Abstract:
:This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the lungs through their potential to cause oxidative stress, inflammation and cancer; they also have the potential to redistribute to other organs following pulmonary deposition. These different CDNP show considerable heterogeneity in composition and solubility, meaning that oxidative stress may originate from different components depending on the particle under consideration. Key CDNP-associated properties of large surface area and the presence of metals and organics all have the potential to produce oxidative stress. CDNP may also exert genotoxic effects, depending on their composition. CDNP and their components also have the potential to translocate to the brain and also the blood, and thereby reach other targets such as the cardiovascular system, spleen and liver. CDNP therefore can be seen as a group of particulate toxins unified by a common mechanism of injury and properties of translocation which have the potential to mediate a range of adverse effects in the lungs and other organs and warrant further research.
journal_name
Part Fibre Toxicoljournal_title
Particle and fibre toxicologyauthors
Donaldson K,Tran L,Jimenez LA,Duffin R,Newby DE,Mills N,MacNee W,Stone Vdoi
10.1186/1743-8977-2-10keywords:
subject
Has Abstractpub_date
2005-10-21 00:00:00pages
10issn
1743-8977pii
1743-8977-2-10journal_volume
2pub_type
杂志文章abstract:BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...
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journal_title:Particle and fibre toxicology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Particle and fibre toxicology
pub_type: 评论,信件
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journal_title:Particle and fibre toxicology
pub_type: 杂志文章
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journal_title:Particle and fibre toxicology
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journal_title:Particle and fibre toxicology
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journal_title:Particle and fibre toxicology
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journal_title:Particle and fibre toxicology
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journal_title:Particle and fibre toxicology
pub_type: 杂志文章
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journal_title:Particle and fibre toxicology
pub_type: 杂志文章
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journal_title:Particle and fibre toxicology
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journal_title:Particle and fibre toxicology
pub_type: 杂志文章,评审
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