Hypertension, dyslipidemia, and insulin resistance: links in a chain or spokes on a wheel?


:Rather than a link in a causal chain leading to hypertension, insulin resistance and resultant hyperinsulinemia may be 'spokes on a wheel', with central or visceral obesity as the postulated hub of the wheel. Hypertension, hypertriglyceridemia and high density lipoprotein cholesterol are depicted as other spokes. Newly identified metabolic pathways in adipose tissue or the modulating effects of various predisposing genes may lead to variable expression of various components of the multiple metabolic syndrome in individuals with a predisposition to the collection of visceral fat.


Curr Opin Lipidol


Hopkins PN,Hunt SC,Wu LL,Williams GH,Williams RR




Has Abstract


1996-08-01 00:00:00












  • HDL infusion for the management of atherosclerosis: current developments and new directions.

    abstract:PURPOSE OF REVIEW:Because human genetic studies and large clinical trials have demonstrated that HDL-cholesterol levels are not causally related to cardiovascular disease risk, attention has shifted toward the functional properties of HDL. Infusion of HDL mimetics containing apolipoprotein A-I remains a potential strat...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Zheng KH,Stroes ES

    更新日期:2016-12-01 00:00:00

  • Long-term follow-up of lipid-lowering trials.

    abstract:PURPOSE OF REVIEW:Most LDL-lowering trials are limited in duration while the disease process occurs over decades. It is informative, therefore, to evaluate the long-term effects of treatment by undertaking extended observation beyond the formal double-blind phase of intervention studies. The current review brings toget...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Packard CJ,Ford I

    更新日期:2015-12-01 00:00:00

  • Functional food science and food for specified health use policy in Japan: state of the art.

    abstract:PURPOSE OF REVIEW:The science and policy of functional foods are a matter of global concern and this review provides up-to-date information about the Japanese 'food for specified health use' policy based on functional food science. RECENT FINDINGS:A great many studies on nonnutritive but physiologically functional foo...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Arai S,Yasuoka A,Abe K

    更新日期:2008-02-01 00:00:00

  • HDL-cholesterol and apolipoproteins in relation to dementia.

    abstract:PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Koch M,Jensen MK

    更新日期:2016-02-01 00:00:00

  • Hepatic Niemann-Pick C1-like 1.

    abstract:PURPOSE OF REVIEW:The discovery of Niemann-Pick C1-like 1 (NPC1L1) and ezetimibe, a drug that lowers intestinal cholesterol absorption, has contributed to the recognition of the intestine as an important organ in whole-body cholesterol homeostasis. Unfortunately, the majority of the studies on NPC1L1 have been conducte...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Pramfalk C,Jiang ZY,Parini P

    更新日期:2011-06-01 00:00:00

  • CIDE proteins and metabolic disorders.

    abstract:PURPOSE OF REVIEW:The cell death-inducing DFF45-like effector (CIDE) family proteins, comprising three members, Cidea, Cideb, and Fsp27 (Cidec), have emerged as important regulators for various aspects of metabolism. This review summarizes our current understanding about the physiological roles of CIDE proteins, their ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Gong J,Sun Z,Li P

    更新日期:2009-04-01 00:00:00

  • Peroxisome proliferator-activated receptors in endothelial cell biology.

    abstract::New insights into the endothelium as a dynamic, interactive organ have generated increased interest in endothelial cell transcriptional regulation. Peroxisomal proliferator-activated receptors (PPARs), as ligand-activated nuclear receptors expressed in endothelial cells, represent one important pathway that likely inf...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Plutzky J

    更新日期:2001-10-01 00:00:00

  • Metabolism of innate immune cells: impact on atherosclerosis.

    abstract:PURPOSE OF REVIEW:It is increasingly recognized that profound metabolic changes occur in activated myeloid cells, which shape their inflammatory phenotype and cellular functions. The purpose of this review is to summarize the accumulating evidence that major metabolic adaptations occur in monocytes and macrophages in t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Riksen NP,Stienstra R

    更新日期:2018-10-01 00:00:00

  • Living up to a name: the role of the VLDL receptor in lipid metabolism.

    abstract::The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially pr...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Tacken PJ,Hofker MH,Havekes LM,van Dijk KW

    更新日期:2001-06-01 00:00:00

  • Oxidized phospholipids as modulators of inflammation in atherosclerosis.

    abstract:PURPOSE OF REVIEW:This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions. RECENT FINDINGS:Structural identification of new biologically active oxidized phospholipids and the finding that they can also be formed at inflammatory s...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Leitinger N

    更新日期:2003-10-01 00:00:00

  • When to lower triglycerides?

    abstract:PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章


    authors: Ganda OP

    更新日期:2020-08-01 00:00:00

  • Echolucent rupture-prone plaques.

    abstract:PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Nordestgaard BG,Grønholdt ML,Sillesen H

    更新日期:2003-10-01 00:00:00

  • Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2.

    abstract:PURPOSE OF REVIEW:Low HDL cholesterol and hypertriglyceridemia as well as lowering of LDL cholesterol with statins increase the risk of T2DM. We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin sensitivity of ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: von Eckardstein A,Sibler RA

    更新日期:2011-02-01 00:00:00

  • The effect of dietary cholesterol on macrophage accumulation in adipose tissue: implications for systemic inflammation and atherosclerosis.

    abstract:PURPOSE OF REVIEW:It is well recognized that adipose tissue in obesity is characterized by macrophage accumulation and local inflammation. This review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its potential link to atherosclerosis. RECENT ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Subramanian S,Chait A

    更新日期:2009-02-01 00:00:00

  • Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly.

    abstract::The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Gordon DA

    更新日期:1997-06-01 00:00:00

  • Pleiotropic effects of proprotein convertase subtilisin/kexin type 9 inhibitors?

    abstract:PURPOSE OF REVIEW:Current data suggest that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors may affect many metabolic pathways beyond lowering LDL cholesterol. The aim of the present manuscript is to present these so-called pleiotropic effects of PCSK9 inhibitors. RECENT FINDINGS:PCSK9 may affect the ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Filippatos TD,Christopoulou EC,Elisaf MS

    更新日期:2018-08-01 00:00:00

  • Defects of lipoprotein metabolism in familial combined hyperlipidaemia.

    abstract::Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: de Graaf J,Stalenhoef AF

    更新日期:1998-06-01 00:00:00

  • Is hypertriglyceridemia atherogenic?

    abstract:PURPOSE OF REVIEW:Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological an...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Huet F,Roubille C,Roubille F

    更新日期:2019-08-01 00:00:00

  • The role of the molecular circadian clock in human energy homeostasis.

    abstract:PURPOSE OF REVIEW:The aim of this review is to present the latest findings on the role of the circadian clock in the control of metabolism, and the therapeutic potential of chronotherapy to regulate energy homeostasis in humans. RECENT FINDINGS:We summarized the recent advances related to circadian clock regulation of...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章


    authors: Dollet L,Pendergrast LA,Zierath JR

    更新日期:2021-02-01 00:00:00

  • Bile acid sequestrants: more than simple resins.

    abstract:PURPOSE OF REVIEW:Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regulators of metabolism via induction of various signal transduction pathways. Consequently, BAS treatment may exert unexpected side-effe...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Out C,Groen AK,Brufau G

    更新日期:2012-02-01 00:00:00

  • Microbiota and HDL metabolism.

    abstract:PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Nakaya K,Ikewaki K

    更新日期:2018-02-01 00:00:00

  • Novel anti-inflammatory strategies in atherosclerosis.

    abstract:PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: van der Valk FM,van Wijk DF,Stroes ES

    更新日期:2012-12-01 00:00:00

  • High-density lipoprotein subclasses.

    abstract::This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Skinner ER

    更新日期:1994-06-01 00:00:00

  • PCSK9 inhibitors.

    abstract:PURPOSE OF REVIEW:To summarize the therapeutic strategies to inhibit PCSK9 and to describe the main results obtained in phase I and II trials with monoclonal antibodies targeting PCSK9. RECENT FINDINGS:Among the various approaches for PCSK9 inhibition, human data are only available for inhibition of PCSK9 binding to L...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Farnier M

    更新日期:2013-06-01 00:00:00

  • Novel B-cell subsets in atherosclerosis.

    abstract:PURPOSE OF REVIEW:The number of deaths associated with cardiovascular disease remains high, despite great advances in treating the associated high levels of cholesterol. The main underlying pathology of cardiovascular disease is atherosclerosis, which is recognized as a chronic autoimmune-like inflammatory disease. Hen...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Douna H,Kuiper J

    更新日期:2016-10-01 00:00:00

  • What have we learnt from the clinical outcomes trials with the cetrapibs?

    abstract:PURPOSE OF REVIEW:The current review considers what we have learnt from the clinical outcome trials with the cetrapibs; the inhibitors of cholesteryl ester transfer protein that increase HDL cholesterol levels; torcetrapib, dalcetrapib, evacetrapib and anacetrapib. RECENT FINDINGS:Although an off-target increase in bl...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Doggrell SA

    更新日期:2018-08-01 00:00:00

  • Statin therapy in heart failure.

    abstract:PURPOSE OF REVIEW:The 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitors, or statins, have been shown to reduce cardiovascular morbidity and mortality among a wide spectrum of patients with established atherosclerotic vascular disease. Mounting experimental and clinical evidence also suggest a potential benefit...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Pham M,Oka RK,Giacomini JC

    更新日期:2005-12-01 00:00:00

  • Role of microRNA-30c in lipid metabolism, adipogenesis, cardiac remodeling and cancer.

    abstract:PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Irani S,Hussain MM

    更新日期:2015-04-01 00:00:00

  • The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation.

    abstract:PURPOSE OF REVIEW:The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concent...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Seidah NG,Chrétien M,Mbikay M

    更新日期:2018-04-01 00:00:00

  • Clinical trials of gene therapy for atherosclerotic cardiovascular disease.

    abstract:PURPOSE OF REVIEW:To provide an update on clinical trials of gene therapy for atherosclerotic cardiovascular disease published since 1 August 2001 and summarize the general advantages and potential problems of gene transfer in these disorders. RECENT FINDINGS:There are two major areas in which gene therapy has entered...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审


    authors: Freedman SB

    更新日期:2002-12-01 00:00:00