An integrated approach for the in vitro dosimetry of engineered nanomaterials.

abstract：BACKGROUND:Given the tremendous potential for graphene quantum dots (QDs) in biomedical applications, a thorough understanding of the interaction of these materials with macrophages is essential because macrophages are one of the most important barriers against exogenous particles. Although the cytotoxicity and cellula...

journal_title：Particle and fibre toxicology

authors： Xu L,Dai Y,Wang Z,Zhao J,Li F,White JC,Xing B

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are classified as high aspect ratio nanomaterials. Our aim was to assess in vivo toxicity of inhaled AO ...

journal_title：Particle and fibre toxicology

authors： Adamcakova-Dodd A,Stebounova LV,O'Shaughnessy PT,Kim JS,Grassian VH,Thorne PS

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...

journal_title：Particle and fibre toxicology

authors： Skovmand A,Erdely A,Antonini JM,Nurkiewicz TR,Shoeb M,Eye T,Kodali V,Loeschner K,Vidmar J,Agerholm JS,Goericke-Pesch S,Vogel U,Hougaard KS

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Exposure to particulate matter is a risk factor for cardiopulmonary disease but the underlying molecular mechanisms remain poorly understood. In the present study we sought to investigate the cardiopulmonary responses on spontaneously hypertensive rats (SHRs) following inhalation of UfCPs (24 h, 172 mug.m-3)...

journal_title：Particle and fibre toxicology

authors： Upadhyay S,Stoeger T,Harder V,Thomas RF,Schladweiler MC,Semmler-Behnke M,Takenaka S,Karg E,Reitmeir P,Bader M,Stampfl A,Kodavanti UP,Schulz H

更新日期：2008-12-04 00:00:00

abstract：:Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several plausible biological mechanisms have been proposed for these associations, however, at present, the pathways ...

journal_title：Particle and fibre toxicology

authors： Robertson S,Miller MR

更新日期：2018-01-03 00:00:00

abstract：INTRODUCTION:Exposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial pressure and left ventricular after-load. We determined the effect of diesel exhaust exposure on a...

journal_title：Particle and fibre toxicology

authors： Lundbäck M,Mills NL,Lucking A,Barath S,Donaldson K,Newby DE,Sandström T,Blomberg A

更新日期：2009-03-13 00:00:00

abstract：BACKGROUND:In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we inves...

journal_title：Particle and fibre toxicology

authors： Peeters PM,Perkins TN,Wouters EF,Mossman BT,Reynaert NL

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...

journal_title：Particle and fibre toxicology

authors： de Oliveira AAF,de Oliveira TF,Dias MF,Medeiros MHG,Di Mascio P,Veras M,Lemos M,Marcourakis T,Saldiva PHN,Loureiro APM

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...

journal_title：Particle and fibre toxicology

authors： Banda NK,Mehta G,Chao Y,Wang G,Inturi S,Fossati-Jimack L,Botto M,Wu L,Moghimi SM,Simberg D

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO2 coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS:Uncoated and SiO2-coated ZnO NPs were ...

journal_title：Particle and fibre toxicology

authors： Konduru NV,Murdaugh KM,Sotiriou GA,Donaghey TC,Demokritou P,Brain JD,Molina RM

更新日期：2014-09-03 00:00:00

abstract：BACKGROUND:The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonar...

journal_title：Particle and fibre toxicology

authors： Noël A,Charbonneau M,Cloutier Y,Tardif R,Truchon G

更新日期：2013-10-04 00:00:00

abstract：BACKGROUND:It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other fibres on a continuum based on length, aspect ratio and biopersistence. Some types of carbon nanotubes satisfy the first two aspects of the fibre paradigm but only ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Poland CA,Murphy F,Waddington L,Morris H,Hawkins SC,Clark S,Aitken R,McCall MJ,Donaldson K

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer sim...

journal_title：Particle and fibre toxicology

authors： Fraser K,Kodali V,Yanamala N,Birch ME,Cena L,Casuccio G,Bunker K,Lersch TL,Evans DE,Stefaniak A,Hammer MA,Kashon ML,Boots T,Eye T,Hubczak J,Friend SA,Dahm M,Schubauer-Berigan MK,Siegrist K,Lowry D,Bauer AK,Sarge

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood brain barrier (BBB) have been implicated as a potential mechanism of air...

journal_title：Particle and fibre toxicology

authors： Oppenheim HA,Lucero J,Guyot AC,Herbert LM,McDonald JD,Mabondzo A,Lund AK

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. RESULTS:We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release...

journal_title：Particle and fibre toxicology

authors： Hillegass JM,Miller JM,MacPherson MB,Westbom CM,Sayan M,Thompson JK,Macura SL,Perkins TN,Beuschel SL,Alexeeva V,Pass HI,Steele C,Mossman BT,Shukla A

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...

journal_title：Particle and fibre toxicology

authors： Mutlu EA,Engen PA,Soberanes S,Urich D,Forsyth CB,Nigdelioglu R,Chiarella SE,Radigan KA,Gonzalez A,Jakate S,Keshavarzian A,Budinger GR,Mutlu GM

更新日期：2011-06-09 00:00:00

abstract：BACKGROUND:Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway. METHODS:We used ba...

journal_title：Particle and fibre toxicology

authors： Tsai DH,Amyai N,Marques-Vidal P,Wang JL,Riediker M,Mooser V,Paccaud F,Waeber G,Vollenweider P,Bochud M

更新日期：2012-07-06 00:00:00

abstract：:There are certain concerns regarding the safety for the environment and human health from the use of engineered nanoparticles (ENPs) which leads to unintended exposures, as opposed to the use of ENPs for medical purposes. This review focuses on the unintended human exposure of ENPs. In particular, possible effects in ...

journal_title：Particle and fibre toxicology

authors： Simkó M,Mattsson MO

更新日期：2010-12-21 00:00:00

abstract：BACKGROUND:Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain far from clear. RESULTS:Here, we evaluated the effects of amorphous nano...

journal_title：Particle and fibre toxicology

authors： Yang X,Liu J,He H,Zhou L,Gong C,Wang X,Yang L,Yuan J,Huang H,He L,Zhang B,Zhuang Z

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are among the more widely used nanoparticles and come in two major commercial forms, single-walled carbon...

journal_title：Particle and fibre toxicology

authors： Sargent LM,Porter DW,Staska LM,Hubbs AF,Lowry DT,Battelli L,Siegrist KJ,Kashon ML,Mercer RR,Bauer AK,Chen BT,Salisbury JL,Frazer D,McKinney W,Andrew M,Tsuruoka S,Endo M,Fluharty KL,Castranova V,Reynolds SH

更新日期：2014-01-09 00:00:00

abstract：OBJECTIVE:The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to support the development of regulations to reduce the risk of particle exposure. We tried to provide fund...

journal_title：Particle and fibre toxicology

authors： Lu S,Zhang W,Zhang R,Liu P,Wang Q,Shang Y,Wu M,Donaldson K,Wang Q

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the aim of this study was to systematically investigate the role of surface charge, oxidative stress and possible involvement ...

journal_title：Particle and fibre toxicology

authors： Bhattacharjee S,de Haan LH,Evers NM,Jiang X,Marcelis AT,Zuilhof H,Rietjens IM,Alink GM

更新日期：2010-09-11 00:00:00

abstract：BACKGROUND:Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related to abnormal calcium handling and energetic failure in cardiomyocytes. Moreover, t...

journal_title：Particle and fibre toxicology

authors： Lozano O,Silva-Platas C,Chapoy-Villanueva H,Pérez BE,Lees JG,Ramachandra CJA,Contreras-Torres FF,Lázaro-Alfaro A,Luna-Figueroa E,Bernal-Ramírez J,Gordillo-Galeano A,Benitez A,Oropeza-Almazán Y,Castillo EC,Koh PL,Hausenloy D

更新日期：2020-05-07 00:00:00

abstract：:Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...

journal_title：Particle and fibre toxicology

authors： Grahame TJ,Schlesinger RB

更新日期：2012-06-19 00:00:00

abstract：: Air Pollution has been associated with significant adverse health effects leading to increased morbidity and mortality. Cumulative epidemiological and experimental data have shown that exposure to air pollutants lead to increased cardiovascular ischemic events and enhanced atherosclerosis. It appears that these assoc...

journal_title：Particle and fibre toxicology

authors： Araujo JA,Nel AE

更新日期：2009-09-18 00:00:00

abstract：BACKGROUND:The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ligand-induced activation keeps the AM quiescent, and thereby contributes to combat invaders and resolve infl...

journal_title：Particle and fibre toxicology

authors： Götz AA,Vidal-Puig A,Rödel HG,de Angelis MH,Stoeger T

更新日期：2011-09-20 00:00:00

abstract：BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...

journal_title：Particle and fibre toxicology

authors： Sehlstedt M,Dove R,Boman C,Pagels J,Swietlicki E,Löndahl J,Westerholm R,Bosson J,Barath S,Behndig AF,Pourazar J,Sandström T,Mudway IS,Blomberg A

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the risk for cardiovascular disease in carbon black exposed populations. An endothelial biosensor assay...

journal_title：Particle and fibre toxicology

authors： Tang J,Cheng W,Gao J,Li Y,Yao R,Rothman N,Lan Q,Campen MJ,Zheng Y,Leng S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized...

journal_title：Particle and fibre toxicology

authors： Balakrishna S,Lomnicki S,McAvey KM,Cole RB,Dellinger B,Cormier SA

更新日期：2009-04-17 00:00:00

abstract：BACKGROUND:Even though a continuously high number of in vitro studies on nanoparticles are being published, the issue of correct dose matter is often not sufficiently taken into account. Due to their size, the diffusion of nanoparticles is slower, as compared to soluble chemicals, and they sediment slowly. Therefore, t...

journal_title：Particle and fibre toxicology

authors： Böhmert L,König L,Sieg H,Lichtenstein D,Paul N,Braeuning A,Voigt A,Lampen A

更新日期：2018-10-30 00:00:00