Niemann-Pick disease type C.

abstract：:Conjugated linoleic acid is a collective name for mixtures of several positional and geometric conjugated dienoic isomers of linoleic acid, which have been shown to impact favorably on several biological processes, particularly carcinogenesis. Recent studies have clearly established that the c9, t11 and t10, c12 isome...

journal_title：Current opinion in lipidology

authors： Khosla P,Fungwe TV

更新日期：2001-02-01 00:00:00

abstract：:Somatic gene therapy for the treatment of dyslipidemia is an area of active investigation. A substantial body of data indicates that the transfer of various lipid-lowering genes to the liver is an effective method of restoring normal plasma lipids in animal models of dyslipidemia. Most studies have used adenoviral vec...

journal_title：Current opinion in lipidology

authors： Oka K,Davis AR,Chan L

更新日期：2000-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD). RECENT FINDINGS:Experimental models highlight several mechanisms connecting gut microbiota to host energy metabolism: ...

journal_title：Current opinion in lipidology

authors： Musso G,Gambino R,Cassader M

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Brown adipose tissue (BAT) is an emerging target to combat cardiometabolic disorders as it can take up substantial amounts of glucose and lipids from the circulation for heat production. This review focuses on new concepts in BAT physiology and discusses the need for new techniques to determine BAT ac...

journal_title：Current opinion in lipidology

authors： Schilperoort M,Hoeke G,Kooijman S,Rensen PC

更新日期：2016-06-01 00:00:00

abstract：:Further understanding of the causative link between plasma lipids and coronary heart disease will come from a deeper appreciation of the impact of lipoprotein heterogeneity on the processes of atherosclerosis and thrombosis. It is now widely appreciated that remnants of triglyceride-rich lipoproteins, IDL and specific...

journal_title：Current opinion in lipidology

authors： Packard CJ

更新日期：1999-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Nutrition recommendations emphasize that not only dietary fat quantity but also fat quality plays a role in the prevention of type 2 diabetes (T2D). The aim of this review is to summarize the evidence for dietary fat and risk of T2D, to highlight recent findings and point out future research direction...

journal_title：Current opinion in lipidology

authors： Schlesinger S,Schwingshackl L,Neuenschwander M

更新日期：2019-02-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：:Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly ABC1). Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by a rapid turnover of plasma apolipoprotein A...

journal_title：Current opinion in lipidology

authors： Oram JF,Vaughan AM

更新日期：2000-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The science and policy of functional foods are a matter of global concern and this review provides up-to-date information about the Japanese 'food for specified health use' policy based on functional food science. RECENT FINDINGS:A great many studies on nonnutritive but physiologically functional foo...

journal_title：Current opinion in lipidology

authors： Arai S,Yasuoka A,Abe K

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Dyslipidaemias are a major risk factor for cardiovascular disease (CVD); in particular, high levels of low-density lipoprotein cholesterol (LDL-C) have been associated to a higher cardiovascular risk. Reducing LDL-C levels decreases the risk of coronary heart disease (CHD), and the greater the LDL-C r...

journal_title：Current opinion in lipidology

authors： Pirillo A,Norata GD,Catapano AL

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Epidemiological and clinical studies link low levels of HDL cholesterol (HDL-C) with increased risk of atherosclerotic cardiovascular disease (CVD). However, genetic polymorphisms linked to HDL-C do not associate consistently with CVD risk, and randomized clinical studies of drugs that elevate HDL-C v...

journal_title：Current opinion in lipidology

authors： Ronsein GE,Heinecke JW

更新日期：2017-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Hepatic steatosis is a leading cause of adult and paediatric liver disease and is inextricably linked to obesity, insulin resistance and cardiovascular disease. Here we summarize our current understanding of the role of the patatin-like phospholipase domain-containing 3 gene (PNPLA3) in hepatic steato...

journal_title：Current opinion in lipidology

authors： Romeo S,Huang-Doran I,Baroni MG,Kotronen A

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and contributes to a high modifiable residual cardiovascula...

journal_title：Current opinion in lipidology

authors： Fruchart JC,Santos RD

更新日期：2019-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Atherosclerosis is a chronic inflammatory disease in which subendothelial infiltration of lipoproteins leads to inflamed lesions in arteries. Despite improvements in secondary prevention, most cardiovascular events cannot be avoided with current therapies. This review focuses on novel mechanistic insi...

journal_title：Current opinion in lipidology

authors： Gisterå A,Ketelhuth DFJ

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In the last 2 years, significant advances in the understanding of HDL particle structure and the associations between particle structure, function, and atherosclerosis have been made. We will review and provide clinical and epidemiological context to these recent advances. RECENT FINDINGS:Several rec...

journal_title：Current opinion in lipidology

authors： Wilkins JT,Seckler HS

更新日期：2019-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The current review considers what we have learnt from the clinical outcome trials with the cetrapibs; the inhibitors of cholesteryl ester transfer protein that increase HDL cholesterol levels; torcetrapib, dalcetrapib, evacetrapib and anacetrapib. RECENT FINDINGS:Although an off-target increase in bl...

journal_title：Current opinion in lipidology

authors： Doggrell SA

更新日期：2018-08-01 00:00:00

abstract：:Expression profiling and genomic DNA sequence comparisons are increasingly being applied to the identification and analysis of the genes that are involved in lipid metabolism. Not only has genome-wide expression profiling aided in the identification of novel genes that are involved in important processes in lipid meta...

journal_title：Current opinion in lipidology

authors： Callow MJ,Rubin EM

更新日期：2002-04-01 00:00:00

abstract：PURPOSE OF REVIEW:It is increasingly recognized that profound metabolic changes occur in activated myeloid cells, which shape their inflammatory phenotype and cellular functions. The purpose of this review is to summarize the accumulating evidence that major metabolic adaptations occur in monocytes and macrophages in t...

journal_title：Current opinion in lipidology

authors： Riksen NP,Stienstra R

更新日期：2018-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The interest for the human HDL system was recently revived by the identification of the ABCA1 as a critical component in the formation and maintenance of plasma HDL levels. The present review focuses on recent progress in our understanding of the basic mechanisms underlying HDL biogenesis pathways. R...

journal_title：Current opinion in lipidology

authors： Krimbou L,Marcil M,Genest J

更新日期：2006-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Control of vascular smooth muscle cell (VSMC) phenotype is essential in the development and maintenance of a healthy vasculature. Acquisition of a synthetic, proproliferative phenotype by VSMCs following vascular insult is central to neointimal formation and the development of vascular pathology. Micr...

journal_title：Current opinion in lipidology

authors： Robinson HC,Baker AH

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall. RECENT FINDINGS:Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the...

journal_title：Current opinion in lipidology

authors： Herz J,Hui DY

更新日期：2004-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review covers recent developments in microarray studies in the field of atherogenesis research. RECENT FINDINGS:During the past year microarrays have been applied to the analysis of pathogenic mechanisms of several atherosclerosis risk factors, including ageing, hypertension, obesity, and cytome...

journal_title：Current opinion in lipidology

authors： Tuomisto TT,Ylä-Herttuala S

更新日期：2005-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic consumption of fructose and fructose-containing sugars leads to dyslipidemia. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose consumption on apoCIII levels and the role of apoCIII in fru...

journal_title：Current opinion in lipidology

authors： Hieronimus B,Stanhope KL

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Most LDL-lowering trials are limited in duration while the disease process occurs over decades. It is informative, therefore, to evaluate the long-term effects of treatment by undertaking extended observation beyond the formal double-blind phase of intervention studies. The current review brings toget...

journal_title：Current opinion in lipidology

authors： Packard CJ,Ford I

更新日期：2015-12-01 00:00:00

abstract：:Thia substituted fatty acids are saturated fatty acids which are modified by insertion of a sulfur atom at specific positions in the carbon backbone. During the last few years pleiotropic effects of the 3-thia fatty acid tetradecylthioacetic acid have been revealed. The biological responses to tetradecylthioacetic aci...

journal_title：Current opinion in lipidology

authors： Berge RK,Skorve J,Tronstad KJ,Berge K,Gudbrandsen OA,Grav H

更新日期：2002-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent advances in eicosanoid biology, especially linked to the cytochrome P450 (CYP)/soluble epoxide hydrolase (sEH) axis in vascular biology and disease. RECENT FINDINGS:Since the first reports that CYP-derived metabolites of arachidonic acid can elicit vascular smooth muscle...

journal_title：Current opinion in lipidology

authors： Fleming I

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...

journal_title：Current opinion in lipidology

authors： Preiss D,Sattar N

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The systematic analysis of the major candidate genes in autosomal dominant hypercholesterolemia (ADH) and the use of next-generation sequencing (NGS) technology have made possible the discovery of several rare gene variants whose pathogenic effect in most cases remains poorly defined. RECENT FINDINGS...

journal_title：Current opinion in lipidology

authors： Calandra S,Tarugi P,Bertolini S

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The review presents recent developments in the identification of specialized proresolving mediators (SPMs) of inflammation following supplementation with n-3 fatty acids in humans. RECENT FINDINGS:A number of reports have measured SPMs in human plasma after n-3 fatty acid supplementation. Although st...

journal_title：Current opinion in lipidology

authors： Barden AE,Mas E,Mori TA

更新日期：2016-02-01 00:00:00