Lipid-driven immunometabolic responses in atherosclerosis.

Abstract:

PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insights on lipid-driven immune activation, which could pave the way for new anti-inflammatory treatments for atherosclerosis. RECENT FINDINGS:Immunometabolic interactions can shape the immune response. Within atherosclerotic plaques, macrophages and T cells are the dominant immune cell populations. Using multiple mechanisms, lipoprotein-derived components activate both the innate and adaptive immune systems. Cholesterol crystals and apolipoprotein B-peptides have been shown to activate macrophages and T cells, respectively. Lipoproteins are also important modulators of regulatory T cells that can hamper vascular inflammation. In the liver, T cells can influence hepatic inflammation and lipoprotein metabolism. Hence, there is an intricate crosstalk between the immune system and lipoprotein metabolism. SUMMARY:Novel treatments are needed to prevent clinical manifestations of atherosclerosis. Improved understanding of lipid-driven immunometabolic responses is likely to reveal new therapeutic targets.

journal_name

Curr Opin Lipidol

authors

Gisterå A,Ketelhuth DFJ

doi

10.1097/MOL.0000000000000540

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

375-380

issue

5

eissn

0957-9672

issn

1473-6535

pii

00041433-201810000-00004

journal_volume

29

pub_type

杂志文章,评审
  • Response of low density lipoprotein cholesterol levels to dietary change: contributions of different mechanisms.

    abstract::In many individuals, LDL-cholesterol levels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturated fatty acids. In others, a reduction of cholesterogenesis fully compensates for these effects. In responding individuals, much of the increase in LDL-cholesterol observed may re...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-199702000-00009

    authors: Fielding CJ

    更新日期:1997-02-01 00:00:00

  • Apolipoprotein B messenger RNA editing: insights into the molecular regulation of post-transcriptional cytidine deamination.

    abstract::A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48. This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-199504000-00002

    authors: Davidson NO,Anant S,MacGinnitie AJ

    更新日期:1995-04-01 00:00:00

  • Update on cardiometabolic health effects of ω-3 fatty acids.

    abstract:PURPOSE OF REVIEW:The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. RECENT FINDI...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000041

    authors: Kromhout D,de Goede J

    更新日期:2014-02-01 00:00:00

  • HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL.

    abstract:PURPOSE OF REVIEW:The absolute level of HDL cholesterol (HDL-C) may not be the only criterion contributing to their antiatherothrombotic effects. This review focuses on evidence in support of the concept that HDL-bound sphingosine-1-phosphate (S1P) plays a role in different HDL atheroprotective properties and may repre...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e328361f822

    authors: Egom EE,Mamas MA,Soran H

    更新日期:2013-08-01 00:00:00

  • Modulation of vascular gene expression by hypoxia.

    abstract:PURPOSE OF REVIEW:Angiogenesis and inflammation are important features in atherosclerotic plaque destabilization. The transcription factors hypoxia-inducible factor-1alpha and Notch are key regulators of angiogenesis. In addition, hypoxia-inducible factor-1alpha has been linked to regulation of inflammatory processes a...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e3282efe49d

    authors: Ruas JL,Lendahl U,Poellinger L

    更新日期:2007-10-01 00:00:00

  • The value of apolipoprotein E knockout mice for studying the effects of dietary fat and cholesterol on atherogenesis.

    abstract::The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200002000-00004

    authors: Osada J,Joven J,Maeda N

    更新日期:2000-02-01 00:00:00

  • Lipoprotein receptors in the vascular wall.

    abstract:PURPOSE OF REVIEW:We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall. RECENT FINDINGS:Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200404000-00010

    authors: Herz J,Hui DY

    更新日期:2004-04-01 00:00:00

  • Possible contributions of lipoproteins and cholesterol to the pathogenesis of diabetes mellitus type 2.

    abstract:PURPOSE OF REVIEW:Low HDL cholesterol and hypertriglyceridemia as well as lowering of LDL cholesterol with statins increase the risk of T2DM. We discuss the recent findings on the effects of lipoproteins and cholesterol on the function and survival of pancreatic β-cells as well as on obesity and insulin sensitivity of ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e3283412279

    authors: von Eckardstein A,Sibler RA

    更新日期:2011-02-01 00:00:00

  • The paraoxonase gene family and coronary heart disease.

    abstract:PURPOSE OF REVIEW:The antioxidant activity of high-density lipoprotein is largely due to the paraoxonase 1 located on it. Experiments with transgenic paraoxonase 1 knock-out mice indicate the potential for this enzyme to protect against atherogenesis. This effect of high-density lipoprotein in decreasing low-density li...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200208000-00002

    authors: Mackness B,Durrington PN,Mackness MI

    更新日期:2002-08-01 00:00:00

  • Epigenetics of paraoxonases.

    abstract:PURPOSE OF REVIEW:Studies have shown the three-member paraoxonase (PON) multigene family to be involved in the development of a large variety of diseases with an inflammatory component. Environmental factors such as lifestyle-related factors differ widely between populations and it is important to consider that their i...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000687

    authors: Mahrooz A,Mackness M

    更新日期:2020-08-01 00:00:00

  • Defects of lipoprotein metabolism in familial combined hyperlipidaemia.

    abstract::Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-199806000-00002

    authors: de Graaf J,Stalenhoef AF

    更新日期:1998-06-01 00:00:00

  • Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery.

    abstract:PURPOSE OF REVIEW:The metabolic syndrome has become a leading health concern in developed countries. In the search for strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an attractive therapeutic strategy. However, recent studies warn of potentially harmful conse...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e32833854ac

    authors: Brown JM,Rudel LL

    更新日期:2010-06-01 00:00:00

  • Expression profiling and comparative sequence derived insights into lipid metabolism.

    abstract::Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes that are involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes that are involved in important processes in lipid meta...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200204000-00009

    authors: Callow MJ,Rubin EM

    更新日期:2002-04-01 00:00:00

  • Exercise and fat accumulation in the human liver.

    abstract:PURPOSE OF REVIEW:Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IH...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e32833ea912

    authors: Magkos F

    更新日期:2010-12-01 00:00:00

  • Ambivalence of progenitor cells in vascular repair and plaque stability.

    abstract:PURPOSE OF REVIEW:To discuss crucial cues (chemokines, adhesion molecules and pharmacological means) that guide and control the context-specific mobilization, recruitment and fate of circulating progenitor cells in arterial repair and plaque stability. RECENT FINDINGS:The mobilization and recruitment of bone marrow de...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e32830dfe33

    authors: Hristov M,Weber C

    更新日期:2008-10-01 00:00:00

  • RNA interference to target lipid disorders.

    abstract:PURPOSE OF REVIEW:This review focuses on proof-of-principle experiments providing validation of new targets for the development of RNA interference-based therapeutics for dyslipidemia. RECENT FINDINGS:Over the past few years, RNA interference has become an accepted approach to manipulate gene expression in mammalian s...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e3282ff861e

    authors: Rondinone CM

    更新日期:2008-06-01 00:00:00

  • Metabolism of oxidized LDL by macrophages.

    abstract::Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on th...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200010000-00005

    authors: Jessup W,Kritharides L

    更新日期:2000-10-01 00:00:00

  • Genetic, biochemical, and clinical features of LCAT deficiency: update for 2020.

    abstract:PURPOSE OF REVIEW:Genetic LCAT deficiency is a rare metabolic disorder characterized by low-plasma HDL cholesterol levels. Clinical manifestations of the disease include corneal opacification, anemia, and renal disease, which represents the major cause of morbidity and mortality in carriers. RECENT FINDINGS:Biochemica...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章

    doi:10.1097/MOL.0000000000000697

    authors: Pavanello C,Calabresi L

    更新日期:2020-08-01 00:00:00

  • The effect of dietary cholesterol on macrophage accumulation in adipose tissue: implications for systemic inflammation and atherosclerosis.

    abstract:PURPOSE OF REVIEW:It is well recognized that adipose tissue in obesity is characterized by macrophage accumulation and local inflammation. This review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its potential link to atherosclerosis. RECENT ...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/mol.0b013e32831bef8b

    authors: Subramanian S,Chait A

    更新日期:2009-02-01 00:00:00

  • Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins.

    abstract:PURPOSE OF REVIEW:To summarize recent advances towards an understanding of the three-dimensional structures of the apolipoprotein components of HDL with a specific focus on high resolution models of apolipoprotein A-I. RECENT FINDINGS:Since the primary sequence was first reported, various models have been advanced for...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mol.0000169349.38321.ad

    authors: Davidson WS,Silva RA

    更新日期:2005-06-01 00:00:00

  • Early initiation of statin treatment in children with familial hypercholesterolaemia.

    abstract:PURPOSE OF REVIEW:This article provides recent insights on the early onset of atherosclerosis in heterozygous familial hypercholesterolemia and reports on novel treatment options as well as on the consequences of long-term statin use in childhood. RECENT FINDINGS:Children with familial hypercholesterolemia have greate...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000177

    authors: Braamskamp MJ,Hutten BA,Wiegman A

    更新日期:2015-06-01 00:00:00

  • Role of microRNA-30c in lipid metabolism, adipogenesis, cardiac remodeling and cancer.

    abstract:PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000162

    authors: Irani S,Hussain MM

    更新日期:2015-04-01 00:00:00

  • Impact of rare variants in autosomal dominant hypercholesterolemia causing genes.

    abstract:PURPOSE OF REVIEW:The systematic analysis of the major candidate genes in autosomal dominant hypercholesterolemia (ADH) and the use of next-generation sequencing (NGS) technology have made possible the discovery of several rare gene variants whose pathogenic effect in most cases remains poorly defined. RECENT FINDINGS...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000414

    authors: Calandra S,Tarugi P,Bertolini S

    更新日期:2017-06-01 00:00:00

  • Population specific genetic heterogeneity of familial hypercholesterolemia in South Africa.

    abstract:PURPOSE OF REVIEW:To describe the prevalence and population-specific genetic heterogeneity of familial hypercholesterolemia in South Africa. RECENT FINDINGS:This review highlights the paucity of data on familial hypercholesterolemia in South Africa, and the urgent need to uncover the mutation profiles in lipid-associa...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000488

    authors: Smyth N,Ramsay M,Raal FJ

    更新日期:2018-04-01 00:00:00

  • Microbiota and HDL metabolism.

    abstract:PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0000000000000472

    authors: Nakaya K,Ikewaki K

    更新日期:2018-02-01 00:00:00

  • Conjugated linoleic acid: effects on plasma lipids and cardiovascular function.

    abstract::Conjugated linoleic acid is a collective name for mixtures of several positional and geometric conjugated dienoic isomers of linoleic acid, which have been shown to impact favorably on several biological processes, particularly carcinogenesis. Recent studies have clearly established that the c9, t11 and t10, c12 isome...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200102000-00006

    authors: Khosla P,Fungwe TV

    更新日期:2001-02-01 00:00:00

  • Circulating oxidized LDL: a biomarker and a pathogenic factor.

    abstract:PURPOSE OF REVIEW:Oxidized LDL (oxLDL) contributes to many atherogenic steps in the vascular wall, but the significance of oxLDL in circulating blood remains unclear. Recent progress in procedures for measuring both human and murine oxLDL has provided growing evidence of the importance of circulating oxLDL. RECENT FIN...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e32832fa58d

    authors: Ishigaki Y,Oka Y,Katagiri H

    更新日期:2009-10-01 00:00:00

  • Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism.

    abstract:PURPOSE OF REVIEW:This review highlights the recent key advances in our understanding of the role of phospholipid transfer protein in lipid and lipoprotein metabolism. RECENT FINDINGS:The overexpression of human phospholipid transfer protein in mice is associated with an increase in atherosclerosis. This is consistent...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200406000-00004

    authors: Albers JJ,Cheung MC

    更新日期:2004-06-01 00:00:00

  • Lipoprotein(a): more interesting than ever after 50 years.

    abstract:PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). RECENT FINDINGS:Recent large-scale meta-analyses have confirmed elevate...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/MOL.0b013e32835111d8

    authors: Dubé JB,Boffa MB,Hegele RA,Koschinsky ML

    更新日期:2012-04-01 00:00:00

  • Recent advances in liver-directed gene therapy: implications for the treatment of dyslipidemia.

    abstract::Somatic gene therapy for the treatment of dyslipidemia is an area of active investigation. A substantial body of data indicates that the transfer of various lipid-lowering genes to the liver is an effective method of restoring normal plasma lipids in animal models of dyslipidemia. Most studies have used adenoviral vec...

    journal_title:Current opinion in lipidology

    pub_type: 杂志文章,评审

    doi:10.1097/00041433-200004000-00011

    authors: Oka K,Davis AR,Chan L

    更新日期:2000-04-01 00:00:00