Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles.

abstract：BACKGROUND:Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related...

journal_title：Particle and fibre toxicology

authors： Pardo M,Li C,He Q,Levin-Zaidman S,Tsoory M,Yu Q,Wang X,Rudich Y

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the reliability of the commonly used limulus amebocyte lysate (LAL) a...

journal_title：Particle and fibre toxicology

authors： Smulders S,Kaiser JP,Zuin S,Van Landuyt KL,Golanski L,Vanoirbeek J,Wick P,Hoet PH

更新日期：2012-11-09 00:00:00

abstract：BACKGROUND:Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway. METHODS:We used ba...

journal_title：Particle and fibre toxicology

authors： Tsai DH,Amyai N,Marques-Vidal P,Wang JL,Riediker M,Mooser V,Paccaud F,Waeber G,Vollenweider P,Bochud M

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood brain barrier (BBB) have been implicated as a potential mechanism of air...

journal_title：Particle and fibre toxicology

authors： Oppenheim HA,Lucero J,Guyot AC,Herbert LM,McDonald JD,Mabondzo A,Lund AK

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Even though a continuously high number of in vitro studies on nanoparticles are being published, the issue of correct dose matter is often not sufficiently taken into account. Due to their size, the diffusion of nanoparticles is slower, as compared to soluble chemicals, and they sediment slowly. Therefore, t...

journal_title：Particle and fibre toxicology

authors： Böhmert L,König L,Sieg H,Lichtenstein D,Paul N,Braeuning A,Voigt A,Lampen A

更新日期：2018-10-30 00:00:00

abstract：:The uncertainty regarding the effects and risks of nanomaterials on human health and the environment, and how they should be tested and assessed in the context of current regulations, is clearly holding back the full exploitation of the innovative potential of nanomaterials. To reduce this uncertainty, the European Un...

journal_title：Particle and fibre toxicology

authors： Teunenbroek TV,Baker J,Dijkzeul A

更新日期：2017-12-19 00:00:00

abstract：BACKGROUND:In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we inves...

journal_title：Particle and fibre toxicology

authors： Peeters PM,Perkins TN,Wouters EF,Mossman BT,Reynaert NL

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...

journal_title：Particle and fibre toxicology

authors： Vignal C,Pichavant M,Alleman LY,Djouina M,Dingreville F,Perdrix E,Waxin C,Ouali Alami A,Gower-Rousseau C,Desreumaux P,Body-Malapel M

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to deciph...

journal_title：Particle and fibre toxicology

authors： Landry M,Pinault M,Tchankouo S,Charon É,Ridoux A,Boczkowski J,Mayne-L'Hermite M,Lanone S

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...

journal_title：Particle and fibre toxicology

authors： Mutlu EA,Engen PA,Soberanes S,Urich D,Forsyth CB,Nigdelioglu R,Chiarella SE,Radigan KA,Gonzalez A,Jakate S,Keshavarzian A,Budinger GR,Mutlu GM

更新日期：2011-06-09 00:00:00

abstract：BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...

journal_title：Particle and fibre toxicology

authors： Gerlofs-Nijland ME,van Berlo D,Cassee FR,Schins RP,Wang K,Campbell A

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening methods is the need for accurate measures of cellular dose. We present here a methodology that enables accurate determination of delivered to cell dos...

journal_title：Particle and fibre toxicology

authors： Cohen JM,Teeguarden JG,Demokritou P

更新日期：2014-05-01 00:00:00

abstract：INTRODUCTION:Exposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial pressure and left ventricular after-load. We determined the effect of diesel exhaust exposure on a...

journal_title：Particle and fibre toxicology

authors： Lundbäck M,Mills NL,Lucking A,Barath S,Donaldson K,Newby DE,Sandström T,Blomberg A

更新日期：2009-03-13 00:00:00

abstract：BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...

journal_title：Particle and fibre toxicology

authors： Sehlstedt M,Dove R,Boman C,Pagels J,Swietlicki E,Löndahl J,Westerholm R,Bosson J,Barath S,Behndig AF,Pourazar J,Sandström T,Mudway IS,Blomberg A

更新日期：2010-08-20 00:00:00

abstract：:This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the...

journal_title：Particle and fibre toxicology

authors： Donaldson K,Tran L,Jimenez LA,Duffin R,Newby DE,Mills N,MacNee W,Stone V

更新日期：2005-10-21 00:00:00

abstract：:Particle biokinetics is important in hazard identification and characterization of inhaled particles. Such studies intend to convert external to internal exposure or biologically effective dose, and may help to set limits in that way. Here we focus on the biokinetics of inhaled nanometer sized particles in comparison ...

journal_title：Particle and fibre toxicology

authors： Geiser M,Kreyling WG

更新日期：2010-01-20 00:00:00

abstract：:Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several plausible biological mechanisms have been proposed for these associations, however, at present, the pathways ...

journal_title：Particle and fibre toxicology

authors： Robertson S,Miller MR

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. To address...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Battelli LA,McKinney W,Friend S,Wolfarth MG,Andrew M,Castranova V,Porter DW

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other fibres on a continuum based on length, aspect ratio and biopersistence. Some types of carbon nanotubes satisfy the first two aspects of the fibre paradigm but only ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Poland CA,Murphy F,Waddington L,Morris H,Hawkins SC,Clark S,Aitken R,McCall MJ,Donaldson K

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a hi...

journal_title：Particle and fibre toxicology

authors： Hou L,Zhang X,Dioni L,Barretta F,Dou C,Zheng Y,Hoxha M,Bertazzi PA,Schwartz J,Wu S,Wang S,Baccarelli AA

更新日期：2013-04-29 00:00:00

abstract：:Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...

journal_title：Particle and fibre toxicology

authors： Grahame TJ,Schlesinger RB

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to pure carbonaceous materials in the nano-size range. C60 fullerenes are nano-sized particles that are...

journal_title：Particle and fibre toxicology

authors： Vesterdal LK,Folkmann JK,Jacobsen NR,Sheykhzade M,Wallin H,Loft S,Møller P

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles, as representative transition and rare earth oxides, exhibit distinct material properties that may result in different hazardous potential in the lung. The current study was undertaken to compare the pulmonar...

journal_title：Particle and fibre toxicology

authors： Sisler JD,Li R,McKinney W,Mercer RR,Ji Z,Xia T,Wang X,Shaffer J,Orandle M,Mihalchik AL,Battelli L,Chen BT,Wolfarth M,Andrew ME,Schwegler-Berry D,Porter DW,Castranova V,Nel A,Qian Y

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:Nano- or microscale copper oxide particles (CuO NP, CuO MP) are increasingly applied as catalysts or antimicrobial additives. This increases the risk of adverse health effects, since copper ions are cytotoxic under overload conditions. METHODS:The extra- and intracellular bioavailability of CuO NP and CuO M...

journal_title：Particle and fibre toxicology

authors： Semisch A,Ohle J,Witt B,Hartwig A

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer desig...

journal_title：Particle and fibre toxicology

authors： Siegrist KJ,Reynolds SH,Porter DW,Mercer RR,Bauer AK,Lowry D,Cena L,Stueckle TA,Kashon ML,Wiley J,Salisbury JL,Mastovich J,Bunker K,Sparrow M,Lupoi JS,Stefaniak AB,Keane MJ,Tsuruoka S,Terrones M,McCawley M,Sargent

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are classified as high aspect ratio nanomaterials. Our aim was to assess in vivo toxicity of inhaled AO ...

journal_title：Particle and fibre toxicology

authors： Adamcakova-Dodd A,Stebounova LV,O'Shaughnessy PT,Kim JS,Grassian VH,Thorne PS

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:Among manufactured or engineered nanoparticles, carbon black (CB) has largest production worldwide and is also an occupational respiratory hazard commonly seen in rubber industry. Few studies have assessed the risk for cardiovascular disease in carbon black exposed populations. An endothelial biosensor assay...

journal_title：Particle and fibre toxicology

authors： Tang J,Cheng W,Gao J,Li Y,Yao R,Rothman N,Lan Q,Campen MJ,Zheng Y,Leng S

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies. METHODS:To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, ...

journal_title：Particle and fibre toxicology

authors： Wyatt LH,Devlin RB,Rappold AG,Case MW,Diaz-Sanchez D

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Epidemiologic and animal studies have shown that particulate air pollution is associated with increased risk of lung and cardiovascular diseases. Although the exact mechanisms by which particles induce cardiovascular diseases are not known, studies suggest involvement of systemic acute phase responses, inclu...

journal_title：Particle and fibre toxicology

authors： Saber AT,Halappanavar S,Folkmann JK,Bornholdt J,Boisen AM,Møller P,Williams A,Yauk C,Vogel U,Loft S,Wallin H

更新日期：2009-04-20 00:00:00

abstract：BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...

journal_title：Particle and fibre toxicology

authors： Skovmand A,Erdely A,Antonini JM,Nurkiewicz TR,Shoeb M,Eye T,Kodali V,Loeschner K,Vidmar J,Agerholm JS,Goericke-Pesch S,Vogel U,Hougaard KS

更新日期：2020-01-10 00:00:00