Abstract:
BACKGROUND:Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related impacts and toxicity are still not well known. This study investigated the toxicity of the water-soluble fraction of pyrolyzed wood tar aerosols in exposed mice and lung epithelial cells. RESULTS:Mice exposed to water-soluble wood tar aerosols showed increased inflammatory and oxidative stress responses. Bronchial epithelial cells exposed to the same water-soluble wood tar aerosols showed increased cell death with apoptotic characteristics. Alterations in oxidative status, including changes in reactive oxygen species (ROS) levels and reductions in the expression of antioxidant genes related to the transcription factor Nrf2, were observed and were confirmed by increased levels of MDA, a lipid peroxidation adduct. Damage to mitochondria was observed as an early event responsible for the aforementioned changes. CONCLUSIONS:The toxicity and health effect-related mechanisms of water-soluble wood tar were investigated for the first time in the context of biomass burning. Wood tar particles may account for major responses such as cell death, oxidative stress, supression of protection mechnaisms and mitochondrial damaged cause by expsoure to biomass burning aerosols.
journal_name
Part Fibre Toxicoljournal_title
Particle and fibre toxicologyauthors
Pardo M,Li C,He Q,Levin-Zaidman S,Tsoory M,Yu Q,Wang X,Rudich Ydoi
10.1186/s12989-020-0337-xsubject
Has Abstractpub_date
2020-01-20 00:00:00pages
4issue
1issn
1743-8977pii
10.1186/s12989-020-0337-xjournal_volume
17pub_type
杂志文章abstract:BACKGROUND:Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the reliability of the commonly used limulus amebocyte lysate (LAL) a...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-9-41
更新日期:2012-11-09 00:00:00
abstract::This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-2-10
更新日期:2005-10-21 00:00:00
abstract::Particle biokinetics is important in hazard identification and characterization of inhaled particles. Such studies intend to convert external to internal exposure or biologically effective dose, and may help to set limits in that way. Here we focus on the biokinetics of inhaled nanometer sized particles in comparison ...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,评审
doi:10.1186/1743-8977-7-2
更新日期:2010-01-20 00:00:00
abstract:BACKGROUND:Photocopiers emit nanoparticles with complex chemical composition. Short-term exposures to modest nanoparticle concentrations triggered upper airway inflammation and oxidative stress in healthy human volunteers in a recent study. To further understand the toxicological properties of copier-emitted nanopartic...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-42
更新日期:2013-08-22 00:00:00
abstract:BACKGROUND:Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway. METHODS:We used ba...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-9-24
更新日期:2012-07-06 00:00:00
abstract:BACKGROUND:Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by changes in exposure. We studied the clearance kinetics of black carbon (BC) in AM, obtained by sput...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-018-0250-8
更新日期:2018-03-14 00:00:00
abstract:BACKGROUND:Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Benzalkonium chloride (BAC or BKC) is a non-toxic substance used to control pests. Recently, BAC has been increasingly us...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-020-0339-8
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-014-0064-2
更新日期:2014-11-26 00:00:00
abstract:BACKGROUND:Inhalation exposure studies of mice were conducted to determine if multi-walled carbon nanotubes (MWCNT) distribute to the tracheobronchial lymphatics, parietal pleura, respiratory musculature and/or extrapulmonary organs. Male C57BL/6 J mice were exposed in a whole-body inhalation system to a 5 mg/m3 MWCNT ...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-38
更新日期:2013-08-09 00:00:00
abstract:BACKGROUND:Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a hi...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-17
更新日期:2013-04-29 00:00:00
abstract:BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-8-19
更新日期:2011-06-09 00:00:00
abstract:BACKGROUND:The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A pu...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-017-0218-0
更新日期:2017-09-13 00:00:00
abstract::In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to...
journal_title:Particle and fibre toxicology
pub_type: 评论,信件
doi:10.1186/s12989-020-00365-z
更新日期:2020-07-16 00:00:00
abstract:BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-017-0227-z
更新日期:2017-11-22 00:00:00
abstract:BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1743-8977-7-21
更新日期:2010-08-20 00:00:00
abstract:BACKGROUND:Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urb...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-017-0213-5
更新日期:2017-08-30 00:00:00
abstract:BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-7-12
更新日期:2010-05-17 00:00:00
abstract::Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, not clearly elucidated. The purpose of the present review was to analyze the key events involved in the lung f...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,评审
doi:10.1186/s12989-016-0123-y
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:Carbon nanotubes (CNTs) are being increasingly industrialized and applied for various products. As of today, although several toxicological evaluations of CNTs have been conducted, designing safer CNTs is not practiced because reaction kinetics of CNTs with bioactive species is not fully understood. RESULTS...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-44
更新日期:2013-09-02 00:00:00
abstract:BACKGROUND:Engineered carbon nanotubes are currently used in many consumer and industrial products such as paints, sunscreens, cosmetics, toiletries, electronic processes and industrial lubricants. Carbon nanotubes are among the more widely used nanoparticles and come in two major commercial forms, single-walled carbon...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-11-3
更新日期:2014-01-09 00:00:00
abstract:BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-019-0334-0
更新日期:2020-01-10 00:00:00
abstract:BACKGROUND:The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonar...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-48
更新日期:2013-10-04 00:00:00
abstract:BACKGROUND:The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxyla...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-018-0285-x
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1.5 - 25 μm; diameter 100 - 160 nm), spherical silver nanoparticles (30 nm) and silver micropa...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-8-36
更新日期:2011-12-30 00:00:00
abstract:BACKGROUND:Epidemiological evidence indicates that diabetic patients have increased susceptibility to adverse cardiovascular outcomes related to acute increases in exposures to particulate air pollution. However, mechanisms underlying these effects remain unclear. METHODS:To evaluate the possible mechanisms underlying...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-10-14
更新日期:2013-04-15 00:00:00
abstract:BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-018-0276-y
更新日期:2018-10-19 00:00:00
abstract::Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,评审
doi:10.1186/1743-8977-9-21
更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to deciph...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/s12989-016-0175-z
更新日期:2016-11-24 00:00:00
abstract::Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several plausible biological mechanisms have been proposed for these associations, however, at present, the pathways ...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章,评审
doi:10.1186/s12989-017-0237-x
更新日期:2018-01-03 00:00:00
abstract:BACKGROUND:Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to pure carbonaceous materials in the nano-size range. C60 fullerenes are nano-sized particles that are...
journal_title:Particle and fibre toxicology
pub_type: 杂志文章
doi:10.1186/1743-8977-6-5
更新日期:2009-02-25 00:00:00