听力与言语-语言病理学

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医学伦理学

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  • Impact drugs targeting cardiometabolic risk on the gut microbiota.

    abstract:PURPOSE OF REVIEW:Alterations in the gut microbiome composition or function are associated with risk factors for cardiometabolic diseases, including hypertension, hyperlipidemia and hyperglycemia. Based on recent evidence that also oral medications used to treat these conditions could alter the gut microbiome compositi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000727

    authors: Balvers M,van den Born BH,Levin E,Nieuwdorp M

    更新日期:2021-02-01 00:00:00

  • The role of the molecular circadian clock in human energy homeostasis.

    abstract:PURPOSE OF REVIEW:The aim of this review is to present the latest findings on the role of the circadian clock in the control of metabolism, and the therapeutic potential of chronotherapy to regulate energy homeostasis in humans. RECENT FINDINGS:We summarized the recent advances related to circadian clock regulation of...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000722

    authors: Dollet L,Pendergrast LA,Zierath JR

    更新日期:2021-02-01 00:00:00

  • Deep dive to the secrets of the PREDIMED trial.

    abstract:PURPOSE OF REVIEW:The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvención con DIeta MEDiterránea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 2003-2010 and represented the largest primary prevention trial ever test...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000731

    authors: Fernández-Lázaro CI,Ruiz-Canela M,Martínez-González MÁ

    更新日期:2021-02-01 00:00:00

  • Genetic, biochemical, and clinical features of LCAT deficiency: update for 2020.

    abstract:PURPOSE OF REVIEW:Genetic LCAT deficiency is a rare metabolic disorder characterized by low-plasma HDL cholesterol levels. Clinical manifestations of the disease include corneal opacification, anemia, and renal disease, which represents the major cause of morbidity and mortality in carriers. RECENT FINDINGS:Biochemica...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000697

    authors: Pavanello C,Calabresi L

    更新日期:2020-08-01 00:00:00

  • Epigenetics of paraoxonases.

    abstract:PURPOSE OF REVIEW:Studies have shown the three-member paraoxonase (PON) multigene family to be involved in the development of a large variety of diseases with an inflammatory component. Environmental factors such as lifestyle-related factors differ widely between populations and it is important to consider that their i...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000687

    authors: Mahrooz A,Mackness M

    更新日期:2020-08-01 00:00:00

  • When to lower triglycerides?

    abstract:PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000694

    authors: Ganda OP

    更新日期:2020-08-01 00:00:00

  • Lipoprotein(a): is it more, less or equal to LDL as a causal factor for cardiovascular disease and mortality?

    abstract:PURPOSE OF REVIEW:To summarize the recent studies directly comparing LDL and lipoprotein(a) as causal factors for cardiovascular disease and mortality. RECENT FINDINGS:In approximately 100,000 individuals from the Copenhagen General Population Study for risk of myocardial infarction, in observational analyses per 39 m...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000681

    authors: Langsted A,Nordestgaard BG

    更新日期:2020-06-01 00:00:00

  • Homozygous familial hypercholesterolemia: what treatments are on the horizon?

    abstract:PURPOSE OF REVIEW:Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor (LDLR) pathway. Because of their molecular defect, current treatment options have limited success in bringing HoFH patient to LDL-C target and morbidit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000677

    authors: Bajaj A,Cuchel M

    更新日期:2020-06-01 00:00:00

  • Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.

    abstract:PURPOSE OF REVIEW:Several mutations in the apolipoprotein (apo) B, proprotein convertase subtilisin kexin 9 (PCSK9) and microsomal triglyceride transfer protein genes result in low or absent levels of apoB and LDL cholesterol (LDL-C) in plasma which cause familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000663

    authors: Welty FK

    更新日期:2020-04-01 00:00:00

  • Dietary fructose and dyslipidemia: new mechanisms involving apolipoprotein CIII.

    abstract:PURPOSE OF REVIEW:Chronic consumption of fructose and fructose-containing sugars leads to dyslipidemia. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose consumption on apoCIII levels and the role of apoCIII in fru...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000653

    authors: Hieronimus B,Stanhope KL

    更新日期:2020-02-01 00:00:00

  • SPPARM alpha: the Lazarus effect.

    abstract:PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000640

    authors: Fruchart JC,Santos RD

    更新日期:2019-12-01 00:00:00

  • Is hypertriglyceridemia atherogenic?

    abstract:PURPOSE OF REVIEW:Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological an...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000622

    authors: Huet F,Roubille C,Roubille F

    更新日期:2019-08-01 00:00:00

  • Role of sortilin in lipid metabolism.

    abstract:PURPOSE OF REVIEW:Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the cell surface. Genome-wide association studies (GWAS) revealed an association between sortilin and reduced plasma LDL-cholesterol (LDL-C) as we...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000598

    authors: Conlon DM

    更新日期:2019-06-01 00:00:00

  • Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application.

    abstract:PURPOSE OF REVIEW:Several members of the fibroblast growth factor (FGF) family have been identified as key regulators of energy metabolism in rodents and nonhuman primates. Translational studies show that their metabolic actions are largely conserved in humans, which led to the development of various FGF-based drugs, i...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000599

    authors: Struik D,Dommerholt MB,Jonker JW

    更新日期:2019-06-01 00:00:00

  • HDL modification: recent developments and their relevance to atherosclerotic cardiovascular disease.

    abstract:PURPOSE OF REVIEW:In the last 2 years, significant advances in the understanding of HDL particle structure and the associations between particle structure, function, and atherosclerosis have been made. We will review and provide clinical and epidemiological context to these recent advances. RECENT FINDINGS:Several rec...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000571

    authors: Wilkins JT,Seckler HS

    更新日期:2019-02-01 00:00:00

  • Dietary fat and risk of type 2 diabetes.

    abstract:PURPOSE OF REVIEW:Nutrition recommendations emphasize that not only dietary fat quantity but also fat quality plays a role in the prevention of type 2 diabetes (T2D). The aim of this review is to summarize the evidence for dietary fat and risk of T2D, to highlight recent findings and point out future research direction...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000567

    authors: Schlesinger S,Schwingshackl L,Neuenschwander M

    更新日期:2019-02-01 00:00:00

  • Lipid-driven immunometabolic responses in atherosclerosis.

    abstract:PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000540

    authors: Gisterå A,Ketelhuth DFJ

    更新日期:2018-10-01 00:00:00

  • Metabolism of innate immune cells: impact on atherosclerosis.

    abstract:PURPOSE OF REVIEW:It is increasingly recognized that profound metabolic changes occur in activated myeloid cells, which shape their inflammatory phenotype and cellular functions. The purpose of this review is to summarize the accumulating evidence that major metabolic adaptations occur in monocytes and macrophages in t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000539

    authors: Riksen NP,Stienstra R

    更新日期:2018-10-01 00:00:00

  • Pleiotropic effects of proprotein convertase subtilisin/kexin type 9 inhibitors?

    abstract:PURPOSE OF REVIEW:Current data suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors may affect many metabolic pathways beyond lowering LDL cholesterol. The aim of the present manuscript is to present these so-called pleiotropic effects of PCSK9 inhibitors. RECENT FINDINGS:PCSK9 may affect the ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000523

    authors: Filippatos TD,Christopoulou EC,Elisaf MS

    更新日期:2018-08-01 00:00:00

  • What have we learnt from the clinical outcomes trials with the cetrapibs?

    abstract:PURPOSE OF REVIEW:The current review considers what we have learnt from the clinical outcome trials with the cetrapibs; the inhibitors of cholesteryl ester transfer protein that increase HDL cholesterol levels; torcetrapib, dalcetrapib, evacetrapib and anacetrapib. RECENT FINDINGS:Although an off-target increase in bl...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000518

    authors: Doggrell SA

    更新日期:2018-08-01 00:00:00

  • Population specific genetic heterogeneity of familial hypercholesterolemia in South Africa.

    abstract:PURPOSE OF REVIEW:To describe the prevalence and population-specific genetic heterogeneity of familial hypercholesterolemia in South Africa. RECENT FINDINGS:This review highlights the paucity of data on familial hypercholesterolemia in South Africa, and the urgent need to uncover the mutation profiles in lipid-associa...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000488

    authors: Smyth N,Ramsay M,Raal FJ

    更新日期:2018-04-01 00:00:00

  • The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.

    abstract:PURPOSE OF REVIEW:The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concent...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000484

    authors: Seidah NG,Chrétien M,Mbikay M

    更新日期:2018-04-01 00:00:00

  • Microbiota and HDL metabolism.

    abstract:PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000472

    authors: Nakaya K,Ikewaki K

    更新日期:2018-02-01 00:00:00

  • Strategies for the use of nonstatin therapies.

    abstract:PURPOSE OF REVIEW:Dyslipidaemias are a major risk factor for cardiovascular disease (CVD); in particular, high levels of low-density lipoprotein cholesterol (LDL-C) have been associated to a higher cardiovascular risk. Reducing LDL-C levels decreases the risk of coronary heart disease (CHD), and the greater the LDL-C r...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000459

    authors: Pirillo A,Norata GD,Catapano AL

    更新日期:2017-12-01 00:00:00

  • The challenges of proprotein convertase subtilisin-kexin-9 inhibitors for lipid guidelines and models of care.

    abstract:PURPOSE OF REVIEW:The article reviews the challenges facing cardiovascular disease (CVD) guidelines committees. RECENT FINDINGS:Clinical trials in high-risk populations have shown additional CVD event reduction with ezetimibe and proprotein convertase subtilisin-kexin-9 inhibitors. These trials recruit middle-aged sec...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000453

    authors: Wierzbicki AS

    更新日期:2017-12-01 00:00:00

  • Time to ditch HDL-C as a measure of HDL function?

    abstract:PURPOSE OF REVIEW:Epidemiological and clinical studies link low levels of HDL cholesterol (HDL-C) with increased risk of atherosclerotic cardiovascular disease (CVD). However, genetic polymorphisms linked to HDL-C do not associate consistently with CVD risk, and randomized clinical studies of drugs that elevate HDL-C v...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000446

    authors: Ronsein GE,Heinecke JW

    更新日期:2017-10-01 00:00:00

  • Cholesterol reduction and macrophage function: role of paraoxonases.

    abstract:PURPOSE OF REVIEW:Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles a...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000444

    authors: White CR,Anantharamaiah GM

    更新日期:2017-10-01 00:00:00

  • Molecular diagnosis of familial hypercholesterolaemia.

    abstract:PURPOSE OF REVIEW:Familial hypercholesterolaemia is a hereditary disorder of lipoprotein metabolism which causes a lifelong increase in LDL-C levels resulting in premature coronary heart disease. The present review looks at some of the recent literature on how molecular methods can be used to assist in the definitive d...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000430

    authors: Graham CA,Latten MJ,Hart PJ

    更新日期:2017-08-01 00:00:00

  • Impact of rare variants in autosomal dominant hypercholesterolemia causing genes.

    abstract:PURPOSE OF REVIEW:The systematic analysis of the major candidate genes in autosomal dominant hypercholesterolemia (ADH) and the use of next-generation sequencing (NGS) technology have made possible the discovery of several rare gene variants whose pathogenic effect in most cases remains poorly defined. RECENT FINDINGS...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000414

    authors: Calandra S,Tarugi P,Bertolini S

    更新日期:2017-06-01 00:00:00

  • The role of registries and genetic databases in familial hypercholesterolemia.

    abstract:PURPOSE OF REVIEW:To review how leveraging familial hypercholesterolemia registries can impact molecular genetic research and precision medicine. RECENT FINDINGS:Familial hypercholesterolemia is both much more common and more phenotypically heterogeneous than previously thought with some evidence for significant genot...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000398

    authors: Kindt I,Mata P,Knowles JW

    更新日期:2017-04-01 00:00:00

  • Phenotype vs. genotype in severe familial hypercholesterolemia: what matters most for the clinician?

    abstract:PURPOSE OF REVIEW:Familial hypercholesterolemia is associated with a high lifetime risk of atherosclerotic cardiovascular disease (ASCVD). However, this risk is variable. This review evaluates recent evidence related to ASCVD risk stratification in familial hypercholesterolemia considering aspects of phenotype and geno...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000391

    authors: Santos RD

    更新日期:2017-04-01 00:00:00

  • Recent explanatory trials of the mode of action of drug therapies on lipoprotein metabolism.

    abstract:PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000348

    authors: Chan DC,Barrett PH,Watts GF

    更新日期:2016-12-01 00:00:00

  • The future of imaging in cardiovascular disease intervention trials: 2017 and beyond.

    abstract:PURPOSE OF REVIEW:As our understanding of cardiovascular disease has advanced over the past decades, multiple novel treatment strategies have been developed with the hope of reducing the global morbidity and mortality associated with this condition. Large-scale trials to test such novel therapies using clinical end poi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000350

    authors: Doris MK,Dweck MR,Fayad ZA

    更新日期:2016-12-01 00:00:00

  • HDL infusion for the management of atherosclerosis: current developments and new directions.

    abstract:PURPOSE OF REVIEW:Because human genetic studies and large clinical trials have demonstrated that HDL-cholesterol levels are not causally related to cardiovascular disease risk, attention has shifted toward the functional properties of HDL. Infusion of HDL mimetics containing apolipoprotein A-I remains a potential strat...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000349

    authors: Zheng KH,Stroes ES

    更新日期:2016-12-01 00:00:00

  • Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease.

    abstract:PURPOSE OF REVIEW:Phospholipids are major constituents in the intestinal lumen after meal consumption. This article highlights current literature suggesting the contributory role of intestinal phospholipid metabolism toward cardiometabolic disease manifestation. RECENT FINDINGS:Group 1b phospholipase A2 (PLA2g1b) cata...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000334

    authors: Hui DY

    更新日期:2016-10-01 00:00:00

  • Novel B-cell subsets in atherosclerosis.

    abstract:PURPOSE OF REVIEW:The number of deaths associated with cardiovascular disease remains high, despite great advances in treating the associated high levels of cholesterol. The main underlying pathology of cardiovascular disease is atherosclerosis, which is recognized as a chronic autoimmune-like inflammatory disease. Hen...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000335

    authors: Douna H,Kuiper J

    更新日期:2016-10-01 00:00:00

  • Vaccine strategies for lowering LDL by immunization against proprotein convertase subtilisin/kexin type 9.

    abstract:PURPOSE OF REVIEW:mAbs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have the potential to become groundbreaking therapies for the treatment of hypercholesterolemia. However, one major drawback of mAb-based therapy for a chronic condition like dyslipidemia is its relatively high cost. This review summ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000312

    authors: Chackerian B,Remaley A

    更新日期:2016-08-01 00:00:00

  • Relevance of lipid metabolism for brown fat visualization and quantification.

    abstract:PURPOSE OF REVIEW:Brown adipose tissue (BAT) is an emerging target to combat cardiometabolic disorders as it can take up substantial amounts of glucose and lipids from the circulation for heat production. This review focuses on new concepts in BAT physiology and discusses the need for new techniques to determine BAT ac...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000296

    authors: Schilperoort M,Hoeke G,Kooijman S,Rensen PC

    更新日期:2016-06-01 00:00:00

  • HDL-cholesterol and apolipoproteins in relation to dementia.

    abstract:PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000257

    authors: Koch M,Jensen MK

    更新日期:2016-02-01 00:00:00

  • n-3 Fatty acid supplementation and proresolving mediators of inflammation.

    abstract:PURPOSE OF REVIEW:The review presents recent developments in the identification of specialized proresolving mediators (SPMs) of inflammation following supplementation with n-3 fatty acids in humans. RECENT FINDINGS:A number of reports have measured SPMs in human plasma after n-3 fatty acid supplementation. Although st...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000262

    authors: Barden AE,Mas E,Mori TA

    更新日期:2016-02-01 00:00:00

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