HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL.

abstract：:A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48. This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 ...

journal_title：Current opinion in lipidology

authors： Davidson NO,Anant S,MacGinnitie AJ

更新日期：1995-04-01 00:00:00

abstract：:PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...

journal_title：Current opinion in lipidology

authors： Klett EL,Patel S

更新日期：2003-08-01 00:00:00

abstract：:The inhibiting effect of insulin on the mobilization of free fatty acids (FFA) from adipose tissue is halted in prevalent conditions with systemic insulin resistance. The nature and cause of this perturbation are unknown, but steroid hormones may be involved. The consequence is the creation or amplification of insulin...

journal_title：Current opinion in lipidology

authors： Björntorp P

更新日期：1994-06-01 00:00:00

abstract：:Based on evidence that hormone replacement therapy is cardioprotective, enthusiasm for universal hormone replacement therapy in postmenopausal women has grown Estrogens lower LDL, raise HDL, dilate arteries and reduce LDL oxidation potential. However, the benefits of hormone replacement therapy must be weighed against...

journal_title：Current opinion in lipidology

authors： Denke MA

更新日期：1996-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor (LDLR) pathway. Because of their molecular defect, current treatment options have limited success in bringing HoFH patient to LDL-C target and morbidit...

journal_title：Current opinion in lipidology

authors： Bajaj A,Cuchel M

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

journal_title：Current opinion in lipidology

authors： Wang S,Kaufman RJ

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Epidemiological and clinical studies link low levels of HDL cholesterol (HDL-C) with increased risk of atherosclerotic cardiovascular disease (CVD). However, genetic polymorphisms linked to HDL-C do not associate consistently with CVD risk, and randomized clinical studies of drugs that elevate HDL-C v...

journal_title：Current opinion in lipidology

authors： Ronsein GE,Heinecke JW

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Dietary and blood carotenoids, including alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and beta-cryptoxanthin, have been examined in a number of epidemiological studies in recent years for the risk of cardiovascular disease. This review assimilated the existing and recent literature on c...

journal_title：Current opinion in lipidology

authors： Sesso HD

更新日期：2006-02-01 00:00:00

abstract：:Thia substituted fatty acids are saturated fatty acids which are modified by insertion of a sulfur atom at specific positions in the carbon backbone. During the last few years pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed. The biological responses to tetradecylthioacetic aci...

journal_title：Current opinion in lipidology

authors： Berge RK,Skorve J,Tronstad KJ,Berge K,Gudbrandsen OA,Grav H

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on recent mechanistic and clinical trial data related to the actions and efficacy of niacin. RECENT FINDINGS:Recent mechanistic studies have provided novel insights regarding the mechanism of action of niacin. Studies of the purported niacin receptor, GPR109A, indicate that niaci...

journal_title：Current opinion in lipidology

authors： Ginsberg HN,Reyes-Soffer G

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The metabolic syndrome has become a leading health concern in developed countries. In the search for strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an attractive therapeutic strategy. However, recent studies warn of potentially harmful conse...

journal_title：Current opinion in lipidology

authors： Brown JM,Rudel LL

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...

journal_title：Current opinion in lipidology

authors： Fruchart JC,Santos RD

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review covers recent developments in microarray studies in the field of atherogenesis research. RECENT FINDINGS:During the past year microarrays have been applied to the analysis of pathogenic mechanisms of several atherosclerosis risk factors, including ageing, hypertension, obesity, and cytome...

journal_title：Current opinion in lipidology

authors： Tuomisto TT,Ylä-Herttuala S

更新日期：2005-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent evidence proposing that lipids and lipoproteins can act as nuclear factors regulating chromatin structure. These novel data broaden our understanding of the mechanisms by which lipoproteins can affect basic biological phenomena such as transcription, genome stability, and c...

journal_title：Current opinion in lipidology

authors： Zaina S,Døssing KB,Lindholm MW,Lund G

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Most LDL-lowering trials are limited in duration while the disease process occurs over decades. It is informative, therefore, to evaluate the long-term effects of treatment by undertaking extended observation beyond the formal double-blind phase of intervention studies. The current review brings toget...

journal_title：Current opinion in lipidology

authors： Packard CJ,Ford I

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides recent insights on the early onset of atherosclerosis in heterozygous familial hypercholesterolemia and reports on novel treatment options as well as on the consequences of long-term statin use in childhood. RECENT FINDINGS:Children with familial hypercholesterolemia have greate...

journal_title：Current opinion in lipidology

authors： Braamskamp MJ,Hutten BA,Wiegman A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Alterations in the gut microbiome composition or function are associated with risk factors for cardiometabolic diseases, including hypertension, hyperlipidemia and hyperglycemia. Based on recent evidence that also oral medications used to treat these conditions could alter the gut microbiome compositi...

journal_title：Current opinion in lipidology

authors： Balvers M,van den Born BH,Levin E,Nieuwdorp M

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvención con DIeta MEDiterránea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 2003-2010 and represented the largest primary prevention trial ever test...

journal_title：Current opinion in lipidology

authors： Fernández-Lázaro CI,Ruiz-Canela M,Martínez-González MÁ

更新日期：2021-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Fatty acid transport proteins are a family of proteins involved in fatty acid uptake and activation. This review summarizes recent progress in elucidating the function of fatty acid transport proteins. RECENT FINDINGS:Recent experiments clearly establish FATP1 as a regulated fatty acid transporter in...

journal_title：Current opinion in lipidology

authors： Gimeno RE

更新日期：2007-06-01 00:00:00

abstract：:The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially pr...

journal_title：Current opinion in lipidology

authors： Tacken PJ,Hofker MH,Havekes LM,van Dijk KW

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Familial hypercholesterolemia is associated with a high lifetime risk of atherosclerotic cardiovascular disease (ASCVD). However, this risk is variable. This review evaluates recent evidence related to ASCVD risk stratification in familial hypercholesterolemia considering aspects of phenotype and geno...

journal_title：Current opinion in lipidology

authors： Santos RD

更新日期：2017-04-01 00:00:00

abstract：:Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

journal_title：Current opinion in lipidology

authors： de Graaf J,Stalenhoef AF

更新日期：1998-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：:Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...

journal_title：Current opinion in lipidology

authors： Liscum L,Klansek JJ

更新日期：1998-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to present the latest findings on the role of the circadian clock in the control of metabolism, and the therapeutic potential of chronotherapy to regulate energy homeostasis in humans. RECENT FINDINGS:We summarized the recent advances related to circadian clock regulation of...

journal_title：Current opinion in lipidology

authors： Dollet L,Pendergrast LA,Zierath JR

更新日期：2021-02-01 00:00:00

abstract：:Atherosclerotic cardiovascular disease is the most common complication of diabetes. Recent guidelines in the USA have underlined the importance of treating lipid abnormalities in people with diabetes in order to reduce the risk of this complication. Should lifestyle approaches not be sufficient drugs will need to be a...

journal_title：Current opinion in lipidology

authors： Steiner G

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of newly described mechanisms by which peroxisome proliferator-activated receptors (PPARs) (α, γ, and δ) regulate several factors associated with cardiovascular risk. RECENT FINDINGS:PPAR agonists have known effects on plasma lipoprotein levels, inflammation, and insu...

journal_title：Current opinion in lipidology

authors： Millar JS

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In the last 2 years, significant advances in the understanding of HDL particle structure and the associations between particle structure, function, and atherosclerosis have been made. We will review and provide clinical and epidemiological context to these recent advances. RECENT FINDINGS:Several rec...

journal_title：Current opinion in lipidology

authors： Wilkins JT,Seckler HS

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent advances towards an understanding of the three-dimensional structures of the apolipoprotein components of HDL with a specific focus on high resolution models of apolipoprotein A-I. RECENT FINDINGS:Since the primary sequence was first reported, various models have been advanced for...

journal_title：Current opinion in lipidology

authors： Davidson WS,Silva RA

更新日期：2005-06-01 00:00:00

abstract：:Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by...

journal_title：Current opinion in lipidology

authors： Ylä-Herttuala S

更新日期：1998-08-01 00:00:00