Abstract：
BACKGROUND:Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway. METHODS:We used baseline data from the CoLaus Study including 6183 adult participants residing in Lausanne, Switzerland. We analyzed the association of short-term exposure to PM(10) (on the day of examination visit) with continuous circulating serum levels of high-sensitive C-reactive protein (hs-CRP), interleukin 1-beta (IL-1β), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-α) by robust linear regressions, controlling for potential confounding factors and assessing effect modification. RESULTS:In adjusted analyses, for every 10 μg/m(3) elevation in PM(10), IL-1ß increased by 0.034 (95 % confidence interval, 0.007-0.060) pg/mL, IL-6 by 0.036 (0.015-0.057) pg/mL, and TNF-α by 0.024 (0.013-0.035) pg/mL, whereas no significant association was found with hs-CRP levels. CONCLUSIONS:Short-term exposure to PM(10) was positively associated with higher levels of circulating IL-1ß, IL-6 and TNF-α in the adult general population. This positive association suggests a link between air pollution and cardiovascular risk, although further studies are needed to clarify the mechanistic pathway linking PM(10) to cardiovascular risk.
journal_name
Part Fibre Toxicoljournal_title
Particle and fibre toxicologyauthors
Tsai DH,Amyai N,Marques-Vidal P,Wang JL,Riediker M,Mooser V,Paccaud F,Waeber G,Vollenweider P,Bochud Mdoi
10.1186/1743-8977-9-24subject
Has Abstractpub_date
2012-07-06 00:00:00pages
24issn
1743-8977pii
1743-8977-9-24journal_volume
9pub_type
杂志文章abstract：BACKGROUND:In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1.5 - 25 μm; diameter 100 - 160 nm), spherical silver nanoparticles (30 nm) and silver micropa...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-8-36
更新日期：2011-12-30 00:00:00
abstract：BACKGROUND:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular mor...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-019-0335-z
更新日期：2020-01-29 00:00:00
abstract：UNLABELLED:A novel methodology to detect unlabeled inorganic nanoparticles was experimentally demonstrated using a mixture of nano-sized (70 nm) and submicron (250 nm) silicon dioxide particles added to mammalian tissue. The size and concentration of environmentally relevant inorganic particles in a tissue sample can b...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-5-18
更新日期：2008-12-03 00:00:00
abstract：:This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-2-10
更新日期：2005-10-21 00:00:00
abstract：:Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several plausible biological mechanisms have been proposed for these associations, however, at present, the pathways ...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章,评审
doi：10.1186/s12989-017-0237-x
更新日期：2018-01-03 00:00:00
abstract：BACKGROUND:Exposure to particulate matter is a risk factor for cardiopulmonary disease but the underlying molecular mechanisms remain poorly understood. In the present study we sought to investigate the cardiopulmonary responses on spontaneously hypertensive rats (SHRs) following inhalation of UfCPs (24 h, 172 mug.m-3)...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-5-19
更新日期：2008-12-04 00:00:00
abstract：BACKGROUND:Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood brain barrier (BBB) have been implicated as a potential mechanism of air...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-10-62
更新日期：2013-12-17 00:00:00
abstract：BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-8-19
更新日期：2011-06-09 00:00:00
abstract：BACKGROUND:Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain far from clear. RESULTS:Here, we evaluated the effects of amorphous nano...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-7-1
更新日期：2010-01-19 00:00:00
abstract：BACKGROUND:Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to pure carbonaceous materials in the nano-size range. C60 fullerenes are nano-sized particles that are...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-6-5
更新日期：2009-02-25 00:00:00
abstract：BACKGROUND:Inhaled nanoparticles have been reported in some instances to translocate from the nostril to the olfactory bulb in exposed rats. In close proximity to the olfactory bulb is the olfactory mucosa, within which resides a niche of multipotent cells. Cells isolated from this area may provide a relevant in vitro ...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-10-54
更新日期：2013-10-21 00:00:00
abstract：BACKGROUND:Epidemiologic and animal studies have shown that particulate air pollution is associated with increased risk of lung and cardiovascular diseases. Although the exact mechanisms by which particles induce cardiovascular diseases are not known, studies suggest involvement of systemic acute phase responses, inclu...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-6-12
更新日期：2009-04-20 00:00:00
abstract：BACKGROUND:Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Benzalkonium chloride (BAC or BKC) is a non-toxic substance used to control pests. Recently, BAC has been increasingly us...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-020-0339-8
更新日期：2020-01-28 00:00:00
abstract：:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on t...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章,评审
doi：10.1186/1743-8977-10-15
更新日期：2013-04-15 00:00:00
abstract：BACKGROUND:There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, ...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-016-0178-9
更新日期：2016-12-12 00:00:00
abstract：:Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章,评审
doi：10.1186/1743-8977-9-21
更新日期：2012-06-19 00:00:00
abstract：BACKGROUND:Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the aim of this study was to systematically investigate the role of surface charge, oxidative stress and possible involvement ...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-7-25
更新日期：2010-09-11 00:00:00
abstract：BACKGROUND:The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonar...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-10-48
更新日期：2013-10-04 00:00:00
abstract：:There are certain concerns regarding the safety for the environment and human health from the use of engineered nanoparticles (ENPs) which leads to unintended exposures, as opposed to the use of ENPs for medical purposes. This review focuses on the unintended human exposure of ENPs. In particular, possible effects in ...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章,评审
doi：10.1186/1743-8977-7-42
更新日期：2010-12-21 00:00:00
abstract：BACKGROUND:Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-020-0337-x
更新日期：2020-01-20 00:00:00
abstract：BACKGROUND:Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-inf...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-016-0181-1
更新日期：2017-01-10 00:00:00
abstract：BACKGROUND:Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of silica is variable, depending on the physico-chemical features of the particles. In the...
journal_title：Particle and fibre toxicology
pub_type： 信件
doi：10.1186/s12989-019-0315-3
更新日期：2019-08-16 00:00:00
abstract：BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1186/1743-8977-7-21
更新日期：2010-08-20 00:00:00
abstract：:Particle biokinetics is important in hazard identification and characterization of inhaled particles. Such studies intend to convert external to internal exposure or biologically effective dose, and may help to set limits in that way. Here we focus on the biokinetics of inhaled nanometer sized particles in comparison ...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章,评审
doi：10.1186/1743-8977-7-2
更新日期：2010-01-20 00:00:00
abstract：BACKGROUND:Tungsten inert gas (TIG) welding represents one of the most widely used metal joining processes in industry. It has been shown to generate a large majority of particles at the nanoscale and to have low mass emission rates when compared to other types of welding. Despite evidence that TIG fume particles may p...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-016-0143-7
更新日期：2016-06-10 00:00:00
abstract：BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-018-0276-y
更新日期：2018-10-19 00:00:00
abstract：BACKGROUND:Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a hi...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/1743-8977-10-17
更新日期：2013-04-29 00:00:00
abstract：BACKGROUND:Even though a continuously high number of in vitro studies on nanoparticles are being published, the issue of correct dose matter is often not sufficiently taken into account. Due to their size, the diffusion of nanoparticles is slower, as compared to soluble chemicals, and they sediment slowly. Therefore, t...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-018-0278-9
更新日期：2018-10-30 00:00:00
abstract：BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-019-0334-0
更新日期：2020-01-10 00:00:00
abstract：BACKGROUND:The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A pu...
journal_title：Particle and fibre toxicology
pub_type： 杂志文章
doi：10.1186/s12989-017-0218-0
更新日期：2017-09-13 00:00:00
