Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins.

abstract：PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...

journal_title：Current opinion in lipidology

authors： Gisterå A,Ketelhuth DFJ

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Response to statin treatment can vary widely from person to person as a result of inherited traits (genotype) and acquired characteristics such as obesity (phenotype). The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to exp...

journal_title：Current opinion in lipidology

authors： Caslake MJ,Packard CJ

更新日期：2004-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to summarize and discuss recent advances in the understanding of the physiological role of lipoprotein lipase in lipid and energy metabolism. RECENT FINDINGS:Studies on the transcriptional and the posttranscriptional level of lipoprotein lipase expression have provided new i...

journal_title：Current opinion in lipidology

authors： Preiss-Landl K,Zimmermann R,Hämmerle G,Zechner R

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Dementia is a major cause of disability and institutionalization. Apart from age and apolipoprotein E (APOE) genotype, there are currently no established, clinically relevant, noninvasive markers of dementia. We conducted a literature search of recent observational epidemiological studies evaluating t...

journal_title：Current opinion in lipidology

authors： Koch M,Jensen MK

更新日期：2016-02-01 00:00:00

abstract：:Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by...

journal_title：Current opinion in lipidology

authors： Ylä-Herttuala S

更新日期：1998-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Angiogenesis and inflammation are important features in atherosclerotic plaque destabilization. The transcription factors hypoxia-inducible factor-1alpha and Notch are key regulators of angiogenesis. In addition, hypoxia-inducible factor-1alpha has been linked to regulation of inflammatory processes a...

journal_title：Current opinion in lipidology

authors： Ruas JL,Lendahl U,Poellinger L

更新日期：2007-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. RECENT FINDI...

journal_title：Current opinion in lipidology

authors： Kromhout D,de Goede J

更新日期：2014-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Capsaicin and its nonpungent analog (capsinoids) are known to be food ingredients that increase energy expenditure and decrease body fat. This article reviews the role of brown adipose tissue (BAT) for the thermogenic effect of these compounds in humans and proposes the possibility of some other antio...

journal_title：Current opinion in lipidology

authors： Saito M,Yoneshiro T

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Several mutations in the apolipoprotein (apo) B, proprotein convertase subtilisin kexin 9 (PCSK9) and microsomal triglyceride transfer protein genes result in low or absent levels of apoB and LDL cholesterol (LDL-C) in plasma which cause familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia...

journal_title：Current opinion in lipidology

authors： Welty FK

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Inherited lipodystrophies are rare autosomal recessive and dominant disorders characterized by selective, but variable, loss of adipose tissue. Marked hypertriglyceridemia is a common feature of these disorders and highlights the role of adipose tissue in lipid homeostasis. In the last decade, advance...

journal_title：Current opinion in lipidology

authors： Simha V,Garg A

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The endoplasmic reticulum (ER) maintains cellular metabolic homeostasis by coordinating protein synthesis, secretion activities, lipid biosynthesis and calcium (Ca²⁺) storage. In this review, we will discuss how altered ER homeostasis contributes to dysregulation of hepatic lipid metabolism and contri...

journal_title：Current opinion in lipidology

authors： Wang S,Kaufman RJ

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the cell surface. Genome-wide association studies (GWAS) revealed an association between sortilin and reduced plasma LDL-cholesterol (LDL-C) as we...

journal_title：Current opinion in lipidology

authors： Conlon DM

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:As our understanding of cardiovascular disease has advanced over the past decades, multiple novel treatment strategies have been developed with the hope of reducing the global morbidity and mortality associated with this condition. Large-scale trials to test such novel therapies using clinical end poi...

journal_title：Current opinion in lipidology

authors： Doris MK,Dweck MR,Fayad ZA

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Control of vascular smooth muscle cell (VSMC) phenotype is essential in the development and maintenance of a healthy vasculature. Acquisition of a synthetic, proproliferative phenotype by VSMCs following vascular insult is central to neointimal formation and the development of vascular pathology. Micr...

journal_title：Current opinion in lipidology

authors： Robinson HC,Baker AH

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have shown the three-member paraoxonase (PON) multigene family to be involved in the development of a large variety of diseases with an inflammatory component. Environmental factors such as lifestyle-related factors differ widely between populations and it is important to consider that their i...

journal_title：Current opinion in lipidology

authors： Mahrooz A,Mackness M

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Phytosterols and stanols are plant derivatives that compete with cholesterol for intestinal absorption and thereby lower serum cholesterol concentrations. They have been developed as food additives to help lower serum cholesterol but there is concern that these additives could inadvertently increase c...

journal_title：Current opinion in lipidology

authors： John S,Sorokin AV,Thompson PD

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor (LDLR) pathway. Because of their molecular defect, current treatment options have limited success in bringing HoFH patient to LDL-C target and morbidit...

journal_title：Current opinion in lipidology

authors： Bajaj A,Cuchel M

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Regulation of cholesterol homeostasis is a complex interplay of a multitude of metabolic pathways situated in different organs. The liver plays a central role and has received most attention of the research community. In this review, we discuss recent progress in the understanding of the emerging role...

journal_title：Current opinion in lipidology

authors： van der Velde AE,Brufau G,Groen AK

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses a syndrome of dyslipidemia and lipodystrophy that has emerged in HIV-infected patients receiving highly active antiretroviral therapy (HAART). The term 'HIV/HAART associated dyslipidemic lipodystrophy (HADL)' describes this syndrome. Although HAART increases patient survival rate...

journal_title：Current opinion in lipidology

authors： Balasubramanyam A,Sekhar RV,Jahoor F,Jones PH,Pownall HJ

更新日期：2004-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The systematic analysis of the major candidate genes in autosomal dominant hypercholesterolemia (ADH) and the use of next-generation sequencing (NGS) technology have made possible the discovery of several rare gene variants whose pathogenic effect in most cases remains poorly defined. RECENT FINDINGS...

journal_title：Current opinion in lipidology

authors： Calandra S,Tarugi P,Bertolini S

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of deaths associated with cardiovascular disease remains high, despite great advances in treating the associated high levels of cholesterol. The main underlying pathology of cardiovascular disease is atherosclerosis, which is recognized as a chronic autoimmune-like inflammatory disease. Hen...

journal_title：Current opinion in lipidology

authors： Douna H,Kuiper J

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins. RECENT FINDINGS:Gpihbp1 knockout mice on a chow diet have milky plasma and plasma triglyceride level...

journal_title：Current opinion in lipidology

authors： Beigneux AP,Weinstein MM,Davies BS,Gin P,Bensadoun A,Fong LG,Young SG

更新日期：2009-06-01 00:00:00

abstract：:Further understanding of the causative link between plasma lipids and coronary heart disease will come from a deeper appreciation of the impact of lipoprotein heterogeneity on the processes of atherosclerosis and thrombosis. It is now widely appreciated that remnants of triglyceride-rich lipoproteins, IDL and specific...

journal_title：Current opinion in lipidology

authors： Packard CJ

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review considers what we have learnt from the clinical outcome trials with the cetrapibs; the inhibitors of cholesteryl ester transfer protein that increase HDL cholesterol levels; torcetrapib, dalcetrapib, evacetrapib and anacetrapib. RECENT FINDINGS:Although an off-target increase in bl...

journal_title：Current opinion in lipidology

authors： Doggrell SA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. RECENT FINDINGS:Several lines of evidence indicate t...

journal_title：Current opinion in lipidology

authors： Ganda OP

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rup...

journal_title：Current opinion in lipidology

authors： Nordestgaard BG,Grønholdt ML,Sillesen H

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Low HDL cholesterol and hypertriglyceridemia as well as lowering of LDL cholesterol with statins increase the risk of T2DM. We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin sensitivity of ...

journal_title：Current opinion in lipidology

authors： von Eckardstein A,Sibler RA

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses how, in atherosclerosis or systemic inflammation, HDL can lose its usual atheroprotective characteristics and even paradoxically assume proinflammatory properties. RECENT FINDINGS:Specific chemical and structural changes within HDL particles can impede reverse cholesterol transp...

journal_title：Current opinion in lipidology

authors： Ansell BJ,Fonarow GC,Fogelman AM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the therapeutic strategies to inhibit PCSK9 and to describe the main results obtained in phase I and II trials with monoclonal antibodies targeting PCSK9. RECENT FINDINGS:Among the various approaches for PCSK9 inhibition, human data are only available for inhibition of PCSK9 binding to L...

journal_title：Current opinion in lipidology

authors： Farnier M

更新日期：2013-06-01 00:00:00

abstract：:The mechanism and regulation of the degradation of cholesterol into bile acids has attracted increased interest, in particular after the recent discovery that nuclear receptors (farnesoid X receptor and liver X receptor) are involved in the regulation of bile acid synthesis. Recently, it has also been shown that the b...

journal_title：Current opinion in lipidology

authors： Björkhem I,Eggertsen G

更新日期：2001-04-01 00:00:00