Dietary fat and risk of type 2 diabetes.

abstract：:Conjugated linoleic acid is a collective name for mixtures of several positional and geometric conjugated dienoic isomers of linoleic acid, which have been shown to impact favorably on several biological processes, particularly carcinogenesis. Recent studies have clearly established that the c9, t11 and t10, c12 isome...

journal_title：Current opinion in lipidology

authors： Khosla P,Fungwe TV

更新日期：2001-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Use of suitable animal models is essential for investigation of the mechanisms underlying cardiac events and development of the therapeutic strategies; however, ideal animal models that can recapitulate human coronary atherosclerosis and subsequent acute myocardial infarction are still lacking. In thi...

journal_title：Current opinion in lipidology

authors： Shiomi M,Fan J

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Metabolomics is emerging as a powerful tool for studying metabolic processes and in recent years, the applications in the area of nutrition have risen rapidly. The present review gives an overview of the current applications in the field of nutrition and identifies areas in need of advancement. RECEN...

journal_title：Current opinion in lipidology

authors： Gibbons H,O'Gorman A,Brennan L

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Adipose tissue is an essential, highly dynamic and metabolically active tissue that vigorously communicates to support its primary function: the storage of lipids. It performs this function to secure energy supply and prevent lipotoxicity. Adipose tissue is essential for maintaining a healthy glucose ...

journal_title：Current opinion in lipidology

authors： Keijer J,van Schothorst EM

更新日期：2008-02-01 00:00:00

abstract：:The plasminogen and coagulation systems have been extensively characterized at the biochemical level. Recent gene targeting and gene transfer studies have provided novel insights into their role in the formation of blood vessels and in the pathogenesis of blood vessel disorders including thrombosis, restenosis and ath...

journal_title：Current opinion in lipidology

authors： Carmeliet P,Collen D

更新日期：1997-04-01 00:00:00

abstract：:Antithrombotic therapy has assumed a central role in the therapy of the acute coronary syndromes and chronic coronary artery disease. The theoretical rationale for antithrombotic therapy, and the established and evolving roles of antiplatelet agents and anticoagulants in coronary disease are reviewed. Emphasis is focu...

journal_title：Current opinion in lipidology

authors： Di Salvo TG,Fuster V

更新日期：1994-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Mesenchymal stem cells (or multipotent stromal cells) are emerging as a potent cell type for cardiac cell therapy. This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics. RECENT FI...

journal_title：Current opinion in lipidology

authors： Atsma DE,Fibbe WE,Rabelink TJ

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant nu...

journal_title：Current opinion in lipidology

authors： Chaabane C,Coen M,Bochaton-Piallat ML

更新日期：2014-10-01 00:00:00

abstract：:The inhibiting effect of insulin on the mobilization of free fatty acids (FFA) from adipose tissue is halted in prevalent conditions with systemic insulin resistance. The nature and cause of this perturbation are unknown, but steroid hormones may be involved. The consequence is the creation or amplification of insulin...

journal_title：Current opinion in lipidology

authors： Björntorp P

更新日期：1994-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. RECENT FINDI...

journal_title：Current opinion in lipidology

authors： Kromhout D,de Goede J

更新日期：2014-02-01 00:00:00

abstract：:The menopause and its biology are as yet still incompletely understood. Very little is known about biological and molecular changes in cardiovascular target tissues and organs after menopause. Experimental and clinical evidence indicate that prevention of cardiovascular disease by estrogens is aimed both at the correc...

journal_title：Current opinion in lipidology

authors： Soma MR,Baetta R,Crosignani P

更新日期：1997-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The metabolic syndrome has become a leading health concern in developed countries. In the search for strategies to combat this growing problem, stearoyl-CoA desaturase 1 (SCD1) inhibition has been proposed as an attractive therapeutic strategy. However, recent studies warn of potentially harmful conse...

journal_title：Current opinion in lipidology

authors： Brown JM,Rudel LL

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...

journal_title：Current opinion in lipidology

authors： Chan DC,Barrett PH,Watts GF

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Several mutations in the apolipoprotein (apo) B, proprotein convertase subtilisin kexin 9 (PCSK9) and microsomal triglyceride transfer protein genes result in low or absent levels of apoB and LDL cholesterol (LDL-C) in plasma which cause familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia...

journal_title：Current opinion in lipidology

authors： Welty FK

更新日期：2020-04-01 00:00:00

abstract：:The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through whi...

journal_title：Current opinion in lipidology

authors： Osada J,Joven J,Maeda N

更新日期：2000-02-01 00:00:00

abstract：:Apolipoprotein A-I-containing lipoproteins represent a heterogeneous group of lipoparticles. Recent studies suggest that a specific subpopulation within the lipoprotein (AI) subclass may be more effective than other lipoproteins in promoting cholesterol efflux from cells and in the different steps of reverse cholester...

journal_title：Current opinion in lipidology

authors： Leroy A,Dallongeville J,Fruchart JC

更新日期：1995-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The metabolic syndrome has been emphasized as affecting an important subset of individuals at high risk for cardiovascular disease leading the National Cholesterol Educational Program Adult Treatment Panel III in highlighting awareness of insulin-resistance syndrome. Insulin resistance is thought to b...

journal_title：Current opinion in lipidology

authors： Perseghin G

更新日期：2005-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The association of dietary intake and fatty liver disease (FLD) is of importance for disease prevention. Dietary pattern analysis enables the investigation of overall diet and permits to take interactions and cumulative effects of dietary components into account. This review summarizes recent findings...

journal_title：Current opinion in lipidology

authors： Koch M,Nöthlings U,Lieb W

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concent...

journal_title：Current opinion in lipidology

authors： Seidah NG,Chrétien M,Mbikay M

更新日期：2018-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Statins are the most prescribed medications worldwide with a proven ability to reduce major cardiovascular events. Recent data have revealed that statin therapy is associated with an increased risk for developing diabetes. We discuss the relevant data including newly published results, which demonstra...

journal_title：Current opinion in lipidology

authors： Preiss D,Sattar N

更新日期：2011-12-01 00:00:00

abstract：:The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially pr...

journal_title：Current opinion in lipidology

authors： Tacken PJ,Hofker MH,Havekes LM,van Dijk KW

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The new risk-based guidelines on blood cholesterol treatment from the American College of Cardiology and the American Heart Association reflect the now widespread international agreement that lipid-lowering treatment decisions should be based primarily on individuals' predicted cardiovascular disease ...

journal_title：Current opinion in lipidology

authors： Jackson R

更新日期：2014-08-01 00:00:00

abstract：:The present review summarizes recent advances in the transcriptional regulation of the human apolipoprotein genes, focusing mostly, but not exclusively, on in-vivo studies and signaling mechanisms that affect apolipoprotein gene transcription. An attempt is made to explain how interactions of transcription factors tha...

journal_title：Current opinion in lipidology

authors： Zannis VI,Kan HY,Kritis A,Zanni EE,Kardassis D

更新日期：2001-04-01 00:00:00

abstract：PURPOSE OF REVIEW:It is well recognized that adipose tissue in obesity is characterized by macrophage accumulation and local inflammation. This review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual, systemic inflammation and its potential link to atherosclerosis. RECENT ...

journal_title：Current opinion in lipidology

authors： Subramanian S,Chait A

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide an update on the most recent and relevant findings in the area of genotype-phenotype associations as well as the relationships between genetic factors and cardiovascular disease risk markers and events. In addition, emphasis will be placed on the methodological pr...

journal_title：Current opinion in lipidology

authors： Visvikis-Siest S,Marteau JB

更新日期：2006-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides recent insights on the early onset of atherosclerosis in heterozygous familial hypercholesterolemia and reports on novel treatment options as well as on the consequences of long-term statin use in childhood. RECENT FINDINGS:Children with familial hypercholesterolemia have greate...

journal_title：Current opinion in lipidology

authors： Braamskamp MJ,Hutten BA,Wiegman A

更新日期：2015-06-01 00:00:00

abstract：:Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction. The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the...

journal_title：Current opinion in lipidology

authors： de Graaf J,Stalenhoef AF

更新日期：1998-06-01 00:00:00

abstract：:New insights into the endothelium as a dynamic, interactive organ have generated increased interest in endothelial cell transcriptional regulation. Peroxisomal proliferator-activated receptors (PPARs), as ligand-activated nuclear receptors expressed in endothelial cells, represent one important pathway that likely inf...

journal_title：Current opinion in lipidology

authors： Plutzky J

更新日期：2001-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, ...

journal_title：Current opinion in lipidology

authors： Schattenberg JM,Schuppan D

更新日期：2011-12-01 00:00:00

abstract：:PURPOSE OF REVIEW This review discusses recent progress in the role of ATP-binding cassette proteins ABCG5 and G8 in dietary sterol absorption, excretion and pathogenesis of cardiovascular disease. RECENT FINDINGS Identification of the genetic defect(s) underlying sitosterolemia has led to a renewed interest in the me...

journal_title：Current opinion in lipidology

authors： Klett EL,Patel S

更新日期：2003-08-01 00:00:00