Modulation of vascular gene expression by hypoxia.

abstract：PURPOSE OF REVIEW:A healthy diet should be rich in vegetables and fruits, whole-grain, high-fiber foods, and fish and should contain a small amount of saturated and trans fats. In addition to these recommendations, some food ingredients such as plant sterol/stanol soy protein and isoflavones may help reduce cholesterol...

journal_title：Current opinion in lipidology

authors： Bruckert E,Rosenbaum D

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concent...

journal_title：Current opinion in lipidology

authors： Seidah NG,Chrétien M,Mbikay M

更新日期：2018-04-01 00:00:00

abstract：:Low folate intake is an important determinant of elevated blood levels of homocysteine. Because elevated homocysteine has been shown to be a possible graded risk factor for CHD, sufficient folate intake may be important in the prevention of CHD. The magnitude of the association between folate and CHD is consistent wit...

journal_title：Current opinion in lipidology

authors： Verhoef P,Stampfer MJ,Rimm EB

更新日期：1998-02-01 00:00:00

abstract：:The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

journal_title：Current opinion in lipidology

authors： Osada J,Joven J,Maeda N

更新日期：2000-02-01 00:00:00

abstract：:Most of the LDL receptor family members recognize apolipoprotein E. The structures of the VLDL receptor, and recently identified apolipoprotein E receptor 2, closely resemble the LDL receptor. Recent studies have demonstrated that the VLDL receptor is responsible for the reproduction of premammalian species by mediati...

journal_title：Current opinion in lipidology

authors： Yamamoto T,Bujo H

更新日期：1996-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

journal_title：Current opinion in lipidology

authors： Li S,Loos RJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The interest for the human HDL system was recently revived by the identification of the ABCA1 as a critical component in the formation and maintenance of plasma HDL levels. The present review focuses on recent progress in our understanding of the basic mechanisms underlying HDL biogenesis pathways. R...

journal_title：Current opinion in lipidology

authors： Krimbou L,Marcil M,Genest J

更新日期：2006-06-01 00:00:00

abstract：:Abetalipoproteinemia is a recessive genetic disease in humans characterized by the virtual absence of apolipoprotein (apo)B and apoB-containing lipoproteins in plasma. Microsomal triglyceride transfer protein (MTP), a resident lipid transfer protein within the endoplasmic reticulum of hepatocytes and enterocytes, has ...

journal_title：Current opinion in lipidology

authors： Gregg RE,Wetterau JR

更新日期：1994-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed. RECENT FINDINGS:Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, p...

journal_title：Current opinion in lipidology

authors： Steffens S,Mach F

更新日期：2006-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Fat accumulation in the liver is strongly associated with metabolic dysfunction. Regular exercise improves many cardiometabolic risks factors; however, its effect on intrahepatic triglyceride (IHTG) content remains elusive. This article summarizes available data regarding the effects of exercise on IH...

journal_title：Current opinion in lipidology

authors： Magkos F

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The occurrence in blood of an electronegatively charged LDL was described in 1988. During the 1990s reports studying electronegative LDL (LDL(-)) were scant and its atherogenic role controversial. Nevertheless, recent reports have provided new evidence on a putative atherogenic role of LDL(-). This re...

journal_title：Current opinion in lipidology

authors： Sánchez-Quesada JL,Benítez S,Ordóñez-Llanos J

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Mesenchymal stem cells (or multipotent stromal cells) are emerging as a potent cell type for cardiac cell therapy. This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics. RECENT FI...

journal_title：Current opinion in lipidology

authors： Atsma DE,Fibbe WE,Rabelink TJ

更新日期：2007-12-01 00:00:00

abstract：:Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

journal_title：Current opinion in lipidology

authors： de Graaf J,Stalenhoef AF

更新日期：1998-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The article reviews the challenges facing cardiovascular disease (CVD) guidelines committees. RECENT FINDINGS:Clinical trials in high-risk populations have shown additional CVD event reduction with ezetimibe and proprotein convertase subtilisin-kexin-9 inhibitors. These trials recruit middle-aged sec...

journal_title：Current opinion in lipidology

authors： Wierzbicki AS

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Brown adipose tissue (BAT) is an emerging target to combat cardiometabolic disorders as it can take up substantial amounts of glucose and lipids from the circulation for heat production. This review focuses on new concepts in BAT physiology and discusses the need for new techniques to determine BAT ac...

journal_title：Current opinion in lipidology

authors： Schilperoort M,Hoeke G,Kooijman S,Rensen PC

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...

journal_title：Current opinion in lipidology

authors： Gisterå A,Ketelhuth DFJ

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Bile acid sequestrants (BAS) have been used for more than 50 years in the treatment of hypercholesterolemia. The last decade, bile acids are emerging as integrated regulators of metabolism via induction of various signal transduction pathways. Consequently, BAS treatment may exert unexpected side-effe...

journal_title：Current opinion in lipidology

authors： Out C,Groen AK,Brufau G

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide an update on the most recent and relevant findings in the area of genotype-phenotype associations as well as the relationships between genetic factors and cardiovascular disease risk markers and events. In addition, emphasis will be placed on the methodological pr...

journal_title：Current opinion in lipidology

authors： Visvikis-Siest S,Marteau JB

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

journal_title：Current opinion in lipidology

authors： Nakaya K,Ikewaki K

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The science and policy of functional foods are a matter of global concern and this review provides up-to-date information about the Japanese 'food for specified health use' policy based on functional food science. RECENT FINDINGS:A great many studies on nonnutritive but physiologically functional foo...

journal_title：Current opinion in lipidology

authors： Arai S,Yasuoka A,Abe K

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the fact that regional differences in the normal arterial intima are critical to atherosclerotic lesion formation driven by systemic risk factors. RECENT FINDINGS:At arterial curvatures, bifurcations and branches unique hemodynamics influence endothelial cell signaling and gene expressio...

journal_title：Current opinion in lipidology

authors： Cybulsky MI,Jongstra-Bilen J

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...

journal_title：Current opinion in lipidology

authors： Fruchart JC,Santos RD

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammation has been widely acknowledged to contribute throughout all stages of atherogenesis. However, these recent advances in our understanding have not been translated into clinical practice in which the mainstay of treatment is still lipid-targeted therapy. This review provides an overview of pr...

journal_title：Current opinion in lipidology

authors： van der Valk FM,van Wijk DF,Stroes ES

更新日期：2012-12-01 00:00:00

abstract：:The Smith-Lemli-Opitz syndrome is a disorder of morphogenesis resulting from an enzymatic defect in the last step of cholesterol metabolism (reduction of 7-dehydrocholesterol). Analysis of the defective gene and identification of mutations therein have paved the way for the study of the molecular genetics of the disor...

journal_title：Current opinion in lipidology

authors： Fitzky BU,Glossmann H,Utermann G,Moebius FF

更新日期：1999-04-01 00:00:00

abstract：:New insights into the endothelium as a dynamic, interactive organ have generated increased interest in endothelial cell transcriptional regulation. Peroxisomal proliferator-activated receptors (PPARs), as ligand-activated nuclear receptors expressed in endothelial cells, represent one important pathway that likely inf...

journal_title：Current opinion in lipidology

authors： Plutzky J

更新日期：2001-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...

journal_title：Current opinion in lipidology

authors： Preiss D,Sattar N

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Several mutations in the apolipoprotein (apo) B, proprotein convertase subtilisin kexin 9 (PCSK9) and microsomal triglyceride transfer protein genes result in low or absent levels of apoB and LDL cholesterol (LDL-C) in plasma which cause familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia...

journal_title：Current opinion in lipidology

authors： Welty FK

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, ...

journal_title：Current opinion in lipidology

authors： Schattenberg JM,Schuppan D

更新日期：2011-12-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

journal_title：Current opinion in lipidology

authors： Irani S,Hussain MM

更新日期：2015-04-01 00:00:00