentrations triggered upper airway inflammation and oxidative stress in healthy human volunteers in a recent study. To further understand the toxicological properties of copier-emitted nanopartic...

    journal_title:Particle and fibre toxicology

    pub_type: 杂志文章


    authors: Khatri M,Bello D,Pal AK,Cohen JM,Woskie S,Gassert T,Lan J,Gu AZ,Demokritou P,Gaines P

    更新日期:2013-08-22 00:00:00

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