HDL-cholesterol and apolipoproteins in relation to dementia.


PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating the relevance of HDL cholesterol (HDL-C) and apolipoproteins as biomarkers of future and prevalent risk of dementia. RECENT FINDINGS:HDL-C and apolipoproteins, such as apoE have been suggested to play important roles in brain function and have been associated with dementia and Alzheimer's disease in observational studies. However, findings have been inconsistent, especially across study designs. In recent years, modern proteomic approaches have enabled the investigation of further apolipoproteins involved in the deposition and clearance of β-amyloid, a determining factor for subsequent neurodegeneration. SUMMARY:Associations in cross-sectional studies are not always indicative of a prospective relationship. Large studies find that plasma HDL-C and apoE are inversely associated with dementia. Higher apoJ levels might be a marker of prevalent dementia, but were not associated with risk of future dementia. The investigation of HDL-C and apolipoproteins in relation to dementia represents an area of opportunity. Additional prospective studies that account for potential confounding factors and that explore potential effect modifiers such as APOE genotype and sex are needed to fully investigate the potential of these noninvasive measures in disease prediction.


Curr Opin Lipidol


Koch M,Jensen MK




Has Abstract


2016-02-01 00:00:00












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    abstract:PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). RECENT FINDINGS:Recent large-scale meta-analyses have confirmed elevate...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Dubé JB,Boffa MB,Hegele RA,Koschinsky ML

    更新日期:2012-04-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed. RECENT FINDINGS:Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, p...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Doris MK,Dweck MR,Fayad ZA

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Conlon DM

    更新日期:2019-06-01 00:00:00

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    journal_title:Current opinion in lipidology

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


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  • Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery.

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    pub_type: 杂志文章,评审


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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    更新日期:2018-08-01 00:00:00

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    abstract::HDL protects LDL from oxidative damage known to contribute to the onset and progression of atherosclerosis. This antioxidant protection by HDL is mediated by intrinsic hydrolytic enzyme systems, by accelerated selective uptake of lipid peroxides from HDL and by antioxidant molecules. Oxidative damage suffered by HDL a...

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    更新日期:2008-02-01 00:00:00

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    更新日期:2017-06-01 00:00:00

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Smyth N,Ramsay M,Raal FJ

    更新日期:2018-04-01 00:00:00

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


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    更新日期:2010-02-01 00:00:00

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: de Graaf J,Stalenhoef AF

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    abstract::The protective effect of HDL against the development of atherosclerosis appears to be multifaceted involving a number of mechanisms. One of the major mechanisms is, however, the ability of HDL to decrease, directly or indirectly, the lipid peroxidation of LDL. The hydrolysis of lipid peroxides by PON1 makes a major co...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Mackness MI,Durrington PN,Mackness B

    更新日期:2000-08-01 00:00:00

  • The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Seidah NG,Chrétien M,Mbikay M

    更新日期:2018-04-01 00:00:00

  • Smooth muscle cell phenotypic switch: implications for foam cell formation.

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    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Chaabane C,Coen M,Bochaton-Piallat ML

    更新日期:2014-10-01 00:00:00