Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation".

abstract：BACKGROUND:Inhaled nanoparticles have been reported in some instances to translocate from the nostril to the olfactory bulb in exposed rats. In close proximity to the olfactory bulb is the olfactory mucosa, within which resides a niche of multipotent cells. Cells isolated from this area may provide a relevant in vitro ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Osmond RI,Oytam Y,McCall MJ,Feltis B,Mackay-Sim A,Wood SA,Cook AL

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer sim...

journal_title：Particle and fibre toxicology

authors： Fraser K,Kodali V,Yanamala N,Birch ME,Cena L,Casuccio G,Bunker K,Lersch TL,Evans DE,Stefaniak A,Hammer MA,Kashon ML,Boots T,Eye T,Hubczak J,Friend SA,Dahm M,Schubauer-Berigan MK,Siegrist K,Lowry D,Bauer AK,Sarge

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...

journal_title：Particle and fibre toxicology

authors： Banda NK,Mehta G,Chao Y,Wang G,Inturi S,Fossati-Jimack L,Botto M,Wu L,Moghimi SM,Simberg D

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized...

journal_title：Particle and fibre toxicology

authors： Balakrishna S,Lomnicki S,McAvey KM,Cole RB,Dellinger B,Cormier SA

更新日期：2009-04-17 00:00:00

abstract：BACKGROUND:Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are classified as high aspect ratio nanomaterials. Our aim was to assess in vivo toxicity of inhaled AO ...

journal_title：Particle and fibre toxicology

authors： Adamcakova-Dodd A,Stebounova LV,O'Shaughnessy PT,Kim JS,Grassian VH,Thorne PS

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...

journal_title：Particle and fibre toxicology

authors： Vignal C,Pichavant M,Alleman LY,Djouina M,Dingreville F,Perdrix E,Waxin C,Ouali Alami A,Gower-Rousseau C,Desreumaux P,Body-Malapel M

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular mor...

journal_title：Particle and fibre toxicology

authors： Carll AP,Salatini R,Pirela SV,Wang Y,Xie Z,Lorkiewicz P,Naeem N,Qian Y,Castranova V,Godleski JJ,Demokritou P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles, as representative transition and rare earth oxides, exhibit distinct material properties that may result in different hazardous potential in the lung. The current study was undertaken to compare the pulmonar...

journal_title：Particle and fibre toxicology

authors： Sisler JD,Li R,McKinney W,Mercer RR,Ji Z,Xia T,Wang X,Shaffer J,Orandle M,Mihalchik AL,Battelli L,Chen BT,Wolfarth M,Andrew ME,Schwegler-Berry D,Porter DW,Castranova V,Nel A,Qian Y

更新日期：2016-08-15 00:00:00

abstract：:Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...

journal_title：Particle and fibre toxicology

authors： Grahame TJ,Schlesinger RB

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other fibres on a continuum based on length, aspect ratio and biopersistence. Some types of carbon nanotubes satisfy the first two aspects of the fibre paradigm but only ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Poland CA,Murphy F,Waddington L,Morris H,Hawkins SC,Clark S,Aitken R,McCall MJ,Donaldson K

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Even though a continuously high number of in vitro studies on nanoparticles are being published, the issue of correct dose matter is often not sufficiently taken into account. Due to their size, the diffusion of nanoparticles is slower, as compared to soluble chemicals, and they sediment slowly. Therefore, t...

journal_title：Particle and fibre toxicology

authors： Böhmert L,König L,Sieg H,Lichtenstein D,Paul N,Braeuning A,Voigt A,Lampen A

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:Epidemiologic and animal studies have shown that particulate air pollution is associated with increased risk of lung and cardiovascular diseases. Although the exact mechanisms by which particles induce cardiovascular diseases are not known, studies suggest involvement of systemic acute phase responses, inclu...

journal_title：Particle and fibre toxicology

authors： Saber AT,Halappanavar S,Folkmann JK,Bornholdt J,Boisen AM,Møller P,Williams A,Yauk C,Vogel U,Loft S,Wallin H

更新日期：2009-04-20 00:00:00

abstract：BACKGROUND:Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Benzalkonium chloride (BAC or BKC) is a non-toxic substance used to control pests. Recently, BAC has been increasingly us...

journal_title：Particle and fibre toxicology

authors： Choi HY,Lee YH,Lim CH,Kim YS,Lee IS,Jo JM,Lee HY,Cha HG,Woo HJ,Seo DS

更新日期：2020-01-28 00:00:00

abstract：:The uncertainty regarding the effects and risks of nanomaterials on human health and the environment, and how they should be tested and assessed in the context of current regulations, is clearly holding back the full exploitation of the innovative potential of nanomaterials. To reduce this uncertainty, the European Un...

journal_title：Particle and fibre toxicology

authors： Teunenbroek TV,Baker J,Dijkzeul A

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. RESULTS:We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release...

journal_title：Particle and fibre toxicology

authors： Hillegass JM,Miller JM,MacPherson MB,Westbom CM,Sayan M,Thompson JK,Macura SL,Perkins TN,Beuschel SL,Alexeeva V,Pass HI,Steele C,Mossman BT,Shukla A

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies. METHODS:To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, ...

journal_title：Particle and fibre toxicology

authors： Wyatt LH,Devlin RB,Rappold AG,Case MW,Diaz-Sanchez D

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to pure carbonaceous materials in the nano-size range. C60 fullerenes are nano-sized particles that are...

journal_title：Particle and fibre toxicology

authors： Vesterdal LK,Folkmann JK,Jacobsen NR,Sheykhzade M,Wallin H,Loft S,Møller P

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:Epidemiological evidence indicates that diabetic patients have increased susceptibility to adverse cardiovascular outcomes related to acute increases in exposures to particulate air pollution. However, mechanisms underlying these effects remain unclear. METHODS:To evaluate the possible mechanisms underlying...

journal_title：Particle and fibre toxicology

authors： Nemmar A,Subramaniyan D,Yasin J,Ali BH

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a hi...

journal_title：Particle and fibre toxicology

authors： Hou L,Zhang X,Dioni L,Barretta F,Dou C,Zheng Y,Hoxha M,Bertazzi PA,Schwartz J,Wu S,Wang S,Baccarelli AA

更新日期：2013-04-29 00:00:00

abstract：BACKGROUND:In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we inves...

journal_title：Particle and fibre toxicology

authors： Peeters PM,Perkins TN,Wouters EF,Mossman BT,Reynaert NL

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...

journal_title：Particle and fibre toxicology

authors： Sehlstedt M,Dove R,Boman C,Pagels J,Swietlicki E,Löndahl J,Westerholm R,Bosson J,Barath S,Behndig AF,Pourazar J,Sandström T,Mudway IS,Blomberg A

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...

journal_title：Particle and fibre toxicology

authors： Gerlofs-Nijland ME,van Berlo D,Cassee FR,Schins RP,Wang K,Campbell A

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...

journal_title：Particle and fibre toxicology

authors： Skovmand A,Erdely A,Antonini JM,Nurkiewicz TR,Shoeb M,Eye T,Kodali V,Loeschner K,Vidmar J,Agerholm JS,Goericke-Pesch S,Vogel U,Hougaard KS

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...

journal_title：Particle and fibre toxicology

authors： Mutlu EA,Engen PA,Soberanes S,Urich D,Forsyth CB,Nigdelioglu R,Chiarella SE,Radigan KA,Gonzalez A,Jakate S,Keshavarzian A,Budinger GR,Mutlu GM

更新日期：2011-06-09 00:00:00

abstract：BACKGROUND:Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. To address...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Battelli LA,McKinney W,Friend S,Wolfarth MG,Andrew M,Castranova V,Porter DW

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxyla...

journal_title：Particle and fibre toxicology

authors： Palmer BC,Phelan-Dickenson SJ,DeLouise LA

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Tungsten inert gas (TIG) welding represents one of the most widely used metal joining processes in industry. It has been shown to generate a large majority of particles at the nanoscale and to have low mass emission rates when compared to other types of welding. Despite evidence that TIG fume particles may p...

journal_title：Particle and fibre toxicology

authors： Graczyk H,Lewinski N,Zhao J,Sauvain JJ,Suarez G,Wild P,Danuser B,Riediker M

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are among the more widely used nanoparticles and come in two major commercial forms, single-walled carbon...

journal_title：Particle and fibre toxicology

authors： Sargent LM,Porter DW,Staska LM,Hubbs AF,Lowry DT,Battelli L,Siegrist KJ,Kashon ML,Mercer RR,Bauer AK,Chen BT,Salisbury JL,Frazer D,McKinney W,Andrew M,Tsuruoka S,Endo M,Fluharty KL,Castranova V,Reynolds SH

更新日期：2014-01-09 00:00:00

abstract：:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on t...

journal_title：Particle and fibre toxicology

authors： Shi H,Magaye R,Castranova V,Zhao J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Inhalation exposure studies of mice were conducted to determine if multi-walled carbon nanotubes (MWCNT) distribute to the tracheobronchial lymphatics, parietal pleura, respiratory musculature and/or extrapulmonary organs. Male C57BL/6 J mice were exposed in a whole-body inhalation system to a 5 mg/m3 MWCNT ...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Wang L,Battelli LA,McKinney W,Castranova V,Porter DW

更新日期：2013-08-09 00:00:00