Opportunities and challenges for mesenchymal stem cell-mediated heart repair.

abstract：PURPOSE OF REVIEW:Epidemiological and clinical studies link low levels of HDL cholesterol (HDL-C) with increased risk of atherosclerotic cardiovascular disease (CVD). However, genetic polymorphisms linked to HDL-C do not associate consistently with CVD risk, and randomized clinical studies of drugs that elevate HDL-C v...

journal_title：Current opinion in lipidology

authors： Ronsein GE,Heinecke JW

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：:Conjugated linoleic acid is a collective name for mixtures of several positional and geometric conjugated dienoic isomers of linoleic acid, which have been shown to impact favorably on several biological processes, particularly carcinogenesis. Recent studies have clearly established that the c9, t11 and t10, c12 isome...

journal_title：Current opinion in lipidology

authors： Khosla P,Fungwe TV

更新日期：2001-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concent...

journal_title：Current opinion in lipidology

authors： Seidah NG,Chrétien M,Mbikay M

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, and type 2 diabetes. Here, we review recent work that clarified lo...

journal_title：Current opinion in lipidology

authors： Williams KJ,Chen K

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Hepatic steatosis is a leading cause of adult and paediatric liver disease and is inextricably linked to obesity, insulin resistance and cardiovascular disease. Here we summarize our current understanding of the role of the patatin-like phospholipase domain-containing 3 gene (PNPLA3) in hepatic steato...

journal_title：Current opinion in lipidology

authors： Romeo S,Huang-Doran I,Baroni MG,Kotronen A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past two decades serious efforts has been invested in the search for genes that predispose to common obesity, but progress has been slow and success limited. Genome-wide association, however, has revived optimism. Here we review recent advances in the field of obesity genetics and discuss the...

journal_title：Current opinion in lipidology

authors： Li S,Loos RJ

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In recent years, many of the concerns surrounding the glycemic index have been addressed by methodological studies and clinical trials comparing diets carefully matched for other nutrients. These findings are reviewed together with new observational evidence for the role of the dietary glycemic index ...

journal_title：Current opinion in lipidology

authors： Brand-Miller J,Buyken AE

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The number of deaths associated with cardiovascular disease remains high, despite great advances in treating the associated high levels of cholesterol. The main underlying pathology of cardiovascular disease is atherosclerosis, which is recognized as a chronic autoimmune-like inflammatory disease. Hen...

journal_title：Current opinion in lipidology

authors： Douna H,Kuiper J

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The effects of hormone-replacement therapy on cardiovascular risk factors are examined. In an attempt to explain the results of recent randomized controlled trials in which no benefit of hormone-replacement therapy for postmenopausal women has been observed, RECENT FINDINGS:Changes in lipoproteins in...

journal_title：Current opinion in lipidology

authors： Seed M,Knopp RH

更新日期：2004-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic approaches to lowering Lp(a). RECENT FINDINGS:Recent large-scale meta-analyses have confirmed elevate...

journal_title：Current opinion in lipidology

authors： Dubé JB,Boffa MB,Hegele RA,Koschinsky ML

更新日期：2012-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Accumulating evidence has provided new insights regarding potentially effective therapeutic options targeting modulation of HDL metabolism, resulting in the prevention of cardiovascular diseases. The gut microbiota has now been convincingly linked to host health, but its impact on host lipid metabolis...

journal_title：Current opinion in lipidology

authors： Nakaya K,Ikewaki K

更新日期：2018-02-01 00:00:00

abstract：:Further understanding of the causative link between plasma lipids and coronary heart disease will come from a deeper appreciation of the impact of lipoprotein heterogeneity on the processes of atherosclerosis and thrombosis. It is now widely appreciated that remnants of triglyceride-rich lipoproteins, IDL and specific...

journal_title：Current opinion in lipidology

authors： Packard CJ

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study was to provide valuable information on the ability of fibrates to reduce cardiovascular risk in type 2 diabetes. The purpose of this review is to analyse results from FIELD and to see whether they may lead to modify t...

journal_title：Current opinion in lipidology

authors： Vergès B

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...

journal_title：Current opinion in lipidology

authors： Fruchart JC,Santos RD

更新日期：2019-12-01 00:00:00

abstract：:Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholester...

journal_title：Current opinion in lipidology

authors： Leroy A,Dallongeville J,Fruchart JC

更新日期：1995-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the fact that regional differences in the normal arterial intima are critical to atherosclerotic lesion formation driven by systemic risk factors. RECENT FINDINGS:At arterial curvatures, bifurcations and branches unique hemodynamics influence endothelial cell signaling and gene expressio...

journal_title：Current opinion in lipidology

authors： Cybulsky MI,Jongstra-Bilen J

更新日期：2010-10-01 00:00:00

abstract：:Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly ABC1). Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A...

journal_title：Current opinion in lipidology

authors： Oram JF,Vaughan AM

更新日期：2000-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The new risk-based guidelines on blood cholesterol treatment from the American College of Cardiology and the American Heart Association reflect the now widespread international agreement that lipid-lowering treatment decisions should be based primarily on individuals' predicted cardiovascular disease ...

journal_title：Current opinion in lipidology

authors： Jackson R

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review addresses a syndrome of dyslipidemia and lipodystrophy that has emerged in HIV-infected patients receiving highly active antiretroviral therapy (HAART). The term 'HIV/HAART associated dyslipidemic lipodystrophy (HADL)' describes this syndrome. Although HAART increases patient survival rate...

journal_title：Current opinion in lipidology

authors： Balasubramanyam A,Sekhar RV,Jahoor F,Jones PH,Pownall HJ

更新日期：2004-02-01 00:00:00

abstract：:The recent discovery of a second estrogen receptor subtype, estrogen receptor-beta, may significantly advance our understanding of tissue specific effects of estrogenic compounds, both natural and synthetic. Although specific effects mediated by estrogen receptor beta in vivo remain to be elucidated, hypothetically th...

journal_title：Current opinion in lipidology

authors： Cassidy A

更新日期：1999-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Genetic LCAT deficiency is a rare metabolic disorder characterized by low-plasma HDL cholesterol levels. Clinical manifestations of the disease include corneal opacification, anemia, and renal disease, which represents the major cause of morbidity and mortality in carriers. RECENT FINDINGS:Biochemica...

journal_title：Current opinion in lipidology

authors： Pavanello C,Calabresi L

更新日期：2020-08-01 00:00:00

abstract：:Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gene on human chromosome 18, which is the major disease locus. Analysis ...

journal_title：Current opinion in lipidology

authors： Liscum L,Klansek JJ

更新日期：1998-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease (CVD) and calcific aortic valve stenosis. We review recent studies that highlight Lp(a) in CVD and calcific aortic valve stenosis and propose pathways to clinical registration of Lp(a)-lowering agents. RECENT FINDINGS:Over the last fe...

journal_title：Current opinion in lipidology

authors： Hung MY,Tsimikas S

更新日期：2014-12-01 00:00:00

abstract：:Somatic gene therapy for the treatment of dyslipidemia is an area of active investigation. A substantial body of data indicates that the transfer of various lipid-lowering genes to the liver is an effective method of restoring normal plasma lipids in animal models of dyslipidemia. Most studies have used adenoviral vec...

journal_title：Current opinion in lipidology

authors： Oka K,Davis AR,Chan L

更新日期：2000-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Phospholipids are major constituents in the intestinal lumen after meal consumption. This article highlights current literature suggesting the contributory role of intestinal phospholipid metabolism toward cardiometabolic disease manifestation. RECENT FINDINGS:Group 1b phospholipase A2 (PLA2g1b) cata...

journal_title：Current opinion in lipidology

authors： Hui DY

更新日期：2016-10-01 00:00:00

abstract：:Common variants at the apolipoprotein B gene locus are associated with hyperlipidaemia, but conflicting data have been presented in the literature concerning the size of the effects and which polymorphisms give the best signal in the different groups of individuals studied. In this review, we will present a critique o...

journal_title：Current opinion in lipidology

authors： Humphries SE,Talmud PJ

更新日期：1995-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Unregulated uptake of oxidized LDL by macrophages to form foam cells is the hallmark for atherosclerosis. The paraoxonase (PON) family of enzymes plays a critical role in attenuating atherosclerotic lesion formation by hydrolyzing lipid peroxides (LOOHs) and preventing the oxidation of LDL particles a...

journal_title：Current opinion in lipidology

authors： White CR,Anantharamaiah GM

更新日期：2017-10-01 00:00:00

abstract：:The protective effect of HDL against the development of atherosclerosis appears to be multifaceted involving a number of mechanisms. One of the major mechanisms is, however, the ability of HDL to decrease, directly or indirectly, the lipid peroxidation of LDL. The hydrolysis of lipid peroxides by PON1 makes a major co...

journal_title：Current opinion in lipidology

authors： Mackness MI,Durrington PN,Mackness B

更新日期：2000-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Dietary and blood carotenoids, including alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and beta-cryptoxanthin, have been examined in a number of epidemiological studies in recent years for the risk of cardiovascular disease. This review assimilated the existing and recent literature on c...

journal_title：Current opinion in lipidology

authors： Sesso HD

更新日期：2006-02-01 00:00:00