Dietary patterns and fatty liver disease.

abstract：PURPOSE OF REVIEW:Remnant lipoproteins that persist in the bloodstream after each meal have become increasingly important contributors to atherosclerotic vascular disease, owing to the spread of overnutrition, underexertion, obesity, insulin resistance, and type 2 diabetes. Here, we review recent work that clarified lo...

journal_title：Current opinion in lipidology

authors： Williams KJ,Chen K

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the role of the microRNA-30c (miR-30c) in lipid metabolism and adipogenesis, to address consequences associated with reduced expression in cancer and cardiac function, and to speculate benefits of overexpressing miR-30c in the treatment of hyperlipidemia, atherosclerosis, and cancer. REC...

journal_title：Current opinion in lipidology

authors： Irani S,Hussain MM

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study was to provide valuable information on the ability of fibrates to reduce cardiovascular risk in type 2 diabetes. The purpose of this review is to analyse results from FIELD and to see whether they may lead to modify t...

journal_title：Current opinion in lipidology

authors： Vergès B

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Proprotein convertase subtilisin kexin type 9 (PCSK9) acts as an endogenous natural inhibitor of the LDL receptor pathway, by targeting the receptor to lysosomes for degradation. Beside the liver, PCSK9 is also expressed at significant levels in other tissues, where its function remains unclear. The c...

journal_title：Current opinion in lipidology

authors： Cariou B,Si-Tayeb K,Le May C

更新日期：2015-06-01 00:00:00

abstract：:The microsomal triglyceride transfer protein is necessary for the assembly and secretion of lipoproteins containing apolipoprotein B. During the past year, significant progress has been made towards understanding the role of microsomal triglyceride transfer protein in lipoprotein assembly at both a cellular and molecu...

journal_title：Current opinion in lipidology

authors： Gordon DA

更新日期：1997-06-01 00:00:00

abstract：:Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by...

journal_title：Current opinion in lipidology

authors： Ylä-Herttuala S

更新日期：1998-08-01 00:00:00

abstract：:A site-specific cytidine deamination (cytidine to uridine) in nuclear apolipoprotein B messenger RNA creates a translational stop codon that produces apolipoprotein B48. This process is mediated by an enzyme composed of distinct subunits, including apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-1 ...

journal_title：Current opinion in lipidology

authors： Davidson NO,Anant S,MacGinnitie AJ

更新日期：1995-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Capsaicin and its nonpungent analog (capsinoids) are known to be food ingredients that increase energy expenditure and decrease body fat. This article reviews the role of brown adipose tissue (BAT) for the thermogenic effect of these compounds in humans and proposes the possibility of some other antio...

journal_title：Current opinion in lipidology

authors： Saito M,Yoneshiro T

更新日期：2013-02-01 00:00:00

abstract：:Apolipoprotein E has key functions in lipoprotein metabolism, and polymorphisms in the apolipoprotein E gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apolipoprotein E has been addressed in many studies. Although results have generally been mixed, the indicati...

journal_title：Current opinion in lipidology

authors： Rubin J,Berglund L

更新日期：2002-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This article provides recent insights on the early onset of atherosclerosis in heterozygous familial hypercholesterolemia and reports on novel treatment options as well as on the consequences of long-term statin use in childhood. RECENT FINDINGS:Children with familial hypercholesterolemia have greate...

journal_title：Current opinion in lipidology

authors： Braamskamp MJ,Hutten BA,Wiegman A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Because human genetic studies and large clinical trials have demonstrated that HDL-cholesterol levels are not causally related to cardiovascular disease risk, attention has shifted toward the functional properties of HDL. Infusion of HDL mimetics containing apolipoprotein A-I remains a potential strat...

journal_title：Current opinion in lipidology

authors： Zheng KH,Stroes ES

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The article reviews the challenges facing cardiovascular disease (CVD) guidelines committees. RECENT FINDINGS:Clinical trials in high-risk populations have shown additional CVD event reduction with ezetimibe and proprotein convertase subtilisin-kexin-9 inhibitors. These trials recruit middle-aged sec...

journal_title：Current opinion in lipidology

authors： Wierzbicki AS

更新日期：2017-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides a concise update of the involvement of endothelial adhesion molecules in atherogenesis, an overview of current advances in the development of adhesion molecule blocking agents, as well as an insight into the potential of these molecules in cardiovascular therapy. RECENT FINDINGS:...

journal_title：Current opinion in lipidology

authors： Lutters BC,Leeuwenburgh MA,Appeldoorn CC,Molenaar TJ,Van Berkel TJ,Biessen EA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Response to statin treatment can vary widely from person to person as a result of inherited traits (genotype) and acquired characteristics such as obesity (phenotype). The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to exp...

journal_title：Current opinion in lipidology

authors： Caslake MJ,Packard CJ

更新日期：2004-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Control of vascular smooth muscle cell (VSMC) phenotype is essential in the development and maintenance of a healthy vasculature. Acquisition of a synthetic, proproliferative phenotype by VSMCs following vascular insult is central to neointimal formation and the development of vascular pathology. Micr...

journal_title：Current opinion in lipidology

authors： Robinson HC,Baker AH

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings suggesting that cannabinoid receptors are potential targets for the treatment of atherosclerosis are reviewed. RECENT FINDINGS:Cannabinoids, such as Delta9-tetrahydrocannabinol, the major psychoactive compound of marijuana, their synthetic analogs and endogenous cannabinoid ligands, p...

journal_title：Current opinion in lipidology

authors： Steffens S,Mach F

更新日期：2006-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite their pathophysiological importance, the molecular mechanisms and enzymatic components of lipid mobilization from intracellular storage compartments are insufficiently understood. The aim of this review is to evaluate the role of hormone-sensitive lipase in this process. RECENT FINDINGS:Hormo...

journal_title：Current opinion in lipidology

authors： Haemmerle G,Zimmermann R,Zechner R

更新日期：2003-06-01 00:00:00

abstract：PURPOSE OF REVIEW:It is increasingly recognized that profound metabolic changes occur in activated myeloid cells, which shape their inflammatory phenotype and cellular functions. The purpose of this review is to summarize the accumulating evidence that major metabolic adaptations occur in monocytes and macrophages in t...

journal_title：Current opinion in lipidology

authors： Riksen NP,Stienstra R

更新日期：2018-10-01 00:00:00

abstract：:Antithrombotic therapy has assumed a central role in the therapy of the acute coronary syndromes and chronic coronary artery disease. The theoretical rationale for antithrombotic therapy, and the established and evolving roles of antiplatelet agents and anticoagulants in coronary disease are reviewed. Emphasis is focu...

journal_title：Current opinion in lipidology

authors： Di Salvo TG,Fuster V

更新日期：1994-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Homozygous familial hypercholesterolemia (HoFH) is a rare disorder associated with early atherosclerotic disease due to impairment of the LDL receptor (LDLR) pathway. Because of their molecular defect, current treatment options have limited success in bringing HoFH patient to LDL-C target and morbidit...

journal_title：Current opinion in lipidology

authors： Bajaj A,Cuchel M

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic consumption of fructose and fructose-containing sugars leads to dyslipidemia. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose consumption on apoCIII levels and the role of apoCIII in fru...

journal_title：Current opinion in lipidology

authors： Hieronimus B,Stanhope KL

更新日期：2020-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Randomized clinical trials provide strong evidence that pharmacological elevation of HDL-cholesterol (HDL-C) fails to reduce cardiovascular disease (CVD) risk in statin-treated humans. It is thus critical to identify new metrics that capture HDL's cardioprotective effects. RECENT FINDINGS:We review r...

journal_title：Current opinion in lipidology

authors： Hutchins PM,Heinecke JW

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Fibrates continue to be a viable treatment option for mixed atherogenic dyslipidemia, and recent reports from clinical studies have shed new light on the therapeutic utility of fibrates for the prevention of microvascular and macrovascular disease, especially in combination with statins. RECENT FINDI...

journal_title：Current opinion in lipidology

authors： Saha SA,Arora RR

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Cardiovascular risk scoring is incorporated in guidelines and recommended for targeting preventive treatment. Evidence is required on the most appropriate method, its accuracy in a given population, and its effectiveness in favourably influencing clinical behaviour and health outcomes. RECENT FINDING...

journal_title：Current opinion in lipidology

authors： Beswick A,Brindle P

更新日期：2006-08-01 00:00:00

abstract：PURPOSE OF REVIEW:It is well accepted that LDLs and its modified form oxidized-LDL (ox-LDL) play a major role in the development of atherosclerosis and foam cell formation. Whereas the majority of these cells have been demonstrated to be derived from macrophages, smooth muscle cells (SMCs) give rise to a significant nu...

journal_title：Current opinion in lipidology

authors： Chaabane C,Coen M,Bochaton-Piallat ML

更新日期：2014-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Dysregulated lipoprotein metabolism leads to increased plasma concentrations of atherogenic lipoproteins. We highlight the findings from recent studies of the effect of lipid-regulating therapies on apolipoprotein metabolism in humans employing endogenous labelling with stable isotopically labelled is...

journal_title：Current opinion in lipidology

authors： Chan DC,Barrett PH,Watts GF

更新日期：2016-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Sortilin, encoded SORT1 gene at chromosome 1p13.3, is a multiligand receptor that traffics protein from the Golgi to the endosomes, secretory vesicles, and the cell surface. Genome-wide association studies (GWAS) revealed an association between sortilin and reduced plasma LDL-cholesterol (LDL-C) as we...

journal_title：Current opinion in lipidology

authors： Conlon DM

更新日期：2019-06-01 00:00:00

abstract：PURPOSE OF REVIEW:mAbs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have the potential to become groundbreaking therapies for the treatment of hypercholesterolemia. However, one major drawback of mAb-based therapy for a chronic condition like dyslipidemia is its relatively high cost. This review summ...

journal_title：Current opinion in lipidology

authors： Chackerian B,Remaley A

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent advances towards an understanding of the three-dimensional structures of the apolipoprotein components of HDL with a specific focus on high resolution models of apolipoprotein A-I. RECENT FINDINGS:Since the primary sequence was first reported, various models have been advanced for...

journal_title：Current opinion in lipidology

authors： Davidson WS,Silva RA

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Genetic LCAT deficiency is a rare metabolic disorder characterized by low-plasma HDL cholesterol levels. Clinical manifestations of the disease include corneal opacification, anemia, and renal disease, which represents the major cause of morbidity and mortality in carriers. RECENT FINDINGS:Biochemica...

journal_title：Current opinion in lipidology

authors： Pavanello C,Calabresi L

更新日期：2020-08-01 00:00:00