Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection.

abstract：BACKGROUND:Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO2 coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS:Uncoated and SiO2-coated ZnO NPs were ...

journal_title：Particle and fibre toxicology

authors： Konduru NV,Murdaugh KM,Sotiriou GA,Donaghey TC,Demokritou P,Brain JD,Molina RM

更新日期：2014-09-03 00:00:00

abstract：BACKGROUND:Traffic-generated air pollution-exposure is associated with adverse effects in the central nervous system (CNS) in both human exposures and animal models, including neuroinflammation and neurodegeneration. While alterations in the blood brain barrier (BBB) have been implicated as a potential mechanism of air...

journal_title：Particle and fibre toxicology

authors： Oppenheim HA,Lucero J,Guyot AC,Herbert LM,McDonald JD,Mabondzo A,Lund AK

更新日期：2013-12-17 00:00:00

abstract：:The uncertainty regarding the effects and risks of nanomaterials on human health and the environment, and how they should be tested and assessed in the context of current regulations, is clearly holding back the full exploitation of the innovative potential of nanomaterials. To reduce this uncertainty, the European Un...

journal_title：Particle and fibre toxicology

authors： Teunenbroek TV,Baker J,Dijkzeul A

更新日期：2017-12-19 00:00:00

abstract：:This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the...

journal_title：Particle and fibre toxicology

authors： Donaldson K,Tran L,Jimenez LA,Duffin R,Newby DE,Mills N,MacNee W,Stone V

更新日期：2005-10-21 00:00:00

abstract：:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on t...

journal_title：Particle and fibre toxicology

authors： Shi H,Magaye R,Castranova V,Zhao J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other fibres on a continuum based on length, aspect ratio and biopersistence. Some types of carbon nanotubes satisfy the first two aspects of the fibre paradigm but only ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Poland CA,Murphy F,Waddington L,Morris H,Hawkins SC,Clark S,Aitken R,McCall MJ,Donaldson K

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Benzalkonium chloride (BAC or BKC) is a non-toxic substance used to control pests. Recently, BAC has been increasingly us...

journal_title：Particle and fibre toxicology

authors： Choi HY,Lee YH,Lim CH,Kim YS,Lee IS,Jo JM,Lee HY,Cha HG,Woo HJ,Seo DS

更新日期：2020-01-28 00:00:00

abstract：:In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to...

journal_title：Particle and fibre toxicology

authors： Driscoll KE,Borm PA,Chaudhuri I,Levy L,Yong M,Warheit D,McCunney R,Oberdörster G

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:Carbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially those with a larger diameter, with computational analyses linking toxicity to their fundamental material characteristics was lacking. It was unclear if all CNT/F confer sim...

journal_title：Particle and fibre toxicology

authors： Fraser K,Kodali V,Yanamala N,Birch ME,Cena L,Casuccio G,Bunker K,Lersch TL,Evans DE,Stefaniak A,Hammer MA,Kashon ML,Boots T,Eye T,Hubczak J,Friend SA,Dahm M,Schubauer-Berigan MK,Siegrist K,Lowry D,Bauer AK,Sarge

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A pu...

journal_title：Particle and fibre toxicology

authors： Nikota J,Banville A,Goodwin LR,Wu D,Williams A,Yauk CL,Wallin H,Vogel U,Halappanavar S

更新日期：2017-09-13 00:00:00

abstract：BACKGROUND:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular mor...

journal_title：Particle and fibre toxicology

authors： Carll AP,Salatini R,Pirela SV,Wang Y,Xie Z,Lorkiewicz P,Naeem N,Qian Y,Castranova V,Godleski JJ,Demokritou P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urb...

journal_title：Particle and fibre toxicology

authors： Hullmann M,Albrecht C,van Berlo D,Gerlofs-Nijland ME,Wahle T,Boots AW,Krutmann J,Cassee FR,Bayer TA,Schins RPF

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of silica is variable, depending on the physico-chemical features of the particles. In the...

journal_title：Particle and fibre toxicology

authors： Pavan C,Delle Piane M,Gullo M,Filippi F,Fubini B,Hoet P,Horwell CJ,Huaux F,Lison D,Lo Giudice C,Martra G,Montfort E,Schins R,Sulpizi M,Wegner K,Wyart-Remy M,Ziemann C,Turci F

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are classified as high aspect ratio nanomaterials. Our aim was to assess in vivo toxicity of inhaled AO ...

journal_title：Particle and fibre toxicology

authors： Adamcakova-Dodd A,Stebounova LV,O'Shaughnessy PT,Kim JS,Grassian VH,Thorne PS

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1.5 - 25 μm; diameter 100 - 160 nm), spherical silver nanoparticles (30 nm) and silver micropa...

journal_title：Particle and fibre toxicology

authors： Stoehr LC,Gonzalez E,Stampfl A,Casals E,Duschl A,Puntes V,Oostingh GJ

更新日期：2011-12-30 00:00:00

abstract：BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...

journal_title：Particle and fibre toxicology

authors： Gerlofs-Nijland ME,van Berlo D,Cassee FR,Schins RP,Wang K,Campbell A

更新日期：2010-05-17 00:00:00

abstract：:Air pollution is a growing public health concern of global significance. Acute and chronic exposure is known to impair cardiovascular function, exacerbate disease and increase cardiovascular mortality. Several plausible biological mechanisms have been proposed for these associations, however, at present, the pathways ...

journal_title：Particle and fibre toxicology

authors： Robertson S,Miller MR

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. METHODS:Scnn1b-Tg and Wt mice inh...

journal_title：Particle and fibre toxicology

authors： Geiser M,Quaile O,Wenk A,Wigge C,Eigeldinger-Berthou S,Hirn S,Schäffler M,Schleh C,Möller W,Mall MA,Kreyling WG

更新日期：2013-05-16 00:00:00

abstract：BACKGROUND:The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxyla...

journal_title：Particle and fibre toxicology

authors： Palmer BC,Phelan-Dickenson SJ,DeLouise LA

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune respons...

journal_title：Particle and fibre toxicology

authors： Vignal C,Pichavant M,Alleman LY,Djouina M,Dingreville F,Perdrix E,Waxin C,Ouali Alami A,Gower-Rousseau C,Desreumaux P,Body-Malapel M

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer desig...

journal_title：Particle and fibre toxicology

authors： Siegrist KJ,Reynolds SH,Porter DW,Mercer RR,Bauer AK,Lowry D,Cena L,Stueckle TA,Kashon ML,Wiley J,Salisbury JL,Mastovich J,Bunker K,Sparrow M,Lupoi JS,Stefaniak AB,Keane MJ,Tsuruoka S,Terrones M,McCawley M,Sargent

更新日期：2019-10-07 00:00:00

abstract：UNLABELLED:A novel methodology to detect unlabeled inorganic nanoparticles was experimentally demonstrated using a mixture of nano-sized (70 nm) and submicron (250 nm) silicon dioxide particles added to mammalian tissue. The size and concentration of environmentally relevant inorganic particles in a tissue sample can b...

journal_title：Particle and fibre toxicology

authors： Deering CE,Tadjiki S,Assemi S,Miller JD,Yost GS,Veranth JM

更新日期：2008-12-03 00:00:00

abstract：BACKGROUND:Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by changes in exposure. We studied the clearance kinetics of black carbon (BC) in AM, obtained by sput...

journal_title：Particle and fibre toxicology

authors： Bai Y,Bové H,Nawrot TS,Nemery B

更新日期：2018-03-14 00:00:00

abstract：BACKGROUND:Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. RESULTS:We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release...

journal_title：Particle and fibre toxicology

authors： Hillegass JM,Miller JM,MacPherson MB,Westbom CM,Sayan M,Thompson JK,Macura SL,Perkins TN,Beuschel SL,Alexeeva V,Pass HI,Steele C,Mossman BT,Shukla A

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Inhalation exposure studies of mice were conducted to determine if multi-walled carbon nanotubes (MWCNT) distribute to the tracheobronchial lymphatics, parietal pleura, respiratory musculature and/or extrapulmonary organs. Male C57BL/6 J mice were exposed in a whole-body inhalation system to a 5 mg/m3 MWCNT ...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Wang L,Battelli LA,McKinney W,Castranova V,Porter DW

更新日期：2013-08-09 00:00:00

abstract：BACKGROUND:There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, ...

journal_title：Particle and fibre toxicology

authors： Tomašek I,Horwell CJ,Damby DE,Barošová H,Geers C,Petri-Fink A,Rothen-Rutishauser B,Clift MJ

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:Nano- or microscale copper oxide particles (CuO NP, CuO MP) are increasingly applied as catalysts or antimicrobial additives. This increases the risk of adverse health effects, since copper ions are cytotoxic under overload conditions. METHODS:The extra- and intracellular bioavailability of CuO NP and CuO M...

journal_title：Particle and fibre toxicology

authors： Semisch A,Ohle J,Witt B,Hartwig A

更新日期：2014-02-13 00:00:00

abstract：BACKGROUND:Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to deciph...

journal_title：Particle and fibre toxicology

authors： Landry M,Pinault M,Tchankouo S,Charon É,Ridoux A,Boczkowski J,Mayne-L'Hermite M,Lanone S

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Given the tremendous potential for graphene quantum dots (QDs) in biomedical applications, a thorough understanding of the interaction of these materials with macrophages is essential because macrophages are one of the most important barriers against exogenous particles. Although the cytotoxicity and cellula...

journal_title：Particle and fibre toxicology

authors： Xu L,Dai Y,Wang Z,Zhao J,Li F,White JC,Xing B

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:The exact role of primary nanoparticle (NP) size and their degree of agglomeration in aerosols on the determination of pulmonary effects is still poorly understood. Smaller NP are thought to have greater biological reactivity, but their level of agglomeration in an aerosol may also have an impact on pulmonar...

journal_title：Particle and fibre toxicology

authors： Noël A,Charbonneau M,Cloutier Y,Tardif R,Truchon G

更新日期：2013-10-04 00:00:00