A new approach to design safe CNTs with an understanding of redox potential.

abstract：BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...

journal_title：Particle and fibre toxicology

authors： Vignal C,Pichavant M,Alleman LY,Djouina M,Dingreville F,Perdrix E,Waxin C,Ouali Alami A,Gower-Rousseau C,Desreumaux P,Body-Malapel M

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer sim...

journal_title：Particle and fibre toxicology

authors： Fraser K,Kodali V,Yanamala N,Birch ME,Cena L,Casuccio G,Bunker K,Lersch TL,Evans DE,Stefaniak A,Hammer MA,Kashon ML,Boots T,Eye T,Hubczak J,Friend SA,Dahm M,Schubauer-Berigan MK,Siegrist K,Lowry D,Bauer AK,Sarge

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Epidemiologic and animal studies have shown that particulate air pollution is associated with increased risk of lung and cardiovascular diseases. Although the exact mechanisms by which particles induce cardiovascular diseases are not known, studies suggest involvement of systemic acute phase responses, inclu...

journal_title：Particle and fibre toxicology

authors： Saber AT,Halappanavar S,Folkmann JK,Bornholdt J,Boisen AM,Møller P,Williams A,Yauk C,Vogel U,Loft S,Wallin H

更新日期：2009-04-20 00:00:00

abstract：BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...

journal_title：Particle and fibre toxicology

authors： Skovmand A,Erdely A,Antonini JM,Nurkiewicz TR,Shoeb M,Eye T,Kodali V,Loeschner K,Vidmar J,Agerholm JS,Goericke-Pesch S,Vogel U,Hougaard KS

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, ...

journal_title：Particle and fibre toxicology

authors： Tomašek I,Horwell CJ,Damby DE,Barošová H,Geers C,Petri-Fink A,Rothen-Rutishauser B,Clift MJ

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:Inhaled nanoparticles have been reported in some instances to translocate from the nostril to the olfactory bulb in exposed rats. In close proximity to the olfactory bulb is the olfactory mucosa, within which resides a niche of multipotent cells. Cells isolated from this area may provide a relevant in vitro ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Osmond RI,Oytam Y,McCall MJ,Feltis B,Mackay-Sim A,Wood SA,Cook AL

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-inf...

journal_title：Particle and fibre toxicology

authors： Sattler C,Moritz F,Chen S,Steer B,Kutschke D,Irmler M,Beckers J,Eickelberg O,Schmitt-Kopplin P,Adler H,Stoeger T

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. To address...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Battelli LA,McKinney W,Friend S,Wolfarth MG,Andrew M,Castranova V,Porter DW

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized...

journal_title：Particle and fibre toxicology

authors： Balakrishna S,Lomnicki S,McAvey KM,Cole RB,Dellinger B,Cormier SA

更新日期：2009-04-17 00:00:00

abstract：BACKGROUND:Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO2 coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS:Uncoated and SiO2-coated ZnO NPs were ...

journal_title：Particle and fibre toxicology

authors： Konduru NV,Murdaugh KM,Sotiriou GA,Donaghey TC,Demokritou P,Brain JD,Molina RM

更新日期：2014-09-03 00:00:00

abstract：BACKGROUND:Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain far from clear. RESULTS:Here, we evaluated the effects of amorphous nano...

journal_title：Particle and fibre toxicology

authors： Yang X,Liu J,He H,Zhou L,Gong C,Wang X,Yang L,Yuan J,Huang H,He L,Zhang B,Zhuang Z

更新日期：2010-01-19 00:00:00

abstract：:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on t...

journal_title：Particle and fibre toxicology

authors： Shi H,Magaye R,Castranova V,Zhao J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of silica is variable, depending on the physico-chemical features of the particles. In the...

journal_title：Particle and fibre toxicology

authors： Pavan C,Delle Piane M,Gullo M,Filippi F,Fubini B,Hoet P,Horwell CJ,Huaux F,Lison D,Lo Giudice C,Martra G,Montfort E,Schins R,Sulpizi M,Wegner K,Wyart-Remy M,Ziemann C,Turci F

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Even though a continuously high number of in vitro studies on nanoparticles are being published, the issue of correct dose matter is often not sufficiently taken into account. Due to their size, the diffusion of nanoparticles is slower, as compared to soluble chemicals, and they sediment slowly. Therefore, t...

journal_title：Particle and fibre toxicology

authors： Böhmert L,König L,Sieg H,Lichtenstein D,Paul N,Braeuning A,Voigt A,Lampen A

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Benzalkonium chloride (BAC or BKC) is a non-toxic substance used to control pests. Recently, BAC has been increasingly us...

journal_title：Particle and fibre toxicology

authors： Choi HY,Lee YH,Lim CH,Kim YS,Lee IS,Jo JM,Lee HY,Cha HG,Woo HJ,Seo DS

更新日期：2020-01-28 00:00:00

abstract：:There are certain concerns regarding the safety for the environment and human health from the use of engineered nanoparticles (ENPs) which leads to unintended exposures, as opposed to the use of ENPs for medical purposes. This review focuses on the unintended human exposure of ENPs. In particular, possible effects in ...

journal_title：Particle and fibre toxicology

authors： Simkó M,Mattsson MO

更新日期：2010-12-21 00:00:00

abstract：BACKGROUND:Given the tremendous potential for graphene quantum dots (QDs) in biomedical applications, a thorough understanding of the interaction of these materials with macrophages is essential because macrophages are one of the most important barriers against exogenous particles. Although the cytotoxicity and cellula...

journal_title：Particle and fibre toxicology

authors： Xu L,Dai Y,Wang Z,Zhao J,Li F,White JC,Xing B

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Nano- or microscale copper oxide particles (CuO NP, CuO MP) are increasingly applied as catalysts or antimicrobial additives. This increases the risk of adverse health effects, since copper ions are cytotoxic under overload conditions. METHODS:The extra- and intracellular bioavailability of CuO NP and CuO M...

journal_title：Particle and fibre toxicology

authors： Semisch A,Ohle J,Witt B,Hartwig A

更新日期：2014-02-13 00:00:00

abstract：:Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several plausible biological mechanisms have been proposed for these associations, however, at present, the pathways ...

journal_title：Particle and fibre toxicology

authors： Robertson S,Miller MR

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are among the more widely used nanoparticles and come in two major commercial forms, single-walled carbon...

journal_title：Particle and fibre toxicology

authors： Sargent LM,Porter DW,Staska LM,Hubbs AF,Lowry DT,Battelli L,Siegrist KJ,Kashon ML,Mercer RR,Bauer AK,Chen BT,Salisbury JL,Frazer D,McKinney W,Andrew M,Tsuruoka S,Endo M,Fluharty KL,Castranova V,Reynolds SH

更新日期：2014-01-09 00:00:00

abstract：:Particle biokinetics is important in hazard identification and characterization of inhaled particles. Such studies intend to convert external to internal exposure or biologically effective dose, and may help to set limits in that way. Here we focus on the biokinetics of inhaled nanometer sized particles in comparison ...

journal_title：Particle and fibre toxicology

authors： Geiser M,Kreyling WG

更新日期：2010-01-20 00:00:00

abstract：BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...

journal_title：Particle and fibre toxicology

authors： de Oliveira AAF,de Oliveira TF,Dias MF,Medeiros MHG,Di Mascio P,Veras M,Lemos M,Marcourakis T,Saldiva PHN,Loureiro APM

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway. METHODS:We used ba...

journal_title：Particle and fibre toxicology

authors： Tsai DH,Amyai N,Marques-Vidal P,Wang JL,Riediker M,Mooser V,Paccaud F,Waeber G,Vollenweider P,Bochud M

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Epidemiological studies suggest that prenatal and early life environmental exposures have adverse effects on pulmonary function and are important contributors in the development of childhood asthma and allergic disease. The mechanism by which environmental tobacco smoke (ETS) exposure in utero promotes the d...

journal_title：Particle and fibre toxicology

authors： Ferrini M,Carvalho S,Cho YH,Postma B,Miranda Marques L,Pinkerton K,Roberts K,Jaffar Z

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer desig...

journal_title：Particle and fibre toxicology

authors： Siegrist KJ,Reynolds SH,Porter DW,Mercer RR,Bauer AK,Lowry D,Cena L,Stueckle TA,Kashon ML,Wiley J,Salisbury JL,Mastovich J,Bunker K,Sparrow M,Lupoi JS,Stefaniak AB,Keane MJ,Tsuruoka S,Terrones M,McCawley M,Sargent

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are classified as high aspect ratio nanomaterials. Our aim was to assess in vivo toxicity of inhaled AO ...

journal_title：Particle and fibre toxicology

authors： Adamcakova-Dodd A,Stebounova LV,O'Shaughnessy PT,Kim JS,Grassian VH,Thorne PS

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1.5 - 25 μm; diameter 100 - 160 nm), spherical silver nanoparticles (30 nm) and silver micropa...

journal_title：Particle and fibre toxicology

authors： Stoehr LC,Gonzalez E,Stampfl A,Casals E,Duschl A,Puntes V,Oostingh GJ

更新日期：2011-12-30 00:00:00

abstract：BACKGROUND:Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urb...

journal_title：Particle and fibre toxicology

authors： Hullmann M,Albrecht C,van Berlo D,Gerlofs-Nijland ME,Wahle T,Boots AW,Krutmann J,Cassee FR,Bayer TA,Schins RPF

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...

journal_title：Particle and fibre toxicology

authors： Banda NK,Mehta G,Chao Y,Wang G,Inturi S,Fossati-Jimack L,Botto M,Wu L,Moghimi SM,Simberg D

更新日期：2014-11-26 00:00:00

abstract：OBJECTIVE:The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to support the development of regulations to reduce the risk of particle exposure. We tried to provide fund...

journal_title：Particle and fibre toxicology

authors： Lu S,Zhang W,Zhang R,Liu P,Wang Q,Shang Y,Wu M,Donaldson K,Wang Q

更新日期：2015-03-19 00:00:00