Deposition and biokinetics of inhaled nanoparticles.

abstract：BACKGROUND:Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the aim of this study was to systematically investigate the role of surface charge, oxidative stress and possible involvement ...

journal_title：Particle and fibre toxicology

authors： Bhattacharjee S,de Haan LH,Evers NM,Jiang X,Marcelis AT,Zuilhof H,Rietjens IM,Alink GM

更新日期：2010-09-11 00:00:00

abstract：BACKGROUND:There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas already exposed to heightened air pollution. The aim of this study was, therefore, to gain an imperative, ...

journal_title：Particle and fibre toxicology

authors： Tomašek I,Horwell CJ,Damby DE,Barošová H,Geers C,Petri-Fink A,Rothen-Rutishauser B,Clift MJ

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:Even though a continuously high number of in vitro studies on nanoparticles are being published, the issue of correct dose matter is often not sufficiently taken into account. Due to their size, the diffusion of nanoparticles is slower, as compared to soluble chemicals, and they sediment slowly. Therefore, t...

journal_title：Particle and fibre toxicology

authors： Böhmert L,König L,Sieg H,Lichtenstein D,Paul N,Braeuning A,Voigt A,Lampen A

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urb...

journal_title：Particle and fibre toxicology

authors： Hullmann M,Albrecht C,van Berlo D,Gerlofs-Nijland ME,Wahle T,Boots AW,Krutmann J,Cassee FR,Bayer TA,Schins RPF

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway. METHODS:We used ba...

journal_title：Particle and fibre toxicology

authors： Tsai DH,Amyai N,Marques-Vidal P,Wang JL,Riediker M,Mooser V,Paccaud F,Waeber G,Vollenweider P,Bochud M

更新日期：2012-07-06 00:00:00

abstract：BACKGROUND:Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related...

journal_title：Particle and fibre toxicology

authors： Pardo M,Li C,He Q,Levin-Zaidman S,Tsoory M,Yu Q,Wang X,Rudich Y

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular mor...

journal_title：Particle and fibre toxicology

authors： Carll AP,Salatini R,Pirela SV,Wang Y,Xie Z,Lorkiewicz P,Naeem N,Qian Y,Castranova V,Godleski JJ,Demokritou P

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...

journal_title：Particle and fibre toxicology

authors： Gerlofs-Nijland ME,van Berlo D,Cassee FR,Schins RP,Wang K,Campbell A

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:Carbon nanotubes (CNTs) are being increasingly industrialized and applied for various products. As of today, although several toxicological evaluations of CNTs have been conducted, designing safer CNTs is not practiced because reaction kinetics of CNTs with bioactive species is not fully understood. RESULTS...

journal_title：Particle and fibre toxicology

authors： Tsuruoka S,Cassee FR,Castranova V

更新日期：2013-09-02 00:00:00

abstract：BACKGROUND:The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace making respiratory exposures likely in workers. The International Agency for Research on Cancer desig...

journal_title：Particle and fibre toxicology

authors： Siegrist KJ,Reynolds SH,Porter DW,Mercer RR,Bauer AK,Lowry D,Cena L,Stueckle TA,Kashon ML,Wiley J,Salisbury JL,Mastovich J,Bunker K,Sparrow M,Lupoi JS,Stefaniak AB,Keane MJ,Tsuruoka S,Terrones M,McCawley M,Sargent

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:The complement system is a key component of innate immunity implicated in the neutralization and clearance of invading pathogens. Dextran coated superparamagnetic iron oxide (SPIO) nanoparticle is a promising magnetic resonance imaging (MRI) contrast agent. However, dextran SPIO has been associated with sign...

journal_title：Particle and fibre toxicology

authors： Banda NK,Mehta G,Chao Y,Wang G,Inturi S,Fossati-Jimack L,Botto M,Wu L,Moghimi SM,Simberg D

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:The effects of carbon nanotubes on skin toxicity have not been extensively studied; however, our lab has previously shown that a carboxylated multi-walled carbon nanotube (MWCNT) exacerbates the 2, 4-dinitrofluorobenzene induced contact hypersensitivity response in mice. Here we examine the role of carboxyla...

journal_title：Particle and fibre toxicology

authors： Palmer BC,Phelan-Dickenson SJ,DeLouise LA

更新日期：2019-01-08 00:00:00

abstract：:Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...

journal_title：Particle and fibre toxicology

authors： Grahame TJ,Schlesinger RB

更新日期：2012-06-19 00:00:00

abstract：UNLABELLED:A novel methodology to detect unlabeled inorganic nanoparticles was experimentally demonstrated using a mixture of nano-sized (70 nm) and submicron (250 nm) silicon dioxide particles added to mammalian tissue. The size and concentration of environmentally relevant inorganic particles in a tissue sample can b...

journal_title：Particle and fibre toxicology

authors： Deering CE,Tadjiki S,Assemi S,Miller JD,Yost GS,Veranth JM

更新日期：2008-12-03 00:00:00

abstract：:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on t...

journal_title：Particle and fibre toxicology

authors： Shi H,Magaye R,Castranova V,Zhao J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to undesirable events. A pu...

journal_title：Particle and fibre toxicology

authors： Nikota J,Banville A,Goodwin LR,Wu D,Williams A,Yauk CL,Wallin H,Vogel U,Halappanavar S

更新日期：2017-09-13 00:00:00

abstract：BACKGROUND:Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of these two factors is highly likely. We hypothesized that NP-exposure of persistently herpesvirus-inf...

journal_title：Particle and fibre toxicology

authors： Sattler C,Moritz F,Chen S,Steer B,Kutschke D,Irmler M,Beckers J,Eickelberg O,Schmitt-Kopplin P,Adler H,Stoeger T

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ligand-induced activation keeps the AM quiescent, and thereby contributes to combat invaders and resolve infl...

journal_title：Particle and fibre toxicology

authors： Götz AA,Vidal-Puig A,Rödel HG,de Angelis MH,Stoeger T

更新日期：2011-09-20 00:00:00

abstract：BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...

journal_title：Particle and fibre toxicology

authors： Mutlu EA,Engen PA,Soberanes S,Urich D,Forsyth CB,Nigdelioglu R,Chiarella SE,Radigan KA,Gonzalez A,Jakate S,Keshavarzian A,Budinger GR,Mutlu GM

更新日期：2011-06-09 00:00:00

abstract：BACKGROUND:Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a hi...

journal_title：Particle and fibre toxicology

authors： Hou L,Zhang X,Dioni L,Barretta F,Dou C,Zheng Y,Hoxha M,Bertazzi PA,Schwartz J,Wu S,Wang S,Baccarelli AA

更新日期：2013-04-29 00:00:00

abstract：BACKGROUND:Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to pure carbonaceous materials in the nano-size range. C60 fullerenes are nano-sized particles that are...

journal_title：Particle and fibre toxicology

authors： Vesterdal LK,Folkmann JK,Jacobsen NR,Sheykhzade M,Wallin H,Loft S,Møller P

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized...

journal_title：Particle and fibre toxicology

authors： Balakrishna S,Lomnicki S,McAvey KM,Cole RB,Dellinger B,Cormier SA

更新日期：2009-04-17 00:00:00

abstract：BACKGROUND:Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the reliability of the commonly used limulus amebocyte lysate (LAL) a...

journal_title：Particle and fibre toxicology

authors： Smulders S,Kaiser JP,Zuin S,Van Landuyt KL,Golanski L,Vanoirbeek J,Wick P,Hoet PH

更新日期：2012-11-09 00:00:00

abstract：BACKGROUND:It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other fibres on a continuum based on length, aspect ratio and biopersistence. Some types of carbon nanotubes satisfy the first two aspects of the fibre paradigm but only ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Poland CA,Murphy F,Waddington L,Morris H,Hawkins SC,Clark S,Aitken R,McCall MJ,Donaldson K

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Nanoparticle pharmacokinetics and biological effects are influenced by several factors. We assessed the effects of amorphous SiO2 coating on the pharmacokinetics of zinc oxide nanoparticles (ZnO NPs) following intratracheal (IT) instillation and gavage in rats. METHODS:Uncoated and SiO2-coated ZnO NPs were ...

journal_title：Particle and fibre toxicology

authors： Konduru NV,Murdaugh KM,Sotiriou GA,Donaghey TC,Demokritou P,Brain JD,Molina RM

更新日期：2014-09-03 00:00:00

abstract：BACKGROUND:Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to deciph...

journal_title：Particle and fibre toxicology

authors： Landry M,Pinault M,Tchankouo S,Charon É,Ridoux A,Boczkowski J,Mayne-L'Hermite M,Lanone S

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1.5 - 25 μm; diameter 100 - 160 nm), spherical silver nanoparticles (30 nm) and silver micropa...

journal_title：Particle and fibre toxicology

authors： Stoehr LC,Gonzalez E,Stampfl A,Casals E,Duschl A,Puntes V,Oostingh GJ

更新日期：2011-12-30 00:00:00

abstract：OBJECTIVE:Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in p...

journal_title：Particle and fibre toxicology

authors： You J,Zhou J,Zhou M,Liu Y,Robertson JD,Liang D,Van Pelt C,Li C

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain far from clear. RESULTS:Here, we evaluated the effects of amorphous nano...

journal_title：Particle and fibre toxicology

authors： Yang X,Liu J,He H,Zhou L,Gong C,Wang X,Yang L,Yuan J,Huang H,He L,Zhang B,Zhuang Z

更新日期：2010-01-19 00:00:00

abstract：:Several experimental studies have shown that carbon nanotubes (CNT) can induce respiratory effects, including lung fibrosis. The cellular and molecular events through which these effects develop are, however, not clearly elucidated. The purpose of the present review was to analyze the key events involved in the lung f...

journal_title：Particle and fibre toxicology

authors： Vietti G,Lison D,van den Brule S

更新日期：2016-02-29 00:00:00