Abstract:
:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on the respiratory system, showing the importance of inhalation as the primary route for TiO2 NP exposure in the workplace. TiO2 NPs may translocate to systemic organs from the lung and gastrointestinal tract (GIT) although the rate of translocation appears low. There have also been studies focusing on other potential routes of human exposure. Oral exposure mainly occurs through food products containing TiO2 NP-additives. Most dermal exposure studies, whether in vivo or in vitro, report that TiO2 NPs do not penetrate the stratum corneum (SC). In the field of nanomedicine, intravenous injection can deliver TiO2 nanoparticulate carriers directly into the human body. Upon intravenous exposure, TiO2 NPs can induce pathological lesions of the liver, spleen, kidneys, and brain. We have also shown here that most of these effects may be due to the use of very high doses of TiO2 NPs. There is also an enormous lack of epidemiological data regarding TiO2 NPs in spite of its increased production and use. However, long-term inhalation studies in rats have reported lung tumors. This review summarizes the current knowledge on the toxicology of TiO2 NPs and points out areas where further information is needed.
journal_name
Part Fibre Toxicoljournal_title
Particle and fibre toxicologyauthors
Shi H,Magaye R,Castranova V,Zhao Jdoi
10.1186/1743-8977-10-15subject
Has Abstractpub_date
2013-04-15 00:00:00pages
15issn
1743-8977pii
1743-8977-10-15journal_volume
10pub_type
杂志文章,评审abstract:BACKGROUND:Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of silica is variable, depending on the physico-chemical features of the particles. In the...
journal_title:Particle and fibre toxicology
pub_type: 信件
doi:10.1186/s12989-019-0315-3
更新日期:2019-08-16 00:00:00
abstract::In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to...
journal_title:Particle and fibre toxicology
pub_type: 评论,信件
doi:10.1186/s12989-020-00365-z
更新日期:2020-07-16 00:00:00
abstract:BACKGROUND:Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are among the more widely used nanoparticles and come in two major commercial forms, single-walled carbon...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-11-3
更新日期:2014-01-09 00:00:00
abstract:BACKGROUND:Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by changes in exposure. We studied the clearance kinetics of black carbon (BC) in AM, obtained by sput...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-018-0250-8
更新日期:2018-03-14 00:00:00
abstract:BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1743-8977-7-21
更新日期:2010-08-20 00:00:00
abstract:BACKGROUND:Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer sim...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-020-00392-w
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain far from clear. RESULTS:Here, we evaluated the effects of amorphous nano...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-7-1
更新日期:2010-01-19 00:00:00
abstract:BACKGROUND:Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the reliability of the commonly used limulus amebocyte lysate (LAL) a...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-9-41
更新日期:2012-11-09 00:00:00
abstract::The uncertainty regarding the effects and risks of nanomaterials on human health and the environment, and how they should be tested and assessed in the context of current regulations, is clearly holding back the full exploitation of the innovative potential of nanomaterials. To reduce this uncertainty, the European Un...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-017-0235-z
更新日期:2017-12-19 00:00:00
abstract:BACKGROUND:Inhalation exposure studies of mice were conducted to determine if multi-walled carbon nanotubes (MWCNT) distribute to the tracheobronchial lymphatics, parietal pleura, respiratory musculature and/or extrapulmonary organs. Male C57BL/6 J mice were exposed in a whole-body inhalation system to a 5 mg/m3 MWCNT ...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-38
更新日期:2013-08-09 00:00:00
abstract:BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-019-0334-0
更新日期:2020-01-10 00:00:00
abstract:BACKGROUND:Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood brain barrier (BBB) have been implicated as a potential mechanism of air...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-62
更新日期:2013-12-17 00:00:00
abstract:OBJECTIVE:The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to support the development of regulations to reduce the risk of particle exposure. We tried to provide fund...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-015-0082-8
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxyla...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-018-0285-x
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the risk for cardiovascular disease in carbon black exposed populations. An endothelial biosensor assay...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-020-00378-8
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-018-0276-y
更新日期:2018-10-19 00:00:00
abstract::Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,评审
doi:10.1186/1743-8977-9-21
更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:Inhaled nanoparticles have been reported in some instances to translocate from the nostril to the olfactory bulb in exposed rats. In close proximity to the olfactory bulb is the olfactory mucosa, within which resides a niche of multipotent cells. Cells isolated from this area may provide a relevant in vitro ...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-54
更新日期:2013-10-21 00:00:00
abstract:BACKGROUND:In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we inves...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-3
更新日期:2013-02-12 00:00:00
abstract:BACKGROUND:The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ligand-induced activation keeps the AM quiescent, and thereby contributes to combat invaders and resolve infl...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-8-28
更新日期:2011-09-20 00:00:00
abstract:BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-017-0227-z
更新日期:2017-11-22 00:00:00
abstract:BACKGROUND:Silica nanoparticles (nanoSiO2) are promising systems that can deliver biologically active compounds to tissues such as the heart in a controllable manner. However, cardiac toxicity induced by nanoSiO2 has been recently related to abnormal calcium handling and energetic failure in cardiomyocytes. Moreover, t...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-020-00346-2
更新日期:2020-05-07 00:00:00
abstract::There are certain concerns regarding the safety for the environment and human health from the use of engineered nanoparticles (ENPs) which leads to unintended exposures, as opposed to the use of ENPs for medical purposes. This review focuses on the unintended human exposure of ENPs. In particular, possible effects in ...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,评审
doi:10.1186/1743-8977-7-42
更新日期:2010-12-21 00:00:00
abstract:BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-014-0064-2
更新日期:2014-11-26 00:00:00
abstract:BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-8-19
更新日期:2011-06-09 00:00:00
abstract:BACKGROUND:There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening methods is the need for accurate measures of cellular dose. We present here a methodology that enables accurate determination of delivered to cell dos...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-11-20
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-020-0337-x
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1.5 - 25 μm; diameter 100 - 160 nm), spherical silver nanoparticles (30 nm) and silver micropa...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-8-36
更新日期:2011-12-30 00:00:00
abstract:BACKGROUND:The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer desig...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-019-0318-0
更新日期:2019-10-07 00:00:00
abstract:BACKGROUND:Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. METHODS:Scnn1b-Tg and Wt mice inh...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-19
更新日期:2013-05-16 00:00:00