Shape matters: effects of silver nanospheres and wires on human alveolar epithelial cells.

abstract：BACKGROUND:Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized...

journal_title：Particle and fibre toxicology

authors： Balakrishna S,Lomnicki S,McAvey KM,Cole RB,Dellinger B,Cormier SA

更新日期：2009-04-17 00:00:00

abstract：BACKGROUND:The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ligand-induced activation keeps the AM quiescent, and thereby contributes to combat invaders and resolve infl...

journal_title：Particle and fibre toxicology

authors： Götz AA,Vidal-Puig A,Rödel HG,de Angelis MH,Stoeger T

更新日期：2011-09-20 00:00:00

abstract：BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...

journal_title：Particle and fibre toxicology

authors： de Oliveira AAF,de Oliveira TF,Dias MF,Medeiros MHG,Di Mascio P,Veras M,Lemos M,Marcourakis T,Saldiva PHN,Loureiro APM

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to pure carbonaceous materials in the nano-size range. C60 fullerenes are nano-sized particles that are...

journal_title：Particle and fibre toxicology

authors： Vesterdal LK,Folkmann JK,Jacobsen NR,Sheykhzade M,Wallin H,Loft S,Møller P

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood brain barrier (BBB) have been implicated as a potential mechanism of air...

journal_title：Particle and fibre toxicology

authors： Oppenheim HA,Lucero J,Guyot AC,Herbert LM,McDonald JD,Mabondzo A,Lund AK

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-inf...

journal_title：Particle and fibre toxicology

authors： Sattler C,Moritz F,Chen S,Steer B,Kutschke D,Irmler M,Beckers J,Eickelberg O,Schmitt-Kopplin P,Adler H,Stoeger T

更新日期：2017-01-10 00:00:00

abstract：UNLABELLED:A novel methodology to detect unlabeled inorganic nanoparticles was experimentally demonstrated using a mixture of nano-sized (70 nm) and submicron (250 nm) silicon dioxide particles added to mammalian tissue. The size and concentration of environmentally relevant inorganic particles in a tissue sample can b...

journal_title：Particle and fibre toxicology

authors： Deering CE,Tadjiki S,Assemi S,Miller JD,Yost GS,Veranth JM

更新日期：2008-12-03 00:00:00

abstract：BACKGROUND:Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. RESULTS:We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release...

journal_title：Particle and fibre toxicology

authors： Hillegass JM,Miller JM,MacPherson MB,Westbom CM,Sayan M,Thompson JK,Macura SL,Perkins TN,Beuschel SL,Alexeeva V,Pass HI,Steele C,Mossman BT,Shukla A

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...

journal_title：Particle and fibre toxicology

authors： Vignal C,Pichavant M,Alleman LY,Djouina M,Dingreville F,Perdrix E,Waxin C,Ouali Alami A,Gower-Rousseau C,Desreumaux P,Body-Malapel M

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:Photocopiers emit nanoparticles with complex chemical composition. Short-term exposures to modest nanoparticle concentrations triggered upper airway inflammation and oxidative stress in healthy human volunteers in a recent study. To further understand the toxicological properties of copier-emitted nanopartic...

journal_title：Particle and fibre toxicology

authors： Khatri M,Bello D,Pal AK,Cohen JM,Woskie S,Gassert T,Lan J,Gu AZ,Demokritou P,Gaines P

更新日期：2013-08-22 00:00:00

abstract：BACKGROUND:Epidemiological evidence indicates that diabetic patients have increased susceptibility to adverse cardiovascular outcomes related to acute increases in exposures to particulate air pollution. However, mechanisms underlying these effects remain unclear. METHODS:To evaluate the possible mechanisms underlying...

journal_title：Particle and fibre toxicology

authors： Nemmar A,Subramaniyan D,Yasin J,Ali BH

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...

journal_title：Particle and fibre toxicology

authors： Banda NK,Mehta G,Chao Y,Wang G,Inturi S,Fossati-Jimack L,Botto M,Wu L,Moghimi SM,Simberg D

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by changes in exposure. We studied the clearance kinetics of black carbon (BC) in AM, obtained by sput...

journal_title：Particle and fibre toxicology

authors： Bai Y,Bové H,Nawrot TS,Nemery B

更新日期：2018-03-14 00:00:00

abstract：BACKGROUND:Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are among the more widely used nanoparticles and come in two major commercial forms, single-walled carbon...

journal_title：Particle and fibre toxicology

authors： Sargent LM,Porter DW,Staska LM,Hubbs AF,Lowry DT,Battelli L,Siegrist KJ,Kashon ML,Mercer RR,Bauer AK,Chen BT,Salisbury JL,Frazer D,McKinney W,Andrew M,Tsuruoka S,Endo M,Fluharty KL,Castranova V,Reynolds SH

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to deciph...

journal_title：Particle and fibre toxicology

authors： Landry M,Pinault M,Tchankouo S,Charon É,Ridoux A,Boczkowski J,Mayne-L'Hermite M,Lanone S

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. METHODS:Scnn1b-Tg and Wt mice inh...

journal_title：Particle and fibre toxicology

authors： Geiser M,Quaile O,Wenk A,Wigge C,Eigeldinger-Berthou S,Hirn S,Schäffler M,Schleh C,Möller W,Mall MA,Kreyling WG

更新日期：2013-05-16 00:00:00

abstract：:There are certain concerns regarding the safety for the environment and human health from the use of engineered nanoparticles (ENPs) which leads to unintended exposures, as opposed to the use of ENPs for medical purposes. This review focuses on the unintended human exposure of ENPs. In particular, possible effects in ...

journal_title：Particle and fibre toxicology

authors： Simkó M,Mattsson MO

更新日期：2010-12-21 00:00:00

abstract：:Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, not clearly elucidated. The purpose of the present review was to analyze the key events involved in the lung f...

journal_title：Particle and fibre toxicology

authors： Vietti G,Lison D,van den Brule S

更新日期：2016-02-29 00:00:00

abstract：OBJECTIVE:Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in p...

journal_title：Particle and fibre toxicology

authors： You J,Zhou J,Zhou M,Liu Y,Robertson JD,Liang D,Van Pelt C,Li C

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonar...

journal_title：Particle and fibre toxicology

authors： Noël A,Charbonneau M,Cloutier Y,Tardif R,Truchon G

更新日期：2013-10-04 00:00:00

abstract：BACKGROUND:Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a hi...

journal_title：Particle and fibre toxicology

authors： Hou L,Zhang X,Dioni L,Barretta F,Dou C,Zheng Y,Hoxha M,Bertazzi PA,Schwartz J,Wu S,Wang S,Baccarelli AA

更新日期：2013-04-29 00:00:00

abstract：BACKGROUND:Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. To address...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Battelli LA,McKinney W,Friend S,Wolfarth MG,Andrew M,Castranova V,Porter DW

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we inves...

journal_title：Particle and fibre toxicology

authors： Peeters PM,Perkins TN,Wouters EF,Mossman BT,Reynaert NL

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening methods is the need for accurate measures of cellular dose. We present here a methodology that enables accurate determination of delivered to cell dos...

journal_title：Particle and fibre toxicology

authors： Cohen JM,Teeguarden JG,Demokritou P

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Carbon nanotubes (CNTs) are being increasingly industrialized and applied for various products. As of today, although several toxicological evaluations of CNTs have been conducted, designing safer CNTs is not practiced because reaction kinetics of CNTs with bioactive species is not fully understood. RESULTS...

journal_title：Particle and fibre toxicology

authors： Tsuruoka S,Cassee FR,Castranova V

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, ...

journal_title：Particle and fibre toxicology

authors： Tomašek I,Horwell CJ,Damby DE,Barošová H,Geers C,Petri-Fink A,Rothen-Rutishauser B,Clift MJ

更新日期：2016-12-12 00:00:00

abstract：:This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the...

journal_title：Particle and fibre toxicology

authors： Donaldson K,Tran L,Jimenez LA,Duffin R,Newby DE,Mills N,MacNee W,Stone V

更新日期：2005-10-21 00:00:00

abstract：BACKGROUND:Inhaled nanoparticles have been reported in some instances to translocate from the nostril to the olfactory bulb in exposed rats. In close proximity to the olfactory bulb is the olfactory mucosa, within which resides a niche of multipotent cells. Cells isolated from this area may provide a relevant in vitro ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Osmond RI,Oytam Y,McCall MJ,Feltis B,Mackay-Sim A,Wood SA,Cook AL

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular mor...

journal_title：Particle and fibre toxicology

authors： Carll AP,Salatini R,Pirela SV,Wang Y,Xie Z,Lorkiewicz P,Naeem N,Qian Y,Castranova V,Godleski JJ,Demokritou P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO2 coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS:Uncoated and SiO2-coated ZnO NPs were ...

journal_title：Particle and fibre toxicology

authors： Konduru NV,Murdaugh KM,Sotiriou GA,Donaghey TC,Demokritou P,Brain JD,Molina RM

更新日期：2014-09-03 00:00:00