A novel method to detect unlabeled inorganic nanoparticles and submicron particles in tissue by sedimentation field-flow fractionation.

abstract：BACKGROUND:Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the reliability of the commonly used limulus amebocyte lysate (LAL) a...

journal_title：Particle and fibre toxicology

authors： Smulders S,Kaiser JP,Zuin S,Van Landuyt KL,Golanski L,Vanoirbeek J,Wick P,Hoet PH

更新日期：2012-11-09 00:00:00

abstract：:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on t...

journal_title：Particle and fibre toxicology

authors： Shi H,Magaye R,Castranova V,Zhao J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to deciph...

journal_title：Particle and fibre toxicology

authors： Landry M,Pinault M,Tchankouo S,Charon É,Ridoux A,Boczkowski J,Mayne-L'Hermite M,Lanone S

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Photocopiers emit nanoparticles with complex chemical composition. Short-term exposures to modest nanoparticle concentrations triggered upper airway inflammation and oxidative stress in healthy human volunteers in a recent study. To further understand the toxicological properties of copier-emitted nanopartic...

journal_title：Particle and fibre toxicology

authors： Khatri M,Bello D,Pal AK,Cohen JM,Woskie S,Gassert T,Lan J,Gu AZ,Demokritou P,Gaines P

更新日期：2013-08-22 00:00:00

abstract：BACKGROUND:Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. RESULTS:We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release...

journal_title：Particle and fibre toxicology

authors： Hillegass JM,Miller JM,MacPherson MB,Westbom CM,Sayan M,Thompson JK,Macura SL,Perkins TN,Beuschel SL,Alexeeva V,Pass HI,Steele C,Mossman BT,Shukla A

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles, as representative transition and rare earth oxides, exhibit distinct material properties that may result in different hazardous potential in the lung. The current study was undertaken to compare the pulmonar...

journal_title：Particle and fibre toxicology

authors： Sisler JD,Li R,McKinney W,Mercer RR,Ji Z,Xia T,Wang X,Shaffer J,Orandle M,Mihalchik AL,Battelli L,Chen BT,Wolfarth M,Andrew ME,Schwegler-Berry D,Porter DW,Castranova V,Nel A,Qian Y

更新日期：2016-08-15 00:00:00

abstract：BACKGROUND:Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urb...

journal_title：Particle and fibre toxicology

authors： Hullmann M,Albrecht C,van Berlo D,Gerlofs-Nijland ME,Wahle T,Boots AW,Krutmann J,Cassee FR,Bayer TA,Schins RPF

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A pu...

journal_title：Particle and fibre toxicology

authors： Nikota J,Banville A,Goodwin LR,Wu D,Williams A,Yauk CL,Wallin H,Vogel U,Halappanavar S

更新日期：2017-09-13 00:00:00

abstract：BACKGROUND:Previous studies have shown that inhalation of welding fumes may induce pulmonary and systemic inflammation and organ accumulation of metal, to which spermatogenesis and endocrine function may be sensitive. Also obesity may induce low-grade systemic inflammation. This study aimed to investigate the effects o...

journal_title：Particle and fibre toxicology

authors： Skovmand A,Erdely A,Antonini JM,Nurkiewicz TR,Shoeb M,Eye T,Kodali V,Loeschner K,Vidmar J,Agerholm JS,Goericke-Pesch S,Vogel U,Hougaard KS

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized...

journal_title：Particle and fibre toxicology

authors： Balakrishna S,Lomnicki S,McAvey KM,Cole RB,Dellinger B,Cormier SA

更新日期：2009-04-17 00:00:00

abstract：BACKGROUND:Epidemiological evidence indicates that diabetic patients have increased susceptibility to adverse cardiovascular outcomes related to acute increases in exposures to particulate air pollution. However, mechanisms underlying these effects remain unclear. METHODS:To evaluate the possible mechanisms underlying...

journal_title：Particle and fibre toxicology

authors： Nemmar A,Subramaniyan D,Yasin J,Ali BH

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies. METHODS:To measure the systemic and cardiopulmonary impacts of low-level PM exposure, we exposed 20 healthy, ...

journal_title：Particle and fibre toxicology

authors： Wyatt LH,Devlin RB,Rappold AG,Case MW,Diaz-Sanchez D

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we inves...

journal_title：Particle and fibre toxicology

authors： Peeters PM,Perkins TN,Wouters EF,Mossman BT,Reynaert NL

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...

journal_title：Particle and fibre toxicology

authors： Mutlu EA,Engen PA,Soberanes S,Urich D,Forsyth CB,Nigdelioglu R,Chiarella SE,Radigan KA,Gonzalez A,Jakate S,Keshavarzian A,Budinger GR,Mutlu GM

更新日期：2011-06-09 00:00:00

abstract：BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...

journal_title：Particle and fibre toxicology

authors： Vignal C,Pichavant M,Alleman LY,Djouina M,Dingreville F,Perdrix E,Waxin C,Ouali Alami A,Gower-Rousseau C,Desreumaux P,Body-Malapel M

更新日期：2017-11-22 00:00:00

abstract：OBJECTIVE:Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in p...

journal_title：Particle and fibre toxicology

authors： You J,Zhou J,Zhou M,Liu Y,Robertson JD,Liang D,Van Pelt C,Li C

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Nano- or microscale copper oxide particles (CuO NP, CuO MP) are increasingly applied as catalysts or antimicrobial additives. This increases the risk of adverse health effects, since copper ions are cytotoxic under overload conditions. METHODS:The extra- and intracellular bioavailability of CuO NP and CuO M...

journal_title：Particle and fibre toxicology

authors： Semisch A,Ohle J,Witt B,Hartwig A

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. METHODS:Scnn1b-Tg and Wt mice inh...

journal_title：Particle and fibre toxicology

authors： Geiser M,Quaile O,Wenk A,Wigge C,Eigeldinger-Berthou S,Hirn S,Schäffler M,Schleh C,Möller W,Mall MA,Kreyling WG

更新日期：2013-05-16 00:00:00

abstract：BACKGROUND:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular mor...

journal_title：Particle and fibre toxicology

authors： Carll AP,Salatini R,Pirela SV,Wang Y,Xie Z,Lorkiewicz P,Naeem N,Qian Y,Castranova V,Godleski JJ,Demokritou P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-inf...

journal_title：Particle and fibre toxicology

authors： Sattler C,Moritz F,Chen S,Steer B,Kutschke D,Irmler M,Beckers J,Eickelberg O,Schmitt-Kopplin P,Adler H,Stoeger T

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...

journal_title：Particle and fibre toxicology

authors： Sehlstedt M,Dove R,Boman C,Pagels J,Swietlicki E,Löndahl J,Westerholm R,Bosson J,Barath S,Behndig AF,Pourazar J,Sandström T,Mudway IS,Blomberg A

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonar...

journal_title：Particle and fibre toxicology

authors： Noël A,Charbonneau M,Cloutier Y,Tardif R,Truchon G

更新日期：2013-10-04 00:00:00

abstract：BACKGROUND:Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. To address...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Battelli LA,McKinney W,Friend S,Wolfarth MG,Andrew M,Castranova V,Porter DW

更新日期：2013-07-30 00:00:00

abstract：:Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, not clearly elucidated. The purpose of the present review was to analyze the key events involved in the lung f...

journal_title：Particle and fibre toxicology

authors： Vietti G,Lison D,van den Brule S

更新日期：2016-02-29 00:00:00

abstract：: Air Pollution has been associated with significant adverse health effects leading to increased morbidity and mortality. Cumulative epidemiological and experimental data have shown that exposure to air pollutants lead to increased cardiovascular ischemic events and enhanced atherosclerosis. It appears that these assoc...

journal_title：Particle and fibre toxicology

authors： Araujo JA,Nel AE

更新日期：2009-09-18 00:00:00

abstract：BACKGROUND:Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the aim of this study was to systematically investigate the role of surface charge, oxidative stress and possible involvement ...

journal_title：Particle and fibre toxicology

authors： Bhattacharjee S,de Haan LH,Evers NM,Jiang X,Marcelis AT,Zuilhof H,Rietjens IM,Alink GM

更新日期：2010-09-11 00:00:00

abstract：BACKGROUND:Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related...

journal_title：Particle and fibre toxicology

authors： Pardo M,Li C,He Q,Levin-Zaidman S,Tsoory M,Yu Q,Wang X,Rudich Y

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain far from clear. RESULTS:Here, we evaluated the effects of amorphous nano...

journal_title：Particle and fibre toxicology

authors： Yang X,Liu J,He H,Zhou L,Gong C,Wang X,Yang L,Yuan J,Huang H,He L,Zhang B,Zhuang Z

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5) on genotoxic and global DNA methylation and hydr...

journal_title：Particle and fibre toxicology

authors： de Oliveira AAF,de Oliveira TF,Dias MF,Medeiros MHG,Di Mascio P,Veras M,Lemos M,Marcourakis T,Saldiva PHN,Loureiro APM

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...

journal_title：Particle and fibre toxicology

authors： Gerlofs-Nijland ME,van Berlo D,Cassee FR,Schins RP,Wang K,Campbell A

更新日期：2010-05-17 00:00:00